Li Lin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint RAGE on the Toll Road?
    Li Lin
    Laboratory of Cardiovascular Sciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Cell Mol Immunol 3:351-8. 2006
  2. pmc Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis
    Wen Wei
    Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 7:e50736. 2012
  3. pmc RAGE signaling in inflammation and arterial aging
    Li Lin
    Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, Maryland, 21224, USA
    Front Biosci (Landmark Ed) 14:1403-13. 2009
  4. pmc Design, generation, and testing of mammalian expression modules that tag membrane proteins
    John Pang
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institute of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Protein Sci 18:1261-71. 2009
  5. ncbi request reprint A p105-based inhibitor broadly represses NF-kappa B activities
    Dexue Fu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 279:12819-26. 2004
  6. doi request reprint GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells
    Wen Wei
    Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, United States
    Protein Expr Purif 95:143-8. 2014
  7. pmc VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway
    Qiangsong Tong
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Respir Res 7:37. 2006
  8. pmc The N-glycoform of sRAGE is the key determinant for its therapeutic efficacy to attenuate injury-elicited arterial inflammation and neointimal growth
    Hyun Jin Tae
    Laboratory of Cardiovascular Science, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD, 21224, USA
    J Mol Med (Berl) 91:1369-81. 2013
  9. ncbi request reprint Stability of the Rel homology domain is critical for generation of NF-kappa B p50 subunit
    Li Lin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:31479-85. 2003
  10. pmc Participation of the PI-3K/Akt-NF-kappa B signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells
    Qiangsong Tong
    Department of Internal Medicine, Saint Louis University, Saint Louis, MO 63110, USA
    Respir Res 7:101. 2006

Collaborators

  • Sungha Park
  • E G Lakatta
  • Noboru Tomiya
  • Dechun Li
  • Geng Li
  • Qiangsong Tong
  • Li Duan Zheng
  • R P Xiao
  • C Huang
  • Wen Wei
  • John Pang
  • Ji Min Kim
  • Hyun Jin Tae
  • Mileka R Gilbert
  • Dexue Fu
  • Danny Medina
  • Natalia Petrashevskaya
  • Rebecca A Riebe
  • Yinghua Zhang
  • Christopher H Morrell
  • Ismayil Ahmet
  • Stefanie Cruschwitz
  • David Browe
  • Mark I Talan
  • Yuan Chuan Lee
  • Leonie Lampe
  • Stephanie Cabantous
  • Bhavana S Vangara
  • Dongmei Yang
  • Geoffrey S Waldo
  • Sarah S Subaran
  • Xiaokun Zeng
  • Diane G Carnathan
  • Patricia C Cogswell
  • Barbara J Vilen
  • Albert S Baldwin
  • Minae Kobayashi

Detail Information

Publications12

  1. ncbi request reprint RAGE on the Toll Road?
    Li Lin
    Laboratory of Cardiovascular Sciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Cell Mol Immunol 3:351-8. 2006
    ..Thus, in this scenario, RAGE may play a prominent role in the regulation of cellular homeostasis in the context of complex disease progression...
  2. pmc Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis
    Wen Wei
    Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 7:e50736. 2012
    ....
  3. pmc RAGE signaling in inflammation and arterial aging
    Li Lin
    Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, Maryland, 21224, USA
    Front Biosci (Landmark Ed) 14:1403-13. 2009
    ..This review attempts to provide a comprehensive summary on both recent findings and missing pieces of the RAGE puzzle...
  4. pmc Design, generation, and testing of mammalian expression modules that tag membrane proteins
    John Pang
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institute of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Protein Sci 18:1261-71. 2009
    ..Thus, the designed modules serve as an effective tool that facilitates biochemical studies of membrane proteins...
  5. ncbi request reprint A p105-based inhibitor broadly represses NF-kappa B activities
    Dexue Fu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 279:12819-26. 2004
    ..Our results suggest that p105(sr) is a broader range and effective NF-kappaB super repressor and can potentially be used in cells where a noncanonical NF-kappaB activity is dominant or multiple NF-kappaB activities are activated...
  6. doi request reprint GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells
    Wen Wei
    Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, United States
    Protein Expr Purif 95:143-8. 2014
    ..We found that the enhanced expression appeared not to affect sRAGE N-glycosylation and bioactivity. Optimization of sRAGE expression provides a basis for future large-scale production of this protein to meet medical needs. ..
  7. pmc VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway
    Qiangsong Tong
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Respir Res 7:37. 2006
    ..In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial growth factor (VEGF) in lung tissues and epithelial cells...
  8. pmc The N-glycoform of sRAGE is the key determinant for its therapeutic efficacy to attenuate injury-elicited arterial inflammation and neointimal growth
    Hyun Jin Tae
    Laboratory of Cardiovascular Science, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD, 21224, USA
    J Mol Med (Berl) 91:1369-81. 2013
    ..Our findings showed that the N-glycoform of sRAGE is the key determinant underlying its bioactivity and thus is an important glycobioengineering target to develop a highly potent therapeutic sRAGE for future clinical applications...
  9. ncbi request reprint Stability of the Rel homology domain is critical for generation of NF-kappa B p50 subunit
    Li Lin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:31479-85. 2003
    ..Our findings highlight the critical role of the unique structure of the RHD for the survival of p50 during proteosomal processing...
  10. pmc Participation of the PI-3K/Akt-NF-kappa B signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells
    Qiangsong Tong
    Department of Internal Medicine, Saint Louis University, Saint Louis, MO 63110, USA
    Respir Res 7:101. 2006
    ..In present work, we tested whether HIMF modulates expression of fetal liver kinase-1 (Flk-1) in endothelial cells, and dissected the possible signaling pathways that link HIMF to Flk-1 upregulation...
  11. pmc Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K/Akt-NF-kappaB signaling pathway
    Qiangsong Tong
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Saint Louis University, 7th Floor, Desloge Towers, MO 63110 2539, USA
    Am J Respir Cell Mol Biol 35:444-56. 2006
    ..Our findings connect HIMF to signaling pathways that regulate inflammation, and thus reveal the critical roles that HIMF plays in lung inflammation...
  12. pmc Dendritic cells from lupus-prone mice are defective in repressing immunoglobulin secretion
    Mileka R Gilbert
    Department of Microbiology Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:4803-10. 2007
    ..Collectively, the data show that MRL/lpr mice are defective in DC/IL-6-mediated tolerance, but that some individuals maintain the ability to repress autoantibody secretion by an alternative mechanism...

Research Grants6

  1. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2009
    ..We will also test whether introducing p105(sr) into skin tumor cells facilitates apoptosis, and whether this approach significantly affects physiologic functions of normal keratinocytes. ..
  2. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2005
    ..We will also test whether introducing p105(sr) into skin tumor cells facilitates apoptosis, and whether this approach significantly affects physiologic functions of normal keratinocytes. ..
  3. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2005
    ..We will also test whether introducing p105(sr) into skin tumor cells facilitates apoptosis, and whether this approach significantly affects physiologic functions of normal keratinocytes. ..
  4. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2007
    ..We will also test whether introducing p105(sr) into skin tumor cells facilitates apoptosis, and whether this approach significantly affects physiologic functions of normal keratinocytes. ..