Research Topics
Genomes and GenesSpecies | Stefano MarencoSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Nicotine-induced dopamine release in primates measured with [11C]raclopride PETStefano Marenco
Clinical Brain Disorders Branch, IRP, NIMH, USA
Neuropsychopharmacology 29:259-68. 2004....
Reproducibility of prefrontal γ-aminobutyric acid measurements with J-edited spectroscopyMatthew Geramita
Unit for Multimodal Imaging Genetics, Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
NMR Biomed 24:1089-98. 2011..This study validates a reproducible method for the quantification of brain metabolites, and provides information on gray/white matter differences that may be important in the interpretation of results in clinical populations...
Genetic association of ErbB4 and human cortical GABA levels in vivoStefano Marenco
Unit for Multimodal Imaging Genetics, Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, NIH, Bethesda, Maryland 20892, USA
J Neurosci 31:11628-32. 2011..These data establish an association of ErbB4 and GABA in human brain and have implications for understanding the pathogenesis of schizophrenia and other psychiatric disorders...- Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMTStefano Marenco
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1708-17. 2010..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia... - No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expressionHeike Tost
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
Biol Psychiatry 68:105-7. 2010..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures... - Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophreniaStefano Marenco
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
Neuropsychopharmacology 37:499-507. 2012..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC... - Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 TeslaAlexa J Stern
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 64:856-62. 2008.... - Effect of Schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteersEugenia Radulescu
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 38:341-9. 2013..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia... - Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortexStefano Marenco
Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 163:740-2. 2006.... - Imaging genetics of structural brain connectivity and neural integrity markersStefano Marenco
Unit for Multimodal Imaging Genetics, Clinical Brain Disorders Branch, GCAP, IRP, NIMH, 10 Center Drive, Building 10, Room 3C103, Bethesda, MD 20892, USA
Neuroimage 53:848-56. 2010.... - Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case seriesStefano Marenco
Intramural Research Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Building 10, Room 4S235, Bethesda, MD 20892, USA
Schizophr Res 57:221-6. 2002..No clear improvement in psychosis or in cognition was observed over the course of the study. CX516 at the doses tested did not appear to yield dramatic effects as a sole agent, but inference from this study is limited... - Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosusLarissa Lapteva
Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 54:2505-14. 2006..To assess the association of cognitive dysfunction and depression with serum antibodies to N-methyl-D-aspartate (NMDA) receptor (anti-NR2) and analyze clinical and neuroimaging correlates in patients with systemic lupus erythematosus (SLE)... - Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confoundsThomas W Weickert
Clinical Brain Disorders Branch, National Institute of Mental Health NIH, Building 10 Room 4N202, MSC 1379, Bethesda, MD 20892, USA
Neuropsychopharmacology 28:1491-500. 2003..These findings suggest that relative to placebo withdrawal, atypicals improve cognitive performance in SC. However, this finding may not be specific to atypicals, since analogous studies of typicals have not been performed... - Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndromeAndreas Meyer-Lindenberg
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, NIH, Department of Health and Human Services, Bethesda, MD 20892 1365, USA
J Clin Invest 115:1888-95. 2005..These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS... - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndromeStefano Marenco
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:15117-22. 2007.... - Single-cue delay and trace classical conditioning in schizophreniaStefano Marenco
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:390-402. 2003..Both the greater CR onset latency during delay and the presence of early nonadaptive responses during trace are compatible with the pattern of responding seen in animals with hippocampal damage... - Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or downJoseph H Callicott
Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
Am J Psychiatry 160:2209-15. 2003..The authors' goal was to explore this phenomenon... - Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disordersStefano Marenco
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
CNS Drugs 20:173-85. 2006..Substantial questions remain concerning which compounds to use, in what dose, for what condition and for how long... - Regional distribution of measurement error in diffusion tensor imagingStefano Marenco
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, IRP, NIMH, Bethesda, MD 20892, USA
Psychiatry Res 147:69-78. 2006..Each one of these measures reveals complementary information that needs to be taken into consideration when performing statistical operations on groups of DT images... - In vivo NMR measures of NAA and the neurobiology of schizophreniaStefano Marenco
Genes, Cognition and Psychosis Program, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Adv Exp Med Biol 576:227-40; discussion 361-3. 2006 - The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophreniaMitsuyuki Matsumoto
Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
Proc Natl Acad Sci U S A 105:6133-8. 2008..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy... - Correction of frequency and phase variations induced by eddy currents in localized spectroscopy with multiple echo timesYan Zhang
National Institute of Mental Health, Bethesda, Maryland 20892 1527, USA
Magn Reson Med 58:174-8. 2007..Also, it is demonstrated that the methyl signals of creatine (Cr) at 3.0 ppm and choline (Cho) at 3.2 ppm can be used as internal references in finding frequency and phase disparities between different TEs...