L A Maier

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease
    Lisa A Maier
    Department of Medicine, Hollis Laboratory of Occupational and Environmental Health, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:6910-8. 2003
  2. doi request reprint Recent chronic beryllium disease in residents surrounding a beryllium facility
    Lisa A Maier
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 177:1012-7. 2008
  3. ncbi request reprint Beryllium-stimulated neopterin as a diagnostic adjunct in chronic beryllium disease
    Lisa A Maier
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Ind Med 43:592-601. 2003
  4. ncbi request reprint Genetic and exposure risks for chronic beryllium disease
    Lisa A Maier
    Department of Medicine, National Jewish Medical and Research Center, Department of Medicine and Department of Preventive Medicine and Biometrics and University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Chest Med 23:827-39. 2002
  5. ncbi request reprint Clinical approach to chronic beryllium disease and other nonpneumoconiotic interstitial lung diseases
    Lisa A Maier
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Thorac Imaging 17:273-84. 2002
  6. ncbi request reprint High beryllium-stimulated TNF-alpha is associated with the -308 TNF-alpha promoter polymorphism and with clinical severity in chronic beryllium disease
    L A Maier
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 164:1192-9. 2001
  7. ncbi request reprint Angiotensin-1 converting enzyme polymorphisms in chronic beryllium disease
    L A Maier
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Am J Respir Crit Care Med 159:1342-50. 1999
  8. pmc CC chemokine receptor 5 gene polymorphisms in beryllium disease
    H Sato
    Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Dept of Medicine, National Jewish Medical Health, 1400 Jackson Street, Denver, CO 80206, USA
    Eur Respir J 36:331-8. 2010
  9. ncbi request reprint Beryllium-stimulated apoptosis in macrophage cell lines
    R T Sawyer
    Division of Environmental and Occupational Health Sciences, Department of Medicine, D309 Neustadt, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Toxicology 149:129-42. 2000
  10. ncbi request reprint IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis
    L A Maier
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Eur Respir J 17:403-15. 2001

Research Grants

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease
    Lisa A Maier
    Department of Medicine, Hollis Laboratory of Occupational and Environmental Health, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:6910-8. 2003
    ..We conclude that DPB1 Glu69 is a marker of sensitization and not specific for disease. Glu(69) homozygosity acts as a functional marker associated with markers of CBD severity...
  2. doi request reprint Recent chronic beryllium disease in residents surrounding a beryllium facility
    Lisa A Maier
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 177:1012-7. 2008
    ..Further surveillance was not performed in these communities, and additional cases have not been reported...
  3. ncbi request reprint Beryllium-stimulated neopterin as a diagnostic adjunct in chronic beryllium disease
    Lisa A Maier
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Ind Med 43:592-601. 2003
    ..We previously found high neopterin levels in CBD patients' serum and questioned whether Be-stimulated neopterin production by peripheral blood cells in vitro might be useful in the diagnosis of CBD...
  4. ncbi request reprint Genetic and exposure risks for chronic beryllium disease
    Lisa A Maier
    Department of Medicine, National Jewish Medical and Research Center, Department of Medicine and Department of Preventive Medicine and Biometrics and University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Chest Med 23:827-39. 2002
    ..Current genetic markers are not ready for clinical use as a screening test for beryllium-related health effects because of the low specificity of the markers and the low prevalence of BeS and CBD...
  5. ncbi request reprint Clinical approach to chronic beryllium disease and other nonpneumoconiotic interstitial lung diseases
    Lisa A Maier
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Thorac Imaging 17:273-84. 2002
    ..Bronchiolitis is a rare manifestation of inhalational exposures but must also be considered in the clinical evaluation of inhalational exposure...
  6. ncbi request reprint High beryllium-stimulated TNF-alpha is associated with the -308 TNF-alpha promoter polymorphism and with clinical severity in chronic beryllium disease
    L A Maier
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 164:1192-9. 2001
    ....
  7. ncbi request reprint Angiotensin-1 converting enzyme polymorphisms in chronic beryllium disease
    L A Maier
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Am J Respir Crit Care Med 159:1342-50. 1999
    ..These findings may indicate that the ACE genotype is important in the immune response to beryllium and in progression to beryllium disease...
  8. pmc CC chemokine receptor 5 gene polymorphisms in beryllium disease
    H Sato
    Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Dept of Medicine, National Jewish Medical Health, 1400 Jackson Street, Denver, CO 80206, USA
    Eur Respir J 36:331-8. 2010
    ..Further studies would be useful to clarify the mechanism whereby CCR5 polymorphisms affect progression of CBD...
  9. ncbi request reprint Beryllium-stimulated apoptosis in macrophage cell lines
    R T Sawyer
    Division of Environmental and Occupational Health Sciences, Department of Medicine, D309 Neustadt, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Toxicology 149:129-42. 2000
    ....
  10. ncbi request reprint IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis
    L A Maier
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Eur Respir J 17:403-15. 2001
    ..Interleukin-4's inability to downregulate any of the beryllium-stimulated cytokines makes it an unlikely therapeutic candidate in chronic beryllium disease...
  11. pmc Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine production
    Dave R Dobis
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 43:458-64. 2010
    ....
  12. ncbi request reprint Efficacy of serial medical surveillance for chronic beryllium disease in a beryllium machining plant
    L S Newman
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Occup Environ Med 43:231-7. 2001
    ..Beryllium sensitization and chronic beryllium disease can occur within 50 days of first exposure in modern industry...
  13. ncbi request reprint Indirect and direct gas exchange at maximum exercise in beryllium sensitization and disease
    R A Lundgren
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 120:1702-8. 2001
    ..9%. CONCLUSIONS: These data suggest that pulse oximetry cannot be used reliably to distinguish between CBD and BeS and, thus, is not an adequate substitute for arterial blood gas analysis with exercise...
  14. ncbi request reprint Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium disease
    Brent E Palmer
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80202, USA
    J Immunol 180:2704-12. 2008
    ..Thus, the PD-1 pathway is active in beryllium-induced disease and plays a key role in controlling beryllium-induced T cell proliferation...
  15. pmc Beryllium lymphocyte proliferation test surveillance identifies clinically significant beryllium disease
    Margaret M Mroz
    Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Am J Ind Med 52:762-73. 2009
    ..Workplace surveillance identifies chronic beryllium disease (CBD) but it remains unknown over what time frame mild CBD will progress to a more severe form...
  16. ncbi request reprint BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals
    H Sato
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Tissue Antigens 70:480-6. 2007
    ..As a result of the small sample size and strong linkage disequilibrium between DRB1*13-DQB1*0603/4/9 and the BTNL2 rs3117099T allele, it is difficult to assess the primary association in DPB1*Glu69-negative CBD cases...
  17. ncbi request reprint TNF polymorphism and bronchoalveolar lavage cell TNF-alpha levels in chronic beryllium disease and beryllium sensitization
    Hiroe Sato
    Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    J Allergy Clin Immunol 119:687-96. 2007
    ..Beryllium stimulates TNF-alpha from chronic beryllium disease (CBD) bronchoalveolar lavage (BAL) cells...
  18. ncbi request reprint CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease
    Brent E Palmer
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Allergy Clin Immunol 120:184-91. 2007
    ..Despite numerous studies in human beings linking surface phenotype of blood T cells with their functional characteristics, little is known about this relationship on antigen-specific CD4(+) T cells residing in a target organ...
  19. pmc Deficient and dysfunctional regulatory T cells in the lungs of chronic beryllium disease subjects
    Douglas G Mack
    Department of Medicine, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 181:1241-9. 2010
    ..Naturally occurring regulatory T (T(reg)) cells modulate adaptive immune responses. The role of this T-cell subset in beryllium-induced lung disease is unknown...
  20. ncbi request reprint Beryllium induces apoptosis in human lung macrophages
    Lori A Kittle
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Sarcoidosis Vasc Diffuse Lung Dis 19:101-13. 2002
    ..We conclude that Be-induced human lung adherent macrophage apoptosis could contribute to the host's continued re-exposure to Be resulting in chronic granulomatous inflammation...
  21. ncbi request reprint Beryllium particulate exposure and disease relations in a beryllium machining plant
    P C Kelleher
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, CO 80206 Denver, USA
    J Occup Environ Med 43:238-49. 2001
    ..20. In conclusion, increased cumulative and LTW exposure to total and respirable beryllium was observed in workers with CBD or BeS compared with the controls. These results support efforts to control beryllium exposure in the workplace...
  22. pmc Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response
    Andrew P Fontenot
    Division of Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 115:2886-93. 2005
    ..Together, these findings indicate that the functional capability of antigen-specific CD4+ T cells is determined by the relative proportion of memory T cell subsets, which may reflect internal organ involvement...
  23. ncbi request reprint Genetic susceptibility and immune-mediated destruction in beryllium-induced disease
    Andrew P Fontenot
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Trends Immunol 26:543-9. 2005
    ..These findings in CBD have important implications for studies in autoimmune diseases, including those in which the inciting antigen is unknown and the target organ is inaccessible...
  24. ncbi request reprint Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain
    Jerome R Bill
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 175:7029-37. 2005
    ..Thus, these results demonstrate that a single amino acid residue of the MHC class II beta-chain dictates beryllium presentation and potentially, disease susceptibility...
  25. ncbi request reprint TGF-beta 1 variants in chronic beryllium disease and sarcoidosis
    Alexas C Jonth
    Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:4255-62. 2007
    ....
  26. pmc 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease
    Douglas G Mack
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 181:4381-8. 2008
    ..Taken together, these findings suggest an important role of 4-1BB in the costimulation of beryllium-responsive CD4(+) T cells in the target organ...
  27. doi request reprint Immunology of chronic beryllium disease
    George Samuel
    Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Allergy Clin Immunol 8:126-34. 2008
    ....
  28. pmc Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease
    Richard T Sawyer
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 36:191-200. 2007
    ..The data suggest that Be exposure induces transcription-dependent TNF-alpha production, potentially due to upregulation of specific transcription factors...
  29. doi request reprint Tumour necrosis factor gene polymorphisms are associated with COPD
    M R Gingo
    Dept of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Eur Respir J 31:1005-12. 2008
    ..22, 95% CI 0.05-0.97). The present study adds further evidence that tumour necrosis factor genotypes play a role in susceptibility to cigarette smoke...
  30. pmc Modulation of lymphocyte proliferation by antioxidants in chronic beryllium disease
    Dave R Dobis
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 177:1002-11. 2008
    ..Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders...
  31. ncbi request reprint A new tool to assess sarcoidosis severity
    Yasmine S Wasfi
    Pulmonary, Allergy, and Critcal Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Chest 129:1234-45. 2006
    ..There are no comprehensive scoring systems for sarcoidosis disease severity. Our goal was to develop and validate an objective and comprehensive sarcoidosis disease severity scoring system...
  32. ncbi request reprint Chronic beryllium disease: a model interaction between innate and acquired immunity
    Richard T Sawyer
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Immunopharmacol 2:249-61. 2002
    ..Rather, it establishes pathways leading to chronic granulomatous inflammation. We will examine recent studies describing the host's cellular and molecular responses to Be, responses that promote granuloma formation...
  33. ncbi request reprint Beryllium-induced tumor necrosis factor-alpha production by CD4+ T cells is mediated by HLA-DP
    Richard T Sawyer
    Department of Medicine, Hollis Laboratory of Environmental and Occupational Health, National Jewish Medical and Research Center, Denver, CO 80206
    Am J Respir Cell Mol Biol 31:122-30. 2004
    ..This study identifies HLA-DP as a regulatory component in the activation of T cell receptors on Be-specific CD4+ T cells from CBD patients resulting in proliferation and proinflammatory cytokine production...
  34. ncbi request reprint Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease
    Richard T Sawyer
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 31:470-7. 2004
    ....
  35. ncbi request reprint Beryllium medical surveillance at a former nuclear weapons facility during cleanup operations
    Holly M Sackett
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Occup Environ Med 46:953-61. 2004
    ..Beryllium medical surveillance detects sensitization and CBD in cleanup workers. Exposure controls and medical surveillance need to be 'broad-based' to include all cleanup workers involved in beryllium-contaminated building remediation...
  36. ncbi request reprint Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease risk
    Lee S Newman
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Room G 010, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:54-60. 2005
    ..We conclude that beryllium sensitization is an adverse health effect in beryllium-exposed workers and merits medical follow-up...
  37. ncbi request reprint Beryllium-stimulated reactive oxygen species and macrophage apoptosis
    Richard T Sawyer
    Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, 1400 Jackson Street, CO 80206, USA
    Free Radic Biol Med 38:928-37. 2005
    ..Our data are the first to demonstrate that Be stimulates macrophage ROS formation which plays an important role in Be-induced macrophage apoptosis...
  38. ncbi request reprint Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease
    Gregory B Pott
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Allergy Clin Immunol 115:1036-42. 2005
    ..Whether biomarkers are present in blood that would allow separation of CBD from beryllium sensitization without invasive pulmonary procedures is unknown...
  39. ncbi request reprint Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung
    Andrew P Fontenot
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 168:3627-34. 2002
    ..These studies using skin patch testing provide new insight into the dynamics of T cell influx and mobilization during granulomatous inflammation...
  40. doi request reprint Developing effective health and safety training materials for workers in beryllium-using industries
    A S Mayer
    National Jewish Health, Division of Environmental and Occupational Health Sciences, Denver, CO, USA
    J Occup Environ Med 55:746-51. 2013
    ..Despite reduced workplace exposures, beryllium sensitization and chronic beryllium disease still occur. Effective health and safety training is needed...
  41. ncbi request reprint Sarcoidosis
    L S Newman
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 336:1224-34. 1997
  42. pmc CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung
    Douglas G Mack
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 182:7317-24. 2009
    ....
  43. ncbi request reprint Beryllium health effects in the era of the beryllium lymphocyte proliferation test
    L A Maier
    Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado, USA
    Appl Occup Environ Hyg 16:514-20. 2001
    ..Thus, research is needed to establish new tests to be used alone or in conjunction with the BeLPT to improve our ability to detect early beryllium health effects...
  44. pmc Gene-environment interactions influence airways function in laboratory animal workers
    Karin A Pacheco
    Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:232-40. 2010
    ..Functional variants of CD14 negatively affect lung function in farm workers and children exposed to animal allergens and endotoxin...
  45. ncbi request reprint Beryllium workers' health risks
    Lee S Newman
    J Occup Environ Hyg 2:D48-50. 2005
  46. ncbi request reprint Chronic beryllium disease and glutathione biosynthesis genes
    Lynn M Bekris
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    J Occup Environ Med 48:599-606. 2006
    ..Glutamate cysteine ligase consists of a catalytic subunit (GCLC) and modifier subunit (GCLM)...
  47. ncbi request reprint Is smoking beneficial for granulomatous lung diseases?
    Lisa A Maier
    Am J Respir Crit Care Med 169:893-5. 2004

Research Grants4

  1. LOCAL ANGIOTENSIN SYSTEM IN LUNG FIBROGENESIS
    Lisa Maier; Fiscal Year: 2002
    ..These studies will help establish a role for the angiotensin system in granulomatous lung disease and the path to fibrogenesis. ..
  2. Shared Genetic Susceptibility in CBD and Sarcoidosis
    Lisa Maier; Fiscal Year: 2007
    ....