Research Topics
Species | David E MalarkeySummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
New insights into functional aspects of liver morphologyDavid E Malarkey
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 33:27-34. 2005..Awareness of the complexities and heterogeneity of the liver will add to a greater understanding of liver function and disease processes that lead to toxicity, cancer, and other diseases...- Gene expression response in target organ and whole blood varies as a function of target organ injury phenotypeEdward K Lobenhofer
Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
Genome Biol 9:R100. 2008..The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data... - Microarray data analysis of mouse neoplasiaDavid E Malarkey
Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 33:127-35. 2005.... - Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient miceGrace E Kissling
Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 107:19-26. 2009..AC mice appear less sensitive to hepatocarcinogenesis than standard rodent models. These results suggest caution for the use of Tg.AC and p53 mice to screen unknown chemicals in drinking water for potential carcinogenicity... - Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experimentsGary A Boorman
Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 86:185-93. 2005..The results of this study demonstrate a prominent circadian rhythm in gene expression in the rat that is a critical factor in planning toxicogenomic experiments... - Testing an aflatoxin B1 gene signature in rat archival tissuesB Alex Merrick
Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
Chem Res Toxicol 25:1132-44. 2012..We conclude that an evaluation of gene signatures in archival tissues can be an important toxicological tool for evaluating critical molecular events associated with chemical exposures... - Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 miceMatthew D Stout
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 36:783-94. 2008..These data suggest that in the initial study, H. hepaticusinfluenced the induction of hepatocellular neoplasms in males, but not in females... - Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 micePo Chuen Chan
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Chin Med 39:779-88. 2011..In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic... - 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth-plate suppressionDanielle N Lewis
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709-9998, USA
Toxicol Pathol 33:272-82. 2005..The Faxitron proved to be an excellent noninvasive tool that can be used in future studies with this animal model to examine treatment modalities for the chronic effects of human thrombotic disorders... - Fourteen-week toxicity study of green tea extract in rats and micePo C Chan
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Toxicol Pathol 38:1070-84. 2010..The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction... - Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 miceChad R Blystone
National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States
Food Chem Toxicol 49:2116-24. 2011..In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats... - No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 daysKristine L Witt
Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Environ Mol Mutagen 51:80-8. 2010..Additionally, no histopathological changes in brain or heart, or elevated serum biomarkers of cardiac injury were observed in these MPH-exposed rats... - Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposureMatthew D Stout
National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 117:716-22. 2009..Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI)... - Histopathological evaluation of the nervous system in National Toxicology Program rodent studies: a modified approachDeepa B Rao
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 39:463-70. 2011..It is expected that this modified approach will increase the sensitivity of detecting neurotoxicants and neurocarcinogens important in human neurologic and neurodegenerative disorders... - Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumorsArun R Pandiri
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Toxicol Pathol 39:1065-74. 2011..In conclusion, the AVNWLE-induced large intestinal tumors in F344 rats share several similarities with hCRC at the morphological and molecular levels... - Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavageMichael C Boyle
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Toxicol Pathol 40:561-76. 2012..However, the resultant clinical spectrum of protein-losing enteropathy was not present... - The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposureAbraham Nyska
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Appl Pharmacol 184:153-64. 2002..Endothelial proliferation may also have been promoted through endothelial arrest at S phase, which was associated with endothelial karyo- and cytomegaly, resulting in hepatocytic hypoxia, triggering VEGF induction... - Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray dataRichard D Irwin
Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 32:72-83. 2004..Most studies will require the input from the disciplines of toxicology, pathology, molecular biology, bioinformatics, biochemistry, and others depending on the types of questions being asked... - Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 ratsDale M Walker
Experimental Pathology Laboratories, Inc, Herndon, Virginia, USA
Environ Mol Mutagen 48:283-98. 2007.... - Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretationEdward K Lobenhofer
Cogenics, Division of Clinical Data, Morrisville, North Carolina 27560, USA
Toxicol Pathol 34:921-8. 2006.... - A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia markerMiriam M Kleiter
College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27514-7512, USA
Int J Radiat Oncol Biol Phys 64:592-602. 2006..Selective cellular uptake and concomitant higher levels of binding in regions of hypoxia at the high end of pH gradients might account for the greater extent of pimonidazole binding... - Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic miceHong Dang
Alpha-Gamma Technologies, Inc, Raleigh, North Carolina, USA
Mol Carcinog 45:126-40. 2006..Additional analyses presented here yield novel insights into the genes and processes involved in papilloma development in Tg.AC mice...