Xuefei Ma

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Mol Biol Cell 18:2305-12. 2007
  2. ncbi request reprint A point mutation in myh10 causes major defects in heart development and body wall closure
    Xuefei Ma
    From the Laboratory of Molecular Cardiology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
    Circ Cardiovasc Genet 7:257-65. 2014
  3. pmc Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Mol Biol Cell 21:3952-62. 2010
  4. pmc Nonmuscle myosin II isoform and domain specificity during early mouse development
    Aibing Wang
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Proc Natl Acad Sci U S A 107:14645-50. 2010
  5. pmc Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 17:2138-49. 2006
  6. pmc Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Circ Res 105:1102-9. 2009
  7. pmc Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4509-14. 2012
  8. ncbi request reprint Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family
    Eliahu Golomb
    Laboratory of Molecular Cardiology, NHLBI, National Institute of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:2800-8. 2004
  9. pmc Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains
    Aibing Wang
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Biochem Soc Trans 39:1131-5. 2011
  10. pmc A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 15:2568-79. 2004

Collaborators

Detail Information

Publications17

  1. pmc Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Mol Biol Cell 18:2305-12. 2007
    ..These studies show that the scaffolding properties of NM II-B play an important role in cell adhesion, thereby preventing hydrocephalus during mouse brain development...
  2. ncbi request reprint A point mutation in myh10 causes major defects in heart development and body wall closure
    Xuefei Ma
    From the Laboratory of Molecular Cardiology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
    Circ Cardiovasc Genet 7:257-65. 2014
    ..Neither NMII-A nor II-C seems to play roles in early myocardial development...
  3. pmc Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Mol Biol Cell 21:3952-62. 2010
    ..Our study shows that NM II is involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics...
  4. pmc Nonmuscle myosin II isoform and domain specificity during early mouse development
    Aibing Wang
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Proc Natl Acad Sci U S A 107:14645-50. 2010
    ..These results highlight the functions of the N-terminal motor and C-terminal rod domains of NM II and their different roles in cell-cell and cell-matrix adhesion...
  5. pmc Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 17:2138-49. 2006
    ..Some of the B2-ablated Purkinje cells are misplaced in the cerebellar molecular layer. All of the B2-ablated mice demonstrated impaired motor coordination...
  6. pmc Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Circ Res 105:1102-9. 2009
    ..Tissue-specific ablation of NMII-B by a Cre recombinase strategy should prevent embryonic lethality and permit study of the function of NMII-B in adult hearts...
  7. pmc Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4509-14. 2012
    ..We propose that the major roles of NM II in vertebrate cell cytokinesis are to bind and cross-link actin filaments and to exert tension on actin during contractile ring constriction...
  8. ncbi request reprint Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family
    Eliahu Golomb
    Laboratory of Molecular Cardiology, NHLBI, National Institute of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:2800-8. 2004
    ..5 + 7.2 microm. HMM II-C1 translocated actin filaments at a rate of 0.05 + 0.011 microm/s in the absence of tropomyosin and at 0.072 + 0.019 microm/s in the presence of tropomyosin in an in vitro motility assay...
  9. pmc Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains
    Aibing Wang
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Biochem Soc Trans 39:1131-5. 2011
    ..However, we also show that certain functions, such as neuronal cell migration in the developing brain and vascularization of the mouse embryo and placenta, specifically require NM II-B and II-A respectively...
  10. pmc A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 15:2568-79. 2004
    ..These studies demonstrate that NMHC II-B is particularly important for normal migration of distinct groups of neurons during mouse brain development...
  11. pmc NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry
    Seham Ebrahim
    Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 23:731-6. 2013
    ..The sarcomeric network also provides a well-defined target to investigate the multiple roles of NMII in junctional homeostasis as well as in development and disease...
  12. ncbi request reprint Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis
    Kazuyo Takeda
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Circ Res 93:330-7. 2003
    ..Whereas cardiac myocytes completely ablated for NMHC II-B show enlargement and binucleation, mice expressing as little as 6% of the normal amount of wild-type NMHC II-B in the heart do not show these abnormalities...
  13. pmc Myosin II regulates extension, growth and patterning in the mammalian cochlear duct
    Norio Yamamoto
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Development 136:1977-86. 2009
    ..Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns...
  14. ncbi request reprint Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice
    Jianjun Bao
    Laboratory of Molecular Cardiology and Transgenic Core, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:22102-11. 2007
    ..Thus, although NMHC II-A can substitute for NMHC II-B to maintain integrity of the spinal canal, NMHC II-B plays an isoform-specific role during cytokinesis in cardiac myocytes and in migration of the facial and pontine neurons...
  15. pmc In vivo studies on nonmuscle myosin II expression and function in heart development
    Xuefei Ma
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    Front Biosci (Landmark Ed) 17:545-55. 2012
    ....
  16. pmc Local cortical tension by myosin II guides 3D endothelial cell branching
    Robert S Fischer
    Laboratory of Cell and Tissue Morphodynamics, Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 19:260-5. 2009
    ..Thus, local downregulation of myosin II cortical contraction allows pseudopodium initiation to mediate EC branching and hence guide directional migration and angiogenesis...
  17. ncbi request reprint Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects
    Xuefei Ma
    Departments of Physiology and Surgery, Faculty of Medicine, University of Manitoba, Manitoba, Winnipeg R3E 3J7, Canada
    Am J Physiol Lung Cell Mol Physiol 283:L1181-9. 2002
    ..04 +/- 0.008, n = 11; P < 0.05). Messages for myosin heavy chain isoforms showed no difference. Increased kinase message content is an index of the mechanism for the increased velocity and capacity of shortening we report...