Elena Martinelli

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
  2. ncbi HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
  3. pmc The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20877-82. 2009
  4. pmc R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3746-51. 2006
  5. ncbi HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Virology 345:105-14. 2006
  6. ncbi CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion
    Riccardo Cassiani-Ingoni
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Glia 52:252-8. 2005
  7. ncbi Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells
    Jenny Ahlqvist
    Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Med Virol 78:1542-53. 2006

Collaborators

Detail Information

Publications7

  1. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
    ....
  2. ncbi HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
    ..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
  3. pmc The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20877-82. 2009
    ..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission...
  4. pmc R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3746-51. 2006
    ..Additionally, signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication...
  5. ncbi HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Virology 345:105-14. 2006
    ..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs...
  6. ncbi CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion
    Riccardo Cassiani-Ingoni
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Glia 52:252-8. 2005
    ..These data suggest a mechanism that involves cell-cell fusion by which certain viruses could spread the infection from the periphery to the cells in the nervous system...
  7. ncbi Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells
    Jenny Ahlqvist
    Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Med Virol 78:1542-53. 2006
    ..The HHV-6 variants behave differently in the same type of cells and have different tropisms for astrocytes, supporting the notion that the variants might induce different diseases...