John H Malone

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Patterns of reproductive isolation in toads
    John H Malone
    Department of Biology, The University of Texas at Arlington, Arlington, Texas, United States of America
    PLoS ONE 3:e3900. 2008
  2. pmc Microarrays, deep sequencing and the true measure of the transcriptome
    John H Malone
    Laboratory of Cellular and Developmental Biology, National Institute of Digestive, Diabetes, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biol 9:34. 2011
  3. pmc Gene expression analysis of the ovary of hybrid females of Xenopus laevis and X. muelleri
    John H Malone
    Department of Biology, The University of Texas Arlington, Box 19498, Arlington, Texas, 76010, USA
    BMC Evol Biol 8:82. 2008
  4. pmc The genomic 'inner fish' and a regulatory enigma in the vertebrates
    John Malone
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    J Biol 8:32. 2009
  5. pmc Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila
    Michael J Parisi
    Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
    BMC Genomics 11:346. 2010
  6. pmc Sterility and gene expression in hybrid males of Xenopus laevis and X. muelleri
    John H Malone
    Department of Biology, The University of Texas at Arlington, Arlington, Texas, United States of America
    PLoS ONE 2:e781. 2007
  7. doi request reprint Physiological sex predicts hybrid sterility regardless of genotype
    John H Malone
    Department of Biology, University of Texas at Arlington, Box 19498, Arlington, TX 76019, USA
    Science 319:59. 2008
  8. pmc Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki)
    David Sturgill
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    BMC Bioinformatics 14:320. 2013
  9. pmc Expression in aneuploid Drosophila S2 cells
    Yu Zhang
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 8:e1000320. 2010
  10. ncbi request reprint Gene expression polymorphism in Drosophila populations
    Pawel Michalak
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019 0498, USA
    Mol Ecol 16:1179-89. 2007

Detail Information

Publications14

  1. pmc Patterns of reproductive isolation in toads
    John H Malone
    Department of Biology, The University of Texas at Arlington, Arlington, Texas, United States of America
    PLoS ONE 3:e3900. 2008
    ..We discuss explanations for these patterns, including the role of Haldane's rule in toads and anurans in general, and suggest mechanisms generating patterns of reproductive isolation in anurans...
  2. pmc Microarrays, deep sequencing and the true measure of the transcriptome
    John H Malone
    Laboratory of Cellular and Developmental Biology, National Institute of Digestive, Diabetes, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biol 9:34. 2011
    ..We conclude that microarrays remain useful and accurate tools for measuring expression levels, and RNA-Seq complements and extends microarray measurements...
  3. pmc Gene expression analysis of the ovary of hybrid females of Xenopus laevis and X. muelleri
    John H Malone
    Department of Biology, The University of Texas Arlington, Box 19498, Arlington, Texas, 76010, USA
    BMC Evol Biol 8:82. 2008
    ..muelleri). In this work, we examine the gene expression pattern in hybrid females of X. laevis x X. muelleri to determine if this asymmetrical pattern of expression also occurs in hybrid females...
  4. pmc The genomic 'inner fish' and a regulatory enigma in the vertebrates
    John Malone
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    J Biol 8:32. 2009
    ..It reveals a core set of genes with similar tissue-expression patterns yet no common regulatory signatures--a gene-expression paradox...
  5. pmc Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila
    Michael J Parisi
    Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
    BMC Genomics 11:346. 2010
    ..We know little about the coordinated regulation of gene expression patterns in distant somatic tissues that support the developmental cost of gamete production...
  6. pmc Sterility and gene expression in hybrid males of Xenopus laevis and X. muelleri
    John H Malone
    Department of Biology, The University of Texas at Arlington, Arlington, Texas, United States of America
    PLoS ONE 2:e781. 2007
    ..muelleri)...
  7. doi request reprint Physiological sex predicts hybrid sterility regardless of genotype
    John H Malone
    Department of Biology, University of Texas at Arlington, Box 19498, Arlington, TX 76019, USA
    Science 319:59. 2008
    ..Gene expression profiles match these adult phenotypes, and our results demonstrate that faster-male evolution is the most likely mechanism producing hybrid male sterility...
  8. pmc Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki)
    David Sturgill
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    BMC Bioinformatics 14:320. 2013
    ..However, methods to analyze splicing are underdeveloped and errors resulting in incorrect splicing calls occur in every experiment...
  9. pmc Expression in aneuploid Drosophila S2 cells
    Yu Zhang
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 8:e1000320. 2010
    ..Our data indicate that expression dosage compensation dampens the effect of altered DNA copy number genome-wide. For the X chromosome, compensation includes fixed and dose-dependent components...
  10. ncbi request reprint Gene expression polymorphism in Drosophila populations
    Pawel Michalak
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019 0498, USA
    Mol Ecol 16:1179-89. 2007
    ..melanogaster/races/strains and predicted to be translational-inactive in Cosmopolitan due to a major deletion, was found to be up-regulated in Zimbabwe and down-regulated, but still expressed, in Cosmopolitan...
  11. pmc The sex chromosome that refused to die
    John H Malone
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Bioessays 30:409-11. 2008
    ..melanogaster genome.1 These results show that variation on Y has an important influence on the deployment of the genome...
  12. ncbi request reprint Testis-derived microRNA profiles of African clawed frogs (Xenopus) and their sterile hybrids
    Pawel Michalak
    Department of Biology, University of Texas Arlington, Box 19498, Arlington, TX 76019, USA
    Genomics 91:158-64. 2008
    ..A number of candidate differential microRNAs from this study have previously been described as testis-specific in the mouse, suggesting that microRNA structural conservation may be associated with functional retention...
  13. pmc Mediation of Drosophila autosomal dosage effects and compensation by network interactions
    John H Malone
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, 50 South Drive, Bethesda, MD 20892, USA
    Genome Biol 13:r28. 2012
    ..While it is often assumed that reducing gene dose by half leads to two-fold less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated by feedback or buffering in expression networks...
  14. ncbi request reprint Sex-biased gene expression in a ZW sex determination system
    John H Malone
    Department of Biology, The University of Texas Arlington, Box 19498, Arlington, TX 76019, USA
    J Mol Evol 63:427-36. 2006
    ....