William W Lockwood

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
    William W Lockwood
    Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19408-13. 2012
  2. pmc Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development
    William W Lockwood
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e37775. 2012
  3. pmc Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma
    William W Lockwood
    Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Clin Cancer Res 18:1936-46. 2012
  4. pmc Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000315. 2010
  5. doi request reprint Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer
    Jennifer M Campbell
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z1L3 Canada
    Genome 51:1032-9. 2008
  6. pmc Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    Kelsie L Thu
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    J Thorac Oncol 6:1521-9. 2011
  7. pmc An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer
    Raj Chari
    Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada
    BMC Syst Biol 4:67. 2010
  8. pmc SIGMA: a system for integrative genomic microarray analysis of cancer genomes
    Raj Chari
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Genomics 7:324. 2006
  9. pmc Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer
    Raj Chari
    Genetics Unit Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Cancer Metastasis Rev 29:73-93. 2010
  10. ncbi request reprint Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 120:436-43. 2007

Detail Information

Publications20

  1. pmc Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
    William W Lockwood
    Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19408-13. 2012
    ....
  2. pmc Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development
    William W Lockwood
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e37775. 2012
    ..Together, our findings suggest that AC and SqCC develop through distinct pathogenetic pathways that have significant implication in our approach to the clinical management of NSCLC...
  3. pmc Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma
    William W Lockwood
    Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Clin Cancer Res 18:1936-46. 2012
    ..We employed an integrative genomics approach to identify novel genes involved in EAC biology that may serve as useful clinical markers...
  4. pmc Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000315. 2010
    ..Identification of the molecular differences between these tumor types will have a significant impact in designing novel therapies that can improve the treatment outcome...
  5. doi request reprint Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer
    Jennifer M Campbell
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z1L3 Canada
    Genome 51:1032-9. 2008
    ..The detection of gene activation in multiple cohorts of samples strongly supports the presence of key genes involved in lung cancer that are distinct from the EGFR and MET loci on chromosome 7...
  6. pmc Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    Kelsie L Thu
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    J Thorac Oncol 6:1521-9. 2011
    ..We investigated complex component gene disruption as a novel genetic mechanism of NF-κB activation in non-small cell lung cancer...
  7. pmc An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer
    Raj Chari
    Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada
    BMC Syst Biol 4:67. 2010
    ..This has afforded the potential for large scale integration of genome and transcriptome data generated from a variety of technology platforms to acquire a better understanding of cancer...
  8. pmc SIGMA: a system for integrative genomic microarray analysis of cancer genomes
    Raj Chari
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Genomics 7:324. 2006
    ..However, tools for direct mining and analysis of array CGH data are limited. Hence, there is a great need for analytical and display software tailored to cross platform integrative analysis of cancer genomes...
  9. pmc Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer
    Raj Chari
    Genetics Unit Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Cancer Metastasis Rev 29:73-93. 2010
    ....
  10. ncbi request reprint Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 120:436-43. 2007
    ..This work represents the highest resolution look at a cervical cancer genome to date and offers definitive characterization of the alteration status of these cancer cell lines...
  11. pmc TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
    Daniel T Starczynowski
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Invest 121:4095-105. 2011
    ..Our findings show that TRAF6 is an oncogene that is important for RAS-mediated oncogenesis and provide a mechanistic explanation for the previously apparent importance of constitutive NF-κB activation in RAS-driven lung cancers...
  12. pmc Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
    Kelsie L Thu
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e33003. 2012
    ..Collectively, our findings provide evidence that these lung tumors are globally and genetically different, which implies they are likely driven by distinct molecular mechanisms...
  13. doi request reprint miR-101 DNA copy loss is a prominent subtype specific event in lung cancer
    Kelsie L Thu
    BC Cancer Research Centre, Vancouver, British Columbia, Canada
    J Thorac Oncol 6:1594-8. 2011
    ..miR-101 is encoded at two loci in the human genome: 1p31.3 (miR-101-1) and 9p24.1 (miR-101-2). We sought to investigate miR-101 locus-specific deletions and genomic loss in the major subtypes of lung cancer...
  14. doi request reprint Comparative genomic hybridization on BAC arrays
    Bradley P Coe
    British Columbia Cancer Research Centre, BC, Canada
    Methods Mol Biol 556:7-19. 2009
    ..In this chapter, we describe in detail the technical procedure required to perform copy number analysis of genomes with BAC aCGH...
  15. doi request reprint Evolving strategies for global gene expression analysis of cancer
    Bradley P Coe
    British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    J Cell Physiol 217:590-7. 2008
    ....
  16. pmc Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1
    Levi J Beverly
    Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:E119-26. 2012
    ....
  17. pmc Cyclin E1 is amplified and overexpressed in osteosarcoma
    William W Lockwood
    British Columbia Cancer Research Center, Vancouver, British Columbia, Canada
    J Mol Diagn 13:289-96. 2011
    ..Fluorescence in situ hybridization and immunohistochemical analysis confirmed the findings. Overexpression of cyclin E1 has potential prognostic and therapeutic implications that are discussed herein...
  18. pmc The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers
    William W Lockwood
    Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e63610. 2013
    ..Importantly, expression of FBXW4 correlates with survival of patients with non-small cell lung cancer. Taken together, we suggest that FBXW4 may be a novel tumor suppressor that regulates important cellular processes...
  19. ncbi request reprint Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells
    Kai Gao
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, Canada
    Int J Oncol 32:1343-9. 2008
    ..In addition, genes located at 14q23.3-31.1 would be promising targets to overcome acquired CPT-resistance in melanoma...
  20. ncbi request reprint High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH
    Cathie Garnis
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 118:1556-64. 2006
    ..In summary, our data demonstrate the unique information generated by high resolution analysis of NSCLC genomes and uncover the presence of genetic alterations prevalent in the different NSCLC subtypes...