Rose G Mage

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genetic contributions to the autoantibody profile in a rabbit model of Systemic Lupus Erythematosus (SLE)
    Nandakumar Puliyath
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Vet Immunol Immunopathol 125:251-67. 2008
  2. pmc Investigations of a rabbit (Oryctolagus cuniculus) model of systemic lupus erythematosus (SLE), BAFF and its receptors
    Jiahui Yang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e8494. 2009
  3. ncbi request reprint B cell and antibody repertoire development in rabbits: the requirement of gut-associated lymphoid tissues
    Rose G Mage
    Laboratory of Immunology, NIAID, NIH, Bethesda, MD, USA
    Dev Comp Immunol 30:137-53. 2006
  4. ncbi request reprint CD5+ B cells are preferentially expanded in rabbit appendix: the role of CD5 in B cell development and selection
    Richard Pospisil
    Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Dev Comp Immunol 30:711-22. 2006
  5. ncbi request reprint Models of systemic lupus erythematosus: development of autoimmunity following peptide immunizations of noninbred pedigreed rabbits
    Geeta Rai
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:660-7. 2006
  6. pmc De novo expression of MECA-79 glycoprotein-determinant on developing B lymphocytes in gut-associated lymphoid tissues
    Rajesh K Sinha
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunology 119:461-9. 2006
  7. pmc Gene expression profiles in a rabbit model of systemic lupus erythematosus autoantibody production
    Geeta Rai
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:4446-56. 2010
  8. pmc Characterization of rabbit CD5 isoforms
    Richard Pospisil
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Mol Immunol 46:2456-64. 2009
  9. pmc Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix
    Guibin Yang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and SAIC Frederick, National Cancer Institute, Frederick, MD 21701, USA
    Proc Natl Acad Sci U S A 102:17083-8. 2005
  10. pmc Expression and localization of rabbit B-cell activating factor (BAFF) and its specific receptor BR3 in cells and tissues of the rabbit immune system
    Jiahui Yang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1892, USA
    Dev Comp Immunol 33:697-708. 2009

Collaborators

Detail Information

Publications23

  1. pmc Genetic contributions to the autoantibody profile in a rabbit model of Systemic Lupus Erythematosus (SLE)
    Nandakumar Puliyath
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Vet Immunol Immunopathol 125:251-67. 2008
    ..It is conceivable that further rigorous pedigree selection for autoantibody responses could lead to development of rabbit models with spontaneous occurrence of SLE like serology and disease phenotypes...
  2. pmc Investigations of a rabbit (Oryctolagus cuniculus) model of systemic lupus erythematosus (SLE), BAFF and its receptors
    Jiahui Yang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e8494. 2009
    ..Although no consistent pattern of elevated expression of BAFF mRNA or protein was found in the rabbits studied, the data collected and reported here build upon previous data to refine understanding of a rabbit model of SLE...
  3. ncbi request reprint B cell and antibody repertoire development in rabbits: the requirement of gut-associated lymphoid tissues
    Rose G Mage
    Laboratory of Immunology, NIAID, NIH, Bethesda, MD, USA
    Dev Comp Immunol 30:137-53. 2006
    ....
  4. ncbi request reprint CD5+ B cells are preferentially expanded in rabbit appendix: the role of CD5 in B cell development and selection
    Richard Pospisil
    Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Dev Comp Immunol 30:711-22. 2006
    ....
  5. ncbi request reprint Models of systemic lupus erythematosus: development of autoimmunity following peptide immunizations of noninbred pedigreed rabbits
    Geeta Rai
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:660-7. 2006
    ..Through selective breeding, it may also ultimately provide additional information about the genetics and etiology of SLE and serve as a model for assessing new treatment options...
  6. pmc De novo expression of MECA-79 glycoprotein-determinant on developing B lymphocytes in gut-associated lymphoid tissues
    Rajesh K Sinha
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunology 119:461-9. 2006
    ....
  7. pmc Gene expression profiles in a rabbit model of systemic lupus erythematosus autoantibody production
    Geeta Rai
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:4446-56. 2010
    ..Our finding of distinct gene expression patterns in rabbits that made anti-dsDNA compared with those that only made other anti-nuclear Abs should be further investigated in subsets of SLE patients with different autoantibody profiles...
  8. pmc Characterization of rabbit CD5 isoforms
    Richard Pospisil
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Mol Immunol 46:2456-64. 2009
    ....
  9. pmc Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix
    Guibin Yang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and SAIC Frederick, National Cancer Institute, Frederick, MD 21701, USA
    Proc Natl Acad Sci U S A 102:17083-8. 2005
    ..Although much work remains to understand fully the mechanism of action of AID and its association with other cellular components, the rabbit system now offers a particularly useful model for future studies of these dynamics...
  10. pmc Expression and localization of rabbit B-cell activating factor (BAFF) and its specific receptor BR3 in cells and tissues of the rabbit immune system
    Jiahui Yang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1892, USA
    Dev Comp Immunol 33:697-708. 2009
    ....
  11. ncbi request reprint A comparison of hydraulic and laser capture microdissection methods for collection of single B cells, PCR, and sequencing of antibody VDJ
    Harold Obiakor
    Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Anal Biochem 306:55-62. 2002
    ..The methods developed have now made LCM an efficient alternative to HM for the collection of single B cells...
  12. ncbi request reprint Regulated expression of peripheral node addressin-positive high endothelial venules controls seeding of B lymphocytes into developing neonatal rabbit appendix
    Rajesh K Sinha
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N311, 10 Center Drive MSC 1892, Bethesda, MD 20892, USA
    Vet Immunol Immunopathol 110:97-108. 2006
    ..Thus, a unique spatiotemporal expression pattern of PNAd(+) HEVs is associated with development of B-cell follicles. This regulates migration of blood-borne B-lymphocytes into developing appendix by interacting with CD62L...
  13. ncbi request reprint Stable expression of the extracellular domains of rabbit recombinant CD5: development and characterization of polyclonal and monoclonal antibodies
    Richard Pospisil
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room llN3ll, 10 Center Drive MSC 1892, Bethesda, MD 20892 1892, USA
    Vet Immunol Immunopathol 103:257-67. 2005
    ....
  14. pmc Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis
    Marcia L Taylor
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Room 11C 205, MSC1881, Bethesda, MD 20892 1881, USA
    J Mol Diagn 6:335-42. 2004
    ..Further, the B cell population is oligoclonal, suggesting that clonal proliferation is unlikely to be the basis of clustering...
  15. pmc Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector
    Thomas Hofer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1203, USA
    J Immunol Methods 318:75-87. 2007
    ....
  16. pmc Accuracy and coverage assessment of Oryctolagus cuniculus (rabbit) genes encoding immunoglobulins in the whole genome sequence assembly (OryCun2.0) and localization of the IGH locus to chromosome 20
    E Michael Gertz
    National Center for Biotechnology Information, NLM, NIH, Bethesda, MD, 20894, USA
    Immunogenetics 65:749-62. 2013
    ....
  17. ncbi request reprint Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: evidence for roles for CD62L/PNAd, CCR7/CCL21, alpha4beta1 and LFA-1
    Rajesh K Sinha
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Heath, Building 10, Room 11N311, 10 Center Drive, MSC 1892, Bethesda, MD 20892, USA
    Dev Comp Immunol 28:829-41. 2004
    ..The cross-reactivity of antibodies to mouse or human adhesion molecules described in this study indicates that some of the structures of these important molecules are conserved across species...
  18. pmc Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev
    Stephen J Stahl
    Protein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 2775, USA
    J Mol Biol 397:697-708. 2010
    ..The corresponding single-chain antibody (scFv) was also prepared, offering the potential of intracellular antibody therapeutics against human immunodeficiency virus type 1...
  19. ncbi request reprint Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones
    Devinder Sehgal
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5424-33. 2002
    ..This diversity of combining sites within B cell clones supports the proposed role of appendix in generating the preimmune repertoire...
  20. ncbi request reprint A comparison of ELISA and flow microsphere-based assays for quantification of immunoglobulins
    Joseph Dasso
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    J Immunol Methods 263:23-33. 2002
    ..Mechanical problems such as microspheres settling to the bottom of wells during analysis by an automated plate reader will likely be overcome, and sensitivity improved as this technology develops...
  21. pmc Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics
    Josh D Nelson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 377:170-83. 2008
    ..Nevertheless, the mAb panel may be useful as tools for elucidating access restrictions to the NHR of gp41 and in designing potential improvements to mimetics of receptor-activated Env...
  22. ncbi request reprint Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library
    Mikhail Popkov
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol Methods 288:149-64. 2004
    ..This report underscores our earlier finding that b9 rabbits are excellent sources for high-affinity cross-reactive antibodies with therapeutic potential...
  23. ncbi request reprint Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display
    Mikhail Popkov
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 325:325-35. 2003
    ..This study revealed that rabbits exhibit an HCDR3 length distribution more closely related to human antibodies than mouse antibodies...