Research Topics
Genomes and Genes | Karin LoreSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infectionKarin Lore
Division of Clinical Virology, Department of Microbiology, Pathology and Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
AIDS 16:683-92. 2002..Dendritic cells (DC) are target cells for HIV-1 and play a key role in antigen presentation and activation of T cells...- The role of dendritic cells in the pathogenesis of HIV-1 infectionKarin Lore
Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3022, USA
APMIS 111:776-88. 2003..In addition, we discuss the mechanisms through which HIV-1-DC interactions could be exploited to optimise the generation and maintenance of HIV-1-specific T cell immunity... - Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responsesKarin Lore
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3022, USA
J Immunol 171:4320-8. 2003.... 
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cellsKarin Lore
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 201:2023-33. 2005..This suggests that the induction of antigen-specific T cell responses by DCs, a process crucial to immune defense, can lead to preferential HIV-1 infection and the deletion of responding CD4(+) T cells...- Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cellsAnna Smed-Sorensen
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59 Huddinge University Hospital, S 141 86 Stockholm, Sweden
J Virol 79:8861-9. 2005..The difference in susceptibility of PDCs and MDCs to HIV-1 may have implications for HIV-1 transmission and DC-mediated transfer of HIV-1 to T cells... - In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaquesKarin Lore
Immunology Laboratory, Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 1202, USA
Stem Cells 24:1539-48. 2006..These results have implications for the design of gene therapy trials, as well as for the use of expanded PBPCs for improved T-cell immune reconstitution after transplantation... - Isolation and immunophenotyping of human and rhesus macaque dendritic cellsKarin Lore
Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892 3022, USA
Methods Cell Biol 75:623-42. 2004 - Enhanced in vivo protein synthesis in circulating immune cells of ICU patientsAnna Januszkiewicz
Department of Anaesthesiology and Intensive Care, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden
J Clin Immunol 27:589-97. 2007..Determination of the in vivo protein synthesis rate may be used as a tool to obtain additional information on activation of the immune system... - IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naïve B cell differentiationCornelia Gujer
Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
J Leukoc Biol 89:811-21. 2011..In summary, PDCs, via their production of IFN-α, may render B cells more responsive to T cell contact, which in turn, facilitates B cell proliferation and differentiation to antibody-producing cells... 
Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGNWilliam C Adams
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Gen Virol 90:1600-10. 2009..A better understanding of the tropism and receptor mechanisms of Ad5 may help explain Ad5 pathogenesis and guide the engineering of improved rAd vectors...- Immunization with wild-type or CD4-binding-defective HIV-1 Env trimers reduces viremia equivalently following heterologous challenge with simian-human immunodeficiency virusChristopher Sundling
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
J Virol 84:9086-95. 2010.... - Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primatesChristopher Sundling
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
J Exp Med 207:2003-17. 2010..These data provide important information for the design and evaluation of vaccines aimed at stimulating protective HIV-1 immune responses in humans... - HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulationAnna Smed-Sorensen
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59 Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
Blood 104:2810-7. 2004..These observations suggest that HIV-1 infection disables DC function, a phenomenon that may be relevant for optimal induction of HIV-1-specific immune responses... - Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulationCornelia Gujer
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Immunology 134:257-69. 2011.... - Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primatesIyadh Douagi
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
J Virol 84:1683-95. 2010..Overall, our studies do not reveal any potential negative effects imparted by the in vivo interaction between WT Env and primate CD4 on the generation of functional T cells and antibodies in response to soluble Env vaccination... - Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responsesKarin Lore
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:1721-9. 2007..Thus, the ability of rAd35 to naturally target important DC subsets, induce their maturation, and appropriately present Ag to T cells may herald greater in vivo immunogenicity than has been observed with rAd5... - The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentrationMichael R Betts
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:6407-17. 2004..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response... - Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cellsIyadh Douagi
Swedish Institute for Infectious Disease Control, Stockholm, Sweden
J Immunol 182:1991-2001. 2009..These data help decipher the different roles of PDCs and MDCs for modulating human B cell responses and can contribute to selection of specific TLR ligands as vaccine adjuvants... - Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicityMatthew J Johnson
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 188:6109-18. 2012..Taken together, our results demonstrate that rAd-induced IFN-α production has multiple effects on T cell immunogenicity, the understanding of which should be considered in the design of rAd vaccine vectors... - Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligationWilliam C Adams
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 108:7499-504. 2011..Our findings provide insights into the basic biology of adenoviruses and indicate that CD46 binding may have an impact on the generation of primary CD4(+) T-cell responses by Ad35... - IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIaAnna Smed-Sorensen
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Blood 111:5037-46. 2008..Our data demonstrate an important role for FcgammaRIIa in regulating the CD1 antigen presentation machinery of human DCs... - Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infectionTaha Hirbod
Infectious Diseases Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
J Acquir Immune Defic Syndr 51:239-47. 2009..Here, we characterized the distribution of various DC subtypes and the density of the CLRs, DC-SIGN, langerin, and mannose receptor in the ectocervix of HIV-seronegative women with low- and high-risk behavior for acquiring HIV... - Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacityEmily Bond
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Immunol Methods 348:42-56. 2009..These methods offer potency for various applications addressing antigen uptake, microbial DC interactions or other antigenic stimulation targeting the skin and can enhance our knowledge of basic DC biology in human skin... - Targeting dendritic cells for improved HIV-1 vaccinesAnna Smed-Sorensen
Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Adv Exp Med Biol 762:263-88. 2013..The susceptibility and responses of DCs to recombinant adenovirus vectors are reviewed, as well as the strategy of directly targeting DCs by using DC marker-specific monoclonal antibodies coupled to an antigen... - Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurationsEmily Bond
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Invest Dermatol 132:114-23. 2012.... - Novel adjuvants for B cell immune responsesKarin Lore
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Curr Opin HIV AIDS 4:441-6. 2009..Both established and new experimental approaches are described and also briefly we discuss how adjuvants and virus-based vaccines interact with the immune system... - HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primatesUlrike Wille-Reece
Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:15190-4. 2005..This type of vaccine formulation should have utility in preventive or therapeutic vaccines in which humoral and cellular immunity is required... - Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob proteinWilliam C Adams
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Gen Virol 93:1339-44. 2012..Thus, the capacity of HAdV-35 to attenuate human CD4(+) T-cell activation depends predominantly on knob interactions with CD46 and can occur independently of infection... - Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodiesLakshmanan Ganesh
Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bldg 40, Rm 4502, MSC 3005, 40 Convent Dr, Bethesda, MD 20892 3005, USA
J Virol 78:11980-7. 2004..This property of DCs may enhance infection, contribute to immune evasion, and could provide a selective advantage for CCR5-tropic virus transmission... - Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaquesRuth Seggewiss
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Blood 110:441-9. 2007..Thus, our findings suggest that KGF may be a useful adjuvant therapy to augment T-cell reconstitution after human PBPC transplantation... - HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clustersMakoto Sugaya
Dermatology Branch, Center for Cancer Research, National Cancer Institute, and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 172:2219-24. 2004..Disrupting cluster formation between LC and memory CD4(+) T cells may be a novel strategy to interfere with sexual transmission of HIV... 
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primatesUlrike Wille-Reece
Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:1249-58. 2006..These data provide insights for designing prime-boost immunization regimens to optimize Th1 and CD8+ T cell responses...- Detection of cytokine- and chemokine-expressing cells at the single cell levelKarin Lore
Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
Methods Mol Biol 249:201-18. 2004 - In vitro stimulation and detection of IFNα production in human plasmacytoid dendritic cellsWilliam C Adams
Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
Methods Mol Biol 820:215-30. 2012..We discuss the key elements for successful isolation of PDCs, stimulation, immunostaining, and identification of IFNα producing cells... - Determination of in vivo protein synthesis in human palatine tonsilAnna Januszkiewicz
Department of Anaesthesiology and Intensive Care, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
Clin Sci (Lond) 108:179-84. 2005..This high metabolic rate may reflect the permanent immunological activity present in human tonsils, although cell phenotypes and activity markers do not explain the differences... - Dendritic cells at the interface of innate and adaptive immunity to HIV-1Anna Smed-Sorensen
Department of Microbiology, Tumor and Cell Biology bCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Curr Opin HIV AIDS 6:405-10. 2011..This review summarizes recent findings on how HIV-1 infection affects dendritic cells in their ability to elicit innate and adaptive immune responses... - Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent mannerRuth Seggewiss
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI, the Immunology Laboratory, NIH/DHHS, Bldg 10, CRC, Rm 4-5140, 10 Center Dr, MSC 1202, Bethesda, MD 20892, USA
Blood 105:2473-9. 2005.... - Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaquesJohan Söderlund
Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
J Med Primatol 33:16-24. 2004..Thus, disease progression to sAIDS was associated with impaired maturation of DC, and lack of CD83, DC-LAMP and S100b expression... - The Toxoplasma gondii-shuttling function of dendritic cells is linked to the parasite genotypeHenrik Lambert
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, SE 14186 Stockholm, Sweden
Infect Immun 77:1679-88. 2009.... - Neutrophil-derived hyperresistinemia in severe acute streptococcal infectionsLinda Johansson
Department of Medicine F59, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
J Immunol 183:4047-54. 2009....