Ying Ma

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography
    Ying Ma
    PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Rm 1C401, 10 Center Drive MSC 1180, Bethesda, MD 20892, USA
    J Chromatogr A 1034:149-53. 2004
  2. ncbi request reprint Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions
    Ying Ma
    PET Department, The Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Nucl Med Biol 30:233-40. 2003
  3. ncbi request reprint Identification of metabolites of fluorine-18-labeled M2 muscarinic receptor agonist, 3-(3-[(3-fluoropropyl)thio]-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine, produced by human and rat hepatocytes
    Ying Ma
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 766:319-29. 2002
  4. ncbi request reprint Liquid chromatography-tandem mass spectrometry identification of metabolites of three phenylcarboxyl derivatives of the 5-HT(1A) antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl) trans-4-fluorocyclohexanecarboxamide (FCWAY), produce
    Ying Ma
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bldg 10 Rm 1C401, 10 Center Drive MSC 1180, Bethesda, MD 20892, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 780:99-110. 2002
  5. pmc MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:1224-33. 2011
  6. pmc Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression
    Xiao Xiang Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    Mol Imaging Biol 15:758-67. 2013
  7. pmc Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas
    Xuyi Yue
    National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Drive, Bethesda, MD 20892, USA
    Bioconjug Chem 24:1191-200. 2013
  8. pmc Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS
    Ying Ma
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Dr, Suite 1C14, Bethesda, MD 20892 2281, USA
    Amino Acids 43:1625-32. 2012
  9. ncbi request reprint Species differences in metabolites of PET ligands: serotonergic 5-HT1A receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY
    Ying Ma
    PET Radiochemistry Group, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 33:1013-9. 2006
  10. pmc An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities
    Bik Kee Vuong
    PET Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892 1180, USA
    Nucl Med Biol 34:433-8. 2007

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography
    Ying Ma
    PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Rm 1C401, 10 Center Drive MSC 1180, Bethesda, MD 20892, USA
    J Chromatogr A 1034:149-53. 2004
    ..Using the second solvent ratio of 4:5:4:5 with the organic phase as a mobile phase, a 2.57 g amount of precursor preparation was successfully purified yielding 2.2 g of the pure precursor by a single run...
  2. ncbi request reprint Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions
    Ying Ma
    PET Department, The Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Nucl Med Biol 30:233-40. 2003
    ....
  3. ncbi request reprint Identification of metabolites of fluorine-18-labeled M2 muscarinic receptor agonist, 3-(3-[(3-fluoropropyl)thio]-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine, produced by human and rat hepatocytes
    Ying Ma
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 766:319-29. 2002
    ..From the knowledge of the structure of the metabolites, we have developed a two-step extraction sequence that allows rapid determination of the parent fraction in plasma without time-consuming chromatographic analysis...
  4. ncbi request reprint Liquid chromatography-tandem mass spectrometry identification of metabolites of three phenylcarboxyl derivatives of the 5-HT(1A) antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl) trans-4-fluorocyclohexanecarboxamide (FCWAY), produce
    Ying Ma
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bldg 10 Rm 1C401, 10 Center Drive MSC 1180, Bethesda, MD 20892, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 780:99-110. 2002
    ..These in vitro metabolic studies demonstrated species differences prior to the acquisition and interpretation of in vivo results...
  5. pmc MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:1224-33. 2011
    ..4 h), using the chelator desferrioxamine-p-SCN (Df) for imaging tumor integrin α(v)β(3)...
  6. pmc Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression
    Xiao Xiang Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    Mol Imaging Biol 15:758-67. 2013
    ..The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of receptor expression level for diagnosis or therapeutic evaluation...
  7. pmc Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas
    Xuyi Yue
    National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Drive, Bethesda, MD 20892, USA
    Bioconjug Chem 24:1191-200. 2013
    ..32 ± 4.36%ID/g at 60 min postinjection) and rapid liver and kidney clearance, which was comparable to the imaging results with [(18)F]FBEM-[cys(40)]-exendin-4 reported by our group. ..
  8. pmc Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS
    Ying Ma
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Dr, Suite 1C14, Bethesda, MD 20892 2281, USA
    Amino Acids 43:1625-32. 2012
    ..The labeled antagonists (FP-NBBN, FB-NBBN, G-NBBN and FP-G-NBBN) displayed lower internalization. The optimal imaging agent will depend on the interplay of ligand metabolism, cellular uptake, and internalization in vivo...
  9. ncbi request reprint Species differences in metabolites of PET ligands: serotonergic 5-HT1A receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY
    Ying Ma
    PET Radiochemistry Group, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 33:1013-9. 2006
    ..In monkeys, both pathways (oxidation and amide hydrolysis) were found in the metabolites. We also found that 3-cis-FCWAY had the slowest defluorination of FCWAY analogues in all species...
  10. pmc An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities
    Bik Kee Vuong
    PET Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892 1180, USA
    Nucl Med Biol 34:433-8. 2007
    ..3% based on the absorbance of FCWAY at 254 nm and with a specific activity of 3433+/-1015 mCi/micromol at the end of bombardment, all calculated from the same 50 runs...
  11. pmc Improvement of CXCR4 tracer specificity for PET imaging
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
    J Control Release 157:216-23. 2012
    ..The tracers reported here may allow the evaluation of CXCR4 expression in primary tumors and metastatic nodules, and enable better informed, more personalized treatment for patients with cancer...
  12. ncbi request reprint Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT
    Elaine M Jagoda
    Positron Emission Tomography PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 59:330-41. 2006
    ..the anesthetized group. These data are best explained by changes in blood flow caused by urethane and fenfluramine, which varies from region to region in the brain...
  13. pmc Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425
    Abesh Kumar Bhattacharjee
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 38:897-906. 2011
    ....
  14. pmc [(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor
    Elaine M Jagoda
    PET Radiochemistry Group, NIBIB, National Institutes of Health, Bethesda, Maryland 20892 1088, USA
    Synapse 65:910-8. 2011
    ....
  15. ncbi request reprint Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3-trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635
    Lixin Lang
    PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Bioorg Med Chem 14:3737-48. 2006
    ....
  16. pmc 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma
    Dale O Kiesewetter
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 39:463-73. 2012
    ..The abundance of GLP-1R in pancreatic β-cells in insulinoma, a cancer of the pancreas, and the activity of GLP-1 in the cardiovascular system have made GLP-1R a target for molecular imaging...
  17. pmc In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity
    Lei Zhu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    Mol Pharm 8:2331-8. 2011
    ..These findings can be widely applied to designing probes and to applications targeting various membrane-anchored proteases in vivo...
  18. pmc PET of insulinoma using ¹⁸F-FBEM-EM3106B, a new GLP-1 analogue
    Haokao Gao
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    Mol Pharm 8:1775-82. 2011
    ..The favorable characteristics of (18)F-FBEM-EM3106B, such as high specific activity and high tumor uptake, and high tumor to nontarget uptake, demonstrate that it is a promising tracer for clinical insulinoma imaging...
  19. pmc Rapid and simple one-step F-18 labeling of peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
    Bioconjug Chem 22:422-8. 2011
    ..Successful introduction of 4-fluoro-3-trifluoromethylbenzamide into RGD peptides may be a general strategy applicable to other biologically active peptides and proteins...
  20. ncbi request reprint Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1,2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine} in muscarinic knockout mice
    Dale O Kiesewetter
    Positron Emission Tomography Radiochemistry Group, NIBIB, NIH, Bethesda, MD 20892, USA
    Nucl Med Biol 34:141-52. 2007
    ..We set out to develop a muscarinic M1-selective agonist (based on the structure of the functionally M1-selective xanomeline) that could be radiolabeled with fluorine-18 for use as an imaging agent for positron emission tomography...
  21. pmc Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY
    Ying Ma
    PET Radiochemistry Group, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 36:389-93. 2009
    ..This concordance indicated that high-sensitivity LC/MS is an indispensable tool in evaluating the quantity of administered chemical in tissue as part of the development of new molecular imaging probes...
  22. doi request reprint Plasmonic nanostars: in vivo volumetric photoacoustic molecular angiography and therapeutic monitoring with targeted plasmonic nanostars (small 8/2014)
    Liming Nie
    Laboratory of Molecular Imaging and Nanomedicine LOMIN National Institute of Biomedical Imaging and Bioengineering NIBIB National Institutes of Health NIH, Bethesda, MD, 20892, USA Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361005, China
    Small 10:1441. 2014
    ..Quantitative volumetric angiography of tumors can be achieved with high resolution and deep penetration by a hemispherical photoacoustic imaging system. It also permits photothermal therapy and sequential therapeutic monitoring. ..
  23. ncbi request reprint Application of LC-MS to the analysis of new radiopharmaceuticals
    Ying Ma
    PET Department, Warren G Magnuson Clinical Center, NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 5:397-403. 2003
    ..The combination of LC-MS and hepatocytes are an indispensable tool in the development of new molecular imaging probes...
  24. ncbi request reprint Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography
    Bill X Huang
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 30:785-90. 2003
    ..The analyses of anions, organics, and isotopic enrichment were applied routinely for quality control of [(18)O]water to predict a satisfactory outcome of 2-[(18)F]FDG production...
  25. pmc Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma
    Dale O Kiesewetter
    1 Laboratory of Molecular Imaging, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD 20892, USA
    Theranostics 2:999-1009. 2012
    ..18)F]AlF-NOTA-MAL-exendin-4 shows high tumor uptake and highly selective GLP-1 tissue uptake (INS-1 tumor, lung, pancreas), but still suffers from high kidney uptake...
  26. ncbi request reprint Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation
    Dale O Kiesewetter
    Positron Emission Tomography Department, Clinical Center, NIH, Bethesda, MD 20892, USA
    Nucl Med Biol 30:11-24. 2003
    ..As a result, [(18)F]fluoropaclitaxel will be a useful radiopharmaceutical for the study of multidrug resistant tumors...
  27. pmc LC/MS evaluation of metabolism and membrane transport of bombesin peptides
    Dongyu Gu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Dr, Suite 1C14, Bethesda, MD, 20892 2281, USA
    Amino Acids 40:669-75. 2011
    ..The antagonist ligand is potentially more useful for receptor-targeted imaging due primarily to its higher metabolic stability...
  28. ncbi request reprint Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs
    Richard E Carson
    Positrom Emission Tomography Department, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 23:249-60. 2003
    ..These results can be used to correct the tissue [ 18F]FCWAY time-activity data for brain uptake of [ 18F]FC using the measured [ 18F]FC input function...
  29. pmc Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography
    Dale O Kiesewetter
    Positron Emission Tomography Radiochemistry Group, NIBIB, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 36:3-10. 2009
    ..Bromine-76-radiolabeled analogues of previously reported high-affinity A(3) adenosine receptor (A(3)AR) nucleoside ligands have been prepared as potential radiotracers for positron emission tomography...
  30. ncbi request reprint In vivo volumetric photoacoustic molecular angiography and therapeutic monitoring with targeted plasmonic nanostars
    Liming Nie
    Laboratory of Molecular Imaging and Nanomedicine LOMIN National Institute of Biomedical Imaging and Bioengineering NIBIB National Institutes of Health NIH, Bethesda, MD, 20892, USA Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361005, China
    Small 10:1585-93, 1441. 2014
    ..This PA technique offers deeper imaging depth with homogeneous resolution over existing optical imaging techniques for early diagnosis of tumor angiogenesis as well as on-the-spot nanotherapeutic evaluation...
  31. doi request reprint Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging
    Zhe Wang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, Bethesda, MD 20892, USA
    Biomaterials 34:6194-201. 2013
    ..This probe may open another avenue for ultrahigh contrast fluorescence molecular imaging in the future...
  32. pmc Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography Imaging
    Hui Wang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Theranostics 2:607-17. 2012
    ..Further study of [(18)F] FBEM-scVEGF to evaluate angiogenesis in cancer and other disease types is warranted...
  33. pmc Real-time monitoring of caspase cascade activation in living cells
    Lei Zhu
    Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005, China
    J Control Release 163:55-62. 2012
    ....
  34. ncbi request reprint Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys
    Giampiero Giovacchini
    PET Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 28:238-48. 2005
    ..These results lend promise to the use of these serotonergic neuroimaging techniques to study neuropsychiatric disorders...
  35. pmc New Methods for Labeling RGD Peptides with Bromine-76
    Lixin Lang
    1 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    Theranostics 1:341-53. 2011
    ..The energy barrier difference of the transition states of bromination between the dimethoxybenzoyl group and the tyrosine residue may account for the reaction selectivity when both groups are present in the same molecule...
  36. pmc pH-sensitive fluorescent dyes: are they really pH-sensitive in cells?
    Xiao Xiang Zhang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    Mol Pharm 10:1910-7. 2013
    ..These findings also imply that the intracellular fluorescence properties of pH-sensitive dyes should be carefully examined before they are used as pH indicators...
  37. pmc Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen
    Dingbin Liu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    ACS Nano 7:5568-76. 2013
    ..The efficiency and robustness of this probe were investigated in patient serum samples, demonstrating the great potential of this probe in real-world applications. ..
  38. pmc Organic high ionic strength aqueous two-phase solvent system series for separation of ultra-polar compounds by spiral high-speed counter-current chromatography
    Yun Zeng
    Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Chromatogr A 1218:8715-7. 2011
    ..The capability of the method is demonstrated by separation of three catecholamines...
  39. pmc Applications of LC-MS in PET radioligand development and metabolic elucidation
    Ying Ma
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Curr Drug Metab 11:483-93. 2010
    ..This review will discuss methods for identifying and quantitating metabolites during the pre-clinical development of radiopharmaceuticals with special emphasis on the application of LC/MS...
  40. ncbi request reprint Quantification of Kryptofix 2.2.2 in 2-[(18)F]FDG and other radiopharmaceuticals by LC/MS/MS
    Ying Ma
    PET Department, Warren G Magnuson Clinical Center, National Institutes of Health, Building 10, Room 1C 401, Bethesda, MD 20892, USA
    Nucl Med Biol 29:125-9. 2002
    ..Excellent linearity (RSQ = 0.9997) was obtained over the range of 1.0-100 ng/ml. Good precision and accuracy were also observed. The method is amenable to the validation of radiosynthetic methods...
  41. pmc Real-time video imaging of protease expression in vivo
    Lei Zhu
    1 Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    Theranostics 1:18-27. 2011
    ....
  42. pmc Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging
    Yunpeng Ye
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Bioorg Med Chem Lett 21:1146-50. 2011
    ..Both 1 and 2 showed significant tumor localization in optical imaging of MDA-MB-435 tumor-bearing mice. The potential of such iRGD compounds in tumor-targeted imaging and drug delivery deserves further exploration...
  43. ncbi request reprint T cell infiltration is associated with increased Lyme arthritis in TLR2-/- mice
    Xiaohui Wang
    Department of Pathology, University of Utah, Salt Lake City, UT 84112 5650, USA
    FEMS Immunol Med Microbiol 52:124-33. 2008
    ..These results suggest that the increased inflammatory cell infiltration in TLR2(-/-) C3H mice is the result of localized overproduction of T cell attracting chemokines...
  44. pmc Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection
    Amanda C Jacobson
    Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112 5650, USA
    Infect Immun 75:2075-8. 2007
    ..Although CD21/35(-/-) mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar...
  45. ncbi request reprint Brain incorporation of [11C]arachidonic acid in young healthy humans measured with positron emission tomography
    Giampiero Giovacchini
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, Maryland, U S A
    J Cereb Blood Flow Metab 22:1453-62. 2002
    ..As brain incorporation of labeled AA has been shown in awake rats to be increased by pharmacological activation associated with phospholipase A2-signaling, PET and [11C]AA may be useful to measure signal transduction in the human brain...
  46. ncbi request reprint Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi
    R Mark Wooten
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, USA
    Vector Borne Zoonotic Dis 2:275-8. 2002
  47. ncbi request reprint MyD88 plays a unique role in host defense but not arthritis development in Lyme disease
    Devin D Bolz
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 173:2003-10. 2004
    ..The findings presented here point to a dichotomy between the recruitment of inflammatory cells to tissue and an inability of these cells to kill localized spirochetes...
  48. ncbi request reprint Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi
    R Mark Wooten
    Department of Pathology, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    J Immunol 168:348-55. 2002
    ..Thus, while TLR2-dependent signaling pathways play a major role in the innate host defense to B. burgdorferi, both inflammatory responses and the development of the acquired humoral response can occur in the absence of TLR2...
  49. ncbi request reprint [Determination of EPA and DHA in marine microalgaes by GC]
    Qiuhui Zhang
    Se Pu 22:662. 2004
  50. doi request reprint Two new diterpenoid acids from Pinus koraiensis
    Xin Yang
    School of Food Science and Engineer, Harbin Institute of Technology, Harbin, 150090, PR China
    Fitoterapia 79:179-81. 2008
    ..By spectral evidence, the structure of the new compounds were elucidated as 7-oxo-13beta,15-dihydroxyabiet-8(14)-en-18-oic acid (1) and 7-oxo-12alpha, 13beta,15-trihydroxyabiet-8(14)-en-18-oic acid (2), respectively...
  51. ncbi request reprint Buildup of gold nanoparticle multilayer thin films based on the covalent-bonding interaction between boronic acids and polyols
    Ying Ma
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
    J Colloid Interface Sci 295:583-8. 2006
    ..The residual boronic acid group on the surface of thin film could incorporate glycosylated-protein horseradish peroxidase (HRP), and good catalytic activity for H2O2 could be observed...
  52. ncbi request reprint Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods
    Nan Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun 130022, China
    Biophys Chem 116:199-205. 2005
    ..These studies are valuable for a better understanding the detailed mode of MTX-DNA interaction, which should be important in deeper insight into the therapeutic efficacy of MTX and design of new DNA targeted drug...