Research Topics
Genomes and GenesSpecies | J C LongSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian populationJ C Long
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110, USA jeff
Am J Med Genet 81:216-21. 1998..8) on chromosome 4p, near the beta1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis...- Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneckR A Kittles
Section on Population Genetics and Linkage, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Phys Anthropol 108:381-99. 1999..In contrast, high levels of genetic diversity for mtDNA and autosomal STRs may be the result of sex-biased gene flow and recent immigration to urban areas from established internal isolates within Finland... 
Dual origins of Finns revealed by Y chromosome haplotype variationR A Kittles
Section on Population Genetics and Linkage, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Am J Hum Genet 62:1171-9. 1998..Also, a northeastern to southwestern gradient of Y haplotype frequencies provides convincing evidence for recent male migration from rural areas into urban Finland...- A tryptophan hydroxylase gene marker for suicidality and alcoholismD A Nielsen
Section of Molecular Genetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 55:593-602. 1998..We previously reported that, in Finns, TPH genotype was associated with suicidality, a pathophysiological mechanism that may involve impaired impulse control... - Mu opioid receptor gene variants: lack of association with alcohol dependenceA W Bergen
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
Mol Psychiatry 2:490-4. 1997.... - A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuseD Goldman
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Alcohol 16:47-52. 1998..The implication is that a DRD2 variant that dramatically impairs receptor function was not sufficient to significantly alter alcoholism vulnerability in a relatively large and also genetically and environmentally homogeneous sample... - Effects of worldwide population subdivision on ALDH2 linkage disequilibriumR J Peterson
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8110 USA
Genome Res 9:844-52. 1999..These results suggest that simple models may not well predict patterns of linkage disequilibrium in human populations... - Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 allelesA Novoradovsky
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20892, USA
Alcohol Clin Exp Res 19:1105-10. 1995..Thus, this second nonconservative ALDH2 substitution occurs within the sequence of the already inactive ALDH2(2) allele... - Ancestral origins and worldwide distribution of the PRNP 200K mutation causing familial Creutzfeldt-Jakob diseaseH S Lee
Clinical Neurogenetics Unit, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
Am J Hum Genet 64:1063-70. 1999..On the basis of this study, we conclude that founder effect and independent mutational events are responsible for the current geographic distribution of hereditary CJD associated with the 200K mutation... - Early experience and serotonin transporter gene variation interact to influence primate CNS functionA J Bennett
National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
Mol Psychiatry 7:118-22. 2002.... - Validity of the CAGE questionnaire in an American Indian populationA Saremi
National Institute of Diabetes and Digestive Kidney Diseases, Phoenix, Arizona 85014, USA
J Stud Alcohol 62:294-300. 2001..The area under the ROC curve was 81% for men and 75% for women. CONCLUSIONS: These findings suggest that the CAGE questionnaire is a valid screening method, in this population, for identifying people likely to have alcohol dependence... - A private allele ubiquitous in the AmericasK B Schroeder
Department of Anthropology, University of California, Davis, CA 95616, USA
Biol Lett 3:218-23. 2007..The simplest explanation for the ubiquity of this allele across the Americas is that the same founding population contributed a large fraction of ancestry to all modern Native American populations...