Genomes and Genes
Mary A Marovich
Affiliation: National Institutes of Health
- Human FcγRII cytoplasmic domains differentially influence antibody-mediated dengue virus infectionKobporn Boonnak
Division of Retrovirology, Henry M Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
J Immunol 190:5659-65. 2013....
- Role of dendritic cells in antibody-dependent enhancement of dengue virus infectionKobporn Boonnak
Department of Medicine, Uniformed Services University of the Health Sciences, Division of Retrovirology, Department of Vaccine R and D, Walter Reed Army Institute of Research, 13 Taft Ct, Suite 200, Rockville, MD 20850, USA
J Virol 82:3939-51. 2008..Studying the cellular targets of DV infection and their susceptibility to ADE will aid our understanding of complex disease and contribute to the field of vaccine development...
- Designing the epitope flanking regions for optimal generation of CTL epitopesNicholas J Steers
United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Rockledge, MD 20852, USA
Vaccine 32:3509-16. 2014..These results highlight the importance of flanking regions in promoting efficient antigen processing and presentation. This concept can have important implications in vaccine design and development strategies. ..
- Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infectionKobporn Boonnak
Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20850, USA
J Virol 85:1671-83. 2011..Our data suggest that ADE effects are cell type specific, are influenced by host genetics, and, depending on relative infection rates, may further contribute to the complexity of DV pathogenesis...
- Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimensSilvia Ratto-Kim
United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
PLoS ONE 7:e45840. 2012..This study supports the rationale for testing heterologous prime-boost regimens in humans...
- Differential effects of dengue virus on infected and bystander dendritic cellsDupeh R Palmer
Department of Viral Diseases, Walter Reed Army Institute of Research, Naval Research Center, Silver Spring, Maryland, USA
J Virol 79:2432-9. 2005..Taken together, these results constitute an immune evasion strategy used by DV that directly impairs antigen-presenting cell function by maturation blockade and induction of apoptosis...
- Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applicationsJeffrey R Currier
US Military HIV Research Program MHRP, Rockville, MD, USA
J Transl Med 9:212. 2011..Assessment of potential HIV strain coverage by candidate T cell-based vaccines (whether natural sequence or computationally optimized products) is now a critical component in interpreting candidate vaccine suitability...
- DC-SIGN (CD209) mediates dengue virus infection of human dendritic cellsBoonrat Tassaneetrithep
Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
J Exp Med 197:823-9. 2003..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
- Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoireNicholas J Steers
Henry Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, Maryland 20850, USA
J Virol 85:1541-53. 2011..These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells...