Jing Ping Lin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  2. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
  3. ncbi request reprint Evidence for linkage of red blood cell size and count: genome-wide scans in the Framingham Heart Study
    Jing Ping Lin
    Office of Biostatistics Research NHLBI NIH, Bethesda, MD 20892 7938, USA
    Am J Hematol 82:605-10. 2007
  4. pmc Bivariate genome scans incorporating factor and principal component analyses to identify common genetic components of alcoholism, event-related potential, and electroencephalogram phenotypes
    Jing Ping Lin
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, 6701 Rockledge Drive, MSC 7938, Bethesda, MD 20892 7938, USA
    BMC Genet 6:S114. 2005
  5. pmc Evidence for a gene influencing serum bilirubin on chromosome 2q telomere: a genomewide scan in the Framingham study
    Jing Ping Lin
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 72:1029-34. 2003
  6. ncbi request reprint Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Salt Lake City, UT 84108 3528, USA
    Chin Med J (Engl) 118:362-9. 2005
  7. pmc Genome-wide scan on plasma triglyceride and high density lipoprotein cholesterol levels, accounting for the effects of correlated quantitative phenotypes
    Jing Ping Lin
    Office of Biostatistics Research, DECA, National Heart, Lung and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, Maryland, USA
    BMC Genet 4:S47. 2003
  8. pmc Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, Department of Population and Public Science, National Heart Lung and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 7913, USA
    Atherosclerosis 206:228-33. 2009
  9. ncbi request reprint Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, NHLBI NIH, 6701 Rockledge Dr, Suite 8110, Bethesda, MD 20892 7938, USA
    Circulation 114:1476-81. 2006
  10. pmc Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene
    Wendy K Steagall
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    Am J Pathol 183:938-50. 2013

Detail Information

Publications27

  1. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  2. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
    ..We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set...
  3. ncbi request reprint Evidence for linkage of red blood cell size and count: genome-wide scans in the Framingham Heart Study
    Jing Ping Lin
    Office of Biostatistics Research NHLBI NIH, Bethesda, MD 20892 7938, USA
    Am J Hematol 82:605-10. 2007
    ..9. These findings suggest that further studies are warranted to identify potential causal genetic variants for RBC size and count and related erythrocyte indices...
  4. pmc Bivariate genome scans incorporating factor and principal component analyses to identify common genetic components of alcoholism, event-related potential, and electroencephalogram phenotypes
    Jing Ping Lin
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, 6701 Rockledge Drive, MSC 7938, Bethesda, MD 20892 7938, USA
    BMC Genet 6:S114. 2005
    ....
  5. pmc Evidence for a gene influencing serum bilirubin on chromosome 2q telomere: a genomewide scan in the Framingham study
    Jing Ping Lin
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 72:1029-34. 2003
    ..Only one other region in the genome produced a multipoint LOD score >1 (LOD = 1.3). Our findings suggest that UGT1A1 may be a major gene controlling serum bilirubin levels in the population...
  6. ncbi request reprint Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Salt Lake City, UT 84108 3528, USA
    Chin Med J (Engl) 118:362-9. 2005
    ..We report here an investigation of the relationship between LDL-C and cholesterol 7alpha-hydroxylase (CYP7), as well as apoE and low-density lipoprotein receptor (LDLR), three pivotal genes in LDL metabolism...
  7. pmc Genome-wide scan on plasma triglyceride and high density lipoprotein cholesterol levels, accounting for the effects of correlated quantitative phenotypes
    Jing Ping Lin
    Office of Biostatistics Research, DECA, National Heart, Lung and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, Maryland, USA
    BMC Genet 4:S47. 2003
    ....
  8. pmc Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, Department of Population and Public Science, National Heart Lung and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 7913, USA
    Atherosclerosis 206:228-33. 2009
    ....
  9. ncbi request reprint Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, NHLBI NIH, 6701 Rockledge Dr, Suite 8110, Bethesda, MD 20892 7938, USA
    Circulation 114:1476-81. 2006
    ..We performed an association study in the Framingham Heart Study population to investigate whether UGT1A1*28 is associated with the risk of CVD events...
  10. pmc Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene
    Wendy K Steagall
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    Am J Pathol 183:938-50. 2013
    ..Based on these data, it appears that OPG may have tumor-promoting roles in the pathogenesis of lymphangioleiomyomatosis, perhaps acting as both autocrine and paracrine factors. ..
  11. pmc A statistical method for adjusting covariates in linkage analysis with sib pairs
    Colin O Wu
    Office of Biostatistics, DECA, National Heart, Lung, and Blood Institute, 2 Rockledge Center, Bethesda, Maryland, USA
    BMC Genet 4:S51. 2003
    ....
  12. pmc Beta-2-adrenergic receptor polymorphisms in cystic fibrosis
    Wendy K Steagall
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    Pharmacogenet Genomics 17:425-30. 2007
    ..We tested the hypothesis that genetic variants of the beta2AR gene, which have been shown to influence receptor desensitization, are more frequent in patients than in controls...
  13. pmc Robust trend tests for genetic association in case-control studies using family data
    Xin Tian
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, 6701 Rockledge Dr, Bethesda, Maryland 20892, USA
    BMC Genet 6:S107. 2005
    ..The trend tests and robust trend tests were applied to a dataset of Genetic Analysis Workshop 14 from the Collaborative Study on the Genetics of Alcoholism...
  14. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  15. ncbi request reprint The C/A(-18) polymorphism in the surfactant protein B gene influences transcription and protein levels of surfactant protein B
    Wendy K Steagall
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 292:L448-53. 2007
    ..Differences in amounts of SP-B resulting from the promoter SNP could affect the clinical presentation of pulmonary disease...
  16. pmc Selection of single-nucleotide polymorphisms in disease association data
    Jungnam Joo
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, 6701 Rockledge Dr, MSC 7938, Maryland 20892, USA
    BMC Genet 6:S93. 2005
    ..The set association methods were then briefly reviewed. Finally, we applied these methods to the data from Collaborative Study on the Genetics of Alcoholism (COGA)...
  17. pmc Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis
    Xiong Cai
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Respir Crit Care Med 182:1410-8. 2010
    ....
  18. pmc Joint analysis of case-parents trio and unrelated case-control designs in large scale association studies
    Jungnam Joo
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, 6701 Rockledge Drive, MSC 7913, Bethesda, MD 20892 7913, USA
    BMC Proc 1:S28. 2007
    ..The performance of the proposed approaches is examined by analyzing the simulated data provided by the Genetic Analysis Workshop 15...
  19. ncbi request reprint Genetic and morphologic determinants of pneumothorax in lymphangioleiomyomatosis
    Wendy K Steagall
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland Bethesda, Maryland 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 293:L800-8. 2007
    ..Polymorphisms in types I and III collagen and matrix metalloproteinase-1 genes may cause differences in lung extracellular matrix that result in greater susceptibility to pneumothorax...
  20. pmc A new family-based association test via a least-squares method
    Song Yang
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    BMC Genet 6:S110. 2005
    ..When applied to the data from Collaborative Study on the Genetics of Alcoholism, this new method shows a significant association between the marker rs1037475 and alcoholism...
  21. doi request reprint Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease
    Jing Ping Lin
    Office of Biostatistics Research, Division of Cardiovascular Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Clin Chem 56:1535-43. 2010
    ..Although the association of serum bilirubin with CVD has been found in both retrospective and prospective studies, less information is available on the role of genes that control bilirubin concentrations and their association with CVD...
  22. pmc Genome-wide linkage and association scans for quantitative trait Loci of serum lactate dehydrogenase-the framingham heart study
    Jing Ping Lin
    Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, NIH 6701 Rockledge Dr Suite 9196, Bethesda, MD 20892 7913, USA
    Hum Genomics Proteomics 2010:905237. 2010
    ..Those genes may be located on chromosomal regions that differ from where the genes encoding LDH isoenzymes reside...
  23. pmc Comparing strategies for evaluation of candidate genes in case-control studies using family data
    Xin Tian
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, 6701 Rockledge Drive, Bethesda, Maryland 20892, USA
    BMC Proc 1:S31. 2007
    ..We compare the power of these test strategies in a simulation study, and apply these methods to a candidate gene dataset of Genetic Analysis Workshop 15 from the North American Rheumatoid Arthritis Consortium...
  24. pmc Robust ranks of true associations in genome-wide case-control association studies
    Gang Zheng
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, 6701 Rockledge Drive, MSC 7938, Bethesda, Maryland 20892 USA
    BMC Proc 1:S165. 2007
    ..We studied this problem with application to Problem 3 of Genetic Analysis Workshop 15. An independent simulation study was also conducted to further evaluate the proposed procedure...
  25. pmc Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene
    Gustavo Pacheco-Rodriguez
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:1270-7. 2009
    ..g., breast cancer and melanoma cells). These observations are consistent with the notion that chemokines such as CCL2 may serve to determine mobility and specify the site of metastasis of the LAM cell...
  26. pmc Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement
    Connie G Glasgow
    Translational Medicine Branch, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Chest 135:1293-300. 2009
    ..We assessed serum VEGF-D concentrations in relationship to clinical phenotype in LAM patients...
  27. ncbi request reprint Effects of covariates: a summary of Group 5 contributions
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 25:S43-9. 2003
    ..Finally, the results of Group 5 studies show that inclusion of covariates can increase the power to detect genes for complex traits, and has the potential to advance an understanding of the role of genes in these complex traits...