Michail S Lionakis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Drosophila and Galleria insect model hosts: new tools for the study of fungal virulence, pharmacology and immunology
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virulence 2:521-7. 2011
  2. doi request reprint New insights into innate immune control of systemic candidiasis
    Michail S Lionakis
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Med Mycol 52:555-64. 2014
  3. pmc Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 8:e1002865. 2012
  4. pmc Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm11N113, Bethesda, MD 20892, USA
    Cardiovasc Res 97:580-8. 2013
  5. pmc Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice
    Wuzhou Wan
    Molecular Signaling Section, Laboratory of Molecular Immunology LMI, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Cardiovasc Res 106:478-87. 2015
  6. pmc Organ-specific innate immune responses in a mouse model of invasive candidiasis
    Michail S Lionakis
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Innate Immun 3:180-99. 2011
  7. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
  8. doi request reprint Regulation of motor function and behavior by atypical chemokine receptor 1
    Erich H Schneider
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID NIH, Bethesda, MD, USA
    Behav Genet 44:498-515. 2014
  9. pmc Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands
    Muthulekha Swamydas
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, Bethesda, MD, 20892, USA
    Cell Mol Life Sci 72:2157-75. 2015
  10. pmc CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans
    Timothy J Break
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    Infect Immun 83:958-65. 2015

Collaborators

Detail Information

Publications12

  1. pmc Drosophila and Galleria insect model hosts: new tools for the study of fungal virulence, pharmacology and immunology
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virulence 2:521-7. 2011
    ..In this review, we discuss how the insects Drosophila melanogaster and Galleria mellonella can be employed for the study of various facets of host-fungal interactions as complementary hosts to conventional vertebrate animal models...
  2. doi request reprint New insights into innate immune control of systemic candidiasis
    Michail S Lionakis
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Med Mycol 52:555-64. 2014
    ..In this review, the new developments in our understanding of how the mammalian immune system responds to systemic Candida challenge are synthesized and important future research directions are highlighted. ..
  3. pmc Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 8:e1002865. 2012
    ..Thus, neutrophil Ccr1 amplifies late renal immunopathology and increases mortality in invasive candidiasis by mediating excessive recruitment of neutrophils from the blood to the target organ...
  4. pmc Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm11N113, Bethesda, MD 20892, USA
    Cardiovasc Res 97:580-8. 2013
    ..Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis...
  5. pmc Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice
    Wuzhou Wan
    Molecular Signaling Section, Laboratory of Molecular Immunology LMI, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Cardiovasc Res 106:478-87. 2015
    ..Here we investigated the role of Ackr1 in chronic inflammation, in particular in the setting of atherogenesis, using the apolipoprotein E-deficient (ApoE(-/-)) mouse model...
  6. pmc Organ-specific innate immune responses in a mouse model of invasive candidiasis
    Michail S Lionakis
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Innate Immun 3:180-99. 2011
    ..The results delineate immune responses to the same pathogen that are highly idiosyncratic for each organ tested. The work provides novel insights into the balance between effective host defense and immunopathology in IC...
  7. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
    ..Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined...
  8. doi request reprint Regulation of motor function and behavior by atypical chemokine receptor 1
    Erich H Schneider
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID NIH, Bethesda, MD, USA
    Behav Genet 44:498-515. 2014
    ..Together, the results suggest that normal motor function and behavior may partly depend on negative regulation of Purkinje cell activity by Ackr1. ..
  9. pmc Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands
    Muthulekha Swamydas
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, Bethesda, MD, 20892, USA
    Cell Mol Life Sci 72:2157-75. 2015
    ..Herein, we critically review how a variety of G-protein coupled chemoattractant receptors and their ligands mediate mononuclear phagocyte recruitment and effector function during infection by the most common human fungal pathogens. ..
  10. pmc CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans
    Timothy J Break
    Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    Infect Immun 83:958-65. 2015
    ....
  11. pmc Drosophila melanogaster as a model organism for invasive aspergillosis
    Michail S Lionakis
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Methods Mol Biol 845:455-68. 2012
    ..These methods can also be adapted to study pathogenesis and antifungal drug activity against other medically important human fungal pathogens...