Research Topics
Genomes and Genes
Species | Bai LuSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neuronsJuan Ji An
Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
Cell 134:175-87. 2008..These results provide insights into local and dendritic actions of BDNF and reveal a mechanism for differential regulation of subcellular functions of proteins...
Pro-region of neurotrophins: role in synaptic modulationBai Lu
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 39:735-8. 2003..These results demonstrate new mechanisms by which neurotrophins regulate synaptic plasticity and memory function...- Acute and long-term synaptic modulation by neurotrophinsBai Lu
Section on Neural Development and Plasticity, NICHD, NIH, Building 49, Rm 6A80, 49 Convent Dr, MSC4480, Bethesda, MD 20892 4480, USA
Prog Brain Res 146:137-50. 2004..Further study of these mechanisms will help us better understand how neurotrophins can achieve diverse and synapse-specific modulation... - Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startleHui Ching Lin
Institute of Basic Medical Sciences and Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan
Learn Mem 13:316-21. 2006..These results suggest that CB1 agonists could impair fear memory via blocking reconsolidation... - The yin and yang of neurotrophin actionBai Lu
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892 3714, USA
Nat Rev Neurosci 6:603-14. 2005..New insights into the 'yin and yang' of neurotrophin activity have profound implications for our understanding of the role of neurotrophins in a wide range of cellular processes... - Neurotrophic regulation of the development and function of the neuromuscular synapsesBai Lu
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892 4480, USA
J Neurocytol 32:931-41. 2003..Further studies of the mechanisms underlying these regulatory effects will help us better understand how neurotrophic factors can achieve diverse and synapse-specific modulation in the brain... - Molecular mechanisms underlying neural circuit formationBai Lu
Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD 20892, United States
Curr Opin Neurobiol 19:162-7. 2009..Intriguingly, several transcription factors, as well as activity-dependent transcription of BDNF through promoter IV, have been shown to selectively regulate cortical inhibitory circuits by promoting GABAergic synapse formation... - BDNF and activity-dependent synaptic modulationBai Lu
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland 20892 4480, USA
Learn Mem 10:86-98. 2003..Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner... - Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memoryBai Lu
Section on Neural Development and Plasticity, NICHD, NIH, Building 35, Rm 1C1004, 35 Convent Dr, MSC 3714, Bethesda, MD 20892 3714, USA
Neuron Glia Biol 1:377-84. 2004..Further study of the relationship between neurotrophins, adult neurogenesis and dentate synaptic plasticity might provide new insights into the mechanisms by which gene-environment interactions control cognition and brain plasticity... - Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learningBrita Fritsch
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 66:198-204. 2010..We propose that tDCS may improve motor skill learning through augmentation of synaptic plasticity that requires BDNF secretion and TrkB activation within M1... - Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesisMingrui Zhao
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Biol Psychiatry 62:381-90. 2007..Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic plasticity and learning and memory... - Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress copingKeri Martinowich
Mood and Anxiety Disorders Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Biol Psychiatry 71:75-83. 2012..This study investigated whether and how p75(NTR), via regulation of the cholinergic system and hippocampal synaptic plasticity, influences stress-related behaviors... - Activation of p75NTR by proBDNF facilitates hippocampal long-term depressionNewton H Woo
Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
Nat Neurosci 8:1069-77. 2005.... - eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translationZhihong Jiang
Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:2582-94. 2010..The present study sheds light on the critical importance of gene-specific translations for hippocampal memory consolidation... - Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expressionTina Tze Tsang Tang
Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Section on Neural Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 106:21395-400. 2009..These results reveal subunit-specific regulation of NMDARs by dysbindin, providing an unexpected link between these two proteins implicated in schizophrenia... 
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neuronsYuanyuan Ji
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Neurosci 13:302-9. 2010..Thus, the kinetics of TrkB activation is critical for cell signaling and functions. This temporal dimension in cellular signaling may also have implications for the therapeutic drug design...- Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapsesH Shawn Je
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 109:15924-9. 2012..Thus, proBDNF and mBDNF may serve as potential "punishment" and "reward" signals for inactive and active terminals, respectively, and activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination... - Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase eHong Lou
Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 45:245-55. 2005..Thus, we have identified a mechanism whereby a specific motif I(16)E(18)I(105)D(106) interacts with CPE to sort proBDNF into regulated pathway vesicles for activity-dependent secretion... - Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapsesFeng Yang
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 185:727-41. 2009..These results support a model in which postsynaptic secretion of a single molecule, pro-BDNF, may stabilize or eliminate presynaptic terminals depending on its proteolytic conversion at the synapses... - Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanismsHyun-Soo Je
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 175:1029-42. 2006..These findings may have implications in the general mechanisms of long-term synaptic modulation by neurotrophins... - NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesisKazuhiro Shimazu
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Learn Mem 13:307-15. 2006..In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory... - Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulationH Shawn Je
Genes, Cognition and Psychosis Program GCAP, National Institute of Mental Health NIH, Bethesda, MD 20892, U S A
Mol Brain 4:1. 2011..However, it is unclear whether the long-term synaptic modulation by neurotrophins depends on protein synthesis in pre- or post-synaptic cells... - Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influxJing Du
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892 4480, USA
J Cell Biol 163:385-95. 2003..These results demonstrate an activity- and Ca2+-dependent modulation of TrkB tyrosine kinase and its internalization, and they provide new insights into the cell biology of tyrosine kinase receptors... - Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout miceRenee F Ren-Patterson
Laboratory of Clinical Science, NIMH, NIH, Bethesda, MD 20892 1264, USA
J Neurosci Res 79:756-71. 2005.... - Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficienciesRenee F Ren-Patterson
Laboratory of Clinical Science, NIMH, Bethesda, MD 20892-1264, USA
Cell Mol Neurobiol 26:755-80. 2006.... - Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityPetti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression... - Cell biology of BDNF and its relevance to schizophreniaBai Lu
Genes, Cognition and Psychosis Program GCAP, NIMH and Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD 20892 3714, USA
Novartis Found Symp 289:119-29; discussion 129-35, 193-5. 2008..Extending these studies to synaptic plasticity in other areas of the brain may help us to better understand how altered BDNF signalling could contribute to intermediate phenotypes associated with schizophrenia... - Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortexKazuko Sakata
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 106:5942-7. 2009..These results demonstrate the importance of promoter IV-dependent Bdnf transcription in GABAergic function and reveal an unexpected regulation of STDP in the PFC by BDNF... - Control of extracellular cleavage of ProBDNF by high frequency neuronal activityGuhan Nagappan
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 106:1267-72. 2009..Our study demonstrates activity-dependent control of extracellular proteolytic cleavage of a secretory protein, and reveals an important mechanism that controls diametrically opposed functions of BDNF isoforms... - TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampusKang Zheng
Gene, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 3714, USA
Proc Natl Acad Sci U S A 108:17201-6. 2011..Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV(-/-) mice, resulting in decreased rhythmic network activity in the gamma-frequency band... - Role of dysbindin in dopamine receptor trafficking and cortical GABA functionYuanyuan Ji
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:19593-8. 2009..Taken together, these results suggest that dysbindin regulates PFC function by facilitating D2-mediated modulation of GABAergic function... - BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?Yuan Lu
Gene, Cognition and Psychosis Program GCAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
Neurobiol Learn Mem 89:312-23. 2008..Finally, specific roles of BDNF in the acquisition, retention or extinction of LTM remain to be established... - Ca2+ influx-independent synaptic potentiation mediated by mitochondrial Na(+)-Ca2+ exchanger and protein kinase CFeng Yang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480, USA
J Cell Biol 163:511-23. 2003..Inhibition of PKC blocked the TISP as well as mitochondrial Ca2+ release. These results reveal a novel form of synaptic plasticity and suggest a role of PKC in mitochondrial Ca2+ release during synaptic transmission... - Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNFPetti T Pang
Section on Neural Development and Plasticity, NICHD, NIH, Building 49, Rm 6A80, 49 Convent Dr, MSC4480 Bethesda, MD 20892 4480, USA
Ageing Res Rev 3:407-30. 2004..Finally, we discuss how the aging process affects L-LTP and long-term memory... - TrkB as a potential synaptic and behavioral tagYuan Lu
Gene, Cognition and Psychosis Program, NIMH, National Institutes of Health, Bethesda, Maryland 20892 3714, USA
J Neurosci 31:11762-71. 2011..Inhibition of TrkB during STM training blocked such consolidation. These results suggest TrkB as a potential tag for synapse-specific expression of L-LTP and LTM... - Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implicationsGuhan Nagappan
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, MSC 3714, Bethesda, MD 20892-4480, USA
Trends Neurosci 28:464-71. 2005..Finally, neuronal activity promotes BDNF-induced TrkB endocytosis, a signaling event important for many long-term BDNF functions. These mechanisms could collectively underlie synapse-specific regulation by BDNF... - Distinct mechanisms for neurotrophin-3-induced acute and long-term synaptic potentiationHyun-Soo Je
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-3714, USA
J Neurosci 25:11719-29. 2005..These results reveal fundamental differences between acute and long-term modulation by neurotrophins... - Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behaviorKeri Martinowich
Genes, Cognition and Psychosis Program GCAP, National Institute of Mental Health NIMH, Bethesda, MD 20892, USA
Mol Brain 4:11. 2011..Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis... - The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionMichael F Egan
Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
Cell 112:257-69. 2003..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF... - Ama "zinc" link between TrkB transactivation and synaptic plasticityGuhan Nagappan
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
Neuron 57:477-9. 2008..have now identified a novel mechanism of TrkB transactivation. They show that zinc ions can transactivate TrkB independent of neurotrophins and that such a transactivation is important for mossy fiber long-term potentiation (LTP)... - Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturinChang Yu Wang
Unit on Synapse Development and Plasticity, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:10614-25. 2002..Neurturin had very similar effects as GDNF. These results suggest that GDNF and NRTN are new neuromodulators that regulate the development of the neuromuscular synapse through both pre- and postsynaptic mechanisms... - A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophreniaStephen J Huffaker
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Nat Med 15:509-18. 2009..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target... - Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synucleinDeborah E Cabin
Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 4472, USA
J Neurosci 22:8797-807. 2002..These results reveal, for the first time, the normal function of endogenous alpha-synuclein in regulating synaptic vesicle mobilization at nerve terminals... - Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicityRyota Hashimoto
Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1363, USA
Neuropharmacology 43:1173-9. 2002..Taken together, these data suggest that the BDNF/TrkB pathway plays an essential role in mediating the neuroprotective effect of lithium... - Regulation of cortical interneurons by neurotrophins: from development to cognitive disordersNewton H Woo
Section on Neural Development and Plasticity, NICHD, Bethesda, MD 20892-3714, USA
Neuroscientist 12:43-56. 2006..The authors also discuss the importance of neurotrophin regulation of GABAergic neurons in schizophrenia and epilepsy... - Cerebellar deficits and hyperactivity in mice lacking Smad4Yong Xing Zhou
Mammalian Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892, USA
J Biol Chem 278:42313-20. 2003..Accompanied by the abnormality in the cerebellum, mutant mice also exhibited significantly increased vertical activity. Thus, our study reveals an unexpected role for Smad4 in cerebellar development and in the control of motor function... - Interaction between BDNF and serotonin: role in mood disordersKeri Martinowich
Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
Neuropsychopharmacology 33:73-83. 2008..There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes... - Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survivalHisatsugu Koshimizu
National Institute of Advanced Industrial Science and Technology AIST, Ikeda, 563 8577 Japan
Mol Brain 2:27. 2009.... - BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmissionEmily G Waterhouse
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA
J Neurosci 32:14318-30. 2012.... - Persistent neural activity in the prefrontal cortex: a mechanism by which BDNF regulates working memory?Evan M Galloway
Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD, USA
Prog Brain Res 169:251-66. 2008..We review the research on persistent activity and suggest that BDNF/TrkB signaling in a distinct class of interneurons plays an important role in organizing persistent neural activity at the single-neuron and network levels... - New insights into BDNF function in depression and anxietyKeri Martinowich
Mood and Anxiety Program, National Institute of Mental Health, Building 35, Room 1C1004, 35 Convent Drive, MSC 3714, Bethesda, Maryland 20892 3714, USA
Nat Neurosci 10:1089-93. 2007..Opposing influences of mBDNF and proBDNF on long-term potentiation and long-term depression might contribute to the dichotomy of BDNF actions on behaviors mediated by the brain stress and reward systems... - Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in miceLiya Shen
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814 2790, USA
Am J Hum Genet 70:435-47. 2002..These findings may have general implications for the genetic analysis of cause and effect in complex human diseases... - SHED: stem cells from human exfoliated deciduous teethMasako Miura
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:5807-12. 2003..Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering... - Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid raftsLi Ma
Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, Birmingham, Alabama 35294 0021, USA
J Neurosci 23:3164-75. 2003..Thus, our results indicate that NRG stimulation causes translocation of ErbB4 into lipid rafts and that lipid rafts are necessary for signaling by ErbB4... - GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neuronsJun Wang
Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China
Neurosignals 12:78-88. 2003.... - Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote miceChristel Genoud
Institut de Biologie Cellulaire et de Morphologie, 1005 Lausanne, Switzerland
J Neurosci 24:2394-400. 2004..These results provide evidence that, in vivo, BDNF plays an important role in the structural rearrangement of adult cortical circuitry as a consequence of an increased sensory input... - Lipid rafts mediate chemotropic guidance of nerve growth conesCarmine Guirland
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Neuron 42:51-62. 2004.... - Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neuronsYuanyuan Ji
Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Nat Neurosci 8:164-72. 2005..These results reveal a specific role of cAMP in controlling BDNF actions in the brain, and provide new insights into the molecular mechanism underlying cAMP gating... - BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulationShingo Suzuki
Research Institute for Cell Engineering, National Institute for Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
J Cell Biol 167:1205-15. 2004..Thus, ligand-induced TrkB translocation into lipid rafts may represent a signaling mechanism selective for synaptic modulation by BDNF in the central nervous system... - Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memoryAndre Fischer
Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA
Neuron 48:825-38. 2005..Our data suggest a role for p25 in synaptic plasticity, synaptogenesis, learning, and memory and provide a model whereby deregulation of a plasticity factor can contribute to neurodegeneration... - Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapseZhen Huang
Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 26:11208-19. 2006.... - Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brainXin Duan
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
Cell 130:1146-58. 2007.... - Calcium- and dynamin-independent endocytosis in dorsal root ganglion neuronsChen Zhang
Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Neuron 42:225-36. 2004..These results reveal a calcium- and dynamin-independent form of endocytosis, which is controlled by neuronal activity and PKA-dependent phosphorylation, in DRG neurons... - Schizophrenia, III: brain-derived neurotropic factor and genetic riskMichael F Egan
Am J Psychiatry 160:1242. 2003 - Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junctionZhonghua Lu
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
J Cell Biol 177:1077-89. 2007..These results identify a synapse-associated E3 ubiquitin ligase as an important regulator of MuSK signaling... - Implication of geranylgeranyltransferase I in synapse formationZhen G Luo
Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Neuron 40:703-17. 2003..These results support the notion that prenylation is necessary for AChR clustering and the NMJ formation and/or maintenance, revealing an active role of GGT in Agrin/MuSK signaling... - Role of beta-catenin in synaptic vesicle localization and presynaptic assemblyShernaz X Bamji
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 40:719-31. 2003..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion... - Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1Zhen G Luo
Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA
Neuron 35:489-505. 2002..Inhibition of PAK1 activity attenuates AChR clustering. These results demonstrate important roles of Dvl and PAK in Agrin/MuSK-induced AChR clustering and reveal a novel function of Dvl in synapse development...