Y Liu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus
    Y Liu
    Section on Developmental Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 21:5660-9. 2001
  2. ncbi request reprint Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2
    M D Hicar
    Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Genomics 71:89-100. 2001
  3. ncbi request reprint Jing: a downstream target of slbo required for developmental control of border cell migration
    Y Liu
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 128:321-30. 2001
  4. ncbi request reprint E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses
    Y Liu
    Department of Medicine, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Ontario, Canada
    Oncogene 19:6065-73. 2000
  5. ncbi request reprint E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis
    Z Jiang
    Department of Medicine, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 67 College Street, Toronto, Ontario, Canada
    Dev Biol 227:8-41. 2000
  6. ncbi request reprint Cloning, characterization, and expression analysis of mouse enamelysin
    J Caterina
    Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4380, USA
    J Dent Res 79:1697-703. 2000
  7. ncbi request reprint Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity
    Y Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 57:167-76. 2000
  8. doi request reprint Cloning and RNAi-mediated functional characterization of MaLac2 of the pine sawyer, Monochamus alternatus
    B L Niu
    Laboratory of Entomo molecular Biology, Sericultural Research Institute, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China
    Insect Mol Biol 17:303-12. 2008
  9. ncbi request reprint Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury
    S S Habeebu
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 56:211-9. 2000
  10. ncbi request reprint Isolation and characterization of novel presenilin binding protein
    A Kashiwa
    Salk Institute for Biological Studies Department of Pathology, University of California, La Jolla, California, USA
    J Neurochem 75:109-16. 2000

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus
    Y Liu
    Section on Developmental Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 21:5660-9. 2001
    ..Chronic exposure to NRG1-beta1 increased the amplitude of ACh-evoked PSCs but not the minimum "quantal" PSC. NRG1-beta1 also increased the percentage of neurons that exhibited ACh-evoked PSCs...
  2. ncbi request reprint Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2
    M D Hicar
    Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Genomics 71:89-100. 2001
    ....
  3. ncbi request reprint Jing: a downstream target of slbo required for developmental control of border cell migration
    Y Liu
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 128:321-30. 2001
    ..We propose that the need to coordinate cell differentiation with nutritional status may be the link between mammalian adipocytes and Drosophila border cells that led to the conservation of C/EBP and AEBP2...
  4. ncbi request reprint E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses
    Y Liu
    Department of Medicine, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Ontario, Canada
    Oncogene 19:6065-73. 2000
    ..Thus, inactivation of E2F1 reduces ectopic cell proliferation and stage-specific p53-dependent apoptosis but does not rescue the differentiation defects associated with loss of Rb during lens development...
  5. ncbi request reprint E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis
    Z Jiang
    Department of Medicine, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 67 College Street, Toronto, Ontario, Canada
    Dev Biol 227:8-41. 2000
    ..Thus, combined inactivation of Rb and p21(Waf1/Cip1) augments endoreduplication and apoptosis, whereas E2F1 and p53 are dispensable during aberrant myogenesis in Rb-deficient fetuses...
  6. ncbi request reprint Cloning, characterization, and expression analysis of mouse enamelysin
    J Caterina
    Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4380, USA
    J Dent Res 79:1697-703. 2000
    ..Characterization of mouse enamelysin demonstrated that it is highly conserved in both its sequence content and pattern of expression relative to the porcine, human, and bovine homologues previously described...
  7. ncbi request reprint Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity
    Y Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 57:167-76. 2000
    ..In conclusion, this study demonstrates that lack of MT renders MT-null mice vulnerable to Cd-induced nephrotoxicity after chronic oral exposure, the primary route of human Cd exposure...
  8. doi request reprint Cloning and RNAi-mediated functional characterization of MaLac2 of the pine sawyer, Monochamus alternatus
    B L Niu
    Laboratory of Entomo molecular Biology, Sericultural Research Institute, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China
    Insect Mol Biol 17:303-12. 2008
    ..The observations reinforce the role of laccase 2 as an essential phenoloxidase for making cuticle...
  9. ncbi request reprint Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury
    S S Habeebu
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 56:211-9. 2000
    ....
  10. ncbi request reprint Isolation and characterization of novel presenilin binding protein
    A Kashiwa
    Salk Institute for Biological Studies Department of Pathology, University of California, La Jolla, California, USA
    J Neurochem 75:109-16. 2000
    ..immunohistochemical studies and cell fractionation analysis show that PBP redistributes from cytoplasm to membranes in the presence of PS. In addition, PBP is deficient in the soluble fraction of sporadic AD brains...
  11. ncbi request reprint Characterization of the human cysteinyl leukotriene 2 receptor
    C E Heise
    Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:30531-6. 2000
    ....
  12. ncbi request reprint Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals
    J Liu
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 55:460-7. 2000
    ....
  13. ncbi request reprint Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium
    S S Habeebu
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 55:223-32. 2000
    ....
  14. ncbi request reprint Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel
    V N Uebele
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 275:23211-8. 2000
    ..The tissue-specific expression of these beta-subunits may allow for the assembly of a large number of distinct BK channels in vivo, contributing to the functional diversity of native BK currents...
  15. ncbi request reprint Molecular cloning and sequencing of the sodB gene from a heterocystous cyanobacterium Anabaena sp. PCC 7120
    Y Liu
    College of Life Sciences, Peking University, Beijing, China
    Biochim Biophys Acta 1491:248-52. 2000
    ..PCC 7120 is transcribed as a single gene and its expression was up-regulated when the cells were subjected to a shift from a nitrogen repletion condition to a nitrogen depletion condition...
  16. ncbi request reprint Identification of four novel human G protein-coupled receptors expressed in the brain
    D K Lee
    Department of Pharmacology, University of Toronto, Medical Science Building, Ontario, M5S 1A8, Toronto, Canada
    Brain Res Mol Brain Res 86:13-22. 2001
    ..Analysis of GPR77 mRNA expression revealed signals in the frontal cortex, hippocampus and hypothalamus with high transcript levels in the liver...
  17. ncbi request reprint Junction adhesion molecule is a receptor for reovirus
    E S Barton
    Department of Microbiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell 104:441-51. 2001
    ..Thus, reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death...
  18. ncbi request reprint RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer
    P A Bignone
    Cancer Research UK, Molecular Oncology Laboratories, Ovarian Cancer Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Oncogene 26:683-700. 2007
    ..In contrast, small interfering RNA against RPS6KA2 showed the opposite effect in 41M cells. The above results suggest that RPS6KA2 is a putative tumour suppressor gene to explain allele loss at 6q27...
  19. ncbi request reprint Significant association of the calpastatin gene with fertility and longevity in dairy cattle
    M D Garcia
    Department of Animal Sciences, Washington State University, Pullman, 99164 6351, USA
    Anim Genet 37:304-5. 2006
  20. ncbi request reprint Interrelation between HeLa-S3 cell transfection and hemolysis in red blood cell suspension using pulsed ultrasound of various duty cycles
    Y Liu
    Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University, Kiryu, Japan
    Eur Biophys J 34:163-9. 2005
    ..Hemolysis in the RBC suspension may be a useful model for determining optimal transfection by pulsed ultrasound of various duty cycles...
  21. ncbi request reprint Alkyl hydroperoxide peroxidase subunit C (ahpC) protects against organic peroxides but does not affect the virulence of Porphyromonas gingivalis W83
    N A Johnson
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Oral Microbiol Immunol 19:233-9. 2004
    ..These findings suggest that the ahpC gene plays a role in peroxide resistance in P. gingivalis but does not contribute significantly to virulence...
  22. ncbi request reprint Identification of a novel HLA-F allele - HLA-F*010102
    X He
    Key Laboratory of Ministry of Education for Tissue Transplantation and Immunology, Guangzhou, People s Republic of China
    Tissue Antigens 63:181-3. 2004
    ..Analysis of the deduced amino acid sequence revealed that the product of this new allele had the identical extracellular domain and transmembrane region but had a shorter cytoplasmic tail...
  23. ncbi request reprint Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice
    J Liu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Appl Pharmacol 176:1-9. 2001
    ..Thus, this study demonstrates that it is genetic strain, not MT genotype, that is mechanistically important in determining susceptibility to Cd-induced testicular injury...
  24. ncbi request reprint Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration
    Y Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA
    Toxicol Appl Pharmacol 175:253-9. 2001
    ..15% after the higher doses in both MT-null and wild-type mice. In summary, this study demonstrates that the absorption and initial distribution of orally administered Cd is dose dependent but is not influenced by MT...
  25. ncbi request reprint Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin
    M J Brown
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 167:641-5. 2001
    ..Plectin is therefore likely to serve as an important organizer of the lymphocyte cytoskeleton and may regulate changes of lymphocyte cytoarchitecture during polarization and extravasation...
  26. ncbi request reprint [Cloning and sequence analysis of a pseudogene of liver regeneration augmenter in rats]
    J Dong
    Gene Therapy Research Center, Institute of Infectious Diseases, 302 nd Hospital of PLA, Beijing 100039, China
    Zhonghua Gan Zang Bing Za Zhi 9:105-7. 2001
    ..8%. CONCLUSIONS: ALR pseudogene is found in rat's genome, implying that there is an ALR multigene family. This finding lays a foundation for further study of ALR molecular evolution mode...
  27. ncbi request reprint rDrak1, a novel kinase related to apoptosis, is strongly expressed in active osteoclasts and induces apoptosis
    H Kojima
    Tissue Engineering Research Center TERC, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba Ibaraki 305 8562, Japan
    J Biol Chem 276:19238-43. 2001
    ..Hence, rDRAK1 may play an important role in the core apoptosis program in osteoclast...
  28. ncbi request reprint Robust prostate-specific expression for targeted gene therapy based on the human kallikrein 2 promoter
    X Xie
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 12:549-61. 2001
    ..hK2-E3/P-EGFP injection led to robust but tumor-restricted EGFP expression. These results suggest that the hk2 multienhancer/promoter should be a powerful novel reagent for safer targeted gene therapy of prostate cancer...
  29. ncbi request reprint Identification of rice black-streaked dwarf fijivirus in maize with rough dwarf disease in China
    S Fang
    National Laboratories for Agrobiotechnology, China Agricultural University, Beijing
    Arch Virol 146:167-70. 2001
    ..Based on these results, it is suggested that the virus which causes this maize disease in China is rice black-streaked dwarf virus...
  30. pmc The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    J L Staudinger
    Department of Molecular Endocrinology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 98:3369-74. 2001
    ..These findings suggest that PXR agonists may prove useful in the treatment of human cholestatic liver disease...
  31. ncbi request reprint Cloning and characterization of additional members of the G protein-coupled receptor family
    D K Lee
    Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ont, Canada
    Biochim Biophys Acta 1490:311-23. 2000
    ..PNR and GPR58 were expressed in COS cells, however no specific binding was observed for various serotonin receptor-specific ligands...
  32. ncbi request reprint Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
    S Witte
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:1902-9. 2000
    ..These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system...
  33. ncbi request reprint Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins
    Y Sun
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:33522-30. 1999
    ..Finally, the presence of cDNAs similar to, yet distinct from, trabeculin-alpha in both human and mouse suggests that trabeculins may form a new subfamily of giant actin-binding/cytoskeletal cross-linking proteins...
  34. ncbi request reprint Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity
    H Zheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Lett 87:139-45. 1996
    ..5-2.0 mM), suggesting that MT does not protect against MNNG-induced cytotoxicity. These results support the hypothesis that constitutive MT levels affect the sensitivity of mammalian cells to Cd and oxidative stress...
  35. ncbi request reprint The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins
    L C Wu
    Department of Medical Biochemistry, Ohio State Biochemistry Program, College of Medicine, Columbus 43210, USA
    Genomics 35:415-24. 1996
    ..The major histocompatibility complex class I gene enhancer binding proteins MBP1 and MBP2 are other representatives of this ZAS protein family...
  36. ncbi request reprint The chsD and chsE genes of Aspergillus nidulans and their roles in chitin synthesis
    C A Specht
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Fungal Genet Biol 20:153-67. 1996
    ..This finding directly demonstrates the importance of chitin to the integrity of the cell wall and indicates that agents that inhibit the chsD-encoded chitin synthase could be useful anti-Aspergillus drugs...
  37. pmc A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA
    S Liang
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Cell Biol 16:5139-46. 1996
    ..Critical residues of Mtr4p, including the mtr4-1 point mutation, have been identified. Mtr4p may serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export...
  38. ncbi request reprint Fatty acid binding protein is induced in neurons of the dorsal root ganglia after peripheral nerve injury
    M De Leon
    Center for Molecular Biology and Gene Therapy, Loma Linda University, CA 92350, USA
    J Neurosci Res 44:283-92. 1996
    ..The induction of DA11 mRNA and protein in DRG neurons suggests, for the first time, the involvement of a neuronal FABP in the process of degeneration and repair in the nervous system...
  39. ncbi request reprint Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment
    Y Liu
    Clinical Pharmacology Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Biochem Biophys Res Commun 224:549-54. 1996
    ..1 fold (p < 0.001). These data suggest that the increase in activity of the liver carboxylase in warfarin treated or fasted rats was not regulated by transcription but more likely was due to a posttranscriptional mechanism...
  40. ncbi request reprint Distribution and retention of cadmium in metallothionein I and II null mice
    J Liu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160, USA
    Toxicol Appl Pharmacol 136:260-8. 1996
    ..These data support the conclusion that the persistence of Cd in the body is at least partially due to Cd binding to MT in tissues...
  41. ncbi request reprint Studies of bacteriophage P2 DNA replication. The DNA sequence of the cis-acting gene A and ori region and construction of a P2 mini-chromosome
    Y Liu
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    J Mol Biol 231:361-74. 1993
    ..Similarities between the products of P2 gene A, 186 gene A and orf2 and orf3 of Ec67 were also found. A P2 mini-chromosome has been constructed that contains only the P2 A gene and the beta-lactamase gene as a marker...
  42. pmc A receptor for interleukin 10 is related to interferon receptors
    A S Ho
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 90:11267-71. 1993
    ..mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways...
  43. ncbi request reprint Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor
    Y Liu
    Department of Pathology, School of Medicine, University of Pittsburgh, PA 15261
    Biochim Biophys Acta 1216:299-303. 1993
    ..Our results suggest the existence of evolutionary pressure to conserve the distinct structure, and presumably the biological functions, of HGF...
  44. ncbi request reprint Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization
    S H Lo
    Dana Farber Cancer Institute, Boston, Massachusetts
    J Biol Chem 269:22310-9. 1994
    ..Immunofluorescence stainings with monoclonal antibodies specific for chick tensin (not cross-reactive with mouse tensin) showed that the expressed protein is indeed localized at focal contacts, as that of native tensin...
  45. pmc Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner
    D Apt
    Institute of Molecular and Cell Biology, National University of Singapore
    Nucleic Acids Res 22:3825-33. 1994
    ..This property, combined with the differential expression of NFI-X, can achieve cell-type specificity of NFI dependent promoters and enhancers...
  46. ncbi request reprint Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression
    H Hori
    Department of Tissue Physiology, Tokyo Medical and Dental University
    J Biochem 116:1212-9. 1994
    ..Immunostaining showed selective distributions of M chain in nerve fibers in the dermis and mesangial matrix of the kidney, and B2 chain in subepidermal and kidney glomerular basement membranes...
  47. ncbi request reprint Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase
    Y Liu
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 272:4419-28. 1997
    ..However, mutational analysis of the R-motifs revealed that the exon 6 and 7 deletions of ADAR-b and -c variants altered the functional importance of each of the three R-motifs...
  48. ncbi request reprint NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing
    Y Liu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore 119260, USA
    J Biol Chem 272:10739-45. 1997
    ..The abundance of NFI-B transcripts varied significantly between different human cell lines and tissues, suggesting a potential involvement of these factors in the complex mechanisms that generate cell type specificity...
  49. pmc Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles
    J A Chiorini
    Molecular Hematology Branch, National Heart Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Virol 71:6823-33. 1997
    ....
  50. ncbi request reprint Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure
    J Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Appl Pharmacol 159:98-108. 1999
    ..In conclusion, the present study demonstrates that repeated injections of Cd produces hematotoxic and immunotoxic effects, and intracellular MT protects against these chronic Cd-induced effects...
  51. ncbi request reprint HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
    S Bao
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 59:2023-8. 1999
    ....
  52. pmc kdgREcc negatively regulates genes for pectinases, cellulase, protease, HarpinEcc, and a global RNA regulator in Erwinia carotovora subsp. carotovora
    Y Liu
    Plant Sciences Unit, University of Missouri, Columbia, Missouri 65211, USA
    J Bacteriol 181:2411-21. 1999
    ..Our findings support the idea that KdgREcc affects transcription by promoter occlusion, i.e., preventing the initiation of transcription, and by a roadblock mechanism, i.e., by affecting the elongation of transcription...
  53. ncbi request reprint Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity
    J Liu
    University of Kansas Medical Center, Kansas City, USA
    J Pharmacol Exp Ther 289:580-6. 1999
    ..The increased sensitivity does not appear to be due to increased acetaminophen activation, glutathione depletion, or covalent binding, but appears to be associated with the antioxidant role of MT...
  54. pmc A new human topoisomerase III that interacts with SGS1 protein
    S W Ng
    Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Nucleic Acids Res 27:993-1000. 1999
    ..The presence of more than one human topoisomerase III is reminiscent of mammalian topoisomerase II, which has two genetically distinct isoforms with different expression patterns and probably different functions in mammalian cells...
  55. ncbi request reprint Identification and genetic mapping of Xenopus TAP2 genes
    Y Ohta
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Immunogenetics 49:171-82. 1999
    ..Similar to LMP7 and class Ia,TAP2 is expressed ubiquitously with highest levels in intestine and spleen...
  56. ncbi request reprint The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint
    S Bao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell Growth Differ 9:961-7. 1998
    ..Taken together, these results suggest that the mammalian Rad24 protein may function as a critical gatekeeper in DNA damage checkpoint control...
  57. ncbi request reprint Proto-oncogene PML controls genes devoted to MHC class I antigen presentation
    P Zheng
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York 10016, USA
    Nature 396:373-6. 1998
    ..PML also regulates MHC expression in untransformed fibroblasts. We conclude that malfunction of PML may enable a tumour to evade the immune defence of its host...
  58. ncbi request reprint Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila
    H de la Vega
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Insect Mol Biol 7:233-9. 1998
    ..Southern blot hybridizations of the PCR products from the species of Anopheles suggest a similar arrangement...
  59. ncbi request reprint A novel 52 kDa protein induces apoptosis and concurrently activates c-Jun N-terminal kinase 1 (JNK1) in mouse C3H10T1/2 fibroblasts
    L Sun
    Friedrich Miescher Institute, Basel, Switzerland
    Gene 208:157-66. 1998
    ..These results indicate that p52 may represent a new cell-death protein inducing apoptosis and activating JNK1 through different pathways...
  60. ncbi request reprint Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity
    J Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Appl Pharmacol 149:24-31. 1998
    ..These results demonstrate that (1) high doses of cisplatin produce hepatotoxicity, with apoptosis as the major lesion, and (2) MT protects against cisplatin-induced liver injury...
  61. ncbi request reprint Cloning and characterization of the 5'-flanking sequence for the human DNA topoisomerase II beta gene
    S W Ng
    Hematology Oncology Division, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Centre, East Campus, Boston, MA 02215, USA
    Gene 203:113-9. 1997
    ..Gel mobility shift studies demonstrate that protein factors from the nuclear extracts can bind specifically to the downstream elements and may participate in transcriptional regulation...
  62. ncbi request reprint Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth
    C Croniger
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 272:26306-12. 1997
    ..We conclude that C/EBPalpha is required for the cAMP induction of PEPCK gene expression in the liver and that C/EBPbeta can compensate for the loss of C/EBPalpha if its concentration is induced to appropriate levels...
  63. pmc Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities
    K M Albers
    Department of Pathology, University of Kentucky College of Medicine, Lexington 40536
    J Cell Biol 128:157-69. 1995
    ..These findings indicate that expression of an abnormal keratin in liver epithelial cells in the in vivo setting can alter the structure and function of a tissue and suggest a role of the keratin network in cellular secretion...