Research Topics
Genomes and Genes | L A MaierSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
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Publications
Angiotensin-1 converting enzyme polymorphisms in chronic beryllium diseaseL A Maier
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Am J Respir Crit Care Med 159:1342-50. 1999..These findings may indicate that the ACE genotype is important in the immune response to beryllium and in progression to beryllium disease...
Recent chronic beryllium disease in residents surrounding a beryllium facilityLisa A Maier
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 177:1012-7. 2008..Further surveillance was not performed in these communities, and additional cases have not been reported...- Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium diseaseLisa A Maier
Department of Medicine, Hollis Laboratory of Occupational and Environmental Health, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 171:6910-8. 2003..We conclude that DPB1 Glu69 is a marker of sensitization and not specific for disease. Glu(69) homozygosity acts as a functional marker associated with markers of CBD severity... - Beryllium-stimulated neopterin as a diagnostic adjunct in chronic beryllium diseaseLisa A Maier
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Ind Med 43:592-601. 2003..We previously found high neopterin levels in CBD patients' serum and questioned whether Be-stimulated neopterin production by peripheral blood cells in vitro might be useful in the diagnosis of CBD... - Genetic and exposure risks for chronic beryllium diseaseLisa A Maier
Department of Medicine, National Jewish Medical and Research Center, Department of Medicine and Department of Preventive Medicine and Biometrics and University of Colorado Health Sciences Center, Denver, CO, USA
Clin Chest Med 23:827-39. 2002..Current genetic markers are not ready for clinical use as a screening test for beryllium-related health effects because of the low specificity of the markers and the low prevalence of BeS and CBD... - Clinical approach to chronic beryllium disease and other nonpneumoconiotic interstitial lung diseasesLisa A Maier
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Thorac Imaging 17:273-84. 2002..Bronchiolitis is a rare manifestation of inhalational exposures but must also be considered in the clinical evaluation of inhalational exposure... - High beryllium-stimulated TNF-alpha is associated with the -308 TNF-alpha promoter polymorphism and with clinical severity in chronic beryllium diseaseL A Maier
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 164:1192-9. 2001.... 
CC chemokine receptor 5 gene polymorphisms in beryllium diseaseH Sato
Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Dept of Medicine, National Jewish Medical Health, 1400 Jackson Street, Denver, CO 80206, USA
Eur Respir J 36:331-8. 2010..Further studies would be useful to clarify the mechanism whereby CCR5 polymorphisms affect progression of CBD...- Beryllium-stimulated apoptosis in macrophage cell linesR T Sawyer
Division of Environmental and Occupational Health Sciences, Department of Medicine, D309 Neustadt, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Toxicology 149:129-42. 2000.... - IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosisL A Maier
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
Eur Respir J 17:403-15. 2001..Interleukin-4's inability to downregulate any of the beryllium-stimulated cytokines makes it an unlikely therapeutic candidate in chronic beryllium disease... - Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine productionDave R Dobis
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 43:458-64. 2010.... - Indirect and direct gas exchange at maximum exercise in beryllium sensitization and diseaseR A Lundgren
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 120:1702-8. 2001..9%. CONCLUSIONS: These data suggest that pulse oximetry cannot be used reliably to distinguish between CBD and BeS and, thus, is not an adequate substitute for arterial blood gas analysis with exercise... - Efficacy of serial medical surveillance for chronic beryllium disease in a beryllium machining plantL S Newman
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Occup Environ Med 43:231-7. 2001..Beryllium sensitization and chronic beryllium disease can occur within 50 days of first exposure in modern industry... - Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium diseaseBrent E Palmer
Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80202, USA
J Immunol 180:2704-12. 2008..Thus, the PD-1 pathway is active in beryllium-induced disease and plays a key role in controlling beryllium-induced T cell proliferation... - Beryllium lymphocyte proliferation test surveillance identifies clinically significant beryllium diseaseMargaret M Mroz
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
Am J Ind Med 52:762-73. 2009..Workplace surveillance identifies chronic beryllium disease (CBD) but it remains unknown over what time frame mild CBD will progress to a more severe form... - BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individualsH Sato
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Tissue Antigens 70:480-6. 2007..As a result of the small sample size and strong linkage disequilibrium between DRB1*13-DQB1*0603/4/9 and the BTNL2 rs3117099T allele, it is difficult to assess the primary association in DPB1*Glu69-negative CBD cases... - CD57 expression correlates with alveolitis severity in subjects with beryllium-induced diseaseBrent E Palmer
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
J Allergy Clin Immunol 120:184-91. 2007..Despite numerous studies in human beings linking surface phenotype of blood T cells with their functional characteristics, little is known about this relationship on antigen-specific CD4(+) T cells residing in a target organ... - Deficient and dysfunctional regulatory T cells in the lungs of chronic beryllium disease subjectsDouglas G Mack
Department of Medicine, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
Am J Respir Crit Care Med 181:1241-9. 2010..Naturally occurring regulatory T (T(reg)) cells modulate adaptive immune responses. The role of this T-cell subset in beryllium-induced lung disease is unknown... - Beryllium induces apoptosis in human lung macrophagesLori A Kittle
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Sarcoidosis Vasc Diffuse Lung Dis 19:101-13. 2002..We conclude that Be-induced human lung adherent macrophage apoptosis could contribute to the host's continued re-exposure to Be resulting in chronic granulomatous inflammation... - TNF polymorphism and bronchoalveolar lavage cell TNF-alpha levels in chronic beryllium disease and beryllium sensitizationHiroe Sato
Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
J Allergy Clin Immunol 119:687-96. 2007..Beryllium stimulates TNF-alpha from chronic beryllium disease (CBD) bronchoalveolar lavage (BAL) cells... - Beryllium particulate exposure and disease relations in a beryllium machining plantP C Kelleher
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, CO 80206 Denver, USA
J Occup Environ Med 43:238-49. 2001..20. In conclusion, increased cumulative and LTW exposure to total and respirable beryllium was observed in workers with CBD or BeS compared with the controls. These results support efforts to control beryllium exposure in the workplace... - Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium diseaseRichard T Sawyer
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Respir Cell Mol Biol 36:191-200. 2007..The data suggest that Be exposure induces transcription-dependent TNF-alpha production, potentially due to upregulation of specific transcription factors... - Immunology of chronic beryllium diseaseGeorge Samuel
Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Curr Opin Allergy Clin Immunol 8:126-34. 2008.... - TGF-beta 1 variants in chronic beryllium disease and sarcoidosisAlexas C Jonth
Robert H Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 179:4255-62. 2007.... - Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chainJerome R Bill
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Immunol 175:7029-37. 2005..Thus, these results demonstrate that a single amino acid residue of the MHC class II beta-chain dictates beryllium presentation and potentially, disease susceptibility... - Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative responseAndrew P Fontenot
Division of Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Clin Invest 115:2886-93. 2005..Together, these findings indicate that the functional capability of antigen-specific CD4+ T cells is determined by the relative proportion of memory T cell subsets, which may reflect internal organ involvement... - Genetic susceptibility and immune-mediated destruction in beryllium-induced diseaseAndrew P Fontenot
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Trends Immunol 26:543-9. 2005..These findings in CBD have important implications for studies in autoimmune diseases, including those in which the inciting antigen is unknown and the target organ is inaccessible... - 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium diseaseDouglas G Mack
Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
J Immunol 181:4381-8. 2008..Taken together, these findings suggest an important role of 4-1BB in the costimulation of beryllium-responsive CD4(+) T cells in the target organ... - Tumour necrosis factor gene polymorphisms are associated with COPDM R Gingo
Dept of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
Eur Respir J 31:1005-12. 2008..22, 95% CI 0.05-0.97). The present study adds further evidence that tumour necrosis factor genotypes play a role in susceptibility to cigarette smoke... - Chronic beryllium disease: a model interaction between innate and acquired immunityRichard T Sawyer
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
Int Immunopharmacol 2:249-61. 2002..Rather, it establishes pathways leading to chronic granulomatous inflammation. We will examine recent studies describing the host's cellular and molecular responses to Be, responses that promote granuloma formation... - Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lungAndrew P Fontenot
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 168:3627-34. 2002..These studies using skin patch testing provide new insight into the dynamics of T cell influx and mobilization during granulomatous inflammation... - Beryllium-induced tumor necrosis factor-alpha production by CD4+ T cells is mediated by HLA-DPRichard T Sawyer
Department of Medicine, Hollis Laboratory of Environmental and Occupational Health, National Jewish Medical and Research Center, Denver, CO 80206
Am J Respir Cell Mol Biol 31:122-30. 2004..This study identifies HLA-DP as a regulatory component in the activation of T cell receptors on Be-specific CD4+ T cells from CBD patients resulting in proliferation and proinflammatory cytokine production... - Modulation of lymphocyte proliferation by antioxidants in chronic beryllium diseaseDave R Dobis
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 177:1002-11. 2008..Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders... - Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium diseaseRichard T Sawyer
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 31:470-7. 2004.... - Beryllium medical surveillance at a former nuclear weapons facility during cleanup operationsHolly M Sackett
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Occup Environ Med 46:953-61. 2004..Beryllium medical surveillance detects sensitization and CBD in cleanup workers. Exposure controls and medical surveillance need to be 'broad-based' to include all cleanup workers involved in beryllium-contaminated building remediation... - Beryllium-stimulated reactive oxygen species and macrophage apoptosisRichard T Sawyer
Department of Medicine, Robert H Hollis Laboratory of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, 1400 Jackson Street, CO 80206, USA
Free Radic Biol Med 38:928-37. 2005..Our data are the first to demonstrate that Be stimulates macrophage ROS formation which plays an important role in Be-induced macrophage apoptosis... - Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced diseaseGregory B Pott
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Allergy Clin Immunol 115:1036-42. 2005..CONCLUSION: The frequency of beryllium-specific T cells in the blood of beryllium-exposed subjects may be a useful biomarker that helps discriminate between beryllium sensitization and progression to CBD... - A new tool to assess sarcoidosis severityYasmine S Wasfi
Pulmonary, Allergy, and Critcal Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Chest 129:1234-45. 2006..This preliminary tool has potential applicability in the assessment of disease severity in sarcoidosis research... - Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease riskLee S Newman
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Room G 010, Denver, CO 80206, USA
Am J Respir Crit Care Med 171:54-60. 2005..We conclude that beryllium sensitization is an adverse health effect in beryllium-exposed workers and merits medical follow-up... - CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lungDouglas G Mack
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
J Immunol 182:7317-24. 2009.... - Beryllium health effects in the era of the beryllium lymphocyte proliferation testL A Maier
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado, USA
Appl Occup Environ Hyg 16:514-20. 2001..Thus, research is needed to establish new tests to be used alone or in conjunction with the BeLPT to improve our ability to detect early beryllium health effects... - Gene-environment interactions influence airways function in laboratory animal workersKarin A Pacheco
Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 126:232-40. 2010..Functional variants of CD14 negatively affect lung function in farm workers and children exposed to animal allergens and endotoxin... - Beryllium workers' health risksLee S Newman
J Occup Environ Hyg 2:D48-50. 2005 - Chronic beryllium disease and glutathione biosynthesis genesLynn M Bekris
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
J Occup Environ Med 48:599-606. 2006..Glutamate cysteine ligase consists of a catalytic subunit (GCLC) and modifier subunit (GCLM)... - Is smoking beneficial for granulomatous lung diseases?Lisa A Maier
Am J Respir Crit Care Med 169:893-5. 2004
Research Grants
- LOCAL ANGIOTENSIN SYSTEM IN LUNG FIBROGENESISLisa Maier; Fiscal Year: 2002..These studies will help establish a role for the angiotensin system in granulomatous lung disease and the path to fibrogenesis. ..
- Shared Genetic Susceptibility in CBD and SarcoidosisLisa Maier; Fiscal Year: 2007....