Research Topics
Genomes and Genes | Yong LinSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulationYong Lin
Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:10822-8. 2004..These results suggest that RIP, TRAF2, and FADD are crucial in mediating ROS accumulation in TNF-induced necrotic cell death...
TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLFYong Lin
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 23:5849-56. 2003..These results reveal a novel aspect of TRAF2 function: by regulating the expression of genes, such as LKLF, TRAF2 controls cell sensitivity to apoptosis...- Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell deathHan Ming Shen
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 24:5914-22. 2004..Therefore, our study uncovers a novel signaling pathway regulating oxidative stress-induced cell death... - The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinasesAnne Devin
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
EMBO Rep 4:623-7. 2003..The activation of these kinases by interleukin-1 is normal in Rip(-/-) cells. More importantly, we showed that the kinase activity of RIP is needed for ERK activation... - Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptorQingFeng Yang
Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 102:9631-6. 2005..All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathways appear to follow from the blockade of this initial upstream signaling event... - Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNKQingFeng Yang
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
EMBO Rep 7:622-7. 2006..We also found that TNFR1 functions downstream of IRE1 and that IRE1 is present in the same complex with TNFR1 under ER stress condition. Therefore, our study shows a novel role of TNFR1 in mediating ER stress-induced JNK activation... - The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activationGang Min Hur
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
Genes Dev 17:873-82. 2003..We also found that RIP forms a complex with IKK in response to DNA damage. Therefore, our study provides a possible mechanism for the initiation of the cytoplasmic signaling to activate NF-kappaB in response to DNA damage... - Rapid detection and curation of conserved DNA via enhanced-BLAT and EvoPrinterHD analysisAmarendra S Yavatkar
1Division of Intramural Research, Information Technology Program, NINDS, NIH, Bethesda, Maryland, USA
BMC Genomics 9:106. 2008..An EvoPrint reveals with near base-pair resolution those sequences that are essential for gene function... - Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteriaThomas Brody
The Neural Cell Fate Determinants Section, National Institutes of Health NIH, Bethesda, Maryland, USA
PLoS ONE 3:e3074. 2008..We have adapted the multi-genome alignment tool EvoPrinter to facilitate discovery of HGT DNA sequences within bacterial genomes and within their mobile genetic elements... - A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2Swati Choksi
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
Mol Cell 42:597-609. 2011..Therefore, ATIA is not only a HIF-1 target that regulates mitochondrial redox pathways but also a potentially diagnostic marker and therapeutic target in human glioblastoma... - The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activationYong Lin
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Biol Chem 281:23525-32. 2006..Taken together, our results indicate that RIP, a key factor in tumor necrosis factor signaling, also plays a pivotal role in IGF-I-induced JNK activation and cell proliferation... - A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genomeHui-Yun Wang
Department of Molecular Genetics, Microbiology and Immunology/The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
Genome Res 15:276-83. 2005.... - Cloning of HBsAg-encoded genes in different vectors and their expression in eukaryotic cellsShan Qin
Key Laboratory for Molecular Biology of Infectious Diseases of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China
World J Gastroenterol 9:1111-3. 2003.... - Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cellsXia Wang
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
Mol Cancer Ther 7:1156-63. 2008..Taken together, these results identify c-FLIP(L) and Mcl-1(L) as the major determinants of acquired TRAIL resistance and could be molecular targets for improving the therapeutic value of TRAIL against lung cancer... - [Present status of gene-modified transplanted hepatocytes]Yong Lin
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Zhonghua Gan Zang Bing Za Zhi 11:376-8. 2003 - Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cellsWenshu Chen
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
Carcinogenesis 28:2114-21. 2007..The potentiation of TRAIL-induced NSCLC cell death could be implicated in lung cancer therapy and prevention... - Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathwaysXia Wang
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Biochem Biophys Res Commun 355:807-12. 2007.... - A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cellsWei Ju
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Mol Pharmacol 71:1381-8. 2007..Taken together, these results suggest that the accumulation of ROS induced by luteolin plays a pivotal role in suppression of NF-kappaB and potentiation of JNK to sensitize lung cancer cells to undergo TNF-induced apoptosis... - The restorative effect of taurine on experimental nonalcoholic steatohepatitisSi-wen Chen
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China
Dig Dis Sci 51:2225-34. 2006..In conclusion, taurine could inhibit lipid peroxidation, improve lipid and glucose metabolism, decrease synthesis of TNF-alpha and TGF-beta(1), promote synthesis of adiponectin, and have a restorative effect on experimental NASH... - Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cordYong Lin
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
J Cereb Blood Flow Metab 27:1010-21. 2007..This modulation may be partially attributed to the ability of HO-1 to stabilize the blood-spinal cord barrier and limit neutrophil infiltration... - Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3Qiaojia Huang
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Immunol 5:98-103. 2004..Note: In the version of this article originally published online, the third author's name was incorrect. The correct author name should be Yong Lin. This error has been corrected for the HTML and print versions of this article. - Improved optimization of soft-partition-weighted-sum filters and their application to image restorationYong Lin
University of Dayton, Ohio 45469 0226, USA
Appl Opt 45:2697-706. 2006..We apply the filters to the problem of noise reduction. The experimental results show that the Soft-PWS filter outperforms the standard partition-weighted-sum filter and the Wiener filter... - 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathwayXia Wang
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Cancer Res 66:1089-95. 2006.... - Analyzing excessive no changes in clinical trials with clustered dataShou-En Lu
Division of Biometrics, University of Medicine and Dentistry of New Jersey, School of Public Health, New Brunswick, New Jersey 08903, USA
Biometrics 60:257-67. 2004..This mixture model includes the two-part model as a special case when one component of the mixture degenerates... - [Application of wavelet transform to monthly runoff time serial analysis in Zagunao watershed, the upper Minjiang river]Yong Lin
Life Sciences, Beijing Normal University, Beijing 100875, China
Ying Yong Sheng Tai Xue Bao 16:1645-9. 2005.... - Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genesYong Lin
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
Liver Int 25:796-807. 2005..CONCLUSIONS: Our study indicated that simultaneous delivery of two antifibrotic genes could confer synergistic effect on hepatic fibrosis... - A mixture model for estimating the local false discovery rate in DNA microarray analysisJ G Liao
Biometrics Division, School of Public Health and The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane West, Piscataway, NJ 08854, USA
Bioinformatics 20:2694-701. 2004..The paper proposes a flexible and robust mixture model for estimating the local FDR which quantifies how plausible each specific gene expresses differentially... - Application of expression genomics for predicting treatment response in cancerKhew Voon Chin
Department of Medicine, Medical University of Ohio at Toledo, Toledo, Ohio 43614 5809, USA
Ann N Y Acad Sci 1058:186-95. 2005..We envision that transcription profiling of the cancer genomes ultimately will not only reveal how altered gene expression results in resistance to treatment, but also be exploited for predicting and personalizing cancer therapy...