R R Lonser

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease
    R R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bldg 10, Rm 5D37, Bethesda, MD 20892 1414, USA
    Neurology 68:254-61. 2007
  2. doi request reprint Prospective evaluation of the characteristics and incidence of adenoma-associated dural invasion in Cushing disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 116:272-9. 2012
  3. ncbi request reprint von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Lancet 361:2059-67. 2003
  4. pmc The vestibular aqueduct: site of origin of endolymphatic sac tumors
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 108:751-6. 2008
  5. ncbi request reprint Tumors of the endolymphatic sac in von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 350:2481-6. 2004
  6. ncbi request reprint Pathogenesis of tumor-associated syringomyelia demonstrated by peritumoral contrast material leakage. Case illustration
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg Spine 4:426. 2006
  7. ncbi request reprint Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:190-7. 2007
  8. ncbi request reprint Convection perfusion of glucocerebrosidase for neuronopathic Gaucher's disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 57:542-8. 2005
  9. ncbi request reprint Edema is a precursor to central nervous system peritumoral cyst formation
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 58:392-9. 2005
  10. ncbi request reprint Malignant cerebellar swelling in Behçet disease. Case illustration
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 103:292. 2005

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease
    R R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bldg 10, Rm 5D37, Bethesda, MD 20892 1414, USA
    Neurology 68:254-61. 2007
    ....
  2. doi request reprint Prospective evaluation of the characteristics and incidence of adenoma-associated dural invasion in Cushing disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 116:272-9. 2012
    ..To characterize the incidence and anatomical distribution of dural invasion by ACTH-secreting adenomas, the authors prospectively and systematically analyzed features of dural invasion in patients with CD...
  3. ncbi request reprint von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Lancet 361:2059-67. 2003
    ..We present an overview of the clinical aspects, management, and treatment options for von Hippel-Lindau disease...
  4. pmc The vestibular aqueduct: site of origin of endolymphatic sac tumors
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 108:751-6. 2008
    ..To determine the precise topographic origin of ELSTs, the authors analyzed the imaging, operative, and pathological findings in patients with von Hippel-Lindau disease (VHL) and ELSTs...
  5. ncbi request reprint Tumors of the endolymphatic sac in von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 350:2481-6. 2004
  6. ncbi request reprint Pathogenesis of tumor-associated syringomyelia demonstrated by peritumoral contrast material leakage. Case illustration
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg Spine 4:426. 2006
  7. ncbi request reprint Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:190-7. 2007
    ..Patients with a variety of intrinsic brainstem and other central nervous system disorders may benefit from a similar treatment paradigm...
  8. ncbi request reprint Convection perfusion of glucocerebrosidase for neuronopathic Gaucher's disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 57:542-8. 2005
    ..Patients with neuronopathic Gaucher's disease and similar central nervous system disorders may benefit from this treatment...
  9. ncbi request reprint Edema is a precursor to central nervous system peritumoral cyst formation
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 58:392-9. 2005
    ..When the delivery of plasma from the tumor exceeds the capacity of the surrounding tissue to absorb the extravasated fluid, edema (with its associated increased interstitial pressure) and subsequent cyst formation occur...
  10. ncbi request reprint Malignant cerebellar swelling in Behçet disease. Case illustration
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 103:292. 2005
  11. ncbi request reprint Spinal cord hemangioblastomas
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Neurosurg Clin N Am 17:37-44. 2006
  12. pmc Pituitary stalk hemangioblastomas in von Hippel-Lindau disease
    Russell R Lonser
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurosurg 110:350-3. 2009
    ..To gain insight into the incidence, clinical effects, and management of pituitary stalk hemangioblastomas, the authors analyzed a series of patients with von Hippel-Lindau (VHL) disease...
  13. ncbi request reprint Surgical management of spinal cord hemangioblastomas in patients with von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 98:106-16. 2003
    ....
  14. ncbi request reprint Surgical management of lumbosacral nerve root hemangioblastomas in von Hippel-Lindau syndrome
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 99:64-9. 2003
    ....
  15. doi request reprint Surgical management of melanoma brain metastases in patients treated with immunotherapy
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D20, Bethesda, Maryland 20892, USA
    J Neurosurg 115:30-6. 2011
    ..The authors undertook this study to determine the effectiveness of resection and the effects of immunotherapy on brain metastasis management...
  16. pmc Acromegaly without imaging evidence of pituitary adenoma
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D20, Bethesda, Maryland 20892 1414, USA
    J Clin Endocrinol Metab 95:4192-6. 2010
    ..GH-secreting pituitary adenomas are nearly always visible on conventional magnetic resonance (MR) imaging. However, management and outcome of acromegalic patients lacking imaging evidence of GH-secreting pituitary adenomas are undefined...
  17. ncbi request reprint Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion
    Russell R Lonser
    Surgical Neurology Branch and Biomedical Engineering and Instrumentation Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 97:905-13. 2002
    ..The authors used convection-enhanced delivery (CED) of a macromolecular tracer visible on magnetic resonance (MR) imaging to examine the utility of CED for safe perfusion of the brainstem...
  18. ncbi request reprint Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to pseudomonas exotoxin
    Gregory J A Murad
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892 1414, USA
    Clin Cancer Res 12:3145-51. 2006
    ....
  19. ncbi request reprint The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease
    John E Wanebo
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 98:82-94. 2003
    ....
  20. ncbi request reprint Metastases to hemangioblastomas in von Hippel-Lindau disease
    S Taylor Jarrell
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 105:256-63. 2006
    ....
  21. ncbi request reprint Cochlear implantation for hearing loss associated with bilateral endolymphatic sac tumors in von Hippel-Lindau disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Otol Neurotol 28:927-30. 2007
    ..Bilateral endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and often underlie significant audiovestibular morbidity, including hearing loss...
  22. ncbi request reprint Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: implications for treatment
    Joshua M Ammerman
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 105:248-55. 2006
    ....
  23. pmc Effect of ependymal and pial surfaces on convection-enhanced delivery
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurosurg 109:547-52. 2008
    ..To determine the effect of these anatomical boundaries on CED, the authors infused low MW and high MW tracers for MR imaging near ependymal (periventricular) and pial (pericisternal) surfaces...
  24. ncbi request reprint Evolution of VHL tumourigenesis in nerve root tissue
    A O Vortmeyer
    Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20892, USA
    J Pathol 210:374-82. 2006
    ..The evolution of frank haemangioblastoma seems to involve multiple steps from a large pool of precursor lesions...
  25. doi request reprint Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease
    Gautam U Mehta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg Spine 12:233-42. 2010
    ....
  26. ncbi request reprint Real-time in vivo imaging of the convective distribution of a low-molecular-weight tracer
    David Croteau
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 102:90-7. 2005
    ..The authors examined the safety and utility of an iodine-based low-molecular-weight surrogate tracer for computerized tomography (CT) scanning during CED...
  27. pmc Convection-enhanced delivery for the treatment of pediatric neurologic disorders
    Debbie K Song
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Child Neurol 23:1231-7. 2008
    ....
  28. ncbi request reprint Image-guided convection-enhanced delivery of gemcitabine to the brainstem
    Gregory J A Murad
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 106:351-6. 2007
    ..This delivery paradigm should allow for direct therapeutic application of gemcitabine to brainstem gliomas while monitoring its distribution to ensure effective tumor coverage and to maximize safety...
  29. ncbi request reprint Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease
    John A Butman
    Diagnostic Radiology Department, The Clinical Center of the National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 298:41-8. 2007
    ..The underlying mechanisms of audiovestibular morbidity remain unclear and optimal timing of treatment is not known...
  30. ncbi request reprint Convective delivery of glial cell line-derived neurotrophic factor in the human putamen
    Paul F Morrison
    Division of Bioengineering and Physical Science, Office of Research Services, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 107:74-83. 2007
    ..The authors conducted an analysis of the distribution of glial cell line-derived neurotrophic factor in the human striatum following convection-enhanced delivery...
  31. ncbi request reprint Endolymphatic sac tumor demonstrated by intralabyrinthine hemorrhage. Case report
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:421-5. 2007
    ..These findings support tumor-associated hemorrhage as a mechanism underlying the audiovestibular dysfunction associated with ELSTs...
  32. pmc Prospective evaluation of radiosurgery for hemangioblastomas in von Hippel-Lindau disease
    Ashok R Asthagiri
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Neuro Oncol 12:80-6. 2010
    ..These results indicate that SRS should not be used to prophylactically treat asymptomatic tumors and should be reserved for the treatment of tumors that are not surgically resectable...
  33. pmc Image-guided convection-enhanced delivery of muscimol to the primate brain
    John D Heiss
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 112:790-5. 2010
    ....
  34. doi request reprint Neurofibromatosis type 2
    Ashok R Asthagiri
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    Lancet 373:1974-86. 2009
    ..We review the molecular pathogenesis, genetics, clinical findings, and management strategies for neurofibromatosis type 2...
  35. ncbi request reprint Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles
    Nicholas J Szerlip
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 107:560-7. 2007
    ....
  36. ncbi request reprint Direct interstitial infusion of NK1-targeted neurotoxin into the spinal cord: a computational model
    Malisa Sarntinoranont
    Drug Delivery and Kinetics Resource, Div of Bioengineering and Physical Science, ORS, NIH, Bldg 13, Rm 3N17, 13 South Dr, Bethesda, MD 20892 5766, USA
    Am J Physiol Regul Integr Comp Physiol 285:R243-54. 2003
    ..Sensitivity of cytotoxic regions to NK1 receptor density and white matter protease activity was also established. These data suggest that intraparenchymal infusions can be useful for treatment of localized chronic pain...
  37. ncbi request reprint A computational model of direct interstitial infusion of macromolecules into the spinal cord
    Malisa Sarntinoranont
    Division of Bioengineering and Physical Science ORS, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Biomed Eng 31:448-61. 2003
    ..Best fits to data at 0.1 microl/min were achieved by porosities characteristic of moderate edema (e.g., 0.26). Distribution also varied with catheter placement with more medial placement resulting in greater distribution volumes...
  38. ncbi request reprint Identification of tumor precursor cells in the brains of primates with radiation-induced de novo glioblastoma multiforme
    Irina A Lubensky
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 5:452-6. 2006
    ..The findings provide insight into the tumorigenesis of de novo GBMs and suggest a new strategy for treatment of these lethal tumors by targeting both inactivation of N-CoR and inhibition of EGFR...
  39. ncbi request reprint Surgical management of brainstem hemangioblastomas in patients with von Hippel-Lindau disease
    Robert J Weil
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 98:95-105. 2003
    ....
  40. ncbi request reprint Somatic mutations in VHL germline deletion kindred correlate with mild phenotype
    Scott D Wait
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20982, USA
    Ann Neurol 55:236-40. 2004
    ..This unique genetic mechanism correlates with and may help to understand the mild clinical phenotype seen in these patients...
  41. doi request reprint Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 108:210-22. 2008
    ..To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in patients with this disease who underwent resection of cerebellar hemangioblastomas...
  42. pmc Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers
    Ryszard M Pluta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e14504. 2011
    ..The study was developed to determine the safety and feasibility of prolonged sodium nitrite infusion...
  43. ncbi request reprint Interspecies comparative genomic hybridization (I-CGH): a new twist to study animal tumor models
    Sivakumar Jaikumar
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 6:836-42. 2007
    ....
  44. ncbi request reprint Coexpression of erythropoietin and its receptor in endolymphatic sac tumors
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 103:284-8. 2005
    ....
  45. pmc Neurologic manifestations of von Hippel-Lindau disease
    John A Butman
    Diagnostic Radiology Department, The Clinical Center of the National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    JAMA 300:1334-42. 2008
    ..Because of the dissimilar pathobiology and clinical course between hemangioblastomas and ELSTs, the optimal management strategies for these neurologic manifestations of VHL are very different...
  46. ncbi request reprint Role of edema in peritumoral cyst formation
    Martin A Baggenstos
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Neurosurg Focus 22:E9. 2007
    ....
  47. ncbi request reprint Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats
    Jeffrey W Degen
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 99:893-8. 2003
    ....
  48. ncbi request reprint Epididymal cystadenomas and epithelial tumourlets: effects of VHL deficiency on the human epididymis
    S Glasker
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Pathol 210:32-41. 2006
    ..Thus, ECA tumorigenesis in VHL disease shares fundamental principles with tumorigenesis in other affected organ systems...
  49. ncbi request reprint Thoracic spinal nerve hemangioblastoma. Case illustration
    Gabriel C Tender
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, and Diagnostic Radiology Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg Spine 1:142. 2004
  50. pmc Progressive peritumoral edema defining the optic fibers and resulting in reversible visual loss
    Martin Baggenstos
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 109:313-7. 2008
    ..Tumor resection led to resolution of the edema and improvement in visual function...
  51. ncbi request reprint Tumor Young Investigator Award: induction of glioblastoma multiforme in primates after fractionated whole-brain irradiation in the therapeutic dose range
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Clin Neurosurg 50:350-73. 2003
  52. ncbi request reprint Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease
    Alexander O Vortmeyer
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Cancer Res 63:7051-5. 2003
    ..Because of VHL deficiency, Epo receptor-expressing, developmentally arrested angioblasts simultaneously coexpress Epo, which may represent a crucial pathogenetic step in tumor formation...
  53. ncbi request reprint Sacral hemangioblastoma in a patient with von Hippel-Lindau disease. Case report and review of the literature
    Ryszard M Pluta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Neurosurg Focus 15:E11. 2003
    ..Because they originate from the nerve root, the nerve root from which the hemangioblastoma originates must be sacrificed to achieve complete resection...
  54. doi request reprint The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma
    Jie Lu
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 113:225-33. 2010
    ....
  55. ncbi request reprint Induction of glioblastoma multiforme in nonhuman primates after therapeutic doses of fractionated whole-brain radiation therapy
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 97:1378-89. 2002
    ....
  56. ncbi request reprint Technique for enhanced accuracy and reliability in non-human primate stereotaxy
    Stuart Walbridge
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    J Neurosci Methods 156:310-3. 2006
    ..We have found that this approach improves stereotaxic targeting reliability and permits accurate reproducible stereotaxic localization at time points distant from the pre-operative imaging...
  57. ncbi request reprint Posterior subtemporal transtentorial approach to intraparenchymal lesions of the anteromedial region of the superior cerebellum
    Joshua M Ammerman
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 103:783-8. 2005
    ..In this paper they describe the surgical technique that they used as well as the operative findings and clinical outcomes observed in patients who underwent resection of tumors in the anteromedial superior cerebellum...
  58. ncbi request reprint Microsurgical resection of spinal cord hemangioblastomas
    Russell R Lonser
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Neurosurgery 57:372-6; discussion 372-6. 2005
    ..Despite their exceptionally vascular nature, these lesions can consistently be resected completely and safely with minimal blood loss. We describe a microsurgical method for removal of these tumors from the spinal cord...
  59. pmc von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells
    Deric M Park
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Med 4:e60. 2007
    ....
  60. ncbi request reprint Effects of VHL deficiency on endolymphatic duct and sac
    Sven Glasker
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 65:10847-53. 2005
    ..Therefore, inactivation of the VHL wild-type allele seems necessary but not sufficient for the formation of tumor...
  61. ncbi request reprint Proteomic profiling: a novel method for differential diagnosis?
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Biol Ther 6:343-5. 2007
    ..Proteomics may complement pathological evaluation and characterization of tumors in the future. Furthermore, these results show that metastasis of malignant RCC is not necessarily equivalent to aggressive growth patterns...
  62. ncbi request reprint Tumors of the endolymphatic sac in patients with von Hippel-Lindau disease: implications for their natural history, diagnosis, and treatment
    H Jeffrey Kim
    Neuro Otology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 102:503-12. 2005
    ..To clarify the uncertainties associated with the pathophysiology and treatment of ELSTs, the authors describe a series of patients with VHL disease in whom serial examinations recorded the development of ELSTs...
  63. ncbi request reprint Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics
    P F Morrison
    Bioengineering and Physical Science Program, Office of Research Services, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 277:R1218-29. 1999
    ....
  64. ncbi request reprint Proteomic analysis of hemangioblastoma cyst fluid
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Biol Ther 5:549-53. 2006
    ..Hemangioblastoma cyst formation is a major cause of morbidity and mortality with these tumors. While peritumoral cysts have been suggested to result from vascular leakage, the mechanism of intratumoral cyst formation is not understood...
  65. ncbi request reprint CNS manifestations of malignancies: case 2. Skull and brain metastasis from tibial osteosarcoma
    Robert J Weil
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
    J Clin Oncol 23:4226-9. 2005
  66. ncbi request reprint Second hit deletion size in von Hippel-Lindau disease
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Rm 5D37, Bethesda, MD 20892, USA
    Ann Neurol 59:105-10. 2006
    ....
  67. pmc Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease
    Gautam U Mehta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neoplasia 10:1146-53. 2008
    ..We conclude epididymal tumorigenesis in VHL disease to occur in two distinct sequential steps: maldevelopment of VHL-deficient mesonephric cells, followed by neoplastic papillary proliferation...
  68. ncbi request reprint Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell
    Sven Glasker
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:4167-72. 2006
    ..Finally, the consistent identification of Scl in the stromal cells may help explain the unique and characteristic topographical distribution of hemangioblastomas within the CNS...
  69. pmc Pathological satiety caused by brainstem hemangioblastoma
    Debbie K Song
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg Pediatr 2:397-401. 2008
    ..Moreover, brainstem hemangioblastomas may present with abnormalities in satiety and feeding that can be effectively reversed with resection...
  70. ncbi request reprint Concept of arteriovenous malformation compartments and surgical management
    Shokei Yamada
    Departments of Neurosurgery, Anesthesiology and Radiology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Neurol Res 26:288-300. 2004
    ..The concept of compartmental treatment of AVMs may be applied in the future to radiosurgery and intravascular embolization of large AVMs...
  71. ncbi request reprint von Hippel-Lindau disease: epididymal cystadenoma targeted by metastatic events
    Gautam U Mehta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    Urology 69:1209.e9-12. 2007
    ..The multiplicity of these metastatic events suggests the epididymal cystadenoma as a preferential site of metastasis for von Hippel-Lindau disease-associated renal clear cell carcinoma...
  72. ncbi request reprint Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy
    John R Pace
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 97:450-4. 2002
    ..The long-term antiseizure effects of local convection-enhanced infusion of the excitotoxin ibotenate were examined in a rat model of temporal lobe epilepsy...
  73. ncbi request reprint Integra Foundation Award: Long-term natural history of hemangioblastomas in Von Hippel-Lindau disease: implications for treatment
    Joshua M Ammerman
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Clin Neurosurg 53:324-31. 2006
  74. ncbi request reprint Symptomatic epidural hematoma caused by lumbar synovial cyst rupture: report of two cases and review of the literature
    Scott D Wait
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Neurosurgery 56:E1157; discussion E1157. 2005
    ..Hemorrhagic rupture of a juxtafacet cyst and the resulting epidural hematoma may cause chronic and/or acute cauda equina compression...
  75. doi request reprint Clinical course of retrobulbar hemangioblastomas in von Hippel-Lindau disease
    Catherine B Meyerle
    National Eye Institute, Bethesda, Maryland 20892, USA
    Ophthalmology 115:1382-9. 2008
    ..To report clinical findings of rare retrobulbar optic nerve hemangioblastomas associated with von Hippel-Lindau disease (VHL)...
  76. ncbi request reprint Selective ablation of nociceptive neurons for elimination of hyperalgesia and neurogenic inflammation
    Gabriel C Tender
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 102:522-5. 2005
    ....
  77. ncbi request reprint Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: implications for targeted therapies
    John S Jarboe
    Surgical and Molecular Neuro oncology Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    Cancer Res 67:7983-6. 2007
    ..These data indicate that prescreening of subjects may be of benefit in future trials of IL13Ralpha2 targeting therapies...
  78. ncbi request reprint Selective excision of metastatic brain tumors originating in the motor cortex with preservation of function
    Robert J Weil
    Brain Tumor Institute, Taussig Cancer Center Desk R 20, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Clin Oncol 23:1209-17. 2005
    ..Brain metastases are common in patients with cancer and can cause considerable morbidity or death. Metastasis in eloquent areas of the brain, particularly the primary motor cortex, may present significant treatment challenges...