Joseph J Lucas

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells
    Joseph J Lucas
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Cancer Res 2:105-14. 2004
  2. pmc Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells
    Masakazu Okamoto
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Int Arch Allergy Immunol 157:65-72. 2012
  3. pmc NF-kappaB-dependent induction of cathelicidin-related antimicrobial peptide in murine mast cells by lipopolysaccharide
    Guiming Li
    Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Int Arch Allergy Immunol 150:122-32. 2009
  4. doi request reprint Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2-dependent pathways are essential for CD8+ T cell-mediated airway hyperresponsiveness and inflammation
    Hiroshi Ohnishi
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO, USA
    J Allergy Clin Immunol 123:249-57. 2009
  5. pmc Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease
    Yi Jia
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 110:8152-7. 2013
  6. pmc Microbial heat shock protein 65 attenuates airway hyperresponsiveness and inflammation by modulating the function of dendritic cells
    Yoo Seob Shin
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 189:3404-10. 2012
  7. pmc Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation
    Yi Jia
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:4056-65. 2013
  8. doi request reprint Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production
    Masakazu Okamoto
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:2995-3003. 2009
  9. ncbi request reprint Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice
    Tricia N Lively
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:88-94. 2008
  10. pmc Susceptibility to vaccinia virus infection and spread in mice is determined by age at infection, allergen sensitization and mast cell status
    Joanne Domenico
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Int Arch Allergy Immunol 158:196-205. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells
    Joseph J Lucas
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Cancer Res 2:105-14. 2004
    ..The results suggest that cdk6 restrains rather than stimulates breast epithelial cell proliferation and that its loss or down-regulation could play a role in breast tumor development...
  2. pmc Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells
    Masakazu Okamoto
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Int Arch Allergy Immunol 157:65-72. 2012
    ....
  3. pmc NF-kappaB-dependent induction of cathelicidin-related antimicrobial peptide in murine mast cells by lipopolysaccharide
    Guiming Li
    Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Int Arch Allergy Immunol 150:122-32. 2009
    ..In this study, mechanisms regulating LPS-induction of CRAMP gene expression in mast cells were investigated. NF-kappaB and MAPK pathways were the focus of investigation...
  4. doi request reprint Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2-dependent pathways are essential for CD8+ T cell-mediated airway hyperresponsiveness and inflammation
    Hiroshi Ohnishi
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO, USA
    J Allergy Clin Immunol 123:249-57. 2009
    ..Phosphorylation of extracellular signal-regulated kinase (ERK) is important in activation and cytokine production from many cell types...
  5. pmc Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease
    Yi Jia
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 110:8152-7. 2013
    ..We demonstrate that Cyp11a1 controls the phenotypic conversion of CD8(+) T cells from IFN-γ to IL-13 production, linking steroidogenesis in CD8(+) T cells, a nonclassical steroidogenic tissue, to a proallergic differentiation pathway...
  6. pmc Microbial heat shock protein 65 attenuates airway hyperresponsiveness and inflammation by modulating the function of dendritic cells
    Yoo Seob Shin
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 189:3404-10. 2012
    ..Thus, HSP65-induced effects on allergen-induced airway hyperresponsiveness and inflammation were associated with increased Delta1 expression on dendritic cells, modulation of dendritic cell function, and CD4(+) Th1 cytokine production...
  7. pmc Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation
    Yi Jia
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:4056-65. 2013
    ....
  8. doi request reprint Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production
    Masakazu Okamoto
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:2995-3003. 2009
    ..These data identify the essential role of the interactions between Notch on CD4(+) T cells and Jagged1 on APCs in the initiation of IL-4 production and Th2 differentiation for the development of AHR and allergic airway inflammation...
  9. ncbi request reprint Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice
    Tricia N Lively
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:88-94. 2008
    ..siRNAs can be synthesized with chemical modifications to increase stability and reduce double-stranded RNA-induced immune responses without affecting their ability to elicit degradation of target mRNA...
  10. pmc Susceptibility to vaccinia virus infection and spread in mice is determined by age at infection, allergen sensitization and mast cell status
    Joanne Domenico
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Int Arch Allergy Immunol 158:196-205. 2012
    ....
  11. ncbi request reprint Contribution of allergen-specific and nonspecific nasal responses to early-phase and late-phase nasal responses
    Satoko Miyahara
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:718-24. 2008
    ..The relative contributions of the allergen-specific early-phase nasal response and nonspecific nasal response and mast cells to the pathophysiology of allergic rhinitis are not well defined...
  12. pmc Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells
    Yi Jia
    Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 9:e97448. 2014
    ....
  13. ncbi request reprint Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways
    Guiming Li
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Cell Immunol 238:10-8. 2005
    ..Since MAPK modules differentially regulate mast cell functions, including degranulation and cytokine production, it is suggested that specific functions could be targeted by inhibiting specific PKC isoforms...
  14. ncbi request reprint Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes
    Guiming Li
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 173:2383-91. 2004
    ..The results indicate that p57(Kip2) is involved in the regulation of several aspects of the T cell cycle...
  15. ncbi request reprint Transforming growth factor-beta antagonizes alveolar type II cell proliferation induced by keratinocyte growth factor
    Feijie Zhang
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 31:679-86. 2004
    ..In summary, TGF-beta inhibits the proliferative effect of KGF in vitro and may be a biologic antagonist of KGF...
  16. pmc Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness
    Shigeki Matsubara
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:56-63. 2006
    ..Spleen tyrosine kinase (Syk) is important for Fc and B-cell receptor-mediated signaling...