B R Ludviksson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Immunol 160:3602-9. 1998
  2. ncbi request reprint Role of IL-12 in intrathymic negative selection
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:4349-59. 1999
  3. ncbi request reprint Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:4975-82. 1999
  4. ncbi request reprint Induction and prevention of colonic inflammation in IL-2-deficient mice
    R O Ehrhardt
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 158:566-73. 1997
  5. ncbi request reprint TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice
    B R Ludviksson
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 159:3622-8. 1997
  6. ncbi request reprint Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes
    B R Ludviksson
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 158:104-11. 1997

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Immunol 160:3602-9. 1998
    ..These data suggest that T cells from WG patients overproduce IFN-gamma and TNF-alpha, probably due to dysregulated IL-12 secretion, and that IL-10 may therefore have therapeutic implications for this disease...
  2. ncbi request reprint Role of IL-12 in intrathymic negative selection
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:4349-59. 1999
    ....
  3. ncbi request reprint Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice
    B R Ludviksson
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:4975-82. 1999
    ..Thus, the above findings demonstrate that the onset and maintenance of inflammatory bowel disease depends on the colonic localization of lamina propria CD4+ lymphocytes expressing alpha E beta 7...
  4. ncbi request reprint Induction and prevention of colonic inflammation in IL-2-deficient mice
    R O Ehrhardt
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 158:566-73. 1997
    ..These findings suggest that in the absence of IL-2 systemic administration of Ag induces primarily Th1 cells driven by overexpression of heterodimeric IL-12...
  5. ncbi request reprint TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice
    B R Ludviksson
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 159:3622-8. 1997
    ....
  6. ncbi request reprint Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes
    B R Ludviksson
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 158:104-11. 1997
    ..Taken together, these data indicate that, in the absence of IL-2, thymocyte maturation is abnormally directed by IL-12 toward the generation of mature, activated Th1-type thymocytes that are capable of mediating colitis...