Teri A Manolio

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi New models for large prospective studies: is there a better way?
    Teri A Manolio
    Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, USA
    Am J Epidemiol 175:859-66. 2012
  2. ncbi A HapMap harvest of insights into the genetics of common disease
    Teri A Manolio
    National Human Genome Research Institute, 31 Center Drive, Room 4B 09, Bethesda, Maryland 20892 2154, USA
    J Clin Invest 118:1590-605. 2008
  3. ncbi Predictors of falling cholesterol levels in older adults: the Cardiovascular Health Study
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Ann Epidemiol 14:325-31. 2004
  4. ncbi Genetics of ultrasonographic carotid atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Arterioscler Thromb Vasc Biol 24:1567-77. 2004
  5. ncbi Sex differences in heritability of sensitization to Blomia tropicalis in asthma using regression of offspring on midparent (ROMP) methods
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm 8160, Bethesda, MD 20892 7934, USA
    Hum Genet 113:437-46. 2003
  6. ncbi Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B 09, 31 Center Drive, MSC 2154, Bethesda, MD 20892 2154, USA
    Pharmacogenomics 10:235-41. 2009
  7. ncbi Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Int Arch Allergy Immunol 131:119-26. 2003
  8. ncbi Hypertension and cognitive function: pathophysiologic effects of hypertension on the brain
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Curr Hypertens Rep 5:255-61. 2003
  9. ncbi New models of collaboration in genome-wide association studies: the Genetic Association Information Network
    Teri A Manolio
    National Human Genome Research Institute, US National Institutes of Health NIH, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 39:1045-51. 2007
  10. ncbi The HapMap and genome-wide association studies in diagnosis and therapy
    Teri A Manolio
    National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Annu Rev Med 60:443-56. 2009

Detail Information

Publications68

  1. ncbi New models for large prospective studies: is there a better way?
    Teri A Manolio
    Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, USA
    Am J Epidemiol 175:859-66. 2012
    ..Whether and how these approaches may be transportable to the United States remain to be explored, but their success in studies such as UK Biobank makes a compelling case for such explorations to begin...
  2. ncbi A HapMap harvest of insights into the genetics of common disease
    Teri A Manolio
    National Human Genome Research Institute, 31 Center Drive, Room 4B 09, Bethesda, Maryland 20892 2154, USA
    J Clin Invest 118:1590-605. 2008
    ..In this review we examine the origin, development, and current status of the HapMap; its prospects for continued evolution; and its current and potential future impact on biomedical science...
  3. ncbi Predictors of falling cholesterol levels in older adults: the Cardiovascular Health Study
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Ann Epidemiol 14:325-31. 2004
    ..To estimate 4-year change in serum total cholesterol levels in a population-based sample of older adults and identify independent predictors of cholesterol decline...
  4. ncbi Genetics of ultrasonographic carotid atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Arterioscler Thromb Vasc Biol 24:1567-77. 2004
    ..Another, PON1 L55 mol/L, is weakly associated in subgroups only. Genetic variants reported to be associated with clinical cardiovascular disease show weak or no relationship to carotid atherosclerosis...
  5. ncbi Sex differences in heritability of sensitization to Blomia tropicalis in asthma using regression of offspring on midparent (ROMP) methods
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm 8160, Bethesda, MD 20892 7934, USA
    Hum Genet 113:437-46. 2003
    ..Adjustment for covariates had minimal impact. This suggests that future investigations of genetic determinants of IgE levels should include approaches that allow for potential sex differences in their expression...
  6. ncbi Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B 09, 31 Center Drive, MSC 2154, Bethesda, MD 20892 2154, USA
    Pharmacogenomics 10:235-41. 2009
    ....
  7. ncbi Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Int Arch Allergy Immunol 131:119-26. 2003
    ..The main objective of this study was to determine prevalence and correlates of sensitivity to these mites in families with asthma and characteristics of persons sensitized to both...
  8. ncbi Hypertension and cognitive function: pathophysiologic effects of hypertension on the brain
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Curr Hypertens Rep 5:255-61. 2003
    ....
  9. ncbi New models of collaboration in genome-wide association studies: the Genetic Association Information Network
    Teri A Manolio
    National Human Genome Research Institute, US National Institutes of Health NIH, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 39:1045-51. 2007
    ..These demonstrate a new commitment to shared scientific knowledge that should facilitate rapid advances in understanding the genetics of complex diseases...
  10. ncbi The HapMap and genome-wide association studies in diagnosis and therapy
    Teri A Manolio
    National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Annu Rev Med 60:443-56. 2009
    ....
  11. ncbi Genes, environment and the value of prospective cohort studies
    Teri A Manolio
    National Human Genome Research Institute, 31 Center Drive, Room 4B09, Bethesda, Maryland 20892 2154, USA
    Nat Rev Genet 7:812-20. 2006
    ..This and other strengths of prospective cohort studies make them invaluable for understanding gene-environment interactions in complex human disease...
  12. ncbi Study designs to enhance identification of genetic factors in healthy aging
    Teri A Manolio
    Office of Population Genomics at the National Human Genetics Research Institute NHGRI, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    Nutr Rev 65:S228-33. 2007
    ..Many such studies are currently supported or being planned across the National Institutes of Health (NIH), and lend themselves to the kind of coordinated clinical research envisioned in programs such as the NIH Roadmap...
  13. ncbi Ethnic differences in the relationship of carotid atherosclerosis to coronary calcification: the Multi-Ethnic Study of Atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 2154, USA
    Atherosclerosis 197:132-8. 2008
    ..These differences should be pursued for relationships to coronary events to determine whether coronary calcium carries the same risk information in other ethnic groups as it does in Whites...
  14. ncbi Left atrial dimensions determined by M-mode echocardiography in black and white older (> or =65 years) adults (The Cardiovascular Health Study)
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
    Am J Cardiol 90:983-7. 2002
    ..Thus, LA dimension is strongly associated with weight and with several echocardiographic valvular abnormalities; its relation with LV fractional shortening is U-shaped with a nadir at the borderline of LV functional impairment...
  15. ncbi Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study
    Jie J Cao
    National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1061, Bldg 10, Room B1D 416, Bethesda, MD 20892, USA
    Circulation 116:32-8. 2007
    ..We investigated the relationship between carotid atherosclerosis and CRP and their joint roles in CVD prediction...
  16. ncbi Comment on "multidimensional results reporting to participants in genomic studies: getting it right"
    Ebony B Bookman
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Sci Transl Med 3:70le1. 2011
    ....
  17. ncbi How to interpret a genome-wide association study
    Thomas A Pearson
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    JAMA 299:1335-44. 2008
    ..This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance...
  18. ncbi Finding the missing heritability of complex diseases
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B09, 31 Center Drive, MSC 2152, Bethesda, Maryland 20892 2152, USA
    Nature 461:747-53. 2009
    ....
  19. ncbi Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study)
    John S Gottdiener
    Division of Cardiology, University of Maryland Medical Center, Baltimore, Maryland, USA
    Am J Cardiol 97:83-9. 2006
    ..LA size is associated with the new development of HF. These findings highlight the important role of the left atrium in HF, with or without a decreased ejection fraction...
  20. ncbi Variation and temporal trends in the use of diagnostic testing during hospitalization for acute myocardial infarction by age, gender, race, and geography (the Atherosclerosis Risk In Communities Study)
    Camille A Pearte
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 101:1219-25. 2008
    ..There may also be continued perception of lower risk in women and blacks without a known diagnosis of MI...
  21. ncbi The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the Cardiovascular Health Study
    Jie J Cao
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Atherosclerosis 187:372-7. 2006
    ..Thus, a hypothesis may be made that the mechanism of association of MA with clinical vascular disease involves destabilization of the vasculature, leading to clinical disease...
  22. ncbi The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine
    Leslie G Biesecker
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1665-74. 2009
    ..The early experiences with ClinSeq illustrate how large-scale medical sequencing can be a practical, productive, and critical component of research in genomic medicine...
  23. ncbi Genomics reaches the clinic: from basic discoveries to clinical impact
    Teri A Manolio
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 147:14-6. 2011
    ..Close interactions among laboratory, computational, and clinical research communities will be crucial to ensure that genomic discoveries advance medical science and, ultimately, improve human health...
  24. ncbi Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    Lucia A Hindorff
    Office of Population Genomics, Genome Technology Branch, National Human Genome Research Institute, and National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:9362-7. 2009
    ..This new online resource, together with bioinformatic predictions of the underlying functionality at trait/disease-associated loci, is well-suited to guide future investigations of the role of common variants in complex disease etiology...
  25. ncbi Genes, environment, health, and disease: facing up to complexity
    Teri A Manolio
    National Human Genome Research Institute, NIH, Bethesda, MD 20892-2152, USA
    Hum Hered 63:63-6. 2007
  26. ncbi Merging and emerging cohorts: necessary but not sufficient
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, 31 Center Drive, Bethesda, Maryland 20892-2152, USA
    Nature 445:259. 2007
  27. ncbi Charting a course for genomic medicine from base pairs to bedside
    Eric D Green
    National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, Bethesda, Maryland 20892 2152, USA
    Nature 470:204-13. 2011
    ..Here we articulate a 2011 vision for the future of genomics research and describe the path towards an era of genomic medicine...
  28. ncbi Genetic architecture of cancer and other complex diseases: lessons learned and future directions
    Lucia A Hindorff
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 9307, USA
    Carcinogenesis 32:945-54. 2011
    ....
  29. ncbi Reporting genetic results in research studies: summary and recommendations of an NHLBI working group
    Ebony B Bookman
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
    Am J Med Genet A 140:1033-40. 2006
    ..Finally, the Working Group recommended procedures for reporting genetic research results and encouraged increased efforts to create uniform guidelines for this activity...
  30. ncbi Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131)
    Angelo Scuteri
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Am Coll Cardiol 43:187-93. 2004
    ..We hypothesized that variant geometric patterns of the common carotid artery (CCA) predict the incidence of cardiovascular disease (CVD), after accounting for CCA intima-medial thickness (IMT)...
  31. ncbi Taking our obligations to research participants seriously: disclosing individual results of genetic research
    Teri A Manolio
    National Human Genome Research Institute, National Institutes of Health, USA
    Am J Bioeth 6:32-4; author reply W10-2. 2006
  32. ncbi A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 95:856-9. 2005
    ..Out-of-hospital coronary heart disease deaths overestimated sudden cardiac death by 47%, suggesting that out-of-hospital coronary heart disease death rates derived from death certificates should be interpreted with caution...
  33. ncbi A stroke prediction score in the elderly: validation and Web-based application
    Thomas Lumley
    University of Washington, CHS Coordinating Center, Plaza 600 Building, Suite 700, 600 Stewart St, Seattle, WA 98101, USA
    J Clin Epidemiol 55:129-36. 2002
    ..Evaluation of the generalizability and clinical usefulness of this prediction model requires further research...
  34. ncbi Fish consumption and stroke risk in elderly individuals: the cardiovascular health study
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 165:200-6. 2005
    ..Additionally, such relationships have not been specifically evaluated in the elderly, in whom disease burden may be high and diet less influential...
  35. ncbi Acculturation is associated with hypertension in a multiethnic sample
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Am J Hypertens 20:354-63. 2007
    ....
  36. ncbi Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, Wash, USA
    Stroke 36:56-61. 2005
    ..Magnetic resonance imaging (MRI) scans in the elderly commonly show white matter findings that may raise concerns. We sought to document incidence, manifestations, and predictors of worsening white matter grade on serial imaging...
  37. ncbi Time trends in high blood pressure control and the use of antihypertensive medications in older adults: the Cardiovascular Health Study
    Bruce M Psaty
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    Arch Intern Med 162:2325-32. 2002
    ..More widespread use of these agents will be an important intervention to prevent the devastating complications of hypertension, including stroke, myocardial infarction, and heart failure...
  38. ncbi Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency
    Michael G Shlipak
    Department of Medicine, University of California, San Francisco, and the Veterans Affairs Medical Center, San Francisco 94121, USA
    Circulation 107:87-92. 2003
    ..Little is known about the association of renal insufficiency with inflammatory and procoagulant markers, which are potential mediators for the cardiovascular risk of kidney disease...
  39. ncbi Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study
    Mark H Drazner
    Heart Failure Research Unit, Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Coll Cardiol 43:2207-15. 2004
    ..Our aim in this study was to determine whether increased left ventricular mass (LVM) is a risk factor for the development of a reduced left ventricular ejection fraction (LVEF)...
  40. ncbi Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  41. ncbi Validity of reported genetic risk factors for acute coronary syndrome
    W Gregory Feero
    JAMA 298:1757; author reply 1759. 2007
  42. ncbi Subclinical cardiovascular disease in older adults: insights from the Cardiovascular Health Study
    Paulo H M Chaves
    Departments of Medicine and Epidemiology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Geriatr Cardiol 13:137-51. 2004
    ..Ongoing research will address the potential use of SCVD for clinical decision making in older adults...
  43. ncbi C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study
    Jie J Cao
    Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Circulation 108:166-70. 2003
    ..We investigated whether elevated CRP is a risk factor for ischemic stroke independent of carotid IMT and studied the interaction between CRP and IMT...
  44. ncbi Intrinsic contribution of gender and ethnicity to normal ankle-brachial index values: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Victor Aboyans
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA
    J Vasc Surg 45:319-27. 2007
    ..Consequently, an ABI threshold that disregards these fundamental gender-related and ethnicity-related differences could partly contribute to reported prevalence differences...
  45. ncbi Incidence of cardiovascular disease in older Americans: the cardiovascular health study
    Alice M Arnold
    Department of Biostatistics, University of Washington, Seattle, USA
    J Am Geriatr Soc 53:211-8. 2005
    ..To estimate incidence rates of major cardiovascular disease (CVD) in older Americans...
  46. ncbi Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study
    Murilo Foppa
    Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Cardiovasc Ultrasound 4:43. 2006
    ..However, the relations between left ventricular structure and diabetes have not been extensively studied in African-Americans...
  47. ncbi Coronary calcium, race, and genes
    Teri A Manolio
    Arterioscler Thromb Vasc Biol 22:359-60. 2002
  48. ncbi 10-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 166:71-8. 2006
    ..The incidence of coronary heart disease (CHD) is very high among individuals 65 years or older...
  49. ncbi C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Circulation 112:25-31. 2005
    ..High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available...
  50. ncbi High rates of obesity and cardiovascular disease risk factors in lower middle class community in Pakistan: the Metroville Health Study
    Barbara Dennis
    Department of Biostatistics, University of North Carolina, Chapel Hill, USA
    J Pak Med Assoc 56:267-72. 2006
    ..For prevention of increasing CVD in urban communities, targeted programs of intervention are required...
  51. ncbi White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, 130 N Bellefield Ave, Rm 550, Pittsburgh, PA 15213, United States
    Neurobiol Aging 28:1307-15. 2007
    ..Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals...
  52. ncbi Obtaining informed consent for genetic studies: The multiethnic study of atherosclerosis
    David Green
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Epidemiol 164:845-51. 2006
    ..The authors concluded that a small percentage of participants in epidemiologic studies refuse consent for DNA studies, and the majority are concerned about sharing their DNA data with industry...
  53. ncbi Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 33:2376-82. 2002
    ..MRI-defined infarcts are common in the elderly. We sought to explore incidence, manifestations, and predictors of such infarcts...
  54. ncbi Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study
    John S Gottdiener
    St Francis Hospital, Roslyn, New York Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 137:631-9. 2002
    ..Most persons with congestive heart failure are elderly, and many elderly persons with congestive heart failure have normal left ventricular systolic function...
  55. ncbi Familial aggregation of atrial fibrillation in Iceland
    David O Arnar
    Department of Medicine, Landspitali University Hospital, Hringbraut, Reykjavik, Iceland
    Eur Heart J 27:708-12. 2006
    ..CONCLUSION: AF shows strong evidence of heritability among unselected patients in Iceland, suggesting that there may be undiscovered genetic variants underlying the risk of the common form of AF...
  56. ncbi A prospective analysis of risk factors for white matter disease in the brain stem: the Cardiovascular Health Study
    Jingzhong Ding
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Room W6009, Baltimore, MD 21205, USA
    Neuroepidemiology 22:275-82. 2003
    ..However, no epidemiologic study has examined the associations between cardiovascular risk factors and WMD in the brain stem...
  57. ncbi Cardiovascular disease risk status in elderly persons with renal insufficiency
    Michael G Shlipak
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    Kidney Int 62:997-1004. 2002
    ..We determined the prevalence of elevated cardiovascular disease risk status among elderly persons with renal insufficiency...
  58. ncbi The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study
    Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 110:658-66. 2003
    ..To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons...
  59. ncbi Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: executive summary
    Noel Bairey Merz
    Circulation 109:805-7. 2004
  60. ncbi Risk factors for declining ankle-brachial index in men and women 65 years or older: the Cardiovascular Health Study
    Margaret Kennedy
    Department of Medicine, University of Vermont, Burlington, USA
    Arch Intern Med 165:1896-902. 2005
    ..74 (95% CI, 1.05-2.89). CONCLUSION: Worsening lower extremity arterial disease, assessed as ABI decline, occurred in 9.5% of this elderly cohort over 6 years and was associated with modifiable vascular disease risk factors...
  61. ncbi Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco 94121, USA
    JAMA 293:1737-45. 2005
    ..Elderly persons with chronic kidney disease have substantial risk for cardiovascular mortality, but the relative importance of traditional and novel risk factors is unknown...
  62. ncbi Blood pressure level and outcomes in adults aged 65 and older with prior ischemic stroke
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 54:1309-16. 2006
    ..To examine the association between blood pressure (BP) levels and long-term stroke outcomes in elderly stroke survivors...
  63. ncbi Associations between findings on cranial magnetic resonance imaging and retinal photography in the elderly: the Cardiovascular Health Study
    Wt Longstreth
    Department of Neurology, University of Washington, Seattle, WA 98104 2420, USA
    Am J Epidemiol 165:78-84. 2007
    ..Evidence of small vessel disease in the retina increases the likelihood of finding it in the brain. Associations were less prominent in this elderly population than have been described in middle-aged people...
  64. ncbi Retinal microvascular signs, cognitive function, and dementia in older persons: the Cardiovascular Health Study
    Michelle L Baker
    Centre for Eye Research Australia, University of Melbourne, East Melbourne Victoria, Australia
    Stroke 38:2041-7. 2007
    ..Cerebral microvascular disease may be a risk factor for the development of dementia in elderly persons. We describe the association of retinal microvascular signs with cognitive function and dementia among older individuals...
  65. ncbi Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists
    Chris L Bryson
    VA Puget Sound Health Services Research and Development, VAMC, Seattle, Washington 98108, USA
    J Am Geriatr Soc 52:1648-54. 2004
    ....
  66. ncbi Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143-0114, USA
    Ann Intern Med 140:237-47. 2004
    ..The persistence of the association after adjustment for right-sided stenosis indicates that the association is not due to underlying vascular risk factors or atherosclerosis in general...
  67. ncbi Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 5: gender-related risk factors for ischemic heart disease
    Leslee J Shaw
    Circulation 109:e56-8. 2004
  68. ncbi Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS)
    Eddy Barasch
    Department of Research and Education, St Francis Hospital, SUNY at Stony Brook, Roslyn, NY, USA
    Am Heart J 151:39-47. 2006
    ..CONCLUSIONS: In free-living elderly, MAC, AAC, and AVS are highly prevalent and are associated with CVD. Mitral annular calcification in particular has strong association with CVD, and with an adverse biomedical profile...