R R Maronpot

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model
    R R Maronpot
    National Institute of Environmental Health Sciences, Laboratory of Experimental Pathology, P O Box 12233, 111 Alexander Drive, Research Triangle Park, NC, USA
    Toxicology 146:149-59. 2000
  2. ncbi Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
  3. ncbi Enhanced histopathology of lymphoid tissues
    R R Maronpot
    National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:631-3. 2006
  4. ncbi Relevance of animal carcinogenesis findings to human cancer predictions and prevention
    R R Maronpot
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:40-8. 2004
  5. ncbi Applications of magnetic resonance microscopy
    Robert R Maronpot
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:42-8. 2004
  6. ncbi A monograph on histomorphologic evaluation of lymphoid organs
    R R Maronpot
    National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:407-8. 2006
  7. ncbi Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies
    J R Hailey
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:602-11. 1998
  8. ncbi High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years
    S Hayashi
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 29:422-9. 2001
  9. ncbi Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains
    T R Devereux
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Mol Carcinog 8:177-85. 1993
  10. ncbi The association between severe nephropathy and pheochromocytoma in the male F344 rat -- the National Toxicology Program experience
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:456-62. 1999

Detail Information

Publications69

  1. ncbi Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model
    R R Maronpot
    National Institute of Environmental Health Sciences, Laboratory of Experimental Pathology, P O Box 12233, 111 Alexander Drive, Research Triangle Park, NC, USA
    Toxicology 146:149-59. 2000
    ..Successful testing of chemicals with less carcinogenic potential may require modifications in study design to include more animals and longer study duration...
  2. ncbi Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
    ..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
  3. ncbi Enhanced histopathology of lymphoid tissues
    R R Maronpot
    National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:631-3. 2006
  4. ncbi Relevance of animal carcinogenesis findings to human cancer predictions and prevention
    R R Maronpot
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:40-8. 2004
    ..Nonetheless public health considerations must take precedence when deciding human safety issues...
  5. ncbi Applications of magnetic resonance microscopy
    Robert R Maronpot
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:42-8. 2004
    ..More specifically, this application is the use of magnetic resonance microscopy (MRM) in conjunction with new staining methodologies that now make MRM routinely available to the widest range of investigators...
  6. ncbi A monograph on histomorphologic evaluation of lymphoid organs
    R R Maronpot
    National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:407-8. 2006
  7. ncbi Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies
    J R Hailey
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:602-11. 1998
    ..hepaticus and that hepatitis may be important in the pathogenesis. Therefore, interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. hepaticus-associated hepatitis...
  8. ncbi High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years
    S Hayashi
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 29:422-9. 2001
    ..major finding of A to T transversions or A to G transitions in forestomach and lung tumors suggests that ADBAQ or its metabolites target adenine bases in the ras proto-oncogenes and that these mutations play a dominant role in multi-organ..
  9. ncbi Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains
    T R Devereux
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Mol Carcinog 8:177-85. 1993
    ..Thus, although Ki-ras activation was detected in some tumors, pathways independent of ras activation and p53 inactivation also appear to be involved in lung tumorigenesis in this resistant mouse strain...
  10. ncbi The association between severe nephropathy and pheochromocytoma in the male F344 rat -- the National Toxicology Program experience
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:456-62. 1999
    ..The possible correlation between the severity of CPN and the incidence of pheochromocytoma may influence interpretation of carcinogenic effects observed at this site...
  11. ncbi Histomorphologic features of spontaneous and chemically-induced pulmonary neoplasms in B6C3F1 mice and Fischer 344 rats
    D Dixon
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 19:540-56. 1991
    ..Other less frequently occurring spontaneous and chemically-induced neoplasms included squamous cell carcinomas, bronchial adenomas and carcinomas, and sarcomas...
  12. ncbi Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation
    M E Hegi
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709
    Cancer Res 54:6257-64. 1994
    ..Finally, an association between K-ras gene activation and allelic imbalances on chromosome 6 was observed for B6C3F1 lung tumors...
  13. ncbi Interactive effects of c-myc and transforming growth factor alpha transgenes on liver tumor development in simian virus 40 T antigen transgenic mice
    A Enomoto
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Vet Pathol 35:283-91. 1998
    ..The results indicate cooperative functions of c-myc and TGFalpha with TAg during development and/or growth of liver tumors in vivo...
  14. ncbi Spontaneous lesions in aging FVB/N mice
    J F Mahler
    Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:710-6. 1996
    ..This tumor profile should be considered in the interpretation of neoplastic phenotypes in FVB/N-derived transgenic lines...
  15. ncbi Alteration in cell kinetics in control B6C3F1 mice infected with Helicobacter hepaticus
    A Nyska
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:591-6. 1997
    ..Furthermore, the absence of enhanced cell proliferation in lungs and kidneys of male and females suggests that neoplastic effects at these sites are not exacerbated by H. hepaticus infection...
  16. ncbi Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-butoxyethanol
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:287-94. 1999
    ..In conclusion, exposure to 500 ppm BE vapors caused acute disseminated thrombosis and bone infarction in female rats. Possible pathogenic mechanisms are discussed...
  17. ncbi Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours
    L A Stanley
    NIEHS, Research Triangle Park, NC 27709
    Carcinogenesis 15:1125-31. 1994
    ..Ras mutations were also detected in some C57BL/10J tumours, providing further evidence that ras oncogenes can participate in hepatocarcinogenesis in resistant mice...
  18. ncbi Altered differentiation of hepatocytes in a transgenic mouse model of hepatocarcinogenesis
    A Enomoto
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:570-8. 1998
    ..Thus, the ductular cells could not be defined as tumor progenitor cells in these mouse livers. However, this model suggests that manipulation of gene expression can alter differentiation of hepatic parenchymal cells...
  19. ncbi A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 rats
    T Suwa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:467-78. 2001
    ..Inflammation was also present in the ampullary glands. We suggest an optimal embedment and trimming method in rat prostate and seminal vesicle to ensure adequate, consistent sampling...
  20. ncbi ras gene activation in rat tumors induced by benzidine congeners and derived dyes
    S H Reynolds
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Cancer Res 50:266-72. 1990
    ....
  21. ncbi High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice
    T E Massey
    Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 16:1065-9. 1995
    ..These results are consistent with previous findings in other mouse hybrids showing parental bias for K-ras mutations and suggest that mutation of the allele of the susceptible parent may provide a growth advantage to the tumor...
  22. ncbi Toxicology and carcinogenesis studies of microencapsulated citral in rats and mice
    N B Ress
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:198-206. 2003
    ..However, the incidences were within the NTP historical control range and could not be clearly related to citral administration...
  23. ncbi Ovarian luteal cell toxicity of ethylene glycol monomethyl ether and methoxy acetic acid in vivo and in vitro
    B J Davis
    Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Toxicol Appl Pharmacol 142:328-37. 1997
    ..Thus, these studies establish that the ovarian luteal cell is a target of EGME and MAA in vivo and in vitro and that the effect on luteal cell progesterone production is likely independent of LH-stimulated cAMP pathways...
  24. ncbi Polymerase chain reaction and in situ hybridization: applications in toxicological pathology
    D E Malarkey
    Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:13-23. 1996
    ..These new and evolving techniques offer tremendous potential in providing new insights into the molecular basis of toxicity and carcinogenesis...
  25. ncbi The contribution of the mouse in hazard identification studies
    R R Maronpot
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:726-31. 1996
    ..To utilize only one species for this important means of protecting human health is premature at this time...
  26. ncbi Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors
    R R Maronpot
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 101:125-56. 1995
    ..Since multiple genetic as well as nongenetic events are associated with tumor development, defining a precise role for ras gene mutations when they occur in mouse liver tumors is often difficult.(ABSTRACT TRUNCATED AT 400 WORDS)..
  27. ncbi Sustainability of forestomach hyperplasia in rats treated with ethyl acrylate for 13 weeks and regression after cessation of dosing
    B I Ghanayem
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 19:273-9. 1991
    ..It, therefore, remains to be determined what duration of exposure or other factors are critical for reversibility or progression of EA-induced forestomach mucosal hyperplasia to neoplasia...
  28. ncbi Documenting foci of hepatocellular alteration in two-year carcinogenicity studies: current practices of the National Toxicology Program
    R R Maronpot
    National Toxicology Program, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 17:675-83; discussion 683-4. 1989
    ..However, such data may form part of weight-of-evidence considerations used by regulatory bodies when accompanied by a concomitant liver tumor response...
  29. ncbi Use of rat liver altered focus models for testing chemicals that have completed two-year carcinogenicity studies
    R R Maronpot
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 17:651-62. 1989
    ..On the basis of the results obtained from these few chemicals, it is suggested that the use of short-term rat liver focus models may represent a reliable means for identifying chemicals with hepatocarcinogenic potential...
  30. ncbi Proliferative and neoplastic lesions in the rodent nasal cavity
    H R Brown
    Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 19:358-72. 1991
    ..More work will be needed to illucidate the mechanisms of nasal carcinogenesis and to further refine the current tumor classification system...
  31. ncbi Furan-induced hepatic cholangiocarcinomas in Fischer 344 rats
    R R Maronpot
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 19:561-70. 1991
    ....
  32. ncbi Epithelial-stromal tumor of the seminal vesicles in the transgenic adenocarcinoma mouse prostate model
    Y Tani
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, PO Box 12233, Mail Drop B3-06, Research Triangle Park, NC 27709, USA
    Vet Pathol 42:306-14. 2005
    ..No conclusive evidence of malignancy (invasion or metastasis) was identified. Our recommended diagnosis of this lesion in the seminal vesicles is epithelial-stromal tumor...
  33. ncbi Induction of tunica vaginalis mesotheliomas in rats by xenobiotics
    R R Maronpot
    Experimental Pathology Laboratories, Inc, PO Box 12766, Research Triangle Park, NC 27709, USA
    Crit Rev Toxicol 39:512-37. 2009
    ..TVM induction is a male F344 rat-specific event, and chemicals/agents that induce only TVM in the male F344 rat from a typical two-sex rat and mouse chronic bioassay are likely irrelevant in human risk assessment...
  34. ncbi Rodent carcinogenicity bioassay: past, present, and future
    G A Boorman
    Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 22:105-11. 1994
    ....
  35. ncbi Importance of and approaches to quantification of hepatocyte apoptosis
    T L Goldsworthy
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:24-35. 1996
    ....
  36. ncbi Magnetic resonance imaging (MRI): a new tool in experimental toxicologic pathology
    D Dixon
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 16:386-91. 1988
    ....
  37. ncbi Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice
    D Dixon
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Exp Lung Res 17:131-55. 1991
    ....
  38. ncbi Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 281:16625-31. 2006
    ..Taken together, these results suggest that ERalpha-mediated repression of hepatic transporters and alterations of bile acid biosynthesis may contribute to development of the EE2-induced hepatotoxicity...
  39. ncbi Association of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat--the National Toxicology Program experience
    Keisuke Ozaki
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:263-70. 2002
    ..Our investigation assessed the strength of these various associations and supports the possible roles of 2 chronic pulmonary lesions-fibrosis and inflammation-and hypoxemia in the induction of pheochromocytoma in the F344 male rat...
  40. ncbi Application of magnetic resonance imaging in developmental neurotoxicity testing: a pilot study
    Kennita Johnson
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIH DHHS, 111 Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, United States
    Neurotoxicology 27:846-51. 2006
    ..It is concluded that MR imaging in rat developmental neurotoxicity studies offers the advantages of in situ volumetric measurements of brain structures while preserving the samples for conventional optical microscopy...
  41. ncbi Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid
    Maria T Gallardo-Williams
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Prostate 54:44-9. 2003
    ..In this study, we have addressed the use of boric acid and 3-nitrophenyl boronic acid (NPBA) as PSA inhibitors in vitro...
  42. ncbi Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:501-10. 2004
    ....
  43. ncbi New insights into functional aspects of liver morphology
    David E Malarkey
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:27-34. 2005
    ..Awareness of the complexities and heterogeneity of the liver will add to a greater understanding of liver function and disease processes that lead to toxicity, cancer, and other diseases...
  44. ncbi Microarray data analysis of mouse neoplasia
    David E Malarkey
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:127-35. 2005
    ....
  45. ncbi An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse
    Andrew W Suttie
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:386-97. 2005
    ..NETs did not stain for cyclo-oxygenase-2 (COX-2) nor androgen receptor (AR). SV40 positive tubulo-acinar tumors seen occasionally in the kidney, did not stain for synaptophysin nor NSE...
  46. ncbi New tools in therapeutic research--prostatic cancer and models
    Abraham Nyska
    National Institute of Environmental Health Sciences, Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:283-7. 2002
  47. ncbi Comparative prevalence, multiplicity, and progression of spontaneous and vinyl carbamate-induced liver lesions in five strains of male mice
    Mimasa Takahashi
    Nippon Veterinary and Animal Science University, Tokyo, Japan
    Toxicol Pathol 30:599-605. 2002
    ....
  48. ncbi Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice--the National Toxicology Program experience
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
    Toxicol Pathol 32:222-8. 2004
    ..The reason for the sex-increased susceptibility for development of hemangiosarcoma is unknown but may be due to a hormone-related, reduced antioxidative defensive capacity through modulation of the activities of antioxidative enzymes...
  49. ncbi The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 184:153-64. 2002
    ..Endothelial proliferation may also have been promoted through endothelial arrest at S phase, which was associated with endothelial karyo- and cytomegaly, resulting in hepatocytic hypoxia, triggering VEGF induction...
  50. ncbi Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 31:39-51. 2003
    ..The anti-oxidative and antiproliferative properties of NAO may explain its efficacy in slowing the spontaneous prostatic carcinogenic process in the TRAMP and its effects in the cell lines...
  51. ncbi Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies
    Darlene Dixon
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:428-39. 2008
    ....
  52. ncbi Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited
    Catherine A Picut
    Biotechnics, Inc, Hillsborough, North Carolina, USA
    Exp Toxicol Pathol 55:1-9. 2003
    ..The earlier results were confirmed. The mechanism of uterine carcinogenesis by chloroethane, bromoethane and ethylene oxide is unclear...
  53. ncbi Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicity
    Katherine A Guindon
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Toxicol Appl Pharmacol 227:179-83. 2008
    ..These results demonstrate that PEG-CAT is not protective against AFB(1) carcinogenicity in mouse lung despite preventing DNA oxidation...
  54. ncbi Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 96:72-82. 2007
    ..We hypothesize that these unique RAMs may be facilitating the tumorigenesis process, and these data support the view that DNA methylation plays a causative role in PB-induced tumorigenesis...
  55. ncbi Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice
    Maria T Gallardo-Williams
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 32:73-8. 2004
    ..These data indicate that low-level dietary boron supplementation reduced tumor size and content of a tumor trophic factor, IGF-1.This promising model is being evaluated in further studies...
  56. ncbi Precancer in mice: animal models used to understand, prevent, and treat human precancers
    Robert D Cardiff
    The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 34:699-707. 2006
    ..These studies suggest that genetically engineered mice are very useful preclinical models for chemoprevention and therapy...
  57. ncbi Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression
    Christopher R Herzog
    Institute for Cancer Prevention, Valhalla, NY 10595, USA
    Oncogene 23:3033-9. 2004
    ....
  58. ncbi Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants
    Neville N C Tam
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Prostate 66:57-69. 2006
    ..CONCLUSIONS: Our data indicate that in TRAMP mice, OS/NS injuries are likely involved in early prostatic tumorigenesis and can be modulated by various antioxidants...
  59. ncbi Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke
    Hanspeter Witschi
    Center for Health and the Environment CHE, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Cancer Lett 241:64-8. 2006
    ..It was concluded that tobacco smoke exposure not simply accelerates the development of lesions that eventually would have developed spontaneously, but induced de novo formation of lung tumors in A/J mice...
  60. ncbi Magnetic resonance histology for morphologic phenotyping
    G Allan Johnson
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Magn Reson Imaging 16:423-9. 2002
    ..MRH exploits the unique contrast mechanisms that have made MRI so successful clinically; 3). MRH is 3-dimensional; and 4). the data are inherently digital. We demonstrate the utility in morphologic phenotyping a whole C57BL/6J mouse...
  61. ncbi Effects of boric acid supplementation on bone histomorphometry, metabolism, and biomechanical properties in aged female F-344 rats
    Maria T Gallardo-Williams
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Biol Trace Elem Res 93:155-70. 2003
    ..At the levels given, boron alone provided no protection against OVX-induced osteopenia. In addition, combination therapy (B + E2) provided no additional benefits over those of 17beta-estradiol treatment alone in this aged rat model...
  62. ncbi DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration
    LILIAN CALDERON-GARCIDUENAS
    Environmental Pathology Program, University of North Carolina at Chapel Hill, North Carolina 27599 7310, USA
    Toxicol Pathol 31:524-38. 2003
    ..These data suggest that Alzheimer's disease may be the sequela of air pollutant exposures and the resulting systemic inflammation...
  63. ncbi Follicular epithelial cell hypertrophy induced by chronic oral administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley rats
    Yoshiro Tani
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:41-9. 2004
    ..These results indicate that the follicular cell response was hypertrophic and reversible. This information should contribute to diagnosis of nonneoplastic thyroid follicular lesions in rats...
  64. ncbi Best practices guideline: toxicologic histopathology
    James W Crissman
    Health and Environmental Sciences, Dow Corning Corporation, Midland, Michigan 48686, USA
    Toxicol Pathol 32:126-31. 2004
  65. ncbi Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium
    Alexander Yu Nikitin
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Cancer Res 64:2307-16. 2004
    ....
  66. ncbi Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family
    Deborah J Stumpo
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 24:6445-55. 2004
    ..We postulate that lack of Zfp36L1 expression during mid-gestation results in the abnormal stabilization of one or more mRNAs whose encoded proteins lead directly or indirectly to abnormal placentation and fetal death...
  67. ncbi The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology and Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research TrianglePark, NC, USA
    Cancer Res 64:7197-200. 2004
    ..The results indicate that CAR is the molecular target of promotion by PB and that activation of this receptor is an essential requirement for liver tumor development...
  68. ncbi Cadmium at a non-toxic dose alters gene expression in mouse testes
    Tong Zhou
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Lett 154:191-200. 2004
    ..These results indicate that changes in gene expression occur well before overt effects of Cd-induced testicular toxicity and carcinogenicity are apparent...
  69. ncbi Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors
    Andrew S Tam
    Queen s University, Department of Pharmacology and Toxicology, Kingston, Ontario K7L 3N6, Canada
    Carcinogenesis 24:121-32. 2003
    ....