R H Lipsky

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Single-nucleotide polymorphism allele frequencies determined by quantitative kinetic assay of pooled DNA
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism NIH, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Rockville, MD 20852, USA
    Clin Chem 48:1605-8. 2002
  2. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005
  3. ncbi request reprint Genomics and variation of ionotropic glutamate receptors: implications for neuroplasticity
    R H Lipsky
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Amino Acids 28:169-75. 2005
  4. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
  5. ncbi request reprint DNA melting analysis for detection of single nucleotide polymorphisms
    R H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Clin Chem 47:635-44. 2001
  6. ncbi request reprint Genomics and variation of ionotropic glutamate receptors
    Robert H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
    Ann N Y Acad Sci 1003:22-35. 2003
  7. ncbi request reprint Nuclear factor kappaB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection
    R H Lipsky
    Laboratory of Neurogenetics, NIAAA, NIH, Rockville, Maryland 20852, USA
    J Neurochem 78:254-64. 2001
  8. ncbi request reprint Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli
    A M Marini
    Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Amino Acids 32:299-304. 2007
  9. ncbi request reprint Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons
    D Zhu
    Department of Neurology and Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Amino Acids 23:11-7. 2002
  10. pmc Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence
    K Xu
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Pharmacogenomics J 7:368-79. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Single-nucleotide polymorphism allele frequencies determined by quantitative kinetic assay of pooled DNA
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism NIH, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Rockville, MD 20852, USA
    Clin Chem 48:1605-8. 2002
  2. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005
    ..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci...
  3. ncbi request reprint Genomics and variation of ionotropic glutamate receptors: implications for neuroplasticity
    R H Lipsky
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Amino Acids 28:169-75. 2005
    ....
  4. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  5. ncbi request reprint DNA melting analysis for detection of single nucleotide polymorphisms
    R H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Clin Chem 47:635-44. 2001
    ..g., denaturing gradient gel electrophoresis and denaturing HPLC) are indirectly based on the principle of differential melting of heteroduplex DNA. We present a method for detecting SNPs that is directly based on this principle...
  6. ncbi request reprint Genomics and variation of ionotropic glutamate receptors
    Robert H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
    Ann N Y Acad Sci 1003:22-35. 2003
    ....
  7. ncbi request reprint Nuclear factor kappaB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection
    R H Lipsky
    Laboratory of Neurogenetics, NIAAA, NIH, Rockville, Maryland 20852, USA
    J Neurochem 78:254-64. 2001
    ..We also determined that BDNF itself induced an NF-kappaB DNA binding activity. Taken together, these data support a mechanism where NF-kappaB plays a critical role in NMDA-mediated neuroprotection...
  8. ncbi request reprint Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli
    A M Marini
    Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Amino Acids 32:299-304. 2007
    ....
  9. ncbi request reprint Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons
    D Zhu
    Department of Neurology and Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Amino Acids 23:11-7. 2002
    ..Therefore, the PI-3 kinase/Akt pathway is co-activated by NMDA and TrkB receptors. The kinetics of BDNF and NMDA-mediated activation of PI-3 kinase/Akt suggests that they have different roles in intraneuronal time-related events...
  10. pmc Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence
    K Xu
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Pharmacogenomics J 7:368-79. 2007
    ..057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD...
  11. ncbi request reprint BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
    Xueying Jiang
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:1353-61. 2005
    ..01). Our results suggest that in this population, the low activity -281 A allele may be protective against anxiety and psychiatric morbidity, whereas Met 66 may be a risk allele...
  12. ncbi request reprint Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Hum Genet 13:341-51. 2005
    ..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function...
  13. pmc Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder
    Colin A Hodgkinson
    Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Am J Hum Genet 75:862-72. 2004
    ..These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders...
  14. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
    ..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function...
  15. pmc Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006
    ..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...
  16. ncbi request reprint Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Arch Gen Psychiatry 61:597-606. 2004
    ..Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial...
  17. ncbi request reprint Sites in the fourth membrane-associated domain regulate alcohol sensitivity of the NMDA receptor
    Yumiko Honse
    Unit on Cellular Neuropharmacology, Laboratory of Molecular and Cellular Neurobiology and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
    Neuropharmacology 46:647-54. 2004
    ..The changes in mean open time did not appear to be able to account for the observed differences in ethanol sensitivity. These results indicate that this region in M4 of the NR2A subunit may be involved in the action of alcohol...
  18. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..As such, CRH gene variation may influence risk for alcohol use and dependence...
  19. ncbi request reprint Zhou et al. reply
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 458:E7. 2009
    ..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results...
  20. ncbi request reprint Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    Xian Zhang Hu
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:783-92. 2007
    ....
  21. ncbi request reprint The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons
    Xueying Jiang
    Department of Neurology and Division of Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurochem 94:713-22. 2005
    ....
  22. pmc The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus
    G Oroszi
    Laboratory of Neurogenetics, National Institute of Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Ann Rheum Dis 65:1330-5. 2006
    ..As cognitive function is commonly impaired in patients with systemic lupus erythematosus (SLE), the association of the BDNF Val66Met with neurocognitive function was studied...
  23. ncbi request reprint Association of COMT Val158Met genotype with executive functioning following traumatic brain injury
    Robert H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    J Neuropsychiatry Clin Neurosci 17:465-71. 2005
    ....
  24. pmc NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons
    Feng Tian
    Section on Cancer Genetics, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Amino Acids 38:1067-74. 2010
    ....
  25. ncbi request reprint Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay
    Guanshan Zhu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Dr, Rockville, MD 20852, USA
    Psychopharmacology (Berl) 177:178-84. 2004
    ..However, disparate findings by another group who used the same method, but in lymphoblasts, raise the issues of tissue specificity, magnitude of differential expression, and identity of loci altering expression...
  26. doi request reprint Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1
    Feng Tian
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    J Neurochem 109:1375-88. 2009
    ..These temporal changes in promoter occupancy could occur thousands of base pairs 5' of the TSS, suggesting a mechanism that produces waves of Bdnf transcription...
  27. ncbi request reprint A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating
    Hong Ren
    Unit on Cellular Neuropharmacology, Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8115, USA
    J Biol Chem 278:276-83. 2003
    ..These results demonstrate an important role for hydrophobic interactions at Met(823) in regulation of NMDA receptor function...
  28. ncbi request reprint Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors
    Ann M Marini
    Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    CNS Neurol Disord Drug Targets 7:382-90. 2008
    ..This mechanism, activation of N-methyl-D-aspartate receptors and its integral relationship with brain-derived neurotrophic factor, may be a critical and general mechanism developed in brain to respond to stressful stimuli...
  29. doi request reprint Human BDNF isoforms are differentially expressed in cocaine addicts and are sorted to the regulated secretory pathway independent of the Met66 substitution
    Xueying Jiang
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892 9412, USA
    Neuromolecular Med 11:1-12. 2009
    ..Together, these findings support a mechanism by which variant BDNF proteins can overcome the functional defect of the Met66 substitution and suggest how functional differences in BDNF may impact brain responses in disease...
  30. doi request reprint Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons
    Feng Tian
    Section on Cancer Genetics, Genetics Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1199:186-93. 2010
    ..Taken together, these findings suggest that inhibition of HDAC activity by TSA activates Bdnf transcription and a compensatory change in HDAC1 expression in neurons. This response may reflect a genome-wide change in gene expression...
  31. ncbi request reprint Hormesis: a promising strategy to sustain endogenous neuronal survival pathways against neurodegenerative disorders
    Ann M Marini
    Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Ageing Res Rev 7:21-33. 2008
    ....
  32. pmc N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway
    Daming Zhu
    Department of Neurology and Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci Res 80:104-13. 2005
    ..By increasing antiapoptotic proteins of the Bcl-2 family, NMDA receptor activation may also promote neuronal survival by preventing apoptosis...
  33. doi request reprint Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome
    James J Crowley
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Psychiatr Genet 18:248-51. 2008
    ..These data do not rule out the possible involvement of SLC18A2 or ADRB1 in antidepressant treatment response as these genes may contribute a small effect size or interact epistatically with other genes...
  34. ncbi request reprint Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype
    Ann M Marini
    Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Restor Neurol Neurosci 22:121-30. 2004
    ....
  35. ncbi request reprint Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity
    Robert H Lipsky
    Section of Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20814, USA
    Ann N Y Acad Sci 1122:130-43. 2007
    ..A better understanding of the influence of BDNF-mediated pathways in cell survival and plasticity will aid in developing new approaches to restoring normal function in disease states...
  36. ncbi request reprint Determination of melting temperature for variant detection using dHPLC: a comparison between an empirical approach and DNA melting prediction software
    Joseph G Rudolph
    Transgenomic, Inc, Gaithersburg, MD 20878, USA
    Genet Test 6:169-76. 2002
    ..A wide range of amplicons, differing in both size and GC composition, were selected for analysis to simulate the broad spectrum of PCR products that may be encountered during a large-scale dHPLC screening project...