Ronald A Lubet

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 123:2254-9. 2008
  2. ncbi request reprint Preventive Effects of NSAIDs, NO-NSAIDs, and NSAIDs Plus Difluoromethylornithine in a Chemically Induced Urinary Bladder Cancer Model
    Holly L Nicastro
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852
    Cancer Prev Res (Phila) 7:246-54. 2014
  3. pmc Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Cancer Prev Res (Phila) 6:448-54. 2013
  4. doi request reprint Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
    Oncol Rep 27:1400-6. 2012
  5. pmc Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Breast Cancer Res 10:R18. 2008
  6. pmc Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism
    Anne Shilkaitis
    Department of Surgical Oncology, University of Illinois, 840 S, Wood Str, Chicago, IL 60612, USA
    Breast Cancer Res 7:R1132-40. 2005
  7. doi request reprint Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    J Urol 183:1598-603. 2010
  8. pmc Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Chem Biol Interact 182:22-8. 2009
  9. ncbi request reprint Chemoprevention of lung cancer in transgenic mice
    Ronald A Lubet
    Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Chest 125:144S-7S. 2004
  10. doi request reprint Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 7:972-9. 2008

Collaborators

Detail Information

Publications80

  1. doi request reprint Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 123:2254-9. 2008
    ..In summary, rosiglitazone over a wide dose range enhanced urinary bladder carcinogenesis in the OH-BBN model in rats...
  2. ncbi request reprint Preventive Effects of NSAIDs, NO-NSAIDs, and NSAIDs Plus Difluoromethylornithine in a Chemically Induced Urinary Bladder Cancer Model
    Holly L Nicastro
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852
    Cancer Prev Res (Phila) 7:246-54. 2014
    ..Thus, naproxen and NO-naproxen were highly effective, whereas sulindac was moderately effective in the OH-BBN model at their HEDs. Cancer Prev Res; 7(2); 246-54. ©2013 AACR. ..
  3. pmc Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Cancer Prev Res (Phila) 6:448-54. 2013
    ..Thus, altering the dose of erlotinib retained most of its preventive and therapeutic efficacy, and based on prior clinical studies, is likely to reduce its toxicity...
  4. doi request reprint Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
    Oncol Rep 27:1400-6. 2012
    ..There was minimal overlap of efficacy. That is, models which were relatively susceptible to NSAIDs or COX-2 inhibitors tended not to be sensitive to Targretin and vice versa...
  5. pmc Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Breast Cancer Res 10:R18. 2008
    ..The cyclooxygenase-2 inhibitor celecoxib (Celebrex) is a nonsteroidal anti-inflammatory drug and as such is a potential candidate for the prevention of hormonally nonresponsive breast cancer...
  6. pmc Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism
    Anne Shilkaitis
    Department of Surgical Oncology, University of Illinois, 840 S, Wood Str, Chicago, IL 60612, USA
    Breast Cancer Res 7:R1132-40. 2005
    ..Here we examine whether DHEA and its analog DHEA 8354 can suppress the progression of hyperplastic and premalignant (carcinoma in situ) lesions in mammary gland toward malignant tumors and the cellular mechanisms involved...
  7. doi request reprint Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    J Urol 183:1598-603. 2010
    ..We optimized agent testing in an in vivo bladder cancer model and determined the most sensitive, relevant protocol to test efficacy in clinical prevention trials...
  8. pmc Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Chem Biol Interact 182:22-8. 2009
    ..g., quinone reductase) is a surrogate for overall Phase II inducing (antioxidant) and potential anti-tumor activity...
  9. ncbi request reprint Chemoprevention of lung cancer in transgenic mice
    Ronald A Lubet
    Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Chest 125:144S-7S. 2004
  10. doi request reprint Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 7:972-9. 2008
    ..Finally, combining suboptimal doses of Iressa with suboptimal doses of vorozole (an aromatase inhibitor) or targretin (a retinoid X receptor agonist) yielded greater chemopreventive efficacy than any of these agents given alone...
  11. ncbi request reprint Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Carcinogenesis 26:441-8. 2005
    ..Determination of serum IGF1 levels showed that treatment of rats with highly effective doses of Targretin at 272 mg/kg diet or at 60 or 20 mg/kg body wt/day by gavage caused significantly decreased serum IGF1 levels...
  12. ncbi request reprint Mouse models incorporating alterations in the major tumor suppressor genes P53 and P16: their use in screening for potential carcinogens, developing further relevant mouse models, and screening for potential chemopreventive and chemotherapetutic agents
    Ronald Lubet
    Chemoprevention Agent Development Research Group, National Cancer Institute, Rockville, MD 20892, USA
    Exp Lung Res 31:117-33. 2005
    ..The primary objective of the present review is to describe more recent studies using mice the dominant-negative P53 mutation as well as to introduce studies with mice with a heterozygous knockout of the P16/Ink4A ARF locus...
  13. ncbi request reprint Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 5:1073-8. 2006
    ..Thus, R115777 was active in the prevention and therapy of these chemically induced mammary cancers, but was strikingly more effective in cancers with HaRas mutations...
  14. ncbi request reprint Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 6:2022-8. 2007
    ..The bioavailability of these tea polyphenols to different organ sites may contribute to the differing preventive efficacy of Polyphenon E against urinary bladder and mammary cancers...
  15. doi request reprint Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, NIH, NCI, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oncol Rep 26:731-6. 2011
    ..In contrast, DIM had minimal effects in either model; arguing that administration of DIM is not analogous to administration of I3C...
  16. doi request reprint Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: dose dependency and modulation of biomarkers
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Blvd, Bethesda, MD 20852, USA
    Oncol Rep 25:1389-97. 2011
    ..In particular, cell cycle genes related to the anaphase protein complex (APC) pathway, including CDC 20, cyclin B1, BUB1 and both of the Aurora kinases, were significantly decreased...
  17. doi request reprint Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis
    Ronald A Lubet
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 2:161-7. 2009
    ..Similarly, atorvastatin failed to alter the development of estrogen receptor-negative mammary carcinomas in a new animal model using bitransgenic mice (MMTV-Neu(+/-)/p53KO(+/-)), whereas bexarotene (250 mg/kg diet) was effective...
  18. pmc Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers
    Vernon E Steele
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 2:951-6. 2009
    ..These data show that both naproxen and NO-naproxen are effective agents against urinary bladder and colon, but not mammary, carcinogenesis...
  19. ncbi request reprint 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin
    Ronald A Lubet
    Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Carcinogenesis 26:571-8. 2005
    ..The anti-apoptotic protein survivin was not expressed in normal bladder epithelium, but was variably expressed in cancers. FHIT and survivin expressions were similar in cancers from indomethacin-treated and non-treated mice...
  20. ncbi request reprint The utility of genetically altered mouse models for nutrition and cancer chemoprevention research
    Stephen D Hursting
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Mutat Res 576:80-92. 2005
    ....
  21. ncbi request reprint Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer
    Vernon E Steele
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 7322, USA
    Mutat Res 523:137-44. 2003
    ..As newer more specific drugs are developed with few adverse effects this important prevention strategy may become a reality...
  22. ncbi request reprint Can animal models help us select specific compounds for cancer prevention trials?
    Ernest T Hawk
    GI and Other Cancers Research Group, National Cancer Institute, Suite 2141, 6130 Executive Boulevard, Bethesda, MD 20892 7317, USA
    Recent Results Cancer Res 166:71-87. 2005
    ....
  23. pmc The use of animal models for cancer chemoprevention drug development
    Vernon E Steele
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA
    Semin Oncol 37:327-38. 2010
    ..Whether validated or not, animal efficacy data remain central to the clinical trial decision-making process...
  24. doi request reprint Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in rats
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, United States
    Chem Biol Interact 179:233-9. 2009
    ..Therefore, more easily accessible plasma salicylate and thromboxane B(2) concentrations were representative of the salicylate exposure and prostaglandin E(2) pharmacodynamic biomarker in the target colon, respectively...
  25. doi request reprint Health disparities in breast cancer: biology meets socioeconomic status
    Barbara K Dunn
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7340, USA
    Breast Cancer Res Treat 121:281-92. 2010
    ..We will attempt to clarify some of the issues, including risk factors, in terms of their contribution to that component of health disparities that involves biological differences in breast cancer between women of AA and white women...
  26. ncbi request reprint Effects of budesonide on overall 5-methylcytosine levels and specific methylation and messenger RNA expression of the insulin-like growth factor II gene in mouse lung tumors
    Ronald Lubet
    Chemopreventive Agent Development Research Group Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852, USA
    Chest 125:157S. 2004
  27. ncbi request reprint 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1
    Haitao Li
    Authors Affiliations The Hormel Institute, University of Minnesota, Austin, Minnesota The National Institutes of Health, National Cancer Institute, Bethesda, Maryland and School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Cancer Res 74:243-52. 2014
    ..Taken together, COX-1 plays a critical role in human colorectal carcinogenesis, and this specific COX-1 inhibitor merits further investigation as a potential preventive agent against colorectal cancer...
  28. doi request reprint Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer
    Tanya Agurs-Collins
    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA
    Semin Oncol 37:384-401. 2010
    ..We will attempt to clarify some of the issues, in terms of their contribution to that component of health disparities that involves biological differences in breast cancer between women of African ancestry and white women...
  29. ncbi request reprint Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice
    Richard Bachelier
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892, USA
    Oncol Rep 14:1117-20. 2005
    ..The data also show that oophorectomy, if performed significantly prior to the time that tumors arise, appears to be quite effective...
  30. doi request reprint Further thoughts on preclinical animal models for cancer prevention: when is it best to start treatment? What are potential histopathologic endpoints?
    Asad Umar
    Division of Cancer Prevention, Gastrointestinal and Other Cancers Research Group, National Cancer Institute, Bethesda, MD, USA
    Semin Oncol 37:339-44. 2010
    ....
  31. ncbi request reprint Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT)
    Fadel S Alyaqoub
    Medical University of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 28:124-9. 2007
    ..These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate end-point biomarker for prevention...
  32. ncbi request reprint p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer
    Zhongqiu Zhang
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Res 4:401-10. 2006
    ....
  33. ncbi request reprint Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT)
    Fadel S Alyaqoub
    Medical University of Ohio, Toledo OH 43614, USA
    Carcinogenesis 27:2442-7. 2006
    ..These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate endpoint biomarker for prevention...
  34. pmc Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine
    Roumen Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 103:7823-8. 2006
    ..In conclusion, heterozygosity for FHIT affects susceptibility of mice to spontaneous alopecia areata and B[a]P-induced preneoplastic lesions of the uterus and does not alter responsiveness to budesonide and NAC...
  35. ncbi request reprint Short-term modulation of cell proliferation and apoptosis and preventive/therapeutic efficacy of various agents in a mammary cancer model
    Konstantin Christov
    Department of Surgical Oncology, University of Illinois at Chicago, Chicago, Illinois, USA
    Clin Cancer Res 13:5488-96. 2007
    ....
  36. doi request reprint Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging
    Joel R Garbow
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:1363-7. 2008
    ..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)...
  37. ncbi request reprint Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors
    Michael A Pereira
    Division of Hematology and Oncology, Ohio State University, College of Medicine, Columbus, OH 43210, USA
    Int J Cancer 120:1150-3. 2007
    ..Hence, budesonide rapidly decreased the size of lung tumors, reversed DNA hypomethylation and modulated mRNA expression of genes; with the molecular alterations requiring continued treatment with the drug for maintenance...
  38. ncbi request reprint Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 4:971-81. 2006
    ..Thus, gefitinib showed highly promising chemopreventive and chemotherapeutic activity in this mouse model of lung carcinogenesis...
  39. ncbi request reprint Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor
    David L McCormick
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Nutr Cancer 57:184-93. 2007
    ....
  40. ncbi request reprint Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats
    Thomas L Horn
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Toxicol Sci 99:612-27. 2007
    ..Differential expression of genes involved in drug and lipid metabolism may underlie the observed effects of BEX on cholesterol and triglyceride levels and its effects on liver histology...
  41. ncbi request reprint Modulation by bexarotene of mRNA expression of genes in mouse lung tumors
    Fadel S Alyaqoub
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, Ohio, USA
    Mol Carcinog 47:165-71. 2008
    ....
  42. ncbi request reprint Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777
    William T Gunning
    Department of Pathology, Medical College of Ohio, Toledo 43614, USA
    Clin Cancer Res 9:1927-30. 2003
    ..The efficacy of R115777 [Zarnestra; (B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] to prevent the development of lung tumors in mice was determined...
  43. ncbi request reprint Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice
    Ying Yan
    Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inhal Toxicol 19:183-7. 2007
    ..These results indicate that a p53 mutation or loss of a Kras2 allele increases susceptibility to MS-induced lung tumor development...
  44. pmc Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 8:52-8. 2006
    ..The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice...
  45. ncbi request reprint Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors
    Michael A Pereira
    Department of Pathology, Medical College of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 25:1917-23. 2004
    ..Celecoxib and DFMO reversed DNA hypomethylation and the hypermethylation of the ER-alpha gene in colon tumors supporting the hypothesis that modulation of methylation is a biomarker of chemoprevention...
  46. ncbi request reprint Gene expression in the lung of p53 mutant mice exposed to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Cancer Res 64:8566-72. 2004
    ..Taken together, these findings may explain the increased susceptibility of p53 mutant mice to smoke-related alterations of intermediate biomarkers and lung carcinogenesis...
  47. ncbi request reprint Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 10:6703-9. 2004
    ....
  48. ncbi request reprint Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 523:237-52. 2003
    ..We are trying to develop a pharmacogenomic approach, e.g. based on genetic metabolic polymorphisms, aimed at predicting not only the risk of developing cancer but also the individual responsiveness to chemopreventive agents...
  49. pmc Differential gene expression in chemically induced mouse lung adenomas
    Ruisheng Yao
    Division of Human Cancer Genetics and School of Public Health, The Ohio State University James Cancer Center, Columbus, OH 43210, USA
    Neoplasia 5:41-52. 2003
    ..These genes may prove to be helpful in our understanding of the genetic basis of lung carcinogenesis and in developing biomarkers for lung cancer chemoprevention studies in mice...
  50. ncbi request reprint Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
    ..It is concluded that the combination of celecoxib and DFMO are potent therapeutic agents for skin cancer, although the benefits are lost with the cessation of treatment...
  51. ncbi request reprint Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:3841-50. 2004
    ..Furthermore, ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas...
  52. ncbi request reprint CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors
    Shuang Yin Han
    Kimmel Cancer Center, Thomas Jefferson University, 1008 BLSB, 233S 10th Street, Philadelphia, PA 19107, USA
    Oncogene 23:3990-8. 2004
    ....
  53. ncbi request reprint Modulation of DNA hypomethylation as a surrogate endpoint biomarker for chemoprevention of colon cancer
    Lianhui Tao
    Department of Pathology, Medical College of Ohio, Toledo, Ohio, USA
    Mol Carcinog 39:79-84. 2004
    ..The results suggest that the ability to reverse the DNA hypomethylation in colon tumors could be useful as a surrogate end-point biomarker for chemoprevention of colon cancer...
  54. ncbi request reprint Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention
    Mark B Cope
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncol Rep 11:465-9. 2004
    ..In both experiments, the two retinoids in combination produced an additive effect, suggesting that they may inhibit mammary cancers by different mechanisms...
  55. ncbi request reprint Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas
    Allison E Bonner
    Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 420 West 12th Avenue, Columbus, OH 43210, USA
    Oncogene 23:1166-76. 2004
    ..We have also attempted to compare the expression profiles found in mouse lung cancers and those in human lung ACs...
  56. ncbi request reprint Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 22:6257-65. 2003
    ..In fact, L-778,123 is more effective in inhibiting primary lung progression in mice with a p53 mutation and/or an Ink4a/Arf deletion than in wild-type animals...
  57. ncbi request reprint Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke
    Silvio De Flora
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Cancer Res 63:793-800. 2003
    ..These findings provide evidence that p53 mutations play a role in smoke-related carcinogenesis not only in humans but also in A/J mice...
  58. ncbi request reprint Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Exp Lung Res 31:19-35. 2005
    ..Smoke-induced genomic and transcriptional alterations were suitable for evaluating their modulation by chemopreventive agent, as shown in studies using the thiol N-acetylcysteine and the nonsteroidal anti-inflammatory drug sulindac...
  59. ncbi request reprint K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Lung Res 31:271-81. 2005
    ..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations...
  60. ncbi request reprint p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas
    Zhongqiu Zhang
    Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, 514 Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Res 62:3024-9. 2002
    ..These results demonstrate a tissue-specific enhancement of tumorigenesis in multiple organs by the mutant p53 transgene and additionally support the utility of (C57BL/6J x UL53-3) F(1) mice for chemoprevention studies...
  61. ncbi request reprint Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 27:1420-31. 2006
    ..Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs...
  62. ncbi request reprint Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas
    Stephan Woditschka
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Cancer Res 66:6884-91. 2006
    ..The model is useful for assessing the efficacy of chemopreventive agents, specifically those compounds that target hormonally nonresponsive tumors...
  63. ncbi request reprint Prevention of mouse lung tumors by budesonide and its modulation of biomarkers
    Michael A Pereira
    Department of Pathology, Medical College of Ohio, HEB, Room 200F, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
    Carcinogenesis 23:1185-92. 2002
    ..Thus, short-term treatment with budesonide modulated biological and molecular end-points in lung tumors that might be developed further as biomarkers for its clinical chemopreventive efficacy in the lung...
  64. ncbi request reprint Prevention of mouse lung tumors by targretin
    Michael A Pereira
    Division of Hematology and Oncology, Ohio State University, College of Medicine, Columbus, OH 43210, USA
    Int J Cancer 118:2359-62. 2006
    ..75 and 4.60 +/- 0.70, respectively. Hence, targretin demonstrated both preventive and therapeutic activity with respect to mouse lung tumors supporting its further development as a preventive and therapeutic agent for lung cancer...
  65. ncbi request reprint Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents
    Lianhui Tao
    Department of Pathology, HEB, Rm 202, Medical College of Ohio, 3055 Arlington Ave, Toledo, OH 43614 5806, USA
    Carcinogenesis 23:1447-54. 2002
    ..Hence, agents that prevented colon cancer decreased the mitotic index and altered the expression of c-myc, p16 and p27 suggesting that modulation in the expression of these genes are potential biomarkers for chemopreventive activity...
  66. ncbi request reprint Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 Euclid Avenue, Box 8109, St Louis, Missouri 63110, USA
    Mol Cancer Res 3:563-74. 2005
    ..The present study provides the first in vivo evidence that a germ line p53 mutation and activated H-ras act synergistically to profoundly enhance tumor progression...
  67. ncbi request reprint Modulation of multigene expression and proteome profiles by chemopreventive agents
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:212-23. 2005
    ..OPZ was poorly effective in lung and considerably altered the basal gene expression in liver. NAC had a medium efficacy and was the safest agent, as also supported by the analysis of 518 proteins in rat lung...
  68. ncbi request reprint Hypermethylation patterns in the Fhit regulatory region are tissue specific
    Gulnur Guler
    Department of Microbiology Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Mol Carcinog 43:175-81. 2005
    ..The specific patterns of hypermethylated CpGs in the Fhit regulatory regions thus appear to be tissue-specific...
  69. ncbi request reprint Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors
    Lianhui Tao
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Mol Carcinog 35:93-102. 2002
    ..The results support the possibility of using decreased mRNA expression and remethylation of the Igf-II and c-myc genes as biomarkers for the efficacy of budesonide...
  70. ncbi request reprint The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin
    Guobin He
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 43:198-206. 2005
    ..Collectively, our data suggest that PPARgamma ligands may not be useful in the prevention of chemically or UV-induced skin tumors...
  71. ncbi request reprint Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice
    Yian Wang
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 63:4389-95. 2003
    ..Thus, the mutant A/J mouse model should prove useful for chemoprevention studies...
  72. pmc Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues
    Amy L McDoniels-Silvers
    Department of Pathology, Medical College of Ohio, Toledo, OH 43614, USA
    Neoplasia 4:141-50. 2002
    ..Regardless, many of these differences may be useful in the diagnosis and/or treatment of this deadly disease...
  73. ncbi request reprint Lung DNA adducts detected in human smokers are unrelated to typical polyaromatic carcinogens
    Jamal M Arif
    Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Chem Res Toxicol 19:295-9. 2006
    ..Taken together, our data demonstrate that cigarette smoke-associated lung DNA adducts appear on chromatograms as DRZs, consistent with the literature, but they are not related to PAHs and aromatic amines...
  74. ncbi request reprint Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:7746-52. 2004
    ..Our results indicate that the chemopreventive effects of budesonide in the mouse lung tumorigenesis assay involved increase and decrease expression of a wide variety of genes in multiple signaling pathways...
  75. ncbi request reprint Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture
    Keith A Crist
    Department of Surgery, Medical College of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 26:951-7. 2005
    ..Thus, the DMBA suture model in rats yields epithelial derived tumors histologically similar to humans and should prove suitable for the testing of preventive or therapeutic agents...
  76. pmc Gene expression profiling of chemically induced rat bladder tumors
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neoplasia 9:207-21. 2007
    ..These results suggest that multiple pathways are involved in rat bladder tumorigenesis, and a common molecular mechanism was found in both rat and mouse bladder tumors...
  77. pmc Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 7:1053-7. 2005
    ..Thus, deguelin appears to be a promising new preventive agent for lung cancer and may be considered for further studies in other animal models and in clinical trials...
  78. ncbi request reprint Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers
    Clinton J Grubbs
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Carcinogenesis 27:1232-9. 2006
    ..In summary, a short-term in vivo method has been identified for screening newly synthesized retinoids both for chemopreventive efficacy and for their adverse effect on serum triglycerides...
  79. ncbi request reprint Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South, Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 5:1060-72. 2006
    ..These expression signatures could provide useful pharmacodynamic biomarkers for retinoid treatment and chemoprevention...
  80. ncbi request reprint Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas
    Amy L McDoniels-Silvers
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Clin Cancer Res 8:1127-38. 2002
    ....