J C Long

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
    J C Long
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA jeff
    Am J Med Genet 81:216-21. 1998
  2. ncbi request reprint Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck
    R A Kittles
    Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Phys Anthropol 108:381-99. 1999
  3. pmc Dual origins of Finns revealed by Y chromosome haplotype variation
    R A Kittles
    Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hum Genet 62:1171-9. 1998
  4. ncbi request reprint A tryptophan hydroxylase gene marker for suicidality and alcoholism
    D A Nielsen
    Section of Molecular Genetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 55:593-602. 1998
  5. ncbi request reprint Mu opioid receptor gene variants: lack of association with alcohol dependence
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Mol Psychiatry 2:490-4. 1997
  6. ncbi request reprint A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse
    D Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Alcohol 16:47-52. 1998
  7. pmc Effects of worldwide population subdivision on ALDH2 linkage disequilibrium
    R J Peterson
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110 USA
    Genome Res 9:844-52. 1999
  8. ncbi request reprint Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles
    A Novoradovsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20892, USA
    Alcohol Clin Exp Res 19:1105-10. 1995
  9. pmc Ancestral origins and worldwide distribution of the PRNP 200K mutation causing familial Creutzfeldt-Jakob disease
    H S Lee
    Clinical Neurogenetics Unit, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Hum Genet 64:1063-70. 1999
  10. ncbi request reprint Early experience and serotonin transporter gene variation interact to influence primate CNS function
    A J Bennett
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
    Mol Psychiatry 7:118-22. 2002

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
    J C Long
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA jeff
    Am J Med Genet 81:216-21. 1998
    ..8) on chromosome 4p, near the beta1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis...
  2. ncbi request reprint Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck
    R A Kittles
    Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Phys Anthropol 108:381-99. 1999
    ..In contrast, high levels of genetic diversity for mtDNA and autosomal STRs may be the result of sex-biased gene flow and recent immigration to urban areas from established internal isolates within Finland...
  3. pmc Dual origins of Finns revealed by Y chromosome haplotype variation
    R A Kittles
    Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hum Genet 62:1171-9. 1998
    ..Also, a northeastern to southwestern gradient of Y haplotype frequencies provides convincing evidence for recent male migration from rural areas into urban Finland...
  4. ncbi request reprint A tryptophan hydroxylase gene marker for suicidality and alcoholism
    D A Nielsen
    Section of Molecular Genetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 55:593-602. 1998
    ..We previously reported that, in Finns, TPH genotype was associated with suicidality, a pathophysiological mechanism that may involve impaired impulse control...
  5. ncbi request reprint Mu opioid receptor gene variants: lack of association with alcohol dependence
    A W Bergen
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Mol Psychiatry 2:490-4. 1997
    ....
  6. ncbi request reprint A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse
    D Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Alcohol 16:47-52. 1998
    ..The implication is that a DRD2 variant that dramatically impairs receptor function was not sufficient to significantly alter alcoholism vulnerability in a relatively large and also genetically and environmentally homogeneous sample...
  7. pmc Effects of worldwide population subdivision on ALDH2 linkage disequilibrium
    R J Peterson
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110 USA
    Genome Res 9:844-52. 1999
    ..These results suggest that simple models may not well predict patterns of linkage disequilibrium in human populations...
  8. ncbi request reprint Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles
    A Novoradovsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20892, USA
    Alcohol Clin Exp Res 19:1105-10. 1995
    ..Thus, this second nonconservative ALDH2 substitution occurs within the sequence of the already inactive ALDH2(2) allele...
  9. pmc Ancestral origins and worldwide distribution of the PRNP 200K mutation causing familial Creutzfeldt-Jakob disease
    H S Lee
    Clinical Neurogenetics Unit, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Hum Genet 64:1063-70. 1999
    ..On the basis of this study, we conclude that founder effect and independent mutational events are responsible for the current geographic distribution of hereditary CJD associated with the 200K mutation...
  10. ncbi request reprint Early experience and serotonin transporter gene variation interact to influence primate CNS function
    A J Bennett
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
    Mol Psychiatry 7:118-22. 2002
    ....
  11. ncbi request reprint Validity of the CAGE questionnaire in an American Indian population
    A Saremi
    National Institute of Diabetes and Digestive Kidney Diseases, Phoenix, Arizona 85014, USA
    J Stud Alcohol 62:294-300. 2001
    ..The area under the ROC curve was 81% for men and 75% for women. CONCLUSIONS: These findings suggest that the CAGE questionnaire is a valid screening method, in this population, for identifying people likely to have alcohol dependence...
  12. pmc A private allele ubiquitous in the Americas
    K B Schroeder
    Department of Anthropology, University of California, Davis, CA 95616, USA
    Biol Lett 3:218-23. 2007
    ..The simplest explanation for the ubiquity of this allele across the Americas is that the same founding population contributed a large fraction of ancestry to all modern Native American populations...