Research Topics
Genomes and GenesSpecies | R S LindsaySummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetesR S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes 49:445-9. 2000..We conclude that the risk of diabetes associated with low birth weight is strongly related to the development of paternal diabetes, suggesting a genetic link between lower birth weight and later diabetes...- Adiponectin and development of type 2 diabetes in the Pima Indian populationRobert S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
Lancet 360:57-8. 2002..01) and individuals with high concentrations of this protein were less likely to develop type 2 diabetes than those with low concentrations (incidence rate ratio 0.63 [95% CI 0.43-0.92]; p=0.02)... - Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of birth weightRobert S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
Hum Genet 110:503-9. 2002..An imprinted gene on chromosome 11 may influence birth weight in the Pima population. This chromosome contains one of the two major known clusters of imprinted genes in the human genome, lending biological plausibility to our findings... - Early excess weight gain of children in the Pima Indian populationRobert S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Pediatrics 109:E33. 2002..To determine the period of childhood in which weight relative to height increases in Pima Indian children and young adults in comparison with the general US population... - Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima IndiansR S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes 50:2850-7. 2001..In conclusion, we determined regions of interest on chromosomes 5, 6, and 10 where imprinted genes might be affecting the risk of type 2 diabetes or obesity in Pima Indians... - Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factorsR S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
J Clin Endocrinol Metab 86:4061-7. 2001..Body mass index is strongly associated with measures of adiposity derived from dual energy x-ray absorptiometry. Both measures show similar associations with cardiovascular risk factors in Pima Indian children... - Gamma globulin levels predict type 2 diabetes in the Pima Indian populationR S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Rd, Phoenix, AZ 85014, USA
Diabetes 50:1598-603. 2001..04 [0.90-1.20]; P = 0.6). Thus, gamma globulin levels predict increased risk of diabetes in the Pima population. We suggest that immune function or activation may play a role in the development of type 2 diabetes... - Secular trends in birth weight, BMI, and diabetes in the offspring of diabetic mothersR S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, Arizona 85014, USA
Diabetes Care 23:1249-54. 2000..We hypothesized that, in light of the historical improvements in the management of diabetes during pregnancy, these late consequences of the early environment might be diminishing with time... - Relationship between birth weight and body composition, energy metabolism, and sympathetic nervous system activity later in lifeC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Obes Res 8:559-65. 2000..Programming of metabolic, endocrine, and/or autonomic pathways during intrauterine development has been proposed to explain this association... - Comparison of plasma insulin levels after a mixed-meal challenge in children with and without intrauterine exposure to diabetesA D Salbe
NIH NIDDK Obesity and Diabetes Clinical Research Section, 4212 North 16th Street, Room 541, Phoenix, Arizona 85016, USA
J Clin Endocrinol Metab 92:624-8. 2007..The diabetic intrauterine environment is a known risk factor for the development of diabetes in the offspring... - Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?C Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Metabolism 50:223-30. 2001.... 
Assessment of parent-of-origin effects in linkage analysis of quantitative traitsR L Hanson
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
Am J Hum Genet 68:951-62. 2001..1 when these effects were ignored. The ability to include parent-of-origin effects within linkage analysis of quantitative traits will facilitate genetic dissection of complex traits...- 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscleS Nair
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetologia 47:1088-95. 2004..We have shown that adipose tissue 11beta-HSD1 mRNA levels were associated with adiposity and insulinaemia. Here we conducted further expression and genetic association studies in Pima Indians... - Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetesScott M Nelson
Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
Diabetes 56:2697-704. 2007..We examined whether these biomarkers were elevated at birth in offspring of type 1 diabetic mothers (OT1DM)... - Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetesHelen C Looker
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85014, USA
J Clin Endocrinol Metab 89:4010-7. 2004..0001). Serum adiponectin is lowest in the presence of impaired glucose regulation and early diabetes. In the presence of diabetes, serum adiponectin is positively associated with abnormal renal function and diabetes duration... - Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima IndiansPaul W Franks
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
Hypertension 44:681-8. 2004..These data demonstrate association between genetic variability at 11betaHSD1 with hypertension, but these effects are modified by environmental factors... - Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima IndiansBarbora Vozarova de Courten
Translational Genomics Research Institute, Diabetes Research Unit, NIDDK, NIH, 400 North 5th St, Phoenix, Arizona, USA
Diabetes 54:284-9. 2005..Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population... - Adiponectin and coronary heart disease: the Strong Heart StudyRobert S Lindsay
Arterioscler Thromb Vasc Biol 25:e15-6. 2005 - Early growth in offspring of diabetic mothersLeslie Touger
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
Diabetes Care 28:585-9. 2005..By age 5 years, offspring of diabetic mothers (ODMs) are heavier and have altered glucose metabolism compared with offspring of mothers without diabetes (non-DMs). This study evaluates the growth pattern of ODMs before the age of 5 years... - 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistanceJuraj Koska
Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
Obesity (Silver Spring) 14:1515-22. 2006.... 
Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetesScott M Nelson
Faculty of Medicine, University of Glasgow, Glasgow, UK
Diabetes Care 31:1123-5. 2008..To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes...- Commentary: Type 2 diabetes and birth weight--genetic and environmental effectsRobert S Lindsay
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK
Int J Epidemiol 37:192-3. 2008 - IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetesScott M Nelson
Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
Diabetes 56:2705-9. 2007..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures... - Inverse changes in fetal insulin-like growth factor (IGF)-1 and IGF binding protein-1 in association with higher birth weight in maternal diabetesRobert S Lindsay
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK
Clin Endocrinol (Oxf) 66:322-8. 2007..We examined IGF-1 and IGF binding protein-1 (IGFBP-1) concentrations in cord blood samples from offspring of mothers with gestational and type 2 diabetes... - High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetesBarbora Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 51:455-61. 2002..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes... - Assessing risk factors for obesity between childhood and adolescence: II. Energy metabolism and physical activityArline D Salbe
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Pediatrics 110:307-14. 2002.... - Low plasma adiponectin concentrations do not predict weight gain in humansBarbora Vozarova
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:2964-7. 2002..Therefore, the predictive effect of low plasma adiponectin concentrations on the development of type 2 diabetes seems to be mediated by factors other than increased adiposity... - The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima populationRobert S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes 52:187-93. 2003..Significant linkage disequilibrium was found between -23Hph1 and birth weight but not type 2 diabetes, an observation that supports a potential functional role of INS polymorphisms in the regulation of birth weight... - High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetesBarbora Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1889-95. 2002..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes... - Incidence of retinopathy and nephropathy in youth-onset compared with adult-onset type 2 diabetesJonathan Krakoff
National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes Care 26:76-81. 2003..To examine the risk of retinopathy and nephropathy in participants in whom type 2 diabetes was diagnosed in youth (before 20 years of age) compared with those in whom type 2 diabetes was diagnosed at older ages... - Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima IndianJonathan Krakoff
Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes Care 26:1745-51. 2003.... - Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and CaucasiansRobert S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona 85016, USA
J Clin Endocrinol Metab 88:2738-44. 2003..Our data support the hypothesis that increased regeneration of cortisol in adipose tissue influences metabolic sequelae of human obesity... - Adiponectin is present in cord blood but is unrelated to birth weightRobert S Lindsay
MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Diabetes Care 26:2244-9. 2003..We assessed whether adiponectin was 1) present in the fetal circulation, 2) altered in the fetal circulation in the presence of maternal diabetes, and 3) had relations to fetal cord blood insulin or adiposity... - Genome-wide linkage analysis of serum adiponectin in the Pima Indian populationRobert S Lindsay
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes 52:2419-25. 2003..Our data suggest that quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations in the Pima population... - Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humansNorbert Stefan
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1884-8. 2002..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans... - Assessing risk factors for obesity between childhood and adolescence: I. Birth weight, childhood adiposity, parental obesity, insulin, and leptinArline D Salbe
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Pediatrics 110:299-306. 2002..To assess the effects of body weight, body composition, parental obesity, and metabolic variables on the development of obesity in a large cohort of 5-year-old Native American children with a high propensity for obesity... - Effects of atorvastatin on bone in postmenopausal women with dyslipidemia: a double-blind, placebo-controlled, dose-ranging trialHenry G Bone
Michigan Bone and Mineral Clinic, 22201 Moross Road, Suite 260, Detroit, Michigan 48236 2175, USA
J Clin Endocrinol Metab 92:4671-7. 2007..Observational studies and secondary analyses from lipid-lowering trials have yielded inconsistent results regarding the effect of these agents on bone mineral density and fracture risk... - Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New ZealandJenny A Westgate
Department of Obstetrics and Gynecology, University of Auckland, Private Bag, 92019 Auckland, New Zealand
Diabetes Care 29:1345-50. 2006..We therefore examined whether cord insulin and leptin concentrations are increased in offspring of Maori and Pacific Island mothers with type 2 and gestational diabetes mellitus (GDM) and varying degrees of glycemic control (HbA(1c))... - Relation between physical activity and obesityArline D Salbe
Am J Clin Nutr 78:193-4; author reply 194-5. 2003 - Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the Strong Heart StudyHelaine E Resnick
Department of Epidemiology, MedStar Research Institute, Hyattsville, Md 20873, USA
Circulation 109:733-9. 2004..The associations of low (<0.90) and high (>1.40) ankle brachial index (ABI) with risk of all-cause and cardiovascular disease (CVD) mortality have not been examined in a population-based setting... - Cardiovascular risk associated with the metabolic syndromeRobert S Lindsay
MedStar Research Institute, 110 Irving Street, Washington Hospital Center, Washington, DC 20010, USA
Curr Diab Rep 4:63-8. 2004....