Research Topics
| Alan G MallingerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior?Alan G Mallinger
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Psychopharmacol Bull 42:64-74. 2009..We report here a comparison of monoamine oxidase inhibitors (MAOIs) with the serotonin reuptake inhibitor paroxetine (PAROX)...- Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanismsAlan G Mallinger
Mood and Anxiety Disorders Program, National Institutes of Health Intramural Research Program, Building 10, Room 3N210, MSC 1290, Bethesda, MD 20892, USA
Bipolar Disord 10:856-66. 2008..Verapamil has shown antimanic activity in some but not all studies. Therefore, we investigated verapamil, used alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate trial of lithium... 
Smaller cingulate volumes in unipolar depressed patientsSheila C Caetano
Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
Biol Psychiatry 59:702-6. 2006..Smaller cingulate volumes in currently depressed patients support the hypothesis that cingulate cortex abnormalities are state dependent, whereas changes in left anterior cingulate might be trait related...- 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patientsPaolo Brambilla
Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
J Affect Disord 86:61-7. 2005..Longitudinal 1H MRS studies should further examine NAA levels in prefrontal cortex regions in untreated bipolar patients before and after mood stabilizing treatment... - Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorderEllen Frank
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:996-1004. 2005..Recent investigations have demonstrated benefits from the addition of psychoeducation or psychotherapy to pharmacotherapy in this population... - 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patientsPaolo Brambilla
Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
Psychiatry Res 138:131-9. 2005..Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder... - Reduced left anterior cingulate volumes in untreated bipolar patientsRoberto B Sassi
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 56:467-75. 2004..Furthermore, our results suggest that lithium treatment might influence cingulate volumes in bipolar patients, which could possibly reflect postulated neuroprotective effects of lithium... - Anatomic evaluation of the orbitofrontal cortex in major depressive disorderAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Biol Psychiatry 55:353-8. 2004..Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative... - Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depressionSheila C Caetano
Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, TX, USA
Psychiatry Res 132:141-7. 2004..A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients... - Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjectsPaolo Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neuropsychopharmacology 27:792-9. 2002..05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial... - Anatomical MRI study of corpus callosum in unipolar depressionAcioly L T Lacerda
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
J Psychiatr Res 39:347-54. 2005..The possible role of callosal abnormalities in the pathogenesis of mood disorders should be further examined... - White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severityRoberto B Sassi
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Affect Disord 77:237-45. 2003..We examined the rates of hyperintense lesions in adult, non-elderly bipolar and unipolar patients, with a relatively mild-to-moderate illness severity, and in matched healthy controls... 
Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI studyFabiano G Nery
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Bipolar Disord 11:145-53. 2009..This anatomical magnetic resonance imaging (MRI) study examined whether BD patients have smaller OFC gray matter volumes compared to healthy comparison subjects (HC)...- Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?Alexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 25:1060-6. 2008..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression... - Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorderPaolo Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 54:1294-7. 2003..05) but not in bipolar patients (p >.05). CONCLUSIONS:Smaller callosal areas may lead to altered inter-hemispheric communication and be involved in the pathophysiology and cognitive impairment found in bipolar disorder... - MRI investigation of temporal lobe structures in bipolar patientsPaolo Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Psychiatr Res 37:287-95. 2003..Longitudinal studies in high-risk offspring and first-episode patients will be needed to examine whether such abnormalities precede the appearance of symptoms, or whether they may appear subsequently as a result of illness course... - Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapyPaola Rucci
Department of Psychiatry, Western Psychiatric Institite and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 159:1160-4. 2002..CONCLUSIONS: A treatment program in a maximally supportive clinical environment can significantly reduce suicidal behavior in high-risk patients with bipolar I disorder... - Anatomical MRI study of basal ganglia in major depressive disorderAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Psychiatry Res 124:129-40. 2003..These findings suggest that abnormalities in lateralization and possibly neurodegenerative changes in basal ganglia structures participate in the pathophysiology of major depressive disorder... - Population-based input function and image-derived input function for [¹¹C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorderPaolo Zanotti-Fregonara
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Neuroimage 63:1532-41. 2012.... - 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administrationPaolo Brambilla
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Neuropsychopharmacology 29:1918-24. 2004.... - The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorderEllen Frank
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 165:1559-65. 2008..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years... - Increased gray matter volume in lithium-treated bipolar disorder patientsRoberto B Sassi
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neurosci Lett 329:243-5. 2002..6; d.f. = 1, 25; P = 0.003) and healthy individuals (675.8 +/- 61.8 cm(3); F = 17.4; d.f. = 1, 59; P < 0.001), suggesting in vivo effects of lithium on gray matter, which could possibly reflect lithium's neurotrophic effects... - Slower treatment response in bipolar depression predicted by lower pretreatment thyroid functionDaniel P Cole
Department of Psychiatry, University of Pittsburgh School of Medicine, USA
Am J Psychiatry 159:116-21. 2002..It remains to be seen whether pharmacological enhancement of thyroid function will facilitate recovery from bipolar depression... - Effects of tranylcypromine on the sleep of patients with anergic bipolar depressionRipu D Jindal
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15313, USA
Psychopharmacol Bull 37:118-26. 2003..Moreover, effective treatment of bipolar depression did not "normalize" the hypersomnolence associated with bipolar depression... - Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depressionLobna Ibrahim
Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, CRC Unit 7 Southeast, Room 7 3445, Bethesda, MD 20892, USA
Prog Neuropsychopharmacol Biol Psychiatry 35:1155-9. 2011..However, it remains unknown whether ketamine is equally effective in patients with MDD who previously also did not respond to electroconvulsive therapy (ECT)... - Prevalence of obesity and weight change during treatment in patients with bipolar I disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 63:528-33. 2002.... - Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorderMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1026, USA
Biol Psychiatry 72:548-54. 2012..This study sought to quantify the binding of 11C-(R)-rolipram, a PDE4 inhibitor, as an indirect measure of this enzyme's activity in the brain of individuals with major depressive disorder (MDD) compared with healthy control subjects... - 1H MRS brain measures and acute lorazepam administration in healthy human subjectsPaolo Brambilla
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 26:546-51. 2002....