Jeih San Liow

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein
    Nicholas Seneca
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:807-13. 2009
  2. ncbi P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys
    Jeih San Liow
    Molecular Imaging Branch, PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 50:108-15. 2009
  3. ncbi Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY
    Jeih San Liow
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:96-105. 2007
  4. ncbi Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates
    Dnyanesh N Tipre
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 1 Rm B3 10, 1 Center Drive, Bethesda, MD 20892 0135, USA
    Nucl Med Commun 25:737-42. 2004
  5. ncbi Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 47:2208-18. 2004
  6. ncbi Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 64:699-703. 2010
  7. ncbi Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET
    Jian Qiang Lu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 45:1555-9. 2004
  8. ncbi D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 50:1402-7. 2010
  9. ncbi Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands
    Garth E Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 51:112-20. 2010
  10. ncbi Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements
    Xiang Yang Zhang
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:469-77. 2007

Detail Information

Publications61

  1. ncbi Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein
    Nicholas Seneca
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 50:807-13. 2009
    ..The purposes of this study were to determine whether (11)C-dLop is a substrate for P-gp at the blood-brain barrier in humans and to measure the distribution of radioactivity in the entire body to estimate radiation exposure...
  2. ncbi P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys
    Jeih San Liow
    Molecular Imaging Branch, PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 50:108-15. 2009
    ..Should further demethylation of 11C-dLop occur, radiometabolites with low entry into the brain are generated. Therefore, we evaluated the ability of 11C-dLop to quantify the function of P-gp at the blood-brain barrier in monkeys...
  3. ncbi Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY
    Jeih San Liow
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:96-105. 2007
    ..The effects of CsA in rats are mediated by both P-gp blockade and displacement of the radiotracer from plasma proteins. Studies with wild type and knockout mice showed that CsA affected only P-gp in this species...
  4. ncbi Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates
    Dnyanesh N Tipre
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 1 Rm B3 10, 1 Center Drive, Bethesda, MD 20892 0135, USA
    Nucl Med Commun 25:737-42. 2004
    ..The aim of the current study was to quantify the distribution of radioactivity in three rhesus monkeys after the injection of approximately 185 MBq (5 mCi) of 18F-FECNT...
  5. ncbi Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 47:2208-18. 2004
    ....
  6. ncbi Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 64:699-703. 2010
    ..In summary, our results suggest that DBH knockout mice have normal levels of D(2) receptors in the high-affinity state and that additional mechanisms contribute to their behavioral sensitivity to psychostimulants...
  7. ncbi Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET
    Jian Qiang Lu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 45:1555-9. 2004
    ..The goal of this study was to provide dosimetry estimates for 11C-DASB based on human whole-body PET...
  8. ncbi D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 50:1402-7. 2010
    ..In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice...
  9. ncbi Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands
    Garth E Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 51:112-20. 2010
    ..We evaluated several promising analogs in the monkey brain and chose the (18)F-di-deutero fluoromethoxy analog ((18)F-FMPEP-d(2)) to evaluate further in the human brain...
  10. ncbi Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements
    Xiang Yang Zhang
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:469-77. 2007
    ..Although prior studies in rodents and nonhuman primates showed [(11)C](R)-(-)-RWAY to be a promising radiotracer, we suspect that a species difference in metabolism caused this serious deficiency in humans...
  11. ncbi Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 34:681-9. 2007
    ..Calculated dosimetry results are comparable with those for other (11)C-labeled brain imaging radioligands...
  12. ncbi 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
    J Nucl Med 49:649-56. 2008
    ..We evaluated 11C-loperamide as a PET radiotracer to measure P-gp function in vivo...
  13. ncbi Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 26:1201-10. 2005
    ..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)...
  14. ncbi Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    J Nucl Med 49:2042-8. 2008
    ....
  15. ncbi Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function
    Neva Lazarova
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Med Chem 51:6034-43. 2008
    ..11)C]3 is an effective new radiotracer for imaging brain P-gp function and, in favor of future successful quantification, appears free of extensive brain-penetrant radiometabolites...
  16. ncbi Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA: a dopamine agonist radioligand
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, Building 31, Bethesda, MD 20892, USA
    Synapse 62:700-9. 2008
    ..4 muSv/MBq (23.5 mrem/mCi). In conclusion, brain uptake of [(11)C]MNPA reflected the density of D(2/3) receptors, quantified relative to serial arterial measurements, and caused moderate to low radiation exposure...
  17. ncbi Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET
    Hiroshi Toyama
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 31:251-6. 2004
    ..Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used...
  18. ncbi P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Nucl Med 51:559-66. 2010
    ..We examined the ability of (11)C-dLop to quantify P-gp function in humans after increasing doses of tariquidar, an inhibitor of P-gp...
  19. ncbi Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis
    David R Sprague
    Molecular Imaging Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 48:100-7. 2007
    ..The aims of this study were to estimate the radiation safety profile and relative risks of [(18)F]SPA-RQ with 3 different methods of image analysis...
  20. ncbi PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole
    Dnyanesh N Tipre
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:345-53. 2006
    ..Our aim was to demonstrate with a rat model that defluorination of 18F-FCWAY may be inhibited in vivo to improve its applicability to measuring brain regional 5-HT1A receptor densities...
  21. ncbi Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain
    Masanori Ichise
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 23:1096-112. 2003
    ..MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies...
  22. ncbi PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:520-7. 2006
    ....
  23. ncbi Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography
    Hiroshi Toyama
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 45:1398-405. 2004
    ..In addition, we compared the rCMR(glc) values under isoflurane, ketamine and xylazine anesthesia, and awake states...
  24. ncbi Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 48:2072-9. 2007
    ..The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein...
  25. ncbi Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS ONE 6:e17056. 2011
    ..Three of the methods required arterial blood samples to scale the image-input, and four were blood-free methods...
  26. ncbi Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1026, USA
    Biol Psychiatry 72:548-54. 2012
    ..This study sought to quantify the binding of 11C-(R)-rolipram, a PDE4 inhibitor, as an indirect measure of this enzyme's activity in the brain of individuals with major depressive disorder (MDD) compared with healthy control subjects...
  27. ncbi Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography
    Garth E Terry
    Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, Bethesda, MD 20892 2035, USA
    Eur J Nucl Med Mol Imaging 37:1499-506. 2010
    ..We recently reported brain imaging of CB(1) receptors with two PET radioligands: (11)C-MePPEP and (18)F-FMPEP-d (2). Here we describe the biodistribution and dosimetry estimates for these two radioligands...
  28. ncbi Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch and Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:148-58. 2008
    ..The ex vivo brain radiometabolites observed in rats have a peripheral origin. Overall, [ (11)C] 7 merits further evaluation in human subjects...
  29. ncbi PET [11C]DASB imaging of serotonin transporters in patients with alcoholism
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 31:28-32. 2007
    ..We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics...
  30. ncbi Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Neuroimage 54:1903-9. 2011
    ..The aims of this study were to perform kinetic modeling of [(11)C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in humans with an image-derived input function...
  31. ncbi Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents
    Garth Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuroimage 41:690-8. 2008
    ..Radiometabolites of [11C]MePPEP in brain caused distribution volume to be overestimated by approximately 13%...
  32. ncbi Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 2035, USA
    Nucl Med Commun 33:982-9. 2012
    ..The present study used both simulated and clinical [11C](R)-rolipram data to assess the robustness of a blood-based IDIF method (a method that is ultimately normalized with blood samples) with regard to motion artifacts...
  33. ncbi Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype
    Xiaofeng Bao
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 55:2406-15. 2012
    ..The nitro compound 12 was found to have even higher H(3) receptor affinity, indicating the potential of this chemotype for the development of further promising PET radioligands...
  34. ncbi N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier
    Pavitra Kannan
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Drug Metab Dispos 38:917-22. 2010
    ..e., a competitive substrate). Because low concentrations of radiotracer are used for PET imaging, [(11)C]dLop acts selectively and only as a substrate for P-gp...
  35. ncbi Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain
    Yong Hoon Ryu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 48:1154-61. 2007
    ..We previously showed that miconazole, an inhibitor of CYP2E1, blocks defluorination of FCWAY in rats. Here, we used (18)F-FCWAY to test the ability of the less toxic agent disulfiram to inhibit defluorination in humans...
  36. ncbi Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I
    H Umesha Shetty
    PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C351, MSC 1003, 10 Center Drive, Bethesda, MD 20892 1003, USA
    Eur J Nucl Med Mol Imaging 34:667-78. 2007
    ..We aimed to determine the composition of radioactivity in rat brain after intravenous administration of the dopamine transporter radioligand, [(11)C]PE2I...
  37. ncbi Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
    Pavitra Kannan
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:2593-8. 2011
    ..In summary, tariquidar and [(11)C]dLop can be used in combination to selectively measure the function of P-gp at the blood-brain barrier...
  38. ncbi Evaluation of 2 scatter correction methods using a striatal phantom for quantitative brain SPECT
    Douglass C Vines
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med Technol 31:157-60. 2003
    ..The first is based on thresholding the energy spectrum (ES), and the second is based on a modification of the transmission-dependent convolution subtraction (TDCS) method...
  39. ncbi Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses
    David R Sprague
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 35:493-500. 2008
    ..The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans...
  40. ncbi Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, I Center Drive, MSC 0135, Bethesda, MD, USA
    Ann Neurol 59:174-7. 2006
    ..Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects...
  41. ncbi Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    Synapse 62:756-63. 2008
    ....
  42. ncbi Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography
    Giuseppe Esposito
    Brain Physiology and Metabolism Section, Bldg 9, Rm 1S128, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Neuroimage 34:1342-51. 2007
    ..This signaling process can be imaged in brain as a regional brain AA incorporation coefficient K*...
  43. ncbi Population-based input function and image-derived input function for [¹¹C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuroimage 63:1532-41. 2012
    ....
  44. ncbi The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans
    Madhav Thambisetty
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 32:676-84. 2012
    ..1-(11)C]AA PET may be useful for studying disturbances of dopaminergic neurotransmission in conditions such as Parkinson's disease and schizophrenia...
  45. ncbi Synthesis and characterization in monkey of [(11)C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors
    Fabrice G Siméon
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Rm B3 C346A, 10 Center Drive, Bethesda, MD, 20892, USA
    Eur J Nucl Med Mol Imaging 39:1949-58. 2012
    ..4 min) and to characterize its behavior as a radioligand with PET in the monkey...
  46. ncbi [¹¹C]Rhodamine-123: synthesis and biodistribution in rodents
    Xiaofeng Bao
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1003, USA
    Nucl Med Biol 39:1128-36. 2012
    ..For this purpose, we aimed to label rhodamine-123 with carbon-11 (t(1/2)=20.4min) and to study its biodistribution in rodents...
  47. ncbi Human biodistribution and dosimetry of ¹¹C-CUMI-101, an agonist radioligand for serotonin-1a receptors in brain
    Christina S Hines
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e25309. 2011
    ..The purpose of this study was to calculate the radiation exposure to organs of the body based on serial whole-body imaging with positron emission tomography (PET) in human subjects...
  48. ncbi Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat br
    H Umesha Shetty
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1003, USA
    J Pharmacol Exp Ther 327:727-35. 2008
    ..Thus, glutathionylation at the 2-fluoromethyl group is responsible for the radiodefluorination of [(18)F]SP203 in rat. This study provides the first demonstration of glutathione-promoted radiodefluorination of a PET radioligand...
  49. ncbi Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease
    José A Rodríguez-Gómez
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, National Institute of Health, Bethesda, Maryland 20892, USA
    Stem Cells 25:918-28. 2007
    ..This work supports continued interest in ES cells as a source of functional DA neurons...
  50. ncbi Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 40:245-53. 2013
    ..Two allosteric modulators of the group I metabotropic glutamate receptors (mGluR1 and mGluR5) were evaluated as positron emission tomography (PET) radioligands for mGluR1...
  51. ncbi Image-derived input function for brain PET studies: many challenges and few opportunities
    Paolo Zanotti-Fregonara
    Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892 2035, USA
    J Cereb Blood Flow Metab 31:1986-98. 2011
    ..Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function...
  52. ncbi Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
    Garth E Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 48:362-70. 2009
    ..These results suggest that brain uptake can be used for within subject studies (e.g., to measure receptor occupancy by medications) but that distribution volume remains the gold standard for accurate measurements between groups...
  53. ncbi Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET
    Giuseppe Esposito
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 49:1414-21. 2008
    ..Data also indicate that neuroinflammation contributes to Alzheimer's disease (AD). On the basis of these observations, K* for AA was hypothesized to be elevated in patients with AD...
  54. ncbi Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ
    Yota Fujimura
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:94-7. 2009
    ..We also sought to determine if a drug-induced panic attack releases substance P in brain, as measured by decreased binding of [(18)F]SPA-RQ...
  55. ncbi Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors
    John L Musachio
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346, 10 Center Drive, Bethesda, MD 20892-1003, USA
    Bioorg Med Chem Lett 16:3101-4. 2006
    ..Contrary to our expectations, both of these ligands provided brain images that were more typical of those shown by agents binding to the DAT...
  56. ncbi Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance
    Joseph Tam
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 16:167-79. 2012
    ..Thus, inverse agonism at peripheral CB(1)R not only improves cardiometabolic risk in obesity but has antiobesity effects by reversing leptin resistance...
  57. ncbi PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
    Hiroshi Toyama
    Department of Radiology, Fujita Health University, 1 98, Dengakugakubo, Kutsukake, Toyoake, 470 1192, Aichi, Japan
    Eur J Nucl Med Mol Imaging 32:593-600. 2005
    ..The purpose of this study was to evaluate the capacity of [11C]6-OH-BTA-1 and positron emission tomography (PET) to quantify beta-amyloid (Abeta) plaques in the Tg2576 mouse model of Alzheimer's disease (AD)...
  58. ncbi Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates
    Nicholas Seneca
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
    Nucl Med Commun 26:695-700. 2005
    ..In this work, we quantified the biodistribution over time and radiation exposure to multiple organs with (S,S)-[F]FMeNER-D2...
  59. ncbi Production and dosimetry of [14O]water for PET activation studies
    Munawwar Sajjad
    PET Imaging Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Appl Radiat Isot 57:607-15. 2002
    ..At their peak activity concentrations the noise equivalent count rate for 14O was found to be about 13% less than that for 15O...
  60. ncbi Repetitive supply-demand ischemia with dobutamine increases glucose uptake in postischemic and remote myocardium
    Edward O McFalls
    Department of Medicine, VA Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Nucl Med 44:85-91. 2003
    ..This would make it difficult to discriminate postischemic from remote myocardium with glucose tracers...
  61. ncbi Glucose uptake and glycogen levels are increased in pig heart after repetitive ischemia
    Edward O McFalls
    Cardiology Dept, 111C, Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Heart Circ Physiol 282:H205-11. 2002
    ....