Jie Liu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Oleanolic acid and ursolic acid: research perspectives
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Ethnopharmacol 100:92-4. 2005
  2. pmc Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 9413, USA
    Gastroenterology 142:1218-1228.e1. 2012
  3. pmc A biosynthetic pathway for anandamide
    Jie Liu
    Laboratories of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:13345-50. 2006
  4. pmc Multiple pathways involved in the biosynthesis of anandamide
    Jie Liu
    Laboratory of Physiologic Studies, NIAAA NIH, 5625 Fishers Lane, MS 9413, Bethesda, MD 20892 9413, USA
    Neuropharmacology 54:1-7. 2008
  5. pmc Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma
    Bani Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    J Biol Chem 285:19002-11. 2010
  6. pmc Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides
    Resat Cinar
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD
    Hepatology 59:143-53. 2014
  7. pmc Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    Douglas Osei-Hyiaman
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA
    J Clin Invest 118:3160-9. 2008
  8. pmc Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase
    Jie Liu
    Laboratory of Physiologic Studies and Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 110:18832-7. 2013
  9. pmc Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
    Joseph Tam
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 120:2953-66. 2010
  10. doi request reprint Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint Oleanolic acid and ursolic acid: research perspectives
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Ethnopharmacol 100:92-4. 2005
    ..A briefly commentary is attempted here for their research perspectives...
  2. pmc Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 9413, USA
    Gastroenterology 142:1218-1228.e1. 2012
    ..We explored the role of hepatic CB(1) in insulin resistance and inhibition of insulin signaling pathways...
  3. pmc A biosynthetic pathway for anandamide
    Jie Liu
    Laboratories of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:13345-50. 2006
    ..Both PTPN22 and endocannabinoids have been implicated in autoimmune diseases, suggesting that the PLC/phosphatase pathway of anandamide synthesis may be a pharmacotherapeutic target...
  4. pmc Multiple pathways involved in the biosynthesis of anandamide
    Jie Liu
    Laboratory of Physiologic Studies, NIAAA NIH, 5625 Fishers Lane, MS 9413, Bethesda, MD 20892 9413, USA
    Neuropharmacology 54:1-7. 2008
    ..In macrophages, the endotoxin-induced synthesis of anandamide proceeds uniquely through the phospholipase C/phosphatase pathway...
  5. pmc Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma
    Bani Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    J Biol Chem 285:19002-11. 2010
    ..We conclude that RARgamma regulates CB(1)R expression and is thus involved in the control of hepatic fat metabolism by endocannabinoids...
  6. pmc Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides
    Resat Cinar
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD
    Hepatology 59:143-53. 2014
    ..Conclusion: ECs induce CB1 R-mediated, endoplasmic reticulum stress-dependent synthesis of specific ceramide subspecies in the liver, which plays a key role in obesity-related hepatic insulin resistance...
  7. pmc Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    Douglas Osei-Hyiaman
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA
    J Clin Invest 118:3160-9. 2008
    ....
  8. pmc Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase
    Jie Liu
    Laboratory of Physiologic Studies and Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 110:18832-7. 2013
    ..We conclude that MUFAs generated via SCD1 activity, but not diet-derived MUFAs, function as endogenous FAAH inhibitors mediating the HFD-induced increase in hepatic AEA, which then activates hepatic CB1R to induce insulin resistance. ..
  9. pmc Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
    Joseph Tam
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 120:2953-66. 2010
    ..These results suggest that targeting peripheral CB1R has therapeutic potential for alleviating cardiometabolic risk in obese patients...
  10. doi request reprint Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
    ..We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation...
  11. pmc Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
    Sandor Batkai
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
    Circulation 110:1996-2002. 2004
    ..Endocannabinoids are novel lipid mediators with hypotensive and cardiodepressor activity. Here, we examined the possible role of the endocannabinergic system in cardiovascular regulation in hypertension...
  12. pmc Wnt signaling regulates hepatic metabolism
    Hongjun Liu
    Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 4:ra6. 2011
    ..These observations implicate Wnt signaling in the modulation of hepatic metabolism and raise the possibility that Wnt signaling may play a similar role in the metabolic regulation of other tissues...
  13. pmc Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase
    Pal Pacher
    National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane MSC 9413, Rm 2S24, Bethesda, MD 20892 9413, USA
    Am J Physiol Heart Circ Physiol 289:H533-41. 2005
    ....
  14. pmc Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
    Tony Jourdan
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland
    Nat Med 19:1132-40. 2013
    ..These findings implicate endocannabinoids and inflammasome activation in beta cell failure and identify macrophage-expressed CB₁R as a therapeutic target in T2DM...
  15. pmc Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver
    Bani Mukhopadhyay
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:6323-8. 2011
    ..We conclude that activation of hepatic CB(1)R by newly synthesized anandamide promotes liver regeneration by controlling the expression of cell-cycle regulators that drive M phase progression...
  16. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005
    ..We conclude that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation...
  17. pmc Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region
    Tao Xie
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Building 10, Room 8C101, Bethesda, Maryland 20892 1752, USA
    Endocrinology 149:2443-50. 2008
    ....
  18. ncbi request reprint Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45034-9. 2003
    ..We conclude that AEA and 2-AG synthesis are differentially regulated in macrophages, and AEA rather than 2-AG is a major contributor to LPS-induced hypotension...
  19. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
    ..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases...
  20. pmc Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects
    Grzegorz Godlewski
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rockville, MD 20852, USA
    Chem Biol 17:1256-66. 2010
    ..This unique activity profile offers improved therapeutic value in hypertension...
  21. ncbi request reprint Evidence for novel cannabinoid receptors
    Malcolm Begg
    National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413 Bethesda, MD 8092 9413, United States
    Pharmacol Ther 106:133-45. 2005
    ..The case for these additional receptors is being reviewed here...
  22. doi request reprint Bmi1 regulates mitochondrial function and the DNA damage response pathway
    Jie Liu
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 459:387-92. 2009
    ....
  23. pmc Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes
    Nolan K Maier
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:763-70. 2014
    ..These findings suggest a novel role in inhibition of the innate immune response for arsenical compounds that have been used as therapeutics for a few hundred years. ..
  24. pmc Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance
    Joseph Tam
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 16:167-79. 2012
    ..Thus, inverse agonism at peripheral CB(1)R not only improves cardiometabolic risk in obesity but has antiobesity effects by reversing leptin resistance...
  25. pmc Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
    Celia Quijano
    Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 11:1383-92. 2012
    ..Furthermore, the inflammatory phenotype that accompanies OIS appears to be related to these underlying changes in cellular metabolism...
  26. doi request reprint Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope
    Tracy J Ruckwardt
    Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:4673-80. 2010
    ..These data demonstrate efficient viral clearance, and a protective effect of subdominant CD8(+) T cell responses...
  27. pmc The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter
    Xin Pan
    1 Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA 2 National Center of Biomedical Analysis, Beijing 100850, China 3
    Nat Cell Biol 15:1464-72. 2013
    ..Taken together, these results clarify how acute alterations in mitochondrial matrix calcium can regulate mammalian physiology. ..
  28. pmc Endocannabinoids in liver disease
    Joseph Tam
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
    Hepatology 53:346-55. 2011
    ..Although the documented therapeutic potential of CB(1) blockade is limited by neuropsychiatric side effects, these may be mitigated by using novel, peripherally restricted CB(1) antagonists...
  29. ncbi request reprint Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor
    Laszlo Offertaler
    Laboratory of Physiologic Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, USA
    Mol Pharmacol 63:699-705. 2003
    ....
  30. pmc Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice
    Lei Wang
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1393-8. 2003
    ....
  31. pmc Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
    Min Chen
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:7386-91. 2005
    ..Differences between E1m-/+ and E1+/p- mice presumably result from differential effects on G(s)alpha expression in tissues where G(s)alpha is normally imprinted...
  32. pmc The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels
    Grzegorz Godlewski
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
    J Pharmacol Exp Ther 328:351-61. 2009
    ..3) Direct BK(Ca) channel activation probably contributes to the endothelium-independent component of ARA-S-induced mesenteric vasorelaxation. 4) O-1918 is a BK(Ca) channel inhibitor...
  33. pmc Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression
    J Julie Wu
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Rep 4:913-20. 2013
    ..Thus, in a mammalian model, while reducing mTOR expression markedly increases overall lifespan, it affects the age-dependent decline in tissue and organ function in a segmental fashion...
  34. doi request reprint Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells
    Philippa Hillyer
    Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA
    Eur J Immunol 43:3197-208. 2013
    ..While type I IFNs may beneficially enhance CD4(+) T-cell memory responses to vaccines or viral pathogens, they may also enhance the function of resident Th2 cells and exacerbate allergic inflammation. ..
  35. pmc Endocannabinoids and the control of energy homeostasis
    George Kunos
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 9413, USA
    J Biol Chem 283:33021-5. 2008
    ..Recent work indicates that activation of peripheral CB1 receptors by ECBs plays a key role in the hormonal/metabolic changes associated with obesity/metabolic syndrome and may be targeted for its pharmacotherapy...
  36. ncbi request reprint Clonotype-specific avidity influences the dynamics and hierarchy of virus-specific regulatory and effector CD4(+) T-cell responses
    Jie Liu
    Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, MD, USA
    Eur J Immunol 44:1058-68. 2014
    ..These data indicate that MHC-peptide-TCR interactions can produce different kinetic and functional profiles in CD4(+) T-cell populations even when responding to the same epitope...
  37. doi request reprint The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
    Nisha Narayan
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 492:199-204. 2012
    ....
  38. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    ..These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels...
  39. pmc A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
    Liu Cao
    Translational Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 35:534-41. 2009
    ..These observations may have important implications for Brca1-mediated tumor formation as well as for the molecular pathway leading from genomic instability to organismal aging...
  40. pmc Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection
    Jie Liu
    Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr, Bethesda, MD 20892 3017, USA
    J Virol 84:10501-9. 2010
    ..Achieving the optimal balance of regulatory and effector T-cell function is an important consideration for designing future vaccines...
  41. pmc Key tissue targets responsible for anthrax-toxin-induced lethality
    Shihui Liu
    Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 501:63-8. 2013
    ..Our findings demonstrate that B. anthracis has evolved to use LT and ET to induce host lethality by coordinately damaging two distinct vital systems. ..
  42. pmc Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDKD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 112:2071-80. 2008
    ..Chromatin immunoprecipitation experiments confirmed the binding of STAT5A/B to these sites. We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription...
  43. pmc T Cell receptor clonotype influences epitope hierarchy in the CD8+ T cell response to respiratory syncytial virus infection
    Padma Billam
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892 3017, USA
    J Biol Chem 286:4829-41. 2011
    ..Defining how epitope structure is interpreted to inform T cell function will improve the design of future gene-based vaccines...
  44. pmc Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis
    Yang Sun
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA
    Toxicology 262:162-70. 2009
    ....
  45. ncbi request reprint The stimulatory G protein alpha-subunit Gs alpha is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B
    Jie Liu
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:4336-41. 2003
    ..This study provides further evidence for tissue-specific imprinting of G(s)alpha in humans and provides a potential mechanism for mild to moderate TSH resistance in PHP1A and borderline resistance in some patients with PHP1B...
  46. doi request reprint Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
    Zhenyu Cai
    1 Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA 2
    Nat Cell Biol 16:55-65. 2014
    ..Hence, our study reveals a crucial mechanism of MLKL-mediated TNF-induced necroptosis. ..
  47. pmc Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model
    Jie Liu
    Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr, Bethesda, MD 20892 3017, USA
    J Virol 83:4934-41. 2009
    ..Characterization of epitope-specific CD4 T cells by novel fluorochrome-conjugated peptide-I-A(b) tetramers allows detailed analysis of their roles in RSV pathogenesis and immunity...
  48. ncbi request reprint Genetic diseases associated with heterotrimeric G proteins
    Lee S Weinstein
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 27:260-6. 2006
    ..g. hypertension and metabolic syndrome). To date, no other G proteins have been implicated directly in human disease...
  49. pmc A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
    In Hye Lee
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 105:3374-9. 2008
    ..These results suggest that the Sirt1 deacetylase is an important in vivo regulator of autophagy and provide a link between sirtuin function and the overall cellular response to limited nutrients...
  50. ncbi request reprint Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, 111, Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 170:55-62. 2002
    ....
  51. ncbi request reprint Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:295-305. 2006
    ..In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES...
  52. ncbi request reprint O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays
    Jie Liu
    Inorganic Carcinogenesis Section, National Cancer Institute at National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 300:18-25. 2002
    ....
  53. pmc Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, NC 27713, USA
    Environ Health Perspect 110:119-22. 2002
    ..The Chinese government and international organizations are attempting to improve the house conditions and the coal source, and thereby protect human health in this area...
  54. ncbi request reprint Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 216:407-15. 2006
    ..Overall, an intricate variety of gene expression changes occur in arsenic-induced malignant transformation of liver cells including oncogene activation and alterations in expression of genes critical to growth regulation...
  55. ncbi request reprint Focal adhesion kinase as a potential target in arsenic toxicity
    Jie Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 84:212-3. 2005
  56. ncbi request reprint Gs(alpha) mutations and imprinting defects in human disease
    Lee S Weinstein
    Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 968:173-97. 2002
    ..This GNAS1 imprinting defect is predicted to decrease Gs(alpha) expression in tissues where Gs(alpha) is normally imprinted and therefore to lead to renal parathyroid hormone resistance...
  57. pmc Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC, USA
    Genomics 94:32-8. 2009
    ..Confocal analysis confirmed key gene changes at the protein levels. Thus, multiple molecular events are associated with JS-K effects in killing HL-60, which could be molecular targets for this novel anticancer NO prodrug...
  58. ncbi request reprint Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Biol Chem 277:20927-33. 2002
    ....
  59. pmc Transplacental arsenic carcinogenesis in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 222:271-80. 2007
    ..Transplacental carcinogenesis clearly occurs with other agents in humans and investigating a potential transplacental component of the human carcinogenic response to arsenic should be a research priority...
  60. pmc Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 220:284-91. 2007
    ..These alterations could disrupt genetic programming at the very early life stage, which could impact tumor formation much later in adulthood...
  61. pmc Arsenic-induced aberrant gene expression in fetal mouse primary liver-cell cultures
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA
    Ann N Y Acad Sci 1140:368-75. 2008
    ....
  62. ncbi request reprint Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice
    Jie Liu
    Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 32:525-35. 2002
    ..Thus, the mechanism of acute cadmium toxicity involves multiple facets including oxidative damage and aberrant gene expression, and absence of MT exacerbates Cd-induced aberrant gene expression...
  63. pmc Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 326:363-8. 2008
    ..Arsenic speciation, bioavailability, and toxicity/benefit should be considered in evaluation of mineral arsenical-containing traditional medicines...
  64. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....
  65. pmc Mercury in traditional medicines: is cinnabar toxicologically similar to common mercurials?
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Exp Biol Med (Maywood) 233:810-7. 2008
    ..In risk assessment, cinnabar is less toxic than many other forms of mercury, but the rationale for its inclusion in traditional Chinese medicines remains to be fully justified...
  66. ncbi request reprint Purine nucleoside phosphorylase: a fortuitous cytosolic arsenate reductase?
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, 111 Alexander Drive, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Sci 70:1-3. 2002
  67. ncbi request reprint Minireview: GNAS: normal and abnormal functions
    Lee S Weinstein
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 145:5459-64. 2004
    ..Mouse knockout models show that G(s)alpha and the alternative G(s)alpha isoform XLalphas that is expressed from the paternal GNAS allele may have opposite effects on energy metabolism in mice...
  68. ncbi request reprint Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
    ..Some of these aberrantly expressed genes could play a role in the development of arsenic-induced tumors, at least in the liver...
  69. ncbi request reprint Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 96:466-74. 2004
    ....
  70. ncbi request reprint Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 208:289-97. 2005
    ....
  71. ncbi request reprint Fas-mediated signaling pathway in ethanol-induced liver apoptosis: inhibition by zinc
    Jie Liu
    Inorganic Carcinogenesis, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Exp Biol Med (Maywood) 229:365-6. 2004
  72. ncbi request reprint Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, MD F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 198:31-8. 2004
    ..In addition, it appears gestational arsenic can act as a tumor initiator in the female mouse liver, inducing liver lesions that can be promoted by TPA...
  73. ncbi request reprint Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, Inorganic Carcinogenesis Section, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 153:357-64. 2004
    ..A nickel dose-related trend for increased lung tumors occurred in MT-transgenic mice but not in WT mice. Thus, the over-expression of MT did not significantly mitigate the carcinogenic response to nickel...
  74. ncbi request reprint Hybridization buffer systems impact the quality of filter array data
    Jie Liu
    Inorganic Carcinogenesis Section, LCC, NCI at NIEHS, 111 Alexander Drive, RTP, NC 27709, USA
    J Pharmacol Toxicol Methods 50:67-71. 2004
    ..A clean hybridization with minimal background is critical for successful microarray analysis and is highly desired. However, clean hybridization alone is not enough; verification is needed...
  75. ncbi request reprint Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 198:377-84. 2004
    ..The development of these animal models should advance our understanding of the mechanisms of inorganic arsenic carcinogenesis...
  76. ncbi request reprint Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 186:7-17. 2003
    ..The development of this rodent model of inorganic arsenic carcinogenesis has important implications in defining the mechanism of action for this common environmental carcinogen...
  77. ncbi request reprint Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 70:144-51. 2005
    ..Thus, the liver-selective NO donor, V-PYRRO/NO, was partially protective against ANIT-induced liver injury, without affecting ANIT-induced cholestasis and cholestasis-related gene expression...
  78. ncbi request reprint Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 213:216-23. 2006
    ....
  79. ncbi request reprint Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, PO Box 12233, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Cancer Res 66:1337-45. 2006
    ..Thus, arsenic acts with estrogens to enhance production of female mouse urogenital cancers...
  80. ncbi request reprint Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Cancer 119:28-32. 2006
    ..Our results indicate that MT-null mice are hypersusceptible to the hepatocarcinogenic effects of cisplatin, and poor MT expression may be a predisposing factor for cisplatin-induced secondary tumors after chemotherapy...
  81. ncbi request reprint Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Int J Toxicol 24:215-20. 2005
    ..Overall, MT-null mice appear no more sensitive to the carcinogenic effects of nickel than WT mice. Thus, poor MT production does not appear to be a predisposing factor for nickel carcinogenesis...
  82. ncbi request reprint The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats
    Chengxiu Li
    Department of Pharmacology, Guiyang Medical College, China
    Life Sci 72:1563-71. 2003
    ..In conclusion, HDGL can effectively reverse chemically induced liver fibrosis, and this appears to be due, at least in part, to the stimulation of hepatic collagenolysis, resulting in a resolution of hepatic fibrosis...
  83. ncbi request reprint The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, NC 27709, USA
    Hepatology 37:324-33. 2003
    ..This protection may involve the reduction of oxidative stress, the inhibition of apoptosis, and possibly the maintenance of hepatic vasculature to prevent congestion...
  84. ncbi request reprint Unresolved questions from the analysis of mice lacking MCU expression
    Elizabeth Murphy
    Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Biochem Biophys Res Commun 449:384-5. 2014
    ..Here, we discuss our findings as well as potential explanations for some of the more unexpected results. ..
  85. ncbi request reprint Differential susceptibility of leukocyte subsets to cytotoxic T cell killing: implications for HIV immunopathogenesis
    Jie Liu
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20895, USA
    Cytometry A 71:94-104. 2007
    ....
  86. ncbi request reprint The quest for a vascular endothelial cannabinoid receptor
    George Kunos
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Drive MSC 8115, Bethesda, MD 20892 8115, USA
    Chem Phys Lipids 121:45-56. 2002
    ..Since vasodilation is often associated with hypotension, mechanisms involved in the hypotensive actions of cannabinoids, including the endocannabinoids anandamide and 2-arachidonoylglycerol, are also briefly reviewed...
  87. pmc A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling
    Jie Liu
    Laboratory of Cardiovascular Science, Intramural Research Program, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore MD 21224, USA
    J Mol Cell Cardiol 51:730-9. 2011
    ..Thus, AC-cAMP-PKA-Ca(2+) signaling cascade is a major mechanism of normal automaticity in mouse SANC...
  88. pmc Oxidants, metabolism, and stem cell biology
    Jie Liu
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Free Radic Biol Med 51:2158-62. 2011
    ..These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging...
  89. ncbi request reprint Cadmium at a non-toxic dose alters gene expression in mouse testes
    Tong Zhou
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Lett 154:191-200. 2004
    ..These results indicate that changes in gene expression occur well before overt effects of Cd-induced testicular toxicity and carcinogenicity are apparent...
  90. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
    ..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...
  91. pmc Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:404-11. 2006
    ..These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis...
  92. pmc Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans
    Kaimei Song
    Inflammation Biology Section, Laboratory of Molecular Immunology and Sections of Human Immunology and ImmunoTechnology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:7916-21. 2005
    ..Rather, developmental pathways branch early on to yield effector/memory populations that are highly heterogeneous and multifunctional and have the potential to become stable resting cells...
  93. pmc Superoxide flashes in single mitochondria
    Wang Wang
    Laboratories of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell 134:279-90. 2008
    ..We propose that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases...
  94. ncbi request reprint Fibroblast growth factor-23 is regulated by 1alpha,25-dihydroxyvitamin D
    Michael T Collins
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4320, USA
    J Bone Miner Res 20:1944-50. 2005
    ..In addition, the phosphaturic effect of FGF-23 may be diminished in the absence of PTH action on the kidney...
  95. ncbi request reprint Augmented Wnt signaling in a mammalian model of accelerated aging
    Hongjun Liu
    Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Science 317:803-6. 2007
    ..Both in vitro and in vivo, continuous Wnt exposure triggered accelerated cellular senescence. Thus, klotho appears to be a secreted Wnt antagonist and Wnt proteins have an unexpected role in mammalian aging...
  96. pmc Stem cells and oxidants: too little of a bad thing
    Jie Liu
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD 20892, USA
    Cell Metab 18:1-2. 2013
    ..Now, a new study (Morimoto et al., 2013) suggests that the self-renewal of certain stem cells may actually require reactive oxygen species (ROS). ..
  97. ncbi request reprint The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice
    Chengxiu Li
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27706, USA
    Toxicology 189:173-80. 2003
    ..The protection is probably due to multiple mechanisms involving attenuation of APAP-induced congestion and lipid peroxidation in the kidney...
  98. pmc Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit
    Jie Liu
    Metabolic Diseases Branch and Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:5513-8. 2005
    ..The 1A region is a maternal imprint mark that contains one or more methylation-sensitive cis-acting elements that suppress G(s)alpha expression from the paternal allele in a tissue-specific manner...
  99. ncbi request reprint Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 122:533-43. 2004
    ..This initial microarray analysis could advance our understanding of cellular responses to ultraviolet A exposure, and provide a platform from which to further study ultraviolet-A-induced apoptosis and carcinogenesis...
  100. ncbi request reprint The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:52390-8. 2004
    ....
  101. ncbi request reprint Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation
    Jaspreet S Gujral
    Liver Research Institute, University of Arizona, Tucson, AZ 85724, USA
    Hepatology 40:998-1007. 2004
    ..In conclusion, liver injury (oncotic necrosis) after BDL correlated with the severity of the inflammatory response. The minimal amount of apoptosis had no effect on inflammation or on the overall injury...