Yuan Liu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Flap endonuclease 1: a central component of DNA metabolism
    Yuan Liu
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Annu Rev Biochem 73:589-615. 2004
  2. ncbi Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability
    Yuan Liu
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Cell Biol 24:4049-64. 2004
  3. ncbi Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate
    Hui I Kao
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 277:14379-89. 2002
  4. ncbi Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion
    Yuan Liu
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13728-39. 2003
  5. ncbi Value added by data sharing: long-term potentiation of neuroscience research. A commentary on the 2007 SfN Satellite Symposium on data sharing
    Yuan Liu
    NINDS, NIH, Bethesda, MD, USA
    Neuroinformatics 5:143-5. 2007
  6. ncbi Digital biology: an emerging and promising discipline
    Richard W Morris
    National Institutes of Health, Bethesda, MD 20892, USA
    Trends Biotechnol 23:113-7. 2005
  7. ncbi Base excision repair and design of small molecule inhibitors of human DNA polymerase β
    Samuel H Wilson
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Cell Mol Life Sci 67:3633-47. 2010
  8. ncbi OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
    Irina V Kovtun
    Department of Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Nature 447:447-52. 2007
  9. ncbi DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair
    Yuan Liu
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:3665-74. 2005
  10. ncbi Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta
    Yuan Liu
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:13532-41. 2007

Collaborators

Detail Information

Publications17

  1. ncbi Flap endonuclease 1: a central component of DNA metabolism
    Yuan Liu
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Annu Rev Biochem 73:589-615. 2004
    ..FEN1 interacts with other nucleases and helicases that allow it to act efficiently on structured flaps. Genetic and biochemical analyses continue to reveal many roles of FEN1...
  2. ncbi Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability
    Yuan Liu
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Cell Biol 24:4049-64. 2004
    ..We present a model to explain how flap equilibration and the unique tracking mechanism of FEN1 can collaborate to remove TNR flaps and prevent repeat expansion...
  3. ncbi Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate
    Hui I Kao
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 277:14379-89. 2002
    ..Rad27p cleaves this substrate in the expected 1-nucleotide 3'-tail configuration. Overall, these results suggest that the double-flap substrate is formed and cleaved during eukaryotic DNA replication in vivo...
  4. ncbi Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion
    Yuan Liu
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13728-39. 2003
    ..In this way FEN1 employs endonuclease rather than exonuclease to prevent expansions. A model is presented describing the roles of DNA structure, DNA ligase I, and FEN1 in sequence expansion...
  5. ncbi Value added by data sharing: long-term potentiation of neuroscience research. A commentary on the 2007 SfN Satellite Symposium on data sharing
    Yuan Liu
    NINDS, NIH, Bethesda, MD, USA
    Neuroinformatics 5:143-5. 2007
  6. ncbi Digital biology: an emerging and promising discipline
    Richard W Morris
    National Institutes of Health, Bethesda, MD 20892, USA
    Trends Biotechnol 23:113-7. 2005
    ..Here we summarize the emergent challenges and offer suggestions to academia, industry and government on how best to expand the role of computation in their scientific activities...
  7. ncbi Base excision repair and design of small molecule inhibitors of human DNA polymerase β
    Samuel H Wilson
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Cell Mol Life Sci 67:3633-47. 2010
    ..With apologies to others, we will emphasize results obtained in our laboratory and those of our collaborators...
  8. ncbi OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
    Irina V Kovtun
    Department of Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Nature 447:447-52. 2007
    ..Age-dependent CAG expansion provides a direct molecular link between oxidative damage and toxicity in post-mitotic neurons through a DNA damage response, and error-prone repair of single-strand breaks...
  9. ncbi DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair
    Yuan Liu
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:3665-74. 2005
    ....
  10. ncbi Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta
    Yuan Liu
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:13532-41. 2007
    ..Pol beta.DNA ternary complex formation with appropriate enzyme expression levels or enzyme recruitment to sites of repair...
  11. ncbi An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes
    Yuan Liu
    Department of Bioinformatics, Merck and Co, Inc, WP53F 3001, West Point, PA 19486, USA
    J Bioinform Comput Biol 1:433-46. 2003
    ..The study described in this paper demonstrates the use of GenoA to study human brain hyperpolarization-activated cation channel genes HCN1 and HCN3...
  12. ncbi Improving the activity and stability of GL-7-ACA acylase CA130 by site-directed mutagenesis
    Wei Zhang
    Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Rd, Shanghai 200032, People's Republic of China
    Appl Environ Microbiol 71:5290-6. 2005
    ..This enzyme was purified and immobilized for catalytic analysis. The immobilized mutant enzyme showed a 34.2% increase in specific activity compared to the immobilized wild-type CA130...
  13. ncbi A view of the digital landscape for neuroscience at NIH
    Michael F Huerta
    Neuroinformatics 4:131-8. 2006
  14. ncbi Runx2 integrates estrogen activity in osteoblasts
    Thomas L McCarthy
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8041, USA
    J Biol Chem 278:43121-9. 2003
    ..These results reveal that Runx2 can integrate complex effects on gene transcription in hormone-, growth factor-, and tissue-restricted ways...
  15. ncbi HMGB1 is a cofactor in mammalian base excision repair
    Rajendra Prasad
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell 27:829-41. 2007
    ..The results suggest HMGB1 is a BER cofactor capable of modulating BER capacity in cells...
  16. ncbi Transcriptional and post-transcriptional regulation of transforming growth factor beta type II receptor expression in osteoblasts
    Weizhong Chang
    Department of Surgery Plastic Surgery Section, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8041, USA
    Gene 299:65-77. 2002
    ..Consequently, several processes can alter functional TbetaRII levels in order to regulate the biological effects of this important growth factor...
  17. ncbi [Recombinant human bone morphogenetic protein-2 transform NIH3T3 fibroblast to osteo-like cells]
    Jun-Lin Wang
    Dept. of Oral Histology and Pathology, The Fourth Military Medical University, Xi'an 710032, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 22:420-2. 2004
    ..RESULTS: The cells showed decreased proliferation ability but enhanced ALP activity and OC quantity. CONCLUSION: 50 microg/L rhBMP-2 can transform NIH3T3 fibroblasts to osteo-like cells...