Research Topics
Genomes and Genes | K S MakarovaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of actionKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Biol Direct 1:7. 2006..However, the proximity of CRISPR and cas genes strongly suggests that they have related functions which is hard to reconcile with the repair hypothesis...- Francisella RNA polymerase contains a heterodimer of non-identical α subunitsDamir Mukhamedyarov
Department of Biochemistry and Molecular Biology and Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
BMC Mol Biol 12:50. 2011..Based on an observation that both α1 and α2 are incorporated into Francisella RNAP, Charity et al. (2007) previously suggested that up to four different species of RNAP core enzyme might form in the same Francisella cell... - The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotesKira S Makarova
National Center for Biotechnology Information, NLM, National Institutes of Health, Bethesda, Maryland 20894, USA
Biol Direct 7:7. 2012..Here we present the results of in-depth phylogenomic analysis of RecJ homologs in archaea... - Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1Jimmy H Saw
Department of Microbiology, University of Hawai i, 2538 The Mall, Honolulu, HI 96822, USA
Genome Biol 9:R161. 2008..The ability of A. flavithermus to grow in super-saturated silica solutions makes it an ideal subject to study the processes of sinter formation, which might be similar to the biomineralization processes that occurred at the dawn of life... - A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitansMircea Podar
Biosciences Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN 37831, USA
Genome Biol 9:R158. 2008..Little is known about the mechanisms that enable this relationship... - Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systemsKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA
Biol Direct 6:38. 2011..Comparative analysis of the Cas protein sequences and structures led to the classification of the CRISPR-Cas systems into three Types (I, II and III)... - The prokaryotic V4R domain is the likely ancestor of a key component of the eukaryotic vesicle transport systemMircea Podar
Biosciences Division and the Bioenergy Science Center, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN 37831, USA
Biol Direct 3:2. 2008..This suggests, for the first time, a prokaryotic origin for one of the key eukaryotic trafficking proteins... - A highly conserved family of inactivated archaeal B family DNA polymerasesIgor B Rogozin
National Center for Biotechnology Information NLM, National Institutes of Health, Bethesda, MD, 20894, USA
Biol Direct 3:32. 2008..The inactivated derivative of the archaeal DNA polymerase could form a complex with the active paralog and play a structural role in DNA replication... - Orthologs of the small RPB8 subunit of the eukaryotic RNA polymerases are conserved in hyperthermophilic Crenarchaeota and "Korarchaeota"Eugene V Koonin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Biol Direct 2:38. 2007..These findings suggest that all 12 core subunits of eukaryotic RNAPs were already present in the last common ancestor of the extant archaea... - Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum VerrucomicrobiaShaobin Hou
Advance Studies in Genomics, Proteomics and Bioinformatics, College of Natural Sciences, University of Hawaii, Keller Hall 319, Honolulu, Hawaii, 96822, USA
Biol Direct 3:26. 2008..Similar organisms were independently isolated from geothermal systems in Italy and Russia... - Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaeaKira S Makarova
National Center for Biotechnology Information, NLM, National Institutes of Health Bethesda, Maryland 20894, USA
Biol Direct 5:33. 2010.... - Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestorsTahir H Tahirov
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
Biol Direct 4:11. 2009..However, the details of the evolutionary relationships between DNA polymerases of archaea and eukaryotes remain unresolved... - Evolutionary primacy of sodium bioenergeticsArmen Y Mulkidjanian
School of Physics, University of Osnabruck, D 49069 Osnabruck, Germany
Biol Direct 3:13. 2008..The prevalent proton-dependent ATPases are generally viewed as the primary form of the enzyme whereas the sodium-translocating ATPases of some prokaryotes are usually construed as an exotic adaptation to survival in extreme environments... - Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in ArchaeaFabian Blombach
Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
Biol Direct 4:39. 2009..These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes... - Comparative genomics of Thermus thermophilus and Deinococcus radiodurans: divergent routes of adaptation to thermophily and radiation resistanceMarina V Omelchenko
Department of Pathology, F E Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
BMC Evol Biol 5:57. 2005..radiodurans is a mesophile, which is highly radiation- and desiccation-resistant. Here we present an in-depth comparison of the genomes of these two related but differently adapted bacteria... 
Specific expansion of protein families in the radioresistant bacterium Deinococcus radioduransK S Makarova
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Genetica 108:25-34. 2000..Such unique proteins are good targets for knock-out and gene expression studies, which are aimed to shed light on the unusual features of this interesting bacterium...- Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elementsKira S Makarova
National Center for Biotechnology Information, NLM, National Institutes of Health, Bethesda, Maryland 20894, USA
Biol Direct 4:29. 2009..Many prokaryotes also encode homologs of Argonaute-PIWI proteins but their functions remain unknown... - Evolutionary genomics of lactic acid bacteriaKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
J Bacteriol 189:1199-208. 2007 - Deinococcus geothermalis: the pool of extreme radiation resistance genes shrinksKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 2:e955. 2007.... - Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotesKira S Makarova
National Center for Biotechnology Information, NLM, National Institutes of Health, Bethesda, Maryland 20894, USA
Biol Direct 4:19. 2009.... - Filling a gap in the central metabolism of archaea: prediction of a novel aconitase by comparative-genomic analysisKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
FEMS Microbiol Lett 227:17-23. 2003..The prediction of aconitase X completes the TCA cycle for Methanothermobacter thermoautotrophicus and Archaeoglobus fulgidus and suggests that most archaea have a full TCA cycle... - Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaeaKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Biol Direct 2:33. 2007..One of the practical strategies involves construction of refined COGs for phylogenetically compact subsets of genomes... - A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysisKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 380, Bethesda, MD 20894, USA
Nucleic Acids Res 30:482-96. 2002.... - Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomicsK S Makarova
Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA
Microbiol Mol Biol Rev 65:44-79. 2001..In combination, these observations suggest that several different biological mechanisms contribute to the multiple DNA repair-dependent phenotypes of this organism... - Lineage-specific gene expansions in bacterial and archaeal genomesI K Jordan
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Genome Res 11:555-65. 2001..The topology of the resulting graph seems to reflect a combined effect of common ancestry, horizontal transfer, and lineage-specific gene loss... - SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectoriesL Aravind
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 28:3417-32. 2000..This analysis resulted in the prediction of numerous previously unnoticed nucleases, some of which are likely to be new restriction enzymes... - Conservation of the binding site for the arginine repressor in all bacterial lineagesK S Makarova
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Genome Biol 2:RESEARCH0013. 2001..Here, we apply the comparative genomic approach to the prediction of the ArgR-binding sites in all completely sequenced bacterial genomes... - Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cellKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 33:4626-38. 2005..The results of this study demonstrate a major increase in the level of gene paralogy as a hallmark of the early evolution of eukaryotes... - The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfersEugene V Koonin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 4:R19. 2003.... - Connected gene neighborhoods in prokaryotic genomesIgor B Rogozin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 30:2212-23. 2002..Gene neighborhoods appear to evolve via complex rearrangement, with different combinations of genes from a neighborhood fixed in different lineages... - Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packagingLakshminarayan M Iyer
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 32:5260-79. 2004.... - Horizontal gene transfer in prokaryotes: quantification and classificationE V Koonin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Annu Rev Microbiol 55:709-42. 2001.... - Two C or not two C: recurrent disruption of Zn-ribbons, gene duplication, lineage-specific gene loss, and horizontal gene transfer in evolution of bacterial ribosomal proteinsK S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 2:RESEARCH 0033. 2001..Here we analyze all such cases and attempt to reconstruct the evolutionary history of these ribosomal proteins... - Gene conversions in genes encoding outer-membrane proteins in H. pylori and C. pneumoniaeI K Jordan
National Center for Biotechnology Information, National Institutes of Health, Building 38A Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
Trends Genet 17:7-10. 2001..pylori strains and two C. pneumoniae strains, we identify multiple independent conversions among these genes. Such recombination events might provide a selective advantage for these bacterial pathogens... - Evolution of eukaryotic gene repertoire and gene structure: discovering the unexpected dynamics of genome evolutionI B Rogozin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
Cold Spring Harb Symp Quant Biol 68:293-301. 2003 - The deep archaeal roots of eukaryotesNatalya Yutin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
Mol Biol Evol 25:1619-30. 2008..Thus, the archaeal genes in eukaryotes appear to descend from a distinct, ancient, and otherwise uncharacterized archaeal lineage that acquired some euryarchaeal and crenarchaeal genes via early horizontal gene transfer... - Congruent evolution of different classes of non-coding DNA in prokaryotic genomesIgor B Rogozin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 30:4264-71. 2002..In contrast, the gene set is optimized for the particular environmental niche of the given microbe, which results in the lack of correlation between the gene number and the characteristics of non-coding regions... - Accumulation of Mn(II) in Deinococcus radiodurans facilitates gamma-radiation resistanceM J Daly
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Science 306:1025-8. 2004..In contrast, Shewanella oneidensis and Pseudomonas putida have high iron but low intracellular manganese concentrations and are very sensitive. We propose that Mn(II) accumulation facilitates recovery from radiation injury... - A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniaeK S Makarova
Dept of Pathology, F.E. Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA
Trends Biochem Sci 25:50-2. 2000 - SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotesKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Trends Biochem Sci 27:384-6. 2002..This domain was designated SWIM after SWI2/SNF2 and MuDR, and is predicted to have DNA-binding and protein-protein interaction functions in different contexts... - Evolution of mosaic operons by horizontal gene transfer and gene displacement in situMarina V Omelchenko
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 4:R55. 2003.... - A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomesEugene V Koonin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 5:R7. 2004.... - Comparative genomics of Archaea: how much have we learned in six years, and what's next?Kira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 4:115. 2003..The majority of archaeal genes have not been experimentally characterized, but novel functional pathways have been predicted... - Cyanobacterial response regulator PatA contains a conserved N-terminal domain (PATAN) with an alpha-helical insertionKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Bioinformatics 22:1297-301. 2006.... - The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteriaKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA
Bioinformatics 22:2581-4. 2006..Thus, the HicAB module is predicted to be a novel TAS whose mechanism involves RNA-binding and, possibly, cleavage... - How radiation kills cells: survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stressDebabrota Ghosal
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
FEMS Microbiol Rev 29:361-75. 2005.... - Computational approaches for the analysis of gene neighbourhoods in prokaryotic genomesIgor B Rogozin
NCBI NLM NIH, 8600 Rockville Pike, Bldg 38A, Bethesda, MD 20894, USA
Brief Bioinform 5:131-49. 2004..In this review, we discuss various computational approaches for identification of conserved gene strings and construction of local alignments of gene orders in prokaryotic genomes... - Evolution of diverse cell division and vesicle formation systems in ArchaeaKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Nat Rev Microbiol 8:731-41. 2010..By contrast, eukaryotes seem to have inherited all three ancestral systems... - Potential genomic determinants of hyperthermophilyKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Trends Genet 19:172-6. 2003.... - Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel familiesElizabeth M Fozo
Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 38:3743-59. 2010..Our results suggest that type I toxin-antitoxin modules are much more widely distributed among bacteria than previously appreciated... - Gene duplication with displacement and rearrangement: origin of the bacterial replication protein PriB from the single-stranded DNA-binding protein SsbVladimir A Ponomarev
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
J Mol Microbiol Biotechnol 5:225-9. 2003.... - The Zn-peptidase superfamily: functional convergence after evolutionary divergenceK S Makarova
National Center for Biotechnology Information National Library of Medicine, National Institutes of Health, Bethesda, MA 20894, USA
J Mol Biol 292:11-7. 1999..This is a result of functional convergence that apparently occurred after the divergence of the two families... - ATGL has a key role in lipid droplet/adiposome degradation in mammalian cellsElena Smirnova
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
EMBO Rep 7:106-13. 2006..Depletion of ATGL by RNA interference leads to a significant increase in the size of LDs. These results show that ATGL has an important role in LD/adiposome turnover in mammalian cells... - Recurrent intragenomic recombination leading to sequence homogenization during the evolution of the lipoyl-binding domainMarina V Omelchenko
Department of Pathology, F.E. Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA
FEMS Microbiol Lett 209:255-60. 2002..This appears to be the first case of sequence homogenization at the level of an individual domain in prokaryotes... - Evolutionary and functional genomics of the ArchaeaKira S Makarova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Curr Opin Microbiol 8:586-94. 2005.... - Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzaeEugene Kolker
BIATECH, 19310 North Creek Parkway, Suite 115, Bothell, WA 98011, USA
Nucleic Acids Res 32:2353-61. 2004.... - The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogensAlexei I Slesarev
Fidelity Systems, Gaithersburg, MD 20879, USA
Proc Natl Acad Sci U S A 99:4644-9. 2002..Also, M. kandleri appears to have fewer genes acquired via lateral transfer than other archaea. These features might reflect the extreme habitat of this organism... 
Small CRISPR RNAs guide antiviral defense in prokaryotesStan J J Brouns
Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, Netherlands
Science 321:960-4. 2008..Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense...- Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiationYongqing Liu
Environmental Sciences and Life Sciences Divisions, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
Proc Natl Acad Sci U S A 100:4191-6. 2003..Components of this network include a predicted distinct ATP-dependent DNA ligase and metabolic pathway switching that could prevent additional genomic damage elicited by metabolism-induced free radicals... - Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energyShaobin Hou
Department of Microbiology, University of Hawaii, Snyder Hall 111, 2538 The Mall, Honolulu, HI 96822, USA
Proc Natl Acad Sci U S A 101:18036-41. 2004..In summary, the I. loihiensis genome reveals an integrated mechanism of metabolic adaptation to the constantly changing deep-sea hydrothermal ecosystem... - Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functionsOlga V Moroz
York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
J Mol Biol 347:243-55. 2005..We outline probable tertiary and quaternary structures of the all-alpha NTP pyrophosphatase superfamily members... - The cyanobacterial genome core and the origin of photosynthesisArmen Y Mulkidjanian
School of Physics, University of Osnabruck, D 49069 Osnabruck, Germany
Proc Natl Acad Sci U S A 103:13126-31. 2006..From procyanobacteria, photosynthesis spread to other phyla by way of lateral gene transfer... - Role of hypermutability in the evolution of the genus OenococcusAngela M Marcobal
Department of Viticulture and Enology, University of California, One Shields Ave, Davis, CA 95616, USA
J Bacteriol 190:564-70. 2008..The hypermutable status of the genus Oenococcus explains the observed high level of allelic polymorphism among known O. oeni isolates and likely contributed to the unique adaptation of this genus to acidic and alcoholic environments... - Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genomeAlexis Dufresne
Station Biologique, , , BP74, 29682 Roscoff Cedex, France
Proc Natl Acad Sci U S A 100:10020-5. 2003..Because of its remarkable compactness, the genome of P. marinus SS120 might approximate the minimal gene complement of a photosynthetic organism... - Identification and functional verification of archaeal-type phosphoenolpyruvate carboxylase, a missing link in archaeal central carbohydrate metabolismThijs J G Ettema
Laboratory of Microbiology, Agrotechnology and Food Sciences, Wageningen University, Wageningen, The Netherlands
J Bacteriol 186:7754-62. 2004..The newly identified atPEPC, with its distinct properties, constitutes yet another example of the versatility of the enzymes of the central carbon metabolic pathways in the archaeal domain... - A korarchaeal genome reveals insights into the evolution of the ArchaeaJames G Elkins
Lehrstuhl fur Mikrobiologie und Archaeenzentrum, Universitat Regensburg, D 93053 Regensburg, Germany
Proc Natl Acad Sci U S A 105:8102-7. 2008..In light of the known composition of archaeal genomes, the Korarchaeota might have retained a set of cellular features that represents the ancestral archaeal form... - Myosin XI-K Is required for rapid trafficking of Golgi stacks, peroxisomes, and mitochondria in leaf cells of Nicotiana benthamianaDror Avisar
Department of Botany and Plant Pathology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331, USA
Plant Physiol 146:1098-108. 2008.... - Inventing the dynamo machine: the evolution of the F-type and V-type ATPasesArmen Y Mulkidjanian
School of Physics, University of Osnabruck, Osnabrück D 49069, Germany
Nat Rev Microbiol 5:892-9. 2007..We suggest that in these ancestral translocases, the position of the central stalk was occupied by the translocated polymer... - In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich MediumAnu Raghunathan
Department of Bioengineering, University of California at San Diego, La Jolla, California, USA
OMICS 8:25-41. 2004..This study demonstrates the significance of an integrated approach to the characterization of H. influenzae metabolism... - Initial proteome analysis of model microorganism Haemophilus influenzae strain Rd KW20Eugene Kolker
BIATECH, Bothell, Washington 98011, USA
J Bacteriol 185:4593-602. 2003..The direct proteomics approach to studying protein expression in vivo reported here is a powerful method that is applicable to proteome analysis of any (micro)organism... - A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeatsNatalia Beloglazova
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
J Biol Chem 283:20361-71. 2008..Thus, CAS2 proteins are sequence-specific endoribonucleases, and we propose that their role in the CRISPR-mediated anti-phage defense might involve degradation of phage or cellular mRNAs...