Alan G Mallinger

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior?
    Alan G Mallinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychopharmacol Bull 42:64-74. 2009
  2. pmc Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms
    Alan G Mallinger
    Mood and Anxiety Disorders Program, National Institutes of Health Intramural Research Program, Building 10, Room 3N210, MSC 1290, Bethesda, MD 20892, USA
    Bipolar Disord 10:856-66. 2008
  3. ncbi request reprint Smaller cingulate volumes in unipolar depressed patients
    Sheila C Caetano
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Biol Psychiatry 59:702-6. 2006
  4. ncbi request reprint 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 86:61-7. 2005
  5. ncbi request reprint Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:996-1004. 2005
  6. ncbi request reprint Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, TX, USA
    Psychiatry Res 132:141-7. 2004
  7. ncbi request reprint 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients
    Paolo Brambilla
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 138:131-9. 2005
  8. ncbi request reprint Reduced left anterior cingulate volumes in untreated bipolar patients
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 56:467-75. 2004
  9. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
  10. ncbi request reprint Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 27:792-9. 2002

Detail Information

Publications29

  1. pmc Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior?
    Alan G Mallinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychopharmacol Bull 42:64-74. 2009
    ..We report here a comparison of monoamine oxidase inhibitors (MAOIs) with the serotonin reuptake inhibitor paroxetine (PAROX)...
  2. pmc Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms
    Alan G Mallinger
    Mood and Anxiety Disorders Program, National Institutes of Health Intramural Research Program, Building 10, Room 3N210, MSC 1290, Bethesda, MD 20892, USA
    Bipolar Disord 10:856-66. 2008
    ..Verapamil has shown antimanic activity in some but not all studies. Therefore, we investigated verapamil, used alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate trial of lithium...
  3. ncbi request reprint Smaller cingulate volumes in unipolar depressed patients
    Sheila C Caetano
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Biol Psychiatry 59:702-6. 2006
    ..This anatomical magnetic resonance imaging (MRI) study compared cingulate cortex volumes in unipolar depressed patients and age- and gender-matched healthy control subjects...
  4. ncbi request reprint 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 86:61-7. 2005
    ..Furthermore, recent MRS reports suggested possible lithium-induced increase in NAA levels in bipolar patients. We examined with in vivo (1)H MRS NAA levels in the DLPFC of adult bipolar patients...
  5. ncbi request reprint Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:996-1004. 2005
    ..Recent investigations have demonstrated benefits from the addition of psychoeducation or psychotherapy to pharmacotherapy in this population...
  6. ncbi request reprint Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, TX, USA
    Psychiatry Res 132:141-7. 2004
    ..A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients...
  7. ncbi request reprint 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients
    Paolo Brambilla
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 138:131-9. 2005
    ..Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder...
  8. ncbi request reprint Reduced left anterior cingulate volumes in untreated bipolar patients
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 56:467-75. 2004
    ....
  9. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects...
  10. ncbi request reprint Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 27:792-9. 2002
    ..05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial...
  11. ncbi request reprint Anatomical MRI study of corpus callosum in unipolar depression
    Acioly L T Lacerda
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
    J Psychiatr Res 39:347-54. 2005
    ..The possible role of callosal abnormalities in the pathogenesis of mood disorders should be further examined...
  12. pmc Population-based input function and image-derived input function for [¹¹C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuroimage 63:1532-41. 2012
    ....
  13. ncbi request reprint White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severity
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 77:237-45. 2003
    ..We examined the rates of hyperintense lesions in adult, non-elderly bipolar and unipolar patients, with a relatively mild-to-moderate illness severity, and in matched healthy controls...
  14. doi request reprint Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI study
    Fabiano G Nery
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Bipolar Disord 11:145-53. 2009
    ..This anatomical magnetic resonance imaging (MRI) study examined whether BD patients have smaller OFC gray matter volumes compared to healthy comparison subjects (HC)...
  15. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  16. ncbi request reprint Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapy
    Paola Rucci
    Department of Psychiatry, Western Psychiatric Institite and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 159:1160-4. 2002
    ..Lifetime rates of suicide attempts among patients with bipolar I disorder were compared to rates during a 2-year period of intensive treatment with pharmacotherapy and with one of two adjunctive psychosocial interventions...
  17. ncbi request reprint Anatomical MRI study of basal ganglia in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 124:129-40. 2003
    ..These findings suggest that abnormalities in lateralization and possibly neurodegenerative changes in basal ganglia structures participate in the pathophysiology of major depressive disorder...
  18. ncbi request reprint MRI investigation of temporal lobe structures in bipolar patients
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Psychiatr Res 37:287-95. 2003
    ..Longitudinal studies in high-risk offspring and first-episode patients will be needed to examine whether such abnormalities precede the appearance of symptoms, or whether they may appear subsequently as a result of illness course...
  19. ncbi request reprint Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 54:1294-7. 2003
    ..This study was conducted to further examine the hypothesis of abnormalities in size of corpus callosum in subjects with bipolar disorder...
  20. ncbi request reprint 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neuropsychopharmacology 29:1918-24. 2004
    ....
  21. pmc The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
    ..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years...
  22. ncbi request reprint Increased gray matter volume in lithium-treated bipolar disorder patients
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurosci Lett 329:243-5. 2002
    ..6; d.f. = 1, 25; P = 0.003) and healthy individuals (675.8 +/- 61.8 cm(3); F = 17.4; d.f. = 1, 59; P < 0.001), suggesting in vivo effects of lithium on gray matter, which could possibly reflect lithium's neurotrophic effects...
  23. ncbi request reprint Slower treatment response in bipolar depression predicted by lower pretreatment thyroid function
    Daniel P Cole
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Am J Psychiatry 159:116-21. 2002
    ..It was hypothesized that subjects with lower thyroid function, even within the normal range, would have a poorer response to initial treatment...
  24. ncbi request reprint Effects of tranylcypromine on the sleep of patients with anergic bipolar depression
    Ripu D Jindal
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15313, USA
    Psychopharmacol Bull 37:118-26. 2003
    ..Moreover, effective treatment of bipolar depression did not "normalize" the hypersomnolence associated with bipolar depression...
  25. ncbi request reprint Prevalence of obesity and weight change during treatment in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:528-33. 2002
    ..Individuals with bipolar disorder tend to be overweight, and their treatment may exacerbate obesity and increase the risk of concurrent medical disease in this population...
  26. pmc Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depression
    Lobna Ibrahim
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, CRC Unit 7 Southeast, Room 7 3445, Bethesda, MD 20892, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1155-9. 2011
    ..However, it remains unknown whether ketamine is equally effective in patients with MDD who previously also did not respond to electroconvulsive therapy (ECT)...
  27. pmc Combining a dopamine agonist and selective serotonin reuptake inhibitor for the treatment of depression: a double-blind, randomized pilot study
    José A Franco-Chaves
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Affect Disord 149:319-25. 2013
    ..This pilot study examined the efficacy and safety of combination therapy with pramipexole and the selective serotonin reuptake inhibitor (SSRI) escitalopram in MDD...
  28. pmc Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1026, USA
    Biol Psychiatry 72:548-54. 2012
    ..This study sought to quantify the binding of 11C-(R)-rolipram, a PDE4 inhibitor, as an indirect measure of this enzyme's activity in the brain of individuals with major depressive disorder (MDD) compared with healthy control subjects...
  29. ncbi request reprint 1H MRS brain measures and acute lorazepam administration in healthy human subjects
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 26:546-51. 2002
    ....