R J Martin

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Location of airway inflammation in asthma and the relationship to circadian change in lung function
    R J Martin
    Department of Medicine, National Jewish Medical and Research Center, Denver CO 80206, USA
    Chronobiol Int 16:623-30. 1999
  2. ncbi request reprint The effects of inhaled interferon gamma in normal human airways
    R J Martin
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Am Rev Respir Dis 148:1677-82. 1993
  3. doi request reprint Inhaled nitric oxide for preterm infants
    William E Truog
    Pediatrics 121:1287-8; author reply 1288-9. 2008
  4. ncbi request reprint Asthma and atypical bacterial infection
    E Rand Sutherland
    National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson St, J220, Denver, CO 80206, USA
    Chest 132:1962-6. 2007
  5. ncbi request reprint A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
    Qun Wu
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1064-72. 2007
  6. ncbi request reprint Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
  7. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
  8. ncbi request reprint Exploring the distal lung: new direction in asthma
    Richard J Martin
    Department of Medicine, National lewish Health, Denver CO 80206, USA
    Isr Med Assoc J 10:846-9. 2008
  9. ncbi request reprint Quality control within the Asthma Clinical Research Network
    R J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Control Clin Trials 22:207S-21S. 2001
  10. ncbi request reprint Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model
    R J Martin
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 24:577-82. 2001

Research Grants

  1. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
  2. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
  3. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007

Detail Information

Publications94

  1. ncbi request reprint Location of airway inflammation in asthma and the relationship to circadian change in lung function
    R J Martin
    Department of Medicine, National Jewish Medical and Research Center, Denver CO 80206, USA
    Chronobiol Int 16:623-30. 1999
    ..Although asthma is considered an airway disease, the location of the inflammatory response may be greater in the alveolar tissue area. If correct, this could alter the therapeutic approach to this disease...
  2. ncbi request reprint The effects of inhaled interferon gamma in normal human airways
    R J Martin
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Am Rev Respir Dis 148:1677-82. 1993
    ..We conclude that, in normal persons, rIFN-gamma can be effectively delivered by inhalation. Future trials using inhaled rIFN-gamma appear to be warranted for certain pulmonary diseases...
  3. doi request reprint Inhaled nitric oxide for preterm infants
    William E Truog
    Pediatrics 121:1287-8; author reply 1288-9. 2008
  4. ncbi request reprint Asthma and atypical bacterial infection
    E Rand Sutherland
    National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson St, J220, Denver, CO 80206, USA
    Chest 132:1962-6. 2007
    ..Current studies will further define the role of macrolide antibiotics in the treatment of stable patients with asthma, ultimately determining whether these therapeutic agents have a place in asthma management...
  5. ncbi request reprint A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
    Qun Wu
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1064-72. 2007
    ..A bacterial infection in asthmatic subjects with weakened TLR2-IFN-gamma signaling may result in an exaggerated airway mucin production...
  6. ncbi request reprint Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
    ..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
  7. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  8. ncbi request reprint Exploring the distal lung: new direction in asthma
    Richard J Martin
    Department of Medicine, National lewish Health, Denver CO 80206, USA
    Isr Med Assoc J 10:846-9. 2008
    ..This review focuses on anatomic airway changes, physiological changes of the distal airways, clinical outcome data, and particle size of inhaled preparations...
  9. ncbi request reprint Quality control within the Asthma Clinical Research Network
    R J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Control Clin Trials 22:207S-21S. 2001
    ..The examples given in this report demonstrate how various aspects of our investigation are performed...
  10. ncbi request reprint Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model
    R J Martin
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 24:577-82. 2001
    ..50, P = 0.022). Thus, M. pneumoniae respiratory infection is associated with BHR in this murine model. It appears that acute mycoplasma infection suppresses IFN-gamma, which may be a pivotal factor in the control of BHR...
  11. ncbi request reprint Interaction between cigarette smoke and mycoplasma infection: a murine model
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    COPD 3:3-8. 2006
    ....
  12. ncbi request reprint Infections and asthma
    Richard J Martin
    National Jewish Medical and Research Center, University of Colorado, 1400 Jackson Street, Office J206, Denver, CO 80206, USA
    Clin Chest Med 27:87-98, vi. 2006
    ..Most recently, studies are also invoking atypical bacterial infections, Mycoplasma pneumoniae and Chlamydia pneumoniae, as factors in both acute exacerbation and chronic asthma...
  13. ncbi request reprint Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD
    R J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 115:1338-45. 1999
    ..Therefore, we investigated whether 4-week treatment with ipratropium bromide inhalation solution 0.02% (qid) could improve sleep characteristics in COPD...
  14. ncbi request reprint Antibiotics in asthma
    David A Beuther
    Division of Pulmonary Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J206, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 4:132-8. 2004
    ....
  15. ncbi request reprint Distal lung dysfunction at night in nocturnal asthma
    M Kraft
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 163:1551-6. 2001
    ..M. (r = 0.71, p = 0.004) and 4:00 A.M. (r = 0.59, p = 0.03). We conclude that the distal lung units, specifically the collateral channels, and may be functionally altered at night in NA...
  16. ncbi request reprint Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma
    M Kraft
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 158:998-1001. 1998
    ..pneumoniae (p = 0.05). M. pneumoniae was present in the lower airways of chronic, stable asthmatics with greater frequency than control subjects, and may play a role in the pathogenesis of chronic asthma...
  17. ncbi request reprint Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
    S E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 156:737-43. 1997
    ..These findings suggest that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids which may be due to the severity of disease, glucocorticoid treatment, or other as yet undefined factors...
  18. ncbi request reprint Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 158:1936-44. 1998
    ..These results suggest that although increased collagen deposition in the SBM at the large airway level is a characteristic of asthma, it may not explain the differences in severity of asthma...
  19. ncbi request reprint Exhaled nitric oxide correlated with induced sputum findings in COPD
    P E Silkoff
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 119:1049-55. 2001
    ..We examined repeated measurements of the fractional concentration of exhaled nitric oxide (FENO) and the correlation with cells and mediators in induced sputum (IS) from patients with COPD...
  20. ncbi request reprint Factors related to the nocturnal worsening of asthma
    R J Martin
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Am Rev Respir Dis 141:33-8. 1990
    ....
  21. ncbi request reprint Effect of lung volume maintenance during sleep in nocturnal asthma
    R J Martin
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206
    J Appl Physiol 75:1467-70. 1993
    ..07 +/- 0.03 vs. 0.04 +/- 0.02 mg/ml, respectively. Thus the fall in lung volume during sleep in the nocturnal asthmatic patient is a result, not a cause, of the overnight worsening of lung function...
  22. ncbi request reprint Evaluation of blood vessels and edema in the airways of asthma patients: regulation with clarithromycin treatment
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 120:416-22. 2001
    ..Clarithromycin treatment in asthmatic patients could reduce the edematous area as identified by alpha(2)-macroglobulin staining, which may lead to airway tissue shrinkage and cause an artificial increase in the number of blood vessels...
  23. ncbi request reprint Serum lidocaine concentrations in asthmatics undergoing research bronchoscopy
    E L Langmack
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 117:1055-60. 2000
    ....
  24. ncbi request reprint Serum cortisol in asthma: marker of nocturnal worsening of symptoms and lung function?
    M Kraft
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine and University of Colorado Health Sciences Center, Denver 80206, USA
    Chronobiol Int 15:85-92. 1998
    ..Therefore, serum levels of cortisol may not be the appropriate measurement to assess the role of cortisol in nocturnal asthma...
  25. ncbi request reprint Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?
    M Kraft
    Departments of Medicine and Pediatrics, National Jewish Medical and Research Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 163:1219-25. 2001
    ..We conclude that the airway macrophage may be the airway inflammatory cell driving the reduction in steroid responsiveness at night in NA, and this function is modulated by IL-13...
  26. pmc A low dose of Mycoplasma pneumoniae infection enhances an established allergic inflammation in mice: the role of the prostaglandin E2 pathway
    Q Wu
    Department of Medicine, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA
    Clin Exp Allergy 39:1754-63. 2009
    ..However, the role of such a low-level Mp infection in the regulation of allergic inflammation remains unknown...
  27. ncbi request reprint A method for the standardized offline collection of exhaled nitric oxide
    P E Silkoff
    Department of Medicine, The National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 116:754-9. 1999
    ..Exhaled nitric oxide (ENO) is a noninvasive marker of airway inflammation. The purpose of this study was to compare a standardized offline ENO measurement apparatus with a validated on-line method...
  28. pmc Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:1328-34.e1. 2009
    ..Although obesity has been hypothesized to worsen asthma, data from studies of subjects with well-characterized asthma are lacking...
  29. pmc Mast cells protect against airway Mycoplasma pneumoniae under allergic conditions
    N M Michels
    National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Exp Allergy 40:1406-13. 2010
    ..Mast cells have previously been shown to promote mycoplasma clearance in mice; however, it is unknown whether mast cells would aid Mp clearance under allergic conditions...
  30. pmc Inhaled corticosteroids reduce the progression of airflow limitation in chronic obstructive pulmonary disease: a meta-analysis
    E R Sutherland
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Thorax 58:937-41. 2003
    ..However, the role of inhaled corticosteroids in the treatment of COPD is controversial. We hypothesised that inhaled corticosteroids reduce the progression of airflow limitation in COPD...
  31. ncbi request reprint Clarithromycin potentiates glucocorticoid responsiveness in patients with asthma: results of a pilot study
    J D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 87:501-5. 2001
    ..Selected macrolide antibiotics have steroid-sparing effects in patients with steroid-dependent asthma. In addition to inhibiting methylprednisolone clearance, macrolides may also display anti-inflammatory effects...
  32. ncbi request reprint Substance P and its receptor neurokinin 1 expression in asthmatic airways
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 106:713-22. 2000
    ..In contrast to substance P, the substance P receptor neurokinin 1 has not been examined at the protein level in asthmatic airways...
  33. ncbi request reprint A link between chronic asthma and chronic infection
    R J Martin
    Department of Medicine, National Jewish Medical and Research Center and The Pulmonary and Critical Care Division, University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
    J Allergy Clin Immunol 107:595-601. 2001
    ..These findings need further delineation but may help us to understand the pathophysiology of asthma and new treatment options...
  34. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
    ..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present...
  35. ncbi request reprint Central effects of endothelin on respiratory output during development
    I A Dreshaj
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol 79:420-7. 1995
    ..These results suggest that endothelin-1 release may cause ventilatory depression mediated through endothelin-A receptors located in the chemosensitive areas of the ventrolateral medulla...
  36. ncbi request reprint Chronobiology and chronotherapy in medicine
    M Kraft
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver, USA
    Dis Mon 41:506-75. 1995
    ..Thus, all biologic functions, from those of the cell, the tissue, the organs, and the entire body, run on a cycle of altering activity and function.(ABSTRACT TRUNCATED AT 400 WORDS)..
  37. ncbi request reprint Safety of sputum induction in moderate-to-severe chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Respir Med 96:482-6. 2002
    ..A protocol for sputum induction which restricts the use of hypertonic saline based on lung function is both safe and effective in subjects with moderate to severe COPD...
  38. doi request reprint Cigarette smoke extract reduces VEGF in primary human airway epithelial cells
    J V Thaikoottathil
    Dept of Medicine, National Jewish Health, Denver, CO, USA
    Eur Respir J 33:835-43. 2009
    ....
  39. ncbi request reprint Current treatment options for asthma in adults
    E M Canham
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO, USA
    Panminerva Med 47:109-22. 2005
    ..This will be particularly true if the cost of the medication is reduced in the future. Asthma control, morbidity, and mortality will improve with a careful and comprehensive medical regimen using the current multiple treatment options...
  40. pmc IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstruction
    A Dakhama
    Department of Pediatrics, National Jewish Health, Denver, CO 80014, USA
    Allergy 68:666-73. 2013
    ..We investigated whether a subset of IL-13-producing BLT1-positive CD8 T lymphocytes are present in asthmatic airways and are associated with impaired lung function...
  41. ncbi request reprint Repeated respiratory Mycoplasma pneumoniae infections in mice: effect of host genetic background
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Microbes Infect 8:1764-72. 2006
    ..Our results suggest that hosts with different genetic background may have different susceptibility to repeated respiratory Mp infections along with inflammatory responses...
  42. ncbi request reprint The effect of telithromycin in acute exacerbations of asthma
    Sebastian L Johnston
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, National Heart and Lung Institute, Imperial College London, United Kingdom
    N Engl J Med 354:1589-600. 2006
    ..We conducted a double-blind, randomized, placebo-controlled study to evaluate the efficacy of telithromycin in patients with acute exacerbations of asthma...
  43. ncbi request reprint Alternatives for measuring endogenous adrenocortical activity in asthmatics treated with inhaled corticosteroids
    Larisa V Buyantseva
    Department of Medicine, Penn State College of Medicine, MC HO41, 500 University Drive, Milton S Hersley Medical Center, Hershey, PA 17033, USA
    Endocr Res 31:245-58. 2005
    ..m. (r = 0.94; 0.93, 0.95); every 2 hours (r = 0. 96; 0.96, 0.97); and every 3 hours (r = 0. 91, 0.91, 0.93). The two-sample alternatives (10 p.m/8 a.m. and 9 p.m/7 a.m.) are accurate, as well as more convenient, economical, and practical...
  44. pmc Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma
    Elena Goleva
    Department of Pediatrics, National Jewish Medical Research Center, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:607-16. 2006
    ..Glucocorticoids (GCs) are highly effective in the treatment of asthma. However, some individuals have GC-insensitive asthma...
  45. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  46. ncbi request reprint Fluticasone propionate plasma concentration and systemic effect: effect of delivery device and duration of administration
    Glenn J Whelan
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:525-30. 2005
    ..Dry powder inhalers (DPIs) generate a larger particle size compared with metered-dose inhalers (MDIs), which affects pulmonary deposition, bioavailability, and subsequent systemic effects of fluticasone propionate (fluticasone)...
  47. ncbi request reprint Targeting the distal lung in asthma: do inhaled corticosteroids treat all areas of inflammation?
    E R Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Treat Respir Med 4:223-9. 2005
    ..Mounting evidence indicates that recognition and treatment of distal lung inflammation may be key components of appropriate asthma pharmacotherapy...
  48. doi request reprint Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages
    Elena Goleva
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:550-9.e3. 2008
    ..The cause of corticosteroid-resistant (CR) asthma is unknown...
  49. ncbi request reprint Short-term mechanical ventilation increases airway reactivity in rat pups
    Sabine C Iben
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Pediatr Res 60:136-40. 2006
    ..This represents a potentially important model to investigate the mechanisms involved in airway hyperreactivity induced by neonatal lung injury...
  50. pmc Airway remodeling and lack of bronchodilator response in steroid-resistant asthma
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 802060, USA
    J Allergy Clin Immunol 120:1065-72. 2007
    ..Steroid-resistant (SR) asthma is characterized by airway inflammation that fails to resolve despite treatment with corticosteroids, raising concerns that resistance to steroid therapy in asthma could lead to airway remodeling...
  51. ncbi request reprint Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 179:3995-4002. 2007
    ....
  52. ncbi request reprint Inhaled nitric oxide in preterm infants undergoing mechanical ventilation
    Roberta A Ballard
    Children s Hospital of Philadelphia, Philadelphia 19104, USA
    N Engl J Med 355:343-53. 2006
    ..In animal models, inhaled nitric oxide improves both gas exchange and lung structural development, but the use of this therapy in infants at risk for bronchopulmonary dysplasia is controversial...
  53. pmc Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  54. pmc IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection
    Qun Wu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Microbes Infect 9:78-86. 2007
    ..These results demonstrate that IL-17/IL-17F production is IL-23-dependent in an acute Mp infection, and contributes to neutrophil recruitment and activity in the lung defense against the infection...
  55. doi request reprint Toll-like receptor 2 down-regulation in established mouse allergic lungs contributes to decreased mycoplasma clearance
    Qun Wu
    National Jewish Medical and Research Center, 1400 Jackson Street, Room A639, Denver, CO 80206, USA
    Am J Respir Crit Care Med 177:720-9. 2008
    ..Objectives: To test whether the established allergic airway inflammation compromises host innate immunity (e.g., Toll-like receptor 2 [TLR2]) to hinder the elimination of Mp from the lungs...
  56. pmc Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress
    Chirag Kariya
    University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Infect Immun 76:4455-62. 2008
    ..These studies suggest that M. pneumoniae infection synergizes with ETS and suppresses the lung's ability to respond appropriately to environmental challenges leading to enhanced oxidative stress...
  57. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  58. ncbi request reprint Inhaled nitric oxide for preterm infants--who benefits?
    Richard J Martin
    N Engl J Med 353:82-4. 2005
  59. ncbi request reprint TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 174:5713-9. 2005
    ..These results clearly demonstrate that respiratory Mp infection increases airway mucin expression, which is dependent on the activation of TLR2 signaling...
  60. ncbi request reprint Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Division of Allergy Clinical Immunology, Department of Pediatrics, Denver, Colorado, USA
    J Pediatr 142:469-75. 2003
    ..Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed...
  61. ncbi request reprint Elevated serum melatonin is associated with the nocturnal worsening of asthma
    E Rand Sutherland
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:513-7. 2003
    ..In vitro studies have shown exogenous melatonin to be pro-inflammatory in asthma, but it is unknown whether endogenous melatonin levels are a controller of airway inflammation in nocturnal asthma...
  62. ncbi request reprint Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids
    Monica Kraft
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 124:42-50. 2003
    ..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)...
  63. ncbi request reprint Altered pituitary-adrenal interaction in nocturnal asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA
    J Allergy Clin Immunol 112:52-7. 2003
    ..Increased airway inflammation at night contributes to the nocturnal worsening of asthma, but the mechanisms regulating circadian variations in airway inflammation are unknown...
  64. ncbi request reprint Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin
    Monica Kraft
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Chest 121:1782-8. 2002
    ..To determine the effect of clarithromycin therapy in patients with asthma...
  65. ncbi request reprint Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-beta 1 in airway epithelial cells by Mycoplasma pneumoniae
    Azzeddine Dakhama
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 29:344-51. 2003
    ..These results suggest that M. pneumoniae infection may contribute to the pathogenesis of chronic asthma at different levels of the airways, by inducing TGF-beta1 in large airways and the chemokine RANTES in small airways...
  66. ncbi request reprint Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis?
    Sebastian L Johnston
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London W2 1PG, UK
    Am J Respir Crit Care Med 172:1078-89. 2005
    ..The possible role of antibacterial therapy in the management of asthma and the need for well-designed studies to investigate this is also discussed...
  67. ncbi request reprint Effects of inhaled fluticasone on bronchial hyperresponsiveness and airway inflammation in Mycoplasma pneumoniae-infected mice
    Hong Wei Chu
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Chest 123:427S. 2003
  68. ncbi request reprint Distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
    Ann Allergy Asthma Immunol 89:119-24; quiz 124-5, 211. 2002
    ..To review the role of distal lung inflammation in asthma...
  69. ncbi request reprint Hygiene hypothesis of asthma: a murine asthma model with Mycoplasma pneumoniae infection
    Hong Wei Chu
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:390S. 2003
  70. pmc Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Infect Immun 71:1520-6. 2003
    ..Our animal models may also provide a new means to understand the role of infection in asthma pathogenesis and give evidence for the asthma hygiene hypothesis...
  71. ncbi request reprint Immunomodulatory effects of melatonin in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Am J Respir Crit Care Med 166:1055-61. 2002
    ..M., suggesting chronic overstimulation in vivo. These results suggest differential immunomodulatory effects of melatonin based on asthma clinical phenotype and may indicate an adverse effect of exogenous melatonin in asthma...
  72. ncbi request reprint Considering therapeutic options in the real world
    Richard J Martin
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 112:S112-5. 2003
    ..Regardless of what treatment regimen a physician chooses to prescribe, the choice of medication depends on many factors, including patient preference, physician comfort with the regimen, and cost...
  73. ncbi request reprint Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colo, USA
    J Allergy Clin Immunol 112:819-27; quiz 828. 2003
    ..The contrasting inflammatory phenotypes of asthma and COPD have important implications for clinical and physiologic manifestations of disease, as well as for therapy...
  74. ncbi request reprint Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  75. ncbi request reprint Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ....
  76. ncbi request reprint Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  77. ncbi request reprint Mycoplasma pneumoniae infection increases airway collagen deposition in a murine model of allergic airway inflammation
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 289:L125-33. 2005
    ..Our results suggest that Mp infections could modulate airway collagen deposition in a murine model of allergic airway inflammation with TGF-beta1 involved in the collagen deposition process...
  78. ncbi request reprint Atypical bacterial pneumonia and asthma risk
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Asthma 41:863-8. 2004
    ..Prospective studies are warranted to more fully evaluate the importance of atypical bacterial pneumonia as an asthma risk factor...
  79. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  80. ncbi request reprint Safety and application of induced sputum analysis in childhood asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:575-82. 2004
    ..The Childhood Asthma Management Program (CAMP) study was designed to evaluate the long-term effects of budesonide and nedocromil compared with placebo in children with mild to moderate asthma across 8 centers...
  81. ncbi request reprint Physiologic correlates of distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 217, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:1046-50. 2004
    ..The distal lung is an important site of inflammation in asthma. Maximal midexpiratory flows and the ratio of maximal:partial flows are purported to reflect distal lung function...
  82. ncbi request reprint Variation in childhood asthma among former preterm infants
    Jonathan Grischkan
    Department of Pediatrics, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    J Pediatr 144:321-6. 2004
    ..Study design Former preterm children (n=251) were identified from a birth cohort. Examinations, including lung function testing, were performed at ages 8 to 11 years. Perinatal exposures were ascertained from neonatal medical records...
  83. ncbi request reprint Inhaled fluticasone propionate reduces concentration of Mycoplasma pneumoniae, inflammation, and bronchial hyperresponsiveness in lungs of mice
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Infect Dis 189:1119-27. 2004
    ..Inhaled corticosteroids are the mainstay of asthma treatment, but their effects on M. pneumoniae and associated airway inflammation and BHR are poorly understood...
  84. ncbi request reprint Therapeutic significance of distal airway inflammation in asthma
    Richard J Martin
    Department of Medicine, Pulmonary Division, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:S447-60. 2002
    ..By extending the delivery of anti-inflammatory medication to the distal lung, the new HFA-based corticosteroids have the potential to treat asthma more effectively and at reduced steroid doses...
  85. ncbi request reprint Pre- and postnatal factors in chronic lung disease: implications for management
    Richard J Martin
    Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Case Western Reserve University School of Medicinem 44106 6010, USA
    Paediatr Respir Rev 5:S235-40. 2004
  86. ncbi request reprint Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma
    David N Pham
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 90:72-8. 2003
    ....
  87. ncbi request reprint Endogenous nitric oxide modulates responses of tissue and airway resistance to vagal stimulation in piglets
    Mohammad Y Khassawneh
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 6010, USA
    J Appl Physiol 93:450-6. 2002
    ..We speculate that activation of the NO/cGMP pathway during cholinergic stimulation plays an important role in modulating peripheral as well as central contractile elements in the developing lung...
  88. ncbi request reprint Nitric oxide and the developing airway
    Robin Steinhorn
    Am J Physiol Lung Cell Mol Physiol 283:L1190-1. 2002
  89. ncbi request reprint Hypothalamic-pituitary-adrenal axis dysfunction during sleep in nocturnal asthma
    E Rand Sutherland
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:405S. 2003
  90. ncbi request reprint Hyperoxic conditions inhibit airway smooth muscle myosin phosphatase in rat pups
    Paul G Smith
    Department of Pediatrics, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Am J Physiol Lung Cell Mol Physiol 292:L68-73. 2007
    ..This mechanism might contribute to increased ASM reactivity seen in bronchopulmonary dysplasia...
  91. ncbi request reprint Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurity
    Carol L Rosen
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6003, USA
    J Pediatr 142:383-9. 2003
    ..To evaluate the extent to which sleep-disordered breathing (SDB) varies with putative demographic and medical risk factors and to estimate the prevalence of undiagnosed SDB...
  92. ncbi request reprint Nitric oxide for preemies--not so fast
    Richard J Martin
    N Engl J Med 349:2157-9. 2003
  93. ncbi request reprint Efficacy of a heat exchanger mask in cold exercise-induced asthma
    David A Beuther
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:1188-93. 2006
    ..To determine the efficacy of a novel mask device in limiting cold air exercise-induced decline in lung function in subjects with a history of exercise-induced asthma (EIA)...
  94. doi request reprint Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants
    William F Malcolm
    Department of Pediatrics Neonatology, Box 3179, Duke University Medical Center, Durham, NC 27710, USA
    Pediatrics 121:22-7. 2008
    ....

Research Grants8

  1. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
    ....
  2. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
    ....
  3. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007
    ..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..