Teri A Manolio

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Finding the missing heritability of complex diseases
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B09, 31 Center Drive, MSC 2152, Bethesda, Maryland 20892 2152, USA
    Nature 461:747-53. 2009
  2. pmc The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine
    Leslie G Biesecker
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1665-74. 2009
  3. pmc Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    Lucia A Hindorff
    Office of Population Genomics, Genome Technology Branch, National Human Genome Research Institute, and National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:9362-7. 2009
  4. pmc Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B 09, 31 Center Drive, MSC 2154, Bethesda, MD 20892 2154, USA
    Pharmacogenomics 10:235-41. 2009
  5. ncbi request reprint The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the Cardiovascular Health Study
    Jie J Cao
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Atherosclerosis 187:372-7. 2006
  6. pmc The HapMap and genome-wide association studies in diagnosis and therapy
    Teri A Manolio
    National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Annu Rev Med 60:443-56. 2009
  7. ncbi request reprint Merging and emerging cohorts: necessary but not sufficient
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, 31 Center Drive, Bethesda, Maryland 20892 2152, USA
    Nature 445:259. 2007
  8. ncbi request reprint Left atrial dimensions determined by M-mode echocardiography in black and white older (> or =65 years) adults (The Cardiovascular Health Study)
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
    Am J Cardiol 90:983-7. 2002
  9. pmc Ethnic differences in the relationship of carotid atherosclerosis to coronary calcification: the Multi-Ethnic Study of Atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 2154, USA
    Atherosclerosis 197:132-8. 2008
  10. pmc Reporting genetic results in research studies: summary and recommendations of an NHLBI working group
    Ebony B Bookman
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
    Am J Med Genet A 140:1033-40. 2006

Detail Information

Publications33

  1. pmc Finding the missing heritability of complex diseases
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B09, 31 Center Drive, MSC 2152, Bethesda, Maryland 20892 2152, USA
    Nature 461:747-53. 2009
    ....
  2. pmc The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine
    Leslie G Biesecker
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:1665-74. 2009
    ..The early experiences with ClinSeq illustrate how large-scale medical sequencing can be a practical, productive, and critical component of research in genomic medicine...
  3. pmc Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    Lucia A Hindorff
    Office of Population Genomics, Genome Technology Branch, National Human Genome Research Institute, and National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:9362-7. 2009
    ..This new online resource, together with bioinformatic predictions of the underlying functionality at trait/disease-associated loci, is well-suited to guide future investigations of the role of common variants in complex disease etiology...
  4. pmc Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B 09, 31 Center Drive, MSC 2154, Bethesda, MD 20892 2154, USA
    Pharmacogenomics 10:235-41. 2009
    ....
  5. ncbi request reprint The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the Cardiovascular Health Study
    Jie J Cao
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Atherosclerosis 187:372-7. 2006
    ..It is not known whether this association is due to the effect of MA on the development of subclinical atherosclerosis or whether MA destabilizes subclinical atherosclerosis, leading to clinical events...
  6. pmc The HapMap and genome-wide association studies in diagnosis and therapy
    Teri A Manolio
    National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Annu Rev Med 60:443-56. 2009
    ....
  7. ncbi request reprint Merging and emerging cohorts: necessary but not sufficient
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, 31 Center Drive, Bethesda, Maryland 20892 2152, USA
    Nature 445:259. 2007
  8. ncbi request reprint Left atrial dimensions determined by M-mode echocardiography in black and white older (> or =65 years) adults (The Cardiovascular Health Study)
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
    Am J Cardiol 90:983-7. 2002
    ..Thus, LA dimension is strongly associated with weight and with several echocardiographic valvular abnormalities; its relation with LV fractional shortening is U-shaped with a nadir at the borderline of LV functional impairment...
  9. pmc Ethnic differences in the relationship of carotid atherosclerosis to coronary calcification: the Multi-Ethnic Study of Atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 2154, USA
    Atherosclerosis 197:132-8. 2008
    ..These differences should be pursued for relationships to coronary events to determine whether coronary calcium carries the same risk information in other ethnic groups as it does in Whites...
  10. pmc Reporting genetic results in research studies: summary and recommendations of an NHLBI working group
    Ebony B Bookman
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7934, USA
    Am J Med Genet A 140:1033-40. 2006
    ..Finally, the Working Group recommended procedures for reporting genetic research results and encouraged increased efforts to create uniform guidelines for this activity...
  11. ncbi request reprint Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Int Arch Allergy Immunol 131:119-26. 2003
    ..The main objective of this study was to determine prevalence and correlates of sensitivity to these mites in families with asthma and characteristics of persons sensitized to both...
  12. ncbi request reprint Hypertension and cognitive function: pathophysiologic effects of hypertension on the brain
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Curr Hypertens Rep 5:255-61. 2003
    ....
  13. ncbi request reprint Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131)
    Angelo Scuteri
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Am Coll Cardiol 43:187-93. 2004
    ..We hypothesized that variant geometric patterns of the common carotid artery (CCA) predict the incidence of cardiovascular disease (CVD), after accounting for CCA intima-medial thickness (IMT)...
  14. ncbi request reprint Predictors of falling cholesterol levels in older adults: the Cardiovascular Health Study
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Ann Epidemiol 14:325-31. 2004
    ..To estimate 4-year change in serum total cholesterol levels in a population-based sample of older adults and identify independent predictors of cholesterol decline...
  15. ncbi request reprint Sex differences in heritability of sensitization to Blomia tropicalis in asthma using regression of offspring on midparent (ROMP) methods
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm 8160, Bethesda, MD 20892 7934, USA
    Hum Genet 113:437-46. 2003
    ..Adjustment for covariates had minimal impact. This suggests that future investigations of genetic determinants of IgE levels should include approaches that allow for potential sex differences in their expression...
  16. ncbi request reprint Genetics of ultrasonographic carotid atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Arterioscler Thromb Vasc Biol 24:1567-77. 2004
    ..Another, PON1 L55 mol/L, is weakly associated in subgroups only. Genetic variants reported to be associated with clinical cardiovascular disease show weak or no relationship to carotid atherosclerosis...
  17. ncbi request reprint A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 95:856-9. 2005
    ..Out-of-hospital coronary heart disease deaths overestimated sudden cardiac death by 47%, suggesting that out-of-hospital coronary heart disease death rates derived from death certificates should be interpreted with caution...
  18. ncbi request reprint Genes, environment, health, and disease: facing up to complexity
    Teri A Manolio
    National Human Genome Research Institute, NIH, Bethesda, MD 20892 2152, USA
    Hum Hered 63:63-6. 2007
  19. doi request reprint How to interpret a genome-wide association study
    Thomas A Pearson
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    JAMA 299:1335-44. 2008
    ..This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance...
  20. pmc A HapMap harvest of insights into the genetics of common disease
    Teri A Manolio
    National Human Genome Research Institute, 31 Center Drive, Room 4B 09, Bethesda, Maryland 20892 2154, USA
    J Clin Invest 118:1590-605. 2008
    ..In this review we examine the origin, development, and current status of the HapMap; its prospects for continued evolution; and its current and potential future impact on biomedical science...
  21. doi request reprint Genomics reaches the clinic: from basic discoveries to clinical impact
    Teri A Manolio
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 147:14-6. 2011
    ..Close interactions among laboratory, computational, and clinical research communities will be crucial to ensure that genomic discoveries advance medical science and, ultimately, improve human health...
  22. doi request reprint Implementing genomic medicine in the clinic: the future is here
    Teri A Manolio
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genet Med 15:258-67. 2013
    ..Much of this work is being done in isolation and would benefit from more structured collaboration and sharing of best practices.Genet Med 2013:15(4):258-267...
  23. pmc A mechanism for controlled access to GWAS data: experience of the GAIN Data Access Committee
    Erin M Ramos
    Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 92:479-88. 2013
    ....
  24. pmc New models for large prospective studies: is there a better way?
    Teri A Manolio
    Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, USA
    Am J Epidemiol 175:859-66. 2012
    ..Whether and how these approaches may be transportable to the United States remain to be explored, but their success in studies such as UK Biobank makes a compelling case for such explorations to begin...
  25. doi request reprint Charting a course for genomic medicine from base pairs to bedside
    Eric D Green
    National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, Bethesda, Maryland 20892 2152, USA
    Nature 470:204-13. 2011
    ..Here we articulate a 2011 vision for the future of genomics research and describe the path towards an era of genomic medicine...
  26. doi request reprint Variation and temporal trends in the use of diagnostic testing during hospitalization for acute myocardial infarction by age, gender, race, and geography (the Atherosclerosis Risk In Communities Study)
    Camille A Pearte
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 101:1219-25. 2008
    ..There may also be continued perception of lower risk in women and blacks without a known diagnosis of MI...
  27. ncbi request reprint Study designs to enhance identification of genetic factors in healthy aging
    Teri A Manolio
    Office of Population Genomics at the National Human Genetics Research Institute NHGRI, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    Nutr Rev 65:S228-33. 2007
    ..Many such studies are currently supported or being planned across the National Institutes of Health (NIH), and lend themselves to the kind of coordinated clinical research envisioned in programs such as the NIH Roadmap...
  28. pmc Genetic architecture of cancer and other complex diseases: lessons learned and future directions
    Lucia A Hindorff
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 9307, USA
    Carcinogenesis 32:945-54. 2011
    ....
  29. doi request reprint Bringing genome-wide association findings into clinical use
    Teri A Manolio
    Division of Genomic Medicine, National Human Genome Research Institute, 5635 Fishers Lane, Room 4113, MSC 9305, Rockville, Maryland 20892 9305, USA
    Nat Rev Genet 14:549-58. 2013
    ....
  30. ncbi request reprint Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study
    Jie J Cao
    National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1061, Bldg 10, Room B1D 416, Bethesda, MD 20892, USA
    Circulation 116:32-8. 2007
    ..We investigated the relationship between carotid atherosclerosis and CRP and their joint roles in CVD prediction...
  31. ncbi request reprint Genes, environment and the value of prospective cohort studies
    Teri A Manolio
    National Human Genome Research Institute, 31 Center Drive, Room 4B09, Bethesda, Maryland 20892 2154, USA
    Nat Rev Genet 7:812-20. 2006
    ..This and other strengths of prospective cohort studies make them invaluable for understanding gene-environment interactions in complex human disease...
  32. ncbi request reprint New models of collaboration in genome-wide association studies: the Genetic Association Information Network
    Teri A Manolio
    National Human Genome Research Institute, US National Institutes of Health NIH, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 39:1045-51. 2007
    ..These demonstrate a new commitment to shared scientific knowledge that should facilitate rapid advances in understanding the genetics of complex diseases...
  33. ncbi request reprint Taking our obligations to research participants seriously: disclosing individual results of genetic research
    Teri A Manolio
    National Human Genome Research Institute, National Institutes of Health, USA
    Am J Bioeth 6:32-4; author reply W10-2. 2006