B Liu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Molecular consequences of activated microglia in the brain: overactivation induces apoptosis
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 77:182-9. 2001
  2. ncbi request reprint Role of nitric oxide in inflammation-mediated neurodegeneration
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27710, USA
    Ann N Y Acad Sci 962:318-31. 2002
  3. ncbi request reprint Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 298:1133-41. 2001
  4. ncbi request reprint Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons
    Yuxin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 302:1212-9. 2002
  5. ncbi request reprint Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 304:1-7. 2003
  6. ncbi request reprint Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Pharmacol Exp Ther 295:125-32. 2000
  7. ncbi request reprint Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, NC 27709, Research Triangle Park, USA
    Neuroscience 97:749-56. 2000
  8. pmc Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1065-73. 2003
  9. ncbi request reprint Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 293:607-17. 2000
  10. ncbi request reprint Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:1228-36. 2003

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Molecular consequences of activated microglia in the brain: overactivation induces apoptosis
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 77:182-9. 2001
    ..Furthermore, overactivation-induced apoptosis of microglia may be a fundamental self-regulatory mechanism devised to limit bystander killing of vulnerable neurons...
  2. ncbi request reprint Role of nitric oxide in inflammation-mediated neurodegeneration
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27710, USA
    Ann N Y Acad Sci 962:318-31. 2002
    ..Among these agents, the opioid receptor antagonist naloxone, especially its non-opioid enantiomer (+)-naloxone, promises to be of potential therapeutic value for the treatment of inflammation-related diseases...
  3. ncbi request reprint Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 298:1133-41. 2001
    ..Understanding the underlying mechanisms of action should further define the roles of dynorphins in the regulation of dopaminergic neurons and help devise novel strategies to combat neurodegenerative diseases...
  4. ncbi request reprint Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons
    Yuxin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 302:1212-9. 2002
    ..Combined with our previous observations with inflammagen-induced neurodegeneration, naloxone analogs, especially (+)-naloxone, may have potential therapeutic efficacy for the treatment of Alzheimer's and Parkinson's disease...
  5. ncbi request reprint Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 304:1-7. 2003
    ..In addition, we also discuss novel approaches to potential therapeutic strategies...
  6. ncbi request reprint Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Pharmacol Exp Ther 295:125-32. 2000
    ..In addition, the inflammation-mediated degeneration of dopaminergic neurons in the rat SN resulting from the targeted injection of LPS may serve as a useful model to gain further insights into the pathogenesis of Parkinson's disease...
  7. ncbi request reprint Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, NC 27709, Research Triangle Park, USA
    Neuroscience 97:749-56. 2000
    ..These results indicate that the neuroprotective effect of naloxone is mediated by its inhibition of microglial activity and may be unrelated to its binding to the classical opioid receptors...
  8. pmc Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1065-73. 2003
    ....
  9. ncbi request reprint Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 293:607-17. 2000
    ....
  10. ncbi request reprint Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:1228-36. 2003
    ..Findings from this study may be highly relevant to the elucidation of the multifactorial etiology of PD and the discovery of effective therapeutic agents for the treatment of the disease...
  11. ncbi request reprint Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Glia 52:78-84. 2005
    ....
  12. ncbi request reprint Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation
    Yuxin Liu
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 305:212-8. 2003
    ..These results suggest that DM may be a promising therapeutic agent for the treatment of Parkinson's disease...
  13. ncbi request reprint Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA
    J Neurochem 88:939-47. 2004
    ..These findings suggest a potential therapeutic intervention strategy for the treatment of inflammation-mediated neurodegenerative diseases...
  14. ncbi request reprint Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures
    Tongguang Wang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroimmunol 147:68-72. 2004
    ..These results indicate that MnTMPyP may potentially be used for the treatment of inflammation-related degenerative neurological disorders...
  15. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
    ....
  16. ncbi request reprint Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 17:1954-6. 2003
    ..This study also suggests that NADPH oxidase may be a promising target for therapeutic interventions in Parkinson's disease...
  17. ncbi request reprint Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 22:782-90. 2002
    ..The results of this study should advance our understanding of the mechanism of action for pesticides in the pathogenesis of Parkinson's disease...
  18. ncbi request reprint Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, North Carolina, USA
    J Neurochem 81:1285-97. 2002
    ....
  19. ncbi request reprint p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures
    Gwang Ho Jeohn
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 962:332-46. 2002
    ..The results suggest that p38 MAPK in glia plays a significant role in the LPS-induced death of mesencephalic neurons through induction of nitric oxide synthase and resulting NO production...
  20. ncbi request reprint Immune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured glia
    R C Chang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Brain Res Mol Brain Res 81:197-201. 2000
    ..These results suggest that neuron-glia interactions via NCAMs play an important role in regulating the activities of glial cells in the brain...
  21. ncbi request reprint Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons
    F Q Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Neural Transm 112:331-47. 2005
    ..We hypothesize that the inhibition of LPS-induced production of NO and free radicals from microglia may underlie the mechanism of baicalein's neuroprotection...
  22. ncbi request reprint Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase
    Wei Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA
    FASEB J 18:589-91. 2004
    ..More importantly, due to its proven safety record of long-term clinical use in humans, DM may be a promising agent for the treatment of degenerative neurological disorders such as PD...
  23. ncbi request reprint Neuroprotective effect of naloxone in inflammation-mediated dopaminergic neurodegeneration. Dissociation from the involvement of opioid receptors
    Bin Liu
    Neuropharmacology Section, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC, USA
    Methods Mol Med 79:43-54. 2003
  24. ncbi request reprint Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:6181-7. 2003
    ..This study also suggested that microglial NADPH oxidase may be a promising target for PD treatment...
  25. ncbi request reprint Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures
    Bin Liu
    Neuropharmacology Section, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC, USA
    Methods Mol Med 79:387-95. 2003
  26. ncbi request reprint Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    FASEB J 17:1957-9. 2003
    ..This study lends strong support for a multifactorial etiology of PD and provides clues for therapeutic interventions...
  27. ncbi request reprint Novel anti-inflammatory therapy for Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Trends Pharmacol Sci 24:395-401. 2003
    ....
  28. ncbi request reprint Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 83:973-83. 2002
    ..This study demonstrates that one of the mechanisms by which microglia can enhance the neurotoxicity of Abeta is via the production of reactive oxygen species...
  29. ncbi request reprint Protective effect of dextromethorphan against endotoxic shock in mice
    Guorong Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NCI, National Institute of Environmental Health Sciences, National Institutes of Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 69:233-40. 2005
    ..This study not only extends neuroprotective effect of DM, but also suggests that DM may be a novel compound for the therapeutic intervention for sepsis...
  30. ncbi request reprint 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, P O Box 12233, NC, USA
    FASEB J 19:395-7. 2005
    ..In view of the well-documented very low toxicity of DM and its analogs, this report may provide an important new direction for the development of therapeutic interventions for inflammation-related diseases such as PD...
  31. ncbi request reprint Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 308:975-83. 2004
    ..In addition, these results indicate that ANDRO may have clinical utility for the treatment of inflammation-related neurodegenerative disorders such as Parkinson's disease...
  32. ncbi request reprint Gö6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation
    G H Jeohn
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neuroscience 114:689-97. 2002
    ..Gö6976 appears to play a novel role in neuroprotection by suppressing the release of pro-inflammatory factors by inhibiting the activation of p38 MAPK in microglia, rather than a PKC isoform...
  33. ncbi request reprint MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:1134-6. 2005
    ..Thus inhibition of microgliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy...
  34. ncbi request reprint Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain
    B Liu
    Departments of Medicine and Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:34472-9. 1998
    ..The significance of these results to the regulation of N-SMase is discussed...
  35. ncbi request reprint Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death
    B Liu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:11313-20. 1998
    ..Taken together, these studies demonstrate a critical role for GSH in TNFalpha action and in connecting major components in the pathways leading to cell death...
  36. ncbi request reprint Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    Na Li
    Department of Physiology, Medical College of Qingdao University, Qingdao 266071, PR China
    J Ethnopharmacol 111:458-63. 2007
    ..In addition, the inhibitory effect of ginsenoside Rg2 against the formation of Abeta1-40 suggests that ginsenoside Rg2 may also represent a potential treatment strategy for Alzheimer's disease...
  37. ncbi request reprint [The effects of somatostatin on serum interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide-induced septic shock: experiment with rats]
    Tuan jie Zhu
    Intensive Care Unit, Hunan Wangwang Hospital, Changsha 410016, China
    Zhonghua Yi Xue Za Zhi 87:345-7. 2007
    ..To explore the effect of somatostatin on serum interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS)-induced septic shock...
  38. pmc Manganese chloride stimulates rat microglia to release hydrogen peroxide
    Ping Zhang
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Toxicol Lett 173:88-100. 2007
    ..These findings may shed significant light on the potential role of microglia in the manganese-induced neurotoxicity...
  39. pmc PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice
    Jennifer E Embury
    Department of Biochemistry and Molecular Biology, PO Box 100245, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1127:136-50. 2007
    ....
  40. pmc Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease
    Bin Liu
    Department of Pharmacodynamics, College of Pharmacy, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    AAPS J 8:E606-21. 2006
    ..This review discusses literature supporting the possibility of modulating the activity of microglia as a neuroprotective strategy for the treatment of PD...
  41. ncbi request reprint Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption
    Xuehai Zhu
    Center for Biomedical Electron Paramagnetic Resonance Spectroscopy and Imaging, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Am J Physiol Heart Circ Physiol 293:H1442-50. 2007
    ..Thus IPC markedly attenuates postischemic myocardial hyperoxygenation with less ROS/RNS generation and preservation of mitochondrial O(2) metabolism because of conserved NADH-DH and CcO activities...
  42. ncbi request reprint Activation of epidermal growth factor receptors in astrocytes: from development to neural injury
    Bin Liu
    Department of Ophthalmology, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Neurosci Res 85:3523-9. 2007
    ..Regulation of EGFR function in astrocytes may be a new therapeutic strategy for the treatment of neural disorders...
  43. ncbi request reprint Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Clin Exp Pharmacol Physiol 34:555-65. 2007
    ..5. Oestrogen was chosen as one of the 12 neuroprotective compounds to be attractive candidates for further clinical trials (Phase II or III) in 2003...
  44. ncbi request reprint Induction of microglial reactive oxygen species production by the organochlorinated pesticide dieldrin
    Haoyu Mao
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1186:267-74. 2007
    ..These findings provide important information on the potential role of microglia in dieldrin-induced neurodegeneration in relevance to the development of idiopathic PD...
  45. doi request reprint Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis
    Bo Dong
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, P R China
    Arterioscler Thromb Vasc Biol 28:1270-6. 2008
    ..The purpose of this study was to test the hypothesis that ACE2 overexpression may enhance atherosclerotic plaque stability by antagonizing ACE activity and converting angiotensin II to angiotensin 1-7...
  46. doi request reprint Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice
    Bin Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xiannongtan Street, Xuanwu District, Beijing 100050, China
    Biochem Biophys Res Commun 376:277-82. 2008
    ..Taken together, our results imply that a deficiency in 19S Rpt6 may be partially related to the MPTP-induced increase in alpha-synuclein in the striatum...
  47. pmc Formation of hydrogen peroxide and reduction of peroxynitrite via dismutation of superoxide at reperfusion enhances myocardial blood flow and oxygen consumption in postischemic mouse heart
    Yi Xu
    The Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, and Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Pharmacol Exp Ther 327:402-10. 2008
    ....
  48. doi request reprint Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin
    Haoyu Mao
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    Neuroreport 19:1317-20. 2008
    ..As microglial ROS is a key contributor to the degeneration of the oxidative damage-vulnerable dopamine neurons, our findings shed significant light on the role of OCPs in the development of Parkinson's disease...
  49. ncbi request reprint Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Neuroendocrinology 83:295-302. 2006
    ..This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease...
  50. ncbi request reprint Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Synapse 60:354-61. 2006
    ..These results demonstrate that the capacity for estrogen to protect or worsen MA-induced neurotoxicity of dopaminergic neurons is limited to female mice and depends on the condition of the NSDA system...
  51. ncbi request reprint Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity
    Bin Liu
    Epithelial Cell Biology Research Centre, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Cell Biol Int 32:86-92. 2008
    ..The present results suggest that BFP is able to protect dopaminergic neurons from neurotoxin-induced neuronal injury with anti-apoptotic activity being one of the possible mechanisms...
  52. ncbi request reprint Neuroprotective effects of Bak Foong Pill in 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease model mice
    Bin Liu
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, P R China
    Biol Pharm Bull 27:1245-50. 2004
    ..These results suggest that BFP is able to protect dopaminergic neurons against MPTP-induced neuronal damage in a mechanism that is different from the protective effect of estrogen...
  53. ncbi request reprint Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine
    Vidhya Kunnathur
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, United States
    Neurotoxicol Teratol 28:557-62. 2006
    ..In particular, the present findings have important implications in suggesting an alternative, non-traditional, mechanism for MA effects and indicate that such a function is limited to females...
  54. ncbi request reprint Glaucomatous optic neuropathy: when glia misbehave
    Arthur H Neufeld
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuroscientist 9:485-95. 2003
    ..Pharmacological inhibition of the activity or the induction of inducible nitric oxide synthase may provide neuroprotection for the treatment of glaucoma...
  55. pmc Phosphorylation state of tyrosine hydroxylase in the stalk-median eminence is decreased by progesterone in cycling female rats
    Bin Liu
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6523, USA
    Endocrinology 149:1462-9. 2008
    ....
  56. doi request reprint The value of antinuclear antibodies in primary biliary cirrhosis
    Lixia Gao
    Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Clin Exp Med 8:9-15. 2008
    ..Although autoantibodies have been used for the diagnosis of primary biliary cirrhosis (PBC), their role has not been clarified. In this study, we try to explore the value of gp210 antibody and anti-centromere antibodies (ACA) in PBC...
  57. doi request reprint Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells
    Su Min Guan
    Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi an, China
    FEMS Microbiol Lett 283:47-53. 2008
    ..Our results demonstrated that P. intermedia may contribute to periodontal tissue destruction during chronic periodontitis by inducing MMP-9 production in hPDL cells...
  58. ncbi request reprint [Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C]
    Ze Hao Zhuang
    Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, China
    Zhonghua Nei Ke Za Zhi 42:701-4. 2003
    ..To study the relationship between COX-2 expression in esophageal cancer cell (EC/CUHK-1) and mitomycin C (MMC) treatment...
  59. doi request reprint Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathway
    Bin Liu
    Department of Pharmacology, College of Medicine, Wuhan University, Wuhan 430071, China Department of Pharmacy, Hubei Cancer Hospital, Wuhan 430079, China
    Eur J Pharmacol 587:257-66. 2008
    ....
  60. ncbi request reprint The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy
    Shannon D Barker
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 5:300-10. 2003
    ..We hypothesize that selective adenovirus-mediated transgene expression could be achieved through the use of the secretory leukoprotease inhibitor (SLPI) promoter in the context of ovarian cancer...
  61. ncbi request reprint Comparison of the signal transduction pathways for the induction of gene expression of nitric oxide synthase-2 in response to two different stimuli
    Arthur H Neufeld
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St Louis, MO 63110, USA
    Nitric Oxide 8:95-102. 2003
    ..Our data suggest that activation of different sites in the promoter region of the NOS-2 gene is needed for these different stimuli to induce NOS-2...
  62. ncbi request reprint Increased dopamine release in vivo by estradiol benzoate from the central amygdaloid nucleus of Parkinson's disease model rats
    Bin Liu
    Department of Physiology, Medical College of Qingdao University, Qingdao, China
    J Neurochem 90:654-8. 2004
    ..The well established neuroprotective effects of estrogen may be beneficial for reducing the dysfunction of dopaminergic neurons in mesolimbic structures of rat PD models and PD patients...
  63. ncbi request reprint Acetylbritannilactone Inhibits Neointimal Hyperplasia after Balloon Injury of Rat Artery by Suppressing Nuclear Factor-{kappa}B Activation
    Bin Liu
    Department of Biochemistry and Molecular Biology, Institute of Basic Medicine, Hebei Medical University, No 361, Zhongshan East Road, Shijiazhuang 050017, People s Republic of China
    J Pharmacol Exp Ther 324:292-8. 2008
    ..These findings suggest that ABL is a potential inhibitor of neointimal formation because it blocks injury-induced NF-kappaB activation and may have beneficial effects in reducing the risk of restenosis after angioplasty...
  64. ncbi request reprint Epidermal growth factor receptor in adult retinal neurons of rat, mouse, and human
    Huiyi Chen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 500:299-310. 2007
    ..Our work localizes EGFR and its ligands in the adult retinas of several species as a step toward investigating the nonmitogenic functions of EGFR in adult neurons...
  65. ncbi request reprint PDGF-BB enhances monocyte chemoattractant protein-1 mRNA stability in smooth muscle cells by downregulating ribonuclease activity
    Bin Liu
    Department of Medicine, University of Rochester, Box 679, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Cell Cardiol 41:160-9. 2006
    ..These studies provide new insights into the mechanisms by which PDGF-BB enhances mRNA accumulation...
  66. ncbi request reprint Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera
    Xiu feng Zhang
    State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080, China
    Bioorg Med Chem Lett 16:949-53. 2006
    ..Only 1 obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages...
  67. ncbi request reprint A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability
    Latika Dhawan
    Cardiovascular Research Institute, University of Rochester, Rochester, New York 14620, USA
    J Biol Chem 282:10146-52. 2007
    ..These data suggest a novel role for the GR in binding to and facilitating mRNA degradation. These results provide novel insights into GR function and may provide a new approach to attenuate the inflammatory response mediated by MCP-1...
  68. pmc Negative regulation of NF-kappaB signaling by PIAS1
    Bin Liu
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    Mol Cell Biol 25:1113-23. 2005
    ..Consistently, Pias1 null mice showed elevated proinflammatory cytokines. Our results identify PIAS1 as a novel negative regulator of NF-kappaB...
  69. ncbi request reprint Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve
    Bin Liu
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 273:297-307. 2004
    ..We hypothesize that in the developing optic nerve, EGFR activity directs the formation of a histo-architectural structure of astrocytes which surrounds axons and provides a permissive environment for axon development...
  70. pmc Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation
    Samuel Tahk
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:11643-8. 2007
    ..Our results demonstrate that PIASy cooperates with PIAS1 to regulate the specificity and magnitude of NF-kappaB/STAT1-mediated gene activation...
  71. ncbi request reprint Transcriptional targeting of tumors with a novel tumor-specific survivin promoter
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
    Cancer Gene Ther 11:256-62. 2004
    ....
  72. ncbi request reprint Towards proteome-wide production of monoclonal antibody by phage display
    Bin Liu
    Department of Anesthesia, University of California, San Francisco, Rm 3C 38, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Mol Biol 315:1063-73. 2002
    ..Automation of this process should allow high throughput production of monoclonal phage antibodies against cellular proteins as well as proteins that are uniquely expressed under pathological conditions...