Affiliation: National Institutes of Health
Liu S, Moayeri M, Leppla S. Anthrax lethal and edema toxins in anthrax pathogenesis. Trends Microbiol. 2014;22:317-25 pubmed publisher
..This review focuses on the activities of anthrax toxins and their roles in initial and late stages of anthrax infection. ..
Liu S, Crown D, Miller Randolph S, Moayeri M, Wang H, Hu H, et al
. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009;106:12424-9 pubmed publisher
..Finally, the CMG2-null mice are also shown to be highly resistant to B. anthracis spore infection, attesting to the importance of both anthrax toxin and CMG2 in anthrax infections. ..
Liu S, Miller Randolph S, Crown D, Moayeri M, Sastalla I, Okugawa S, et al
. Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice. Cell Host Microbe. 2010;8:455-62 pubmed publisher
..This work demonstrates that anthrax toxin uptake through CMG2 and the resulting impairment of myeloid cells are essential to anthrax infection. ..
Liu S, Bachran C, Gupta P, Miller Randolph S, Wang H, Crown D, et al
. Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development. Proc Natl Acad Sci U S A. 2012;109:13817-22 pubmed publisher
..We confirmed that the diphthamide modification is essential for eEF2 to prevent -1 frameshifting during translation and show that the Gly(717)-to-Arg mutation cannot rescue this defect. ..
Liu S, Zhang Y, Hoover B, Leppla S. The receptors that mediate the direct lethality of anthrax toxin. Toxins (Basel). 2012;5:1-8 pubmed publisher
..These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role. ..
Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah R, et al
. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013;501:63-8 pubmed publisher
..Our findings demonstrate that B. anthracis has evolved to use LT and ET to induce host lethality by coordinately damaging two distinct vital systems. ..