Yong Lin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation
    Yong Lin
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:10822-8. 2004
  2. pmc TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF
    Yong Lin
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:5849-56. 2003
  3. pmc The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases
    Anne Devin
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    EMBO Rep 4:623-7. 2003
  4. pmc Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death
    Han Ming Shen
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:5914-22. 2004
  5. pmc Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK
    QingFeng Yang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    EMBO Rep 7:622-7. 2006
  6. pmc Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
    QingFeng Yang
    Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:9631-6. 2005
  7. pmc The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
    Gang Min Hur
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Genes Dev 17:873-82. 2003
  8. pmc A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2
    Swati Choksi
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
    Mol Cell 42:597-609. 2011
  9. pmc Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria
    Thomas Brody
    The Neural Cell Fate Determinants Section, National Institutes of Health NIH, Bethesda, Maryland, USA
    PLoS ONE 3:e3074. 2008
  10. pmc Rapid detection and curation of conserved DNA via enhanced-BLAT and EvoPrinterHD analysis
    Amarendra S Yavatkar
    1Division of Intramural Research, Information Technology Program, NINDS, NIH, Bethesda, Maryland, USA
    BMC Genomics 9:106. 2008

Collaborators

  • Zheng Gang Liu
  • Amarendra S Yavatkar
  • Thomas Brody
  • Tao Li
  • Wei Huang
  • Li Chen
  • Meera Srivastava
  • Michael Karin
  • Len Neckers
  • Michael Morgan
  • Alexander Kuzin
  • Li Shen
  • Honglian Shi
  • Shan Qin
  • Y Tesfaigzi
  • Russell Hardie
  • H Nakano
  • Xia Wang
  • Wenshu Chen
  • QingFeng Yang
  • Swati Choksi
  • Steven A Belinsky
  • Wei Ju
  • You Sun Kim
  • Si Wen Chen
  • Hui Yun Wang
  • Khew Voon Chin
  • Joseph Lewis
  • Zachariah E Selvanayagam
  • Han Ming Shen
  • J G Liao
  • Shou En Lu
  • Qiaojia Huang
  • Anne Devin
  • Gang Min Hur
  • Chung Park
  • Siriporn Jitkaew
  • Michael Birre
  • Yelena Pobezinskaya
  • Grace Shih
  • Hong Sug Kim
  • Xiumei Cao
  • Chu Xia Deng
  • Peter Levitt
  • Lang Bai
  • Weihua Zeng
  • Lin Zhang
  • Jianguo Zhuang
  • Yue Xiang Chen
  • Wei fen Xie
  • Jordan Renouard
  • Jian Shi
  • James Aden
  • Harvey B Pollard
  • Xiangfeng Cui
  • Marco A Azaro
  • Qifeng Yang
  • Minjie Luo
  • Danielle M Frikker
  • Honghua Li
  • Mirta Glasman
  • Kazuya Kudoh
  • Yick Fu Wong
  • Irina V Tereshchenko
  • Kazuyuki Fujii
  • William Gillette
  • Hung Caohuy
  • Richeng Gao
  • Manousos E Kambouris
  • Catherine Jozwik
  • Leah Alabanza
  • Guohong Hu
  • Weichung Shih
  • Dominic Esposito
  • Yoshihiro Kikuchi
  • James Y Li
  • James Hartley
  • Wei Chung Shih
  • Yi Chu
  • Tsunekazu Kita
  • Tian Jin
  • Wei Chung Joe Shih
  • Lufen Chang
  • Jianhua Yang
  • Bing Su
  • Weichung Joe Shih
  • Christopher Walker
  • Jianke Zhang
  • Jinke Cheng
  • Jamie Tran

Detail Information

Publications28

  1. ncbi request reprint Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation
    Yong Lin
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:10822-8. 2004
    ..These results suggest that RIP, TRAF2, and FADD are crucial in mediating ROS accumulation in TNF-induced necrotic cell death...
  2. pmc TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF
    Yong Lin
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:5849-56. 2003
    ..These results reveal a novel aspect of TRAF2 function: by regulating the expression of genes, such as LKLF, TRAF2 controls cell sensitivity to apoptosis...
  3. pmc The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases
    Anne Devin
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    EMBO Rep 4:623-7. 2003
    ..The activation of these kinases by interleukin-1 is normal in Rip(-/-) cells. More importantly, we showed that the kinase activity of RIP is needed for ERK activation...
  4. pmc Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death
    Han Ming Shen
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:5914-22. 2004
    ..Therefore, our study uncovers a novel signaling pathway regulating oxidative stress-induced cell death...
  5. pmc Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK
    QingFeng Yang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    EMBO Rep 7:622-7. 2006
    ..We also found that TNFR1 functions downstream of IRE1 and that IRE1 is present in the same complex with TNFR1 under ER stress condition. Therefore, our study shows a novel role of TNFR1 in mediating ER stress-induced JNK activation...
  6. pmc Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
    QingFeng Yang
    Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:9631-6. 2005
    ..All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathways appear to follow from the blockade of this initial upstream signaling event...
  7. pmc The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
    Gang Min Hur
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Genes Dev 17:873-82. 2003
    ..We also found that RIP forms a complex with IKK in response to DNA damage. Therefore, our study provides a possible mechanism for the initiation of the cytoplasmic signaling to activate NF-kappaB in response to DNA damage...
  8. pmc A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2
    Swati Choksi
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
    Mol Cell 42:597-609. 2011
    ..Therefore, ATIA is not only a HIF-1 target that regulates mitochondrial redox pathways but also a potentially diagnostic marker and therapeutic target in human glioblastoma...
  9. pmc Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria
    Thomas Brody
    The Neural Cell Fate Determinants Section, National Institutes of Health NIH, Bethesda, Maryland, USA
    PLoS ONE 3:e3074. 2008
    ..We have adapted the multi-genome alignment tool EvoPrinter to facilitate discovery of HGT DNA sequences within bacterial genomes and within their mobile genetic elements...
  10. pmc Rapid detection and curation of conserved DNA via enhanced-BLAT and EvoPrinterHD analysis
    Amarendra S Yavatkar
    1Division of Intramural Research, Information Technology Program, NINDS, NIH, Bethesda, Maryland, USA
    BMC Genomics 9:106. 2008
    ..An EvoPrint reveals with near base-pair resolution those sequences that are essential for gene function...
  11. ncbi request reprint The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation
    Yong Lin
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Biol Chem 281:23525-32. 2006
    ..Taken together, our results indicate that RIP, a key factor in tumor necrosis factor signaling, also plays a pivotal role in IGF-I-induced JNK activation and cell proliferation...
  12. ncbi request reprint Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord
    Yong Lin
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    J Cereb Blood Flow Metab 27:1010-21. 2007
    ..This modulation may be partially attributed to the ability of HO-1 to stabilize the blood-spinal cord barrier and limit neutrophil infiltration...
  13. ncbi request reprint The restorative effect of taurine on experimental nonalcoholic steatohepatitis
    Si Wen Chen
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China
    Dig Dis Sci 51:2225-34. 2006
    ..In conclusion, taurine could inhibit lipid peroxidation, improve lipid and glucose metabolism, decrease synthesis of TNF-alpha and TGF-beta(1), promote synthesis of adiponectin, and have a restorative effect on experimental NASH...
  14. ncbi request reprint A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells
    Wei Ju
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Mol Pharmacol 71:1381-8. 2007
    ..Taken together, these results suggest that the accumulation of ROS induced by luteolin plays a pivotal role in suppression of NF-kappaB and potentiation of JNK to sensitize lung cancer cells to undergo TNF-induced apoptosis...
  15. ncbi request reprint Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathways
    Xia Wang
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Biochem Biophys Res Commun 355:807-12. 2007
    ....
  16. ncbi request reprint Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells
    Wenshu Chen
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
    Carcinogenesis 28:2114-21. 2007
    ..The potentiation of TRAIL-induced NSCLC cell death could be implicated in lung cancer therapy and prevention...
  17. pmc Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells
    Xia Wang
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
    Mol Cancer Ther 7:1156-63. 2008
    ..Taken together, these results identify c-FLIP(L) and Mcl-1(L) as the major determinants of acquired TRAIL resistance and could be molecular targets for improving the therapeutic value of TRAIL against lung cancer...
  18. ncbi request reprint A mixture model for estimating the local false discovery rate in DNA microarray analysis
    J G Liao
    Biometrics Division, School of Public Health and The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane West, Piscataway, NJ 08854, USA
    Bioinformatics 20:2694-701. 2004
    ..The paper proposes a flexible and robust mixture model for estimating the local FDR which quantifies how plausible each specific gene expresses differentially...
  19. ncbi request reprint Cloning of HBsAg-encoded genes in different vectors and their expression in eukaryotic cells
    Shan Qin
    Key Laboratory for Molecular Biology of Infectious Diseases of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China
    World J Gastroenterol 9:1111-3. 2003
    ....
  20. ncbi request reprint Analyzing excessive no changes in clinical trials with clustered data
    Shou En Lu
    Division of Biometrics, University of Medicine and Dentistry of New Jersey, School of Public Health, New Brunswick, New Jersey 08903, USA
    Biometrics 60:257-67. 2004
    ..This mixture model includes the two-part model as a special case when one component of the mixture degenerates...
  21. pmc A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genome
    Hui Yun Wang
    Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Genome Res 15:276-83. 2005
    ....
  22. ncbi request reprint Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
    Qiaojia Huang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Immunol 5:98-103. 2004
    ..Note: In the version of this article originally published online, the third author's name was incorrect. The correct author name should be Yong Lin. This error has been corrected for the HTML and print versions of this article.
  23. ncbi request reprint Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes
    Yong Lin
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Liver Int 25:796-807. 2005
    ..To investigate the effect of combinational delivery of urokinase-type plasminogen activator (uPA) and hepatocyte growth factor (HGF) genes on hepatic fibrosis...
  24. ncbi request reprint [Application of wavelet transform to monthly runoff time serial analysis in Zagunao watershed, the upper Minjiang river]
    Yong Lin
    Life Sciences, Beijing Normal University, Beijing 100875, China
    Ying Yong Sheng Tai Xue Bao 16:1645-9. 2005
    ....
  25. ncbi request reprint [Present status of gene-modified transplanted hepatocytes]
    Yong Lin
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhonghua Gan Zang Bing Za Zhi 11:376-8. 2003
  26. ncbi request reprint 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway
    Xia Wang
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Cancer Res 66:1089-95. 2006
    ....
  27. ncbi request reprint Improved optimization of soft-partition-weighted-sum filters and their application to image restoration
    Yong Lin
    University of Dayton, Ohio 45469 0226, USA
    Appl Opt 45:2697-706. 2006
    ..We apply the filters to the problem of noise reduction. The experimental results show that the Soft-PWS filter outperforms the standard partition-weighted-sum filter and the Wiener filter...
  28. ncbi request reprint Application of expression genomics for predicting treatment response in cancer
    Khew Voon Chin
    Department of Medicine, Medical University of Ohio at Toledo, Toledo, Ohio 43614 5809, USA
    Ann N Y Acad Sci 1058:186-95. 2005
    ..We envision that transcription profiling of the cancer genomes ultimately will not only reveal how altered gene expression results in resistance to treatment, but also be exploited for predicting and personalizing cancer therapy...