Research Topics
Genomes and Genes
| Dragan MaricSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
SUMOylation participates in induction of ischemic toleranceYang ja Lee
Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurochem 109:257-67. 2009..These findings suggest that maintenance of a globally elevated SUMO-1 (and maybe SUMO-2/3) conjugation level as revealed by immunoblot assays is a component of ischemic tolerance...- Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cellsMarco Bisaglia
Department of Biology, University of Padova, 35121 Padova, Italy
BMC Neurosci 11:41. 2010.... 
GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor/Cl- channelsD Maric
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 21:2343-60. 2001..These results reveal a morphogenic role for GABA during embryonic neocortical neuron development that involves GABA(A) autoreceptors and L-type Ca(2+) channels...- Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptorsDragan Maric
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:1836-52. 2007..These results provide new insights regarding the roles of FGFRs in diversification of NSC properties and initiation of neural lineage-restricted differentiation... - Neural stem cells redefined: a FACS perspectiveDragan Maric
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Mol Neurobiol 30:49-76. 2004..Thus, the strategies presented here provide a framework for more precise studies of NSC and LRP cell biology in the future... - Prospective cell sorting of embryonic rat neural stem cells and neuronal and glial progenitors reveals selective effects of basic fibroblast growth factor and epidermal growth factor on self-renewal and differentiationDragan Maric
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 23:240-51. 2003.... - Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesisJoseph A Nielsen
Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
BMC Neurosci 10:98. 2009.... - MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1Ombretta Salvucci
Laboratory of Cellular Oncology, CCR, NCI, NIH, Bethesda, MD 20892, USA
Haematologica 97:818-26. 2012..Since hematopoietic stem/progenitor cells represent a minority of all blood cells mobilized by granulocyte colony-stimulating factor, the underlying mechanisms need to be understood in order to develop selective drugs... - Effect of brain- and tumor-derived connective tissue growth factor on glioma invasionLincoln A Edwards
Neuro Oncology Branch, National Cancer Institute National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1002, USA
J Natl Cancer Inst 103:1162-78. 2011..Connective tissue growth factor (CTGF) has been previously implicated in cancer metastasis and invasion in various tumors. We explored the mechanism of CTGF-mediated glioma cell infiltration and examined potential therapeutic targets... - The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1Maria De La Luz Sierra
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD, USA
Blood 115:3970-9. 2010..These results uncover a previously unknown function of Gfi1 as a regulator of RasGRP1 and link Gfi1 transcriptional control to G-CSF signaling and regulation of granulopoiesis... - Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patientsTanya Bogoslovsky
Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1401, USA
J Transl Med 9:145. 2011.... - Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulationSvetlana Kotliarova
Neuro Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 68:6643-51. 2008..GSK3 may therefore be an important therapeutic target for gliomas. Future studies will further define the optimal combinations of GSK3 inhibitors and cytotoxic agents for use in gliomas and other cancers... - Identification of a novel oligodendrocyte cell adhesion protein using gene expression profilingJoseph A Nielsen
Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 26:9881-91. 2006..Together, our results highlight the usefulness of this discovery-driven experimental strategy to identify genes relevant to oligodendrocyte differentiation and myelination... - Prediction of Associations between microRNAs and Gene Expression in Glioma BiologyStefan Wuchty
Neuro Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e14681. 2011.... - Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemiaBolanle M Famakin
Stroke Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Rm 5B06, MSC 1401, Bethesda, MD 20892 1401, USA
Brain Res 1388:148-56. 2011..4mm(3). These findings show that disruption of MyD88 or TRIF signaling does not confer protection in brain ischemia and suggests the possibility of additional or alternate downstream adaptors during TLR signaling in cerebral ischemia... 
Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-MycHong Sug Kim
Neuro Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Cancer Res 72:6065-75. 2012..We propose that p53 mutations contribute to gliomagenesis by both allowing the overexpression of c-Myc through downregulation of Fbxw7 and by protecting against c-Myc-induced apoptosis...- Fluorescence-based sorting of neural stem cells and progenitorsDragan Maric
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Curr Protoc Neurosci . 2005..Thus, the strategy presented here provides a framework for more precise studies of NSC and LRP cell biology in the future, which can be applied to all vertebrates, including humans... - GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cellsSilvia Selleri
Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
J Transl Med 6:17. 2008..Whether this secretion affects in an autocrine loop the CTLs themselves is unknown... - EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structuresOmbretta Salvucci
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Blood 114:1707-16. 2009..These results reveal a role for EphrinB signaling in orchestrating pericyte/endothelial cell assembly, and suggest that therapeutic targeting of EphrinB may prove useful for disrupting angiogenesis when it contributes to disease... - Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosisWenzheng Jiang
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 187:781-90. 2011..Our study describes the important physiological role that GrK plays in immunoregulation of adaptive immunity in humans and indicates that therapeutic exploitation of this pathway is beneficial in controlling autoimmunity... - Canonical transient receptor potential 1 plays a role in basic fibroblast growth factor (bFGF)/FGF receptor-1-induced Ca2+ entry and embryonic rat neural stem cell proliferationAlessandra Fiorio Pla
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 25:2687-701. 2005..Together, these results show that TRPC1 contributes to bFGF/FGFR-1-induced Ca2+ influx, which is involved in self-renewal of embryonic rat NSCs... - Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signalingPaola Gasperini
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 72:1157-69. 2012..One important implication of our findings is that therapeutic approaches to disrupt the Notch pathway may offer novel approaches for KS treatment... - Induction of cell death after localization to the host cell mitochondria by the Mycobacterium tuberculosis PE_PGRS33 proteinNathalie Cadieux
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
Microbiology 157:793-804. 2011..Considering the importance of primary necrosis in Mycobacterium tuberculosis dissemination during natural infection, the PE_PGRS33 protein may play a crucial role in the pathogenesis of tuberculosis... - Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive ratsSatoru Ishibashi
Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health NIH, Bethesda, Maryland 20892 4476, USA
J Cereb Blood Flow Metab 29:606-20. 2009..These studies suggest that E-selectin-specific Tregs can modulate the efficacy of neurogenesis after ischemia and promote repair after brain injury... - Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neuronsCheol Lee
Neuroscience Program, School of Medicine, USUHS, Bethesda, MD 20814, USA
Cereb Cortex 18:2909-19. 2008..These results suggest that AUF1 is involved in integrating genetic and epigenetic signals during cortical development through recruiting HDAC1 and MTA2 to AT-rich DNA elements... - Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiationYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
Mol Biol Cell 21:3601-14. 2010..Cdk5 phosphorylation of p27(Kip1), a modular molecule, may regulate the progress of neuronal differentiation from cell cycle arrest through differentiation, neurite outgrowth, and migration... - A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapySimone C Wuest
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
Nat Med 17:604-9. 2011..Our data reveal a previously unknown mechanism for the IL-2 receptor system in DC-mediated activation of T cells... - Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cellsJeongwu Lee
Neuro Oncology Branch, National Cancer Institute, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Cell 13:69-80. 2008.... - The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutationIakov N Rudenko
Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Biochem J 446:99-111. 2012..These results may be important in understanding the differing mechanism(s) by which mutations in LRRK2 act and may also have implications for therapeutic strategies for PD... - In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factorJulien Debbache
Mammalian Development Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health, Bethesda, MD 20892, USA
Genetics 191:133-44. 2012..These results underscore, in vivo, the importance of the link between alternative splicing and post-translational modifications and may bear on the recent observation that exon 2B skipping can be found in metastatic melanoma... - Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cellsJoelle A Hillion
1Stroke Branch, Department of Health and Human Services, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4476, USA
J Cereb Blood Flow Metab 26:1323-31. 2006..This work suggests that in the context of tolerance downregulation of Akt is beneficial... - A role for semaphorins and neuropilins in oligodendrocyte guidanceRick I Cohen
Laboratory of Developmental Neurogenetics, The National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland, USA
J Neurochem 85:1262-78. 2003..Our data support a role for neuropilins and semaphorins in orchestrating the migration patterns of developing oligodendrocytes in the CNS... - MITF and cell proliferation: the role of alternative splice formsKeren Bismuth
Mammalian Development Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Pigment Cell Res 18:349-59. 2005..The results suggest that one or several aminoterminal domains cooperate with the alternatively spliced hexapeptide to render MITF anti-proliferative in a way that does not depend on direct E box binding... - Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patientsTanya Bogoslovsky
Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, National Institute of Nursing Research, National Institutes of Health, 12725 Twinbrook Parkway, Rockville, MD 20852, USA
Stroke 42:618-25. 2011..We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and stroke severity in acute stroke patients... - Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatumIgor Nasonkin
Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Stem Cells 27:2414-26. 2009.... - Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosisTodd M Wilson
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892 1881, USA
Haematologica 96:459-63. 2011..Unlike other mature lineages, mast cell survival is dependent on KIT and the presence of these two activating mutations may have a greater impact on the expansion of this cell compartment and in resultant disease severity... - Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferationBenjamin W Purow
Neuro Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Res 65:2353-63. 2005..Notch-1 and its ligands may present novel therapeutic targets in the treatment of glioma... - Functional properties of ryanodine receptors in hippocampal neurons change during early differentiation in cultureManana Sukhareva
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurophysiol 88:1077-87. 2002..The mode of activation of L-type voltage-gated Ca(2+) channels with either membrane depolarization or specific pharmacological agents affects the coupled activity of RyRs differently as neurons differentiate processes and networks... - Development of an ischemic tolerance model in a PC12 cell lineJoelle A Hillion
Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4128, USA
J Cereb Blood Flow Metab 25:154-62. 2005..This model may be useful to investigate the cellular mechanisms involved in neuronal transient tolerance following ischemia... - Human immunodeficiency virus type 1 infection of human brain-derived progenitor cellsDiane M P Lawrence
Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 78:7319-28. 2004..Using this cell culture system of multipotential human brain-derived progenitor cells, we provide evidence that progenitor cells may be a reservoir for HIV-1 in the brains of AIDS patients... - Human herpesvirus-6 entry into the central nervous system through the olfactory pathwayErin Harberts
Viral Immunology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:13734-9. 2011..Collectively, these results support HHV-6 utilization of the olfactory pathway as a route of entry into the CNS... - Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosisUnsong Oh
Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke NINDS, National Institutes of Health, Bethesda, Maryland, USA
Arch Neurol 66:471-9. 2009..We examined changes to CD4+CD25+ Treg in patients with MS receiving maintenance anti-CD25 monoclonal antibody treatment to determine the effect of treatment on Treg and, consequently, on immunological tolerance... - Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growthMarta Segarra
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
Blood 112:1904-11. 2008.... - Monocytes form a vascular barrier and participate in vessel repair after brain injuryJohn Glod
Neuro-Oncology Branch, National Cancer Institute, and Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Blood 107:940-6. 2006..We also demonstrate that these cells associate with repairing vasculature in areas of brain and skin injury. Our data suggest that CD14+ peripheral blood monocytes participate in the repair of the vascular barrier after brain injury... - In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotypeJames P Sumner
Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD 20892, USA
Neuroimage 44:671-8. 2009..Using MRI to visualize neural progenitor cell behavior in individual animals during plasticity or disease models should be a useful tool, especially in combination with other information that MRI can supply... - Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactionsSara Deola
Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Immunol 180:1362-72. 2008..This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo... - Layer-specific variation of iron content in cerebral cortex as a source of MRI contrastMasaki Fukunaga
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:3834-9. 2010..The results show that iron is distributed over laminae in a pattern that is suggestive of each region's myeloarchitecture and forms the dominant source of the observed MRI contrast... - DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagyKelly Jean Thomas
Laboratory of Neurogenetics, National Institute on Aging, Flow Cytometry Core Facility, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20982 3707, USA
Hum Mol Genet 20:40-50. 2011..None of the three proteins complex together using size exclusion chromatography. These data suggest that DJ-1 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment... - The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureasTeri T B Ngo
Surgical and Molecular Neuro oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
J Natl Cancer Inst 99:639-52. 2007.... - Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infectionsUtano Tomaru
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Nat Med 9:469-76. 2003..This approach will be a powerful tool in understanding the role of antigen-specific T-cell responses in health and disease... - Toluene inhibits muscarinic receptor-mediated cytosolic Ca2+ responses in neural precursor cellsM Wu
Naval Research Laboratory, Center for Bio Molecular Science and Engineering, Washington, DC 20375, USA
Neurotoxicology 23:61-8. 2002....