David E Malarkey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint New insights into functional aspects of liver morphology
    David E Malarkey
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:27-34. 2005
  2. pmc Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
  3. ncbi request reprint Microarray data analysis of mouse neoplasia
    David E Malarkey
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:127-35. 2005
  4. pmc Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice
    Grace E Kissling
    Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 107:19-26. 2009
  5. ncbi request reprint Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:185-93. 2005
  6. pmc Testing an aflatoxin B1 gene signature in rat archival tissues
    B Alex Merrick
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Chem Res Toxicol 25:1132-44. 2012
  7. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008
  8. doi request reprint Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage
    Michael C Boyle
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Pathol 40:561-76. 2012
  9. ncbi request reprint Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Chin Med 39:779-88. 2011
  10. ncbi request reprint 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth-plate suppression
    Danielle N Lewis
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 9998, USA
    Toxicol Pathol 33:272-82. 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint New insights into functional aspects of liver morphology
    David E Malarkey
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:27-34. 2005
    ..Awareness of the complexities and heterogeneity of the liver will add to a greater understanding of liver function and disease processes that lead to toxicity, cancer, and other diseases...
  2. pmc Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
    ..The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data...
  3. ncbi request reprint Microarray data analysis of mouse neoplasia
    David E Malarkey
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:127-35. 2005
    ....
  4. pmc Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice
    Grace E Kissling
    Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 107:19-26. 2009
    ..AC mice appear less sensitive to hepatocarcinogenesis than standard rodent models. These results suggest caution for the use of Tg.AC and p53 mice to screen unknown chemicals in drinking water for potential carcinogenicity...
  5. ncbi request reprint Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:185-93. 2005
    ..The results of this study demonstrate a prominent circadian rhythm in gene expression in the rat that is a critical factor in planning toxicogenomic experiments...
  6. pmc Testing an aflatoxin B1 gene signature in rat archival tissues
    B Alex Merrick
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Chem Res Toxicol 25:1132-44. 2012
    ..We conclude that an evaluation of gene signatures in archival tissues can be an important toxicological tool for evaluating critical molecular events associated with chemical exposures...
  7. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008
    ..These data suggest that in the initial study, H. hepaticusinfluenced the induction of hepatocellular neoplasms in males, but not in females...
  8. doi request reprint Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage
    Michael C Boyle
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Pathol 40:561-76. 2012
    ..However, the resultant clinical spectrum of protein-losing enteropathy was not present...
  9. ncbi request reprint Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Chin Med 39:779-88. 2011
    ..In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic...
  10. ncbi request reprint 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth-plate suppression
    Danielle N Lewis
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 9998, USA
    Toxicol Pathol 33:272-82. 2005
    ..The Faxitron proved to be an excellent noninvasive tool that can be used in future studies with this animal model to examine treatment modalities for the chronic effects of human thrombotic disorders...
  11. pmc Fourteen-week toxicity study of green tea extract in rats and mice
    Po C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 38:1070-84. 2010
    ..The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction...
  12. pmc Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice
    Chad R Blystone
    National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 49:2116-24. 2011
    ..In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats...
  13. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
    ..Additionally, no histopathological changes in brain or heart, or elevated serum biomarkers of cardiac injury were observed in these MPH-exposed rats...
  14. pmc Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:716-22. 2009
    ..Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI)...
  15. doi request reprint Histopathological evaluation of the nervous system in National Toxicology Program rodent studies: a modified approach
    Deepa B Rao
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:463-70. 2011
    ..It is expected that this modified approach will increase the sensitivity of detecting neurotoxicants and neurocarcinogens important in human neurologic and neurodegenerative disorders...
  16. doi request reprint Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors
    Arun R Pandiri
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:1065-74. 2011
    ..In conclusion, the AVNWLE-induced large intestinal tumors in F344 rats share several similarities with hCRC at the morphological and molecular levels...
  17. ncbi request reprint The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 184:153-64. 2002
    ..Endothelial proliferation may also have been promoted through endothelial arrest at S phase, which was associated with endothelial karyo- and cytomegaly, resulting in hepatocytic hypoxia, triggering VEGF induction...
  18. ncbi request reprint Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data
    Richard D Irwin
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:72-83. 2004
    ..Most studies will require the input from the disciplines of toxicology, pathology, molecular biology, bioinformatics, biochemistry, and others depending on the types of questions being asked...
  19. ncbi request reprint Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats
    Dale M Walker
    Experimental Pathology Laboratories, Inc, Herndon, Virginia, USA
    Environ Mol Mutagen 48:283-98. 2007
    ....
  20. ncbi request reprint Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Morrisville, North Carolina 27560, USA
    Toxicol Pathol 34:921-8. 2006
    ....
  21. ncbi request reprint A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker
    Miriam M Kleiter
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27514 7512, USA
    Int J Radiat Oncol Biol Phys 64:592-602. 2006
    ..Pimonidazole HCl is widely used in immunohistochemical analyses of hypoxia in normal and malignant tissues. The present study investigates oral administration as a means of minimizing invasiveness...
  22. ncbi request reprint Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice
    Hong Dang
    Alpha Gamma Technologies, Inc, Raleigh, North Carolina, USA
    Mol Carcinog 45:126-40. 2006
    ..Additional analyses presented here yield novel insights into the genes and processes involved in papilloma development in Tg.AC mice...