M P Little

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Impact of Uncertainties in Exposure Assessment on Estimates of Thyroid Cancer Risk among Ukrainian Children and Adolescents Exposed from the Chernobyl Accident
    Mark P Little
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 9:e85723. 2014
  2. pmc A review of non-cancer effects, especially circulatory and ocular diseases
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, 9609 Medical Center Drive MSC 9778, Bethesda, MD, 20892 9778, USA
    Radiat Environ Biophys 52:435-49. 2013
  3. pmc Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, 9609 Medical Center Drive, MSC 9778, Bethesda, MD 20892 9778, USA Electronic address
    Mutat Res 753:50-67. 2013
  4. pmc Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852 7238, USA
    Environ Health Perspect 120:1503-11. 2012
  5. pmc A reanalysis of curvature in the dose response for cancer and modifications by age at exposure following radiation therapy for benign disease
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, Rockville, Maryland 20852 7238, USA
    Int J Radiat Oncol Biol Phys 85:451-9. 2013
  6. pmc Analysis of dose response for circulatory disease after radiotherapy for benign disease
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland, USA
    Int J Radiat Oncol Biol Phys 84:1101-9. 2012
  7. pmc Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States
    M P Little
    Radiation Epidemiology Branch, National Cancer Institute, Rockville, MD 20852 7238, USA
    BMJ 344:e1147. 2012
  8. pmc Analysis of retinoblastoma age incidence data using a fully stochastic cancer model
    Mark P Little
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, NIH, Bethesda, MD 20852 7238, USA
    Int J Cancer 130:631-40. 2012
  9. pmc The statistical power of epidemiological studies analyzing the relationship between exposure to ionizing radiation and cancer, with special reference to childhood leukemia and natural background radiation
    M P Little
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College Faculty of Medicine, London W2 1PG, United Kingdom
    Radiat Res 174:387-402. 2010
  10. pmc Do non-targeted effects increase or decrease low dose risk in relation to the linear-non-threshold (LNT) model?
    M P Little
    Department of Epidemiology and Biostatistics, Imperial College School of Public Health, Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Mutat Res 687:17-27. 2010

Detail Information

Publications17

  1. pmc Impact of Uncertainties in Exposure Assessment on Estimates of Thyroid Cancer Risk among Ukrainian Children and Adolescents Exposed from the Chernobyl Accident
    Mark P Little
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 9:e85723. 2014
    ..In conclusion, dose-error adjustment has comparatively modest effects on regression parameters, a consequence of the relatively small errors, of a mixture of Berkson and classical form, associated with thyroid dose assessment. ..
  2. pmc A review of non-cancer effects, especially circulatory and ocular diseases
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, 9609 Medical Center Drive MSC 9778, Bethesda, MD, 20892 9778, USA
    Radiat Environ Biophys 52:435-49. 2013
    ..However, because these are generally only observed in isolated groups, or because the evidence is excessively heterogeneous, these associations must be treated with caution. ..
  3. pmc Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, 9609 Medical Center Drive, MSC 9778, Bethesda, MD 20892 9778, USA Electronic address
    Mutat Res 753:50-67. 2013
    ..Further research that may help resolve the apparent discrepancies between cellular/animal studies and studies of human health are outlined. ..
  4. pmc Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852 7238, USA
    Environ Health Perspect 120:1503-11. 2012
    ..However, recent analyses suggest excess relative risks at occupational exposure levels...
  5. pmc A reanalysis of curvature in the dose response for cancer and modifications by age at exposure following radiation therapy for benign disease
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, Rockville, Maryland 20852 7238, USA
    Int J Radiat Oncol Biol Phys 85:451-9. 2013
    ..To assess the shape of the dose response for various cancer endpoints and modifiers by age and time...
  6. pmc Analysis of dose response for circulatory disease after radiotherapy for benign disease
    Mark P Little
    Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland, USA
    Int J Radiat Oncol Biol Phys 84:1101-9. 2012
    ..To assess the shape of the dose-response for various circulatory disease endpoints, and modifiers by age and time since exposure...
  7. pmc Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States
    M P Little
    Radiation Epidemiology Branch, National Cancer Institute, Rockville, MD 20852 7238, USA
    BMJ 344:e1147. 2012
    ....
  8. pmc Analysis of retinoblastoma age incidence data using a fully stochastic cancer model
    Mark P Little
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, NIH, Bethesda, MD 20852 7238, USA
    Int J Cancer 130:631-40. 2012
    ..The results strongly suggest that knockout of the two alleles of the RB1 gene is necessary and may be largely sufficient for the development of RB, in support of Knudson's two-hit hypothesis...
  9. pmc The statistical power of epidemiological studies analyzing the relationship between exposure to ionizing radiation and cancer, with special reference to childhood leukemia and natural background radiation
    M P Little
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College Faculty of Medicine, London W2 1PG, United Kingdom
    Radiat Res 174:387-402. 2010
    ..Sufficiently large studies should be capable of detecting the predicted risk attributable to natural background radiation...
  10. pmc Do non-targeted effects increase or decrease low dose risk in relation to the linear-non-threshold (LNT) model?
    M P Little
    Department of Epidemiology and Biostatistics, Imperial College School of Public Health, Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Mutat Res 687:17-27. 2010
    ..If there is to be modification by low doses of ionizing radiation of cardiovascular disease through this mechanism, a role for non-DNA-targeted effects cannot be excluded...
  11. doi request reprint Leukaemia following childhood radiation exposure in the Japanese atomic bomb survivors and in medically exposed groups
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Radiat Prot Dosimetry 132:156-65. 2008
    ..The effects of cell sterilisation can largely explain the discrepancy between the Japanese and the medical series...
  12. ncbi request reprint A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London W2 1PG, United Kingdom
    Radiat Res 169:99-109. 2008
    ..Further epidemiological and biological evidence will allow a firmer conclusion to be drawn...
  13. ncbi request reprint On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer
    T Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Radiat Environ Biophys 40:191-7. 2001
    ..e. considerably less than the total number of follicular cells in the thyroid gland...
  14. ncbi request reprint The bystander effect model of Brenner and Sachs fitted to lung cancer data in 11 cohorts of underground miners, and equivalence of fit of a linear relative risk model with adjustment for attained age and age at exposure
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Radiol Prot 24:243-55. 2004
    ..In particular, both models are capable of describing the observed inverse dose rate effect in this data set...
  15. ncbi request reprint The bystander effect in C3H 10T cells and radon-induced lung cancer
    M P Little
    Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    Radiat Res 156:695-9. 2001
    ..As a consequence, the bystander effect observed in the experimental C3H 10T(1/2) cell system probably does not play a large part in the process of radon-induced lung carcinogenesis in humans...
  16. pmc Systems biological and mechanistic modelling of radiation-induced cancer
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London W2 1PG, UK
    Radiat Environ Biophys 47:39-47. 2008
    ....
  17. ncbi request reprint A model for radiation-induced bystander effects, with allowance for spatial position and the effects of cell turnover
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    J Theor Biol 232:329-38. 2005
    ..It is shown that the generally intractable solution of the full stochastic system can be considerably simplified by assumption of pairwise conditional dependence that varies exponentially over time...