J D Lifson
Affiliation: National Cancer Institute
- Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challengeJ D Lifson
AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, MD 21702, USA
J Med Primatol 31:205-16. 2002..Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naïve controls...
- Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatmentJ D Lifson
AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
J Virol 74:2584-93. 2000..These findings may be particularly important in relation to prospects for control of primate lentiviruses in the settings of both prophylactic and therapeutic vaccination for prevention of AIDS...
- Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatmentJ D Lifson
Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
J Virol 75:10187-99. 2001..The results help establish the underlying feasibility of efforts to develop vaccines for the prevention of AIDS, although the exact nature of the protective host responses involved remains to be elucidated...
- Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivoR J Gorelick
AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland, 21702 1201, USA
Virology 253:259-70. 1999..NC mutations can therefore be used to generate replication defective virions for candidate vaccines in the SIV macaque model for primate lentiviral diseases...
- Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallengeJ D Lifson
Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
J Med Primatol 32:201-10. 2003..Comparative analysis of virologic and immunologic parameters in this model system may provide important insights for understanding the basis of effective immunologic control of SIV infection...
- The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infectionJ D Lifson
AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702, USA
J Virol 71:9508-14. 1997....
- Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequencesR J Gorelick
SAIC Frederick, National Cancer Institute, Frederick, Maryland, 21702 1201
Virology 256:92-104. 1999..The evolutionary pressure to maintain CCHC NC Zn2+ fingers depends mainly on its function in infection processes, in addition to its function in genome packaging...
- Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1M T Esser
AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
J Virol 75:1152-64. 2001..The results suggest that the immunopathogenesis of HIV infection may not depend solely on direct cytopathic effects of HIV replication, but that effects due to noninfectious HIV-1 virions may also contribute importantly...
- Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCsI Frank
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York, 10021, USA
J Virol 76:2936-51. 2002....
- Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphomaB Ling
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
J Med Primatol 31:154-63. 2002..The SIVmac infected Ch Rh subspecies are an acceptable model for HIV/AIDS...
- Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivoL Villamide-Herrera
Center for Biomedical Research, Population Council, New York, New York 10021, USA
AIDS Res Hum Retroviruses 20:871-84. 2004..This pilot study provides the proof of principle that sc injected ex vivo SIV-recombinant canarypox-infected DCs safely induce low-level SIV-specific immune responses in vivo...
- CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaquesN Teleshova
Population Council, 1230 York Avenue, New York, NY 10021, USA
J Leukoc Biol 79:257-67. 2006..The ability of C274 to stimulate B cells and DCs in healthy and infected monkeys suggests its possible use as a broad-acting adjuvant to be applied in the rhesus macaque model for the development of preventative and therapeutic vaccines...
- Evaluation of aldrithiol-2-inactivated preparations of HIV type 1 subtypes A, B, and D as reagents to monitor T cell responsesA Rutebemberwa
U S Military HIV Research Program Henry Jackson Foundation, 13 Taft Court, Rockville, MD 20850, USA
AIDS Res Hum Retroviruses 23:532-42. 2007..In conclusion, AT-2-inactivated HIV-1 virions stimulated both CD4 and CD8 HIV-1-specific responses and may provide an additional reagent for screening HIV-1-specific responses in HIV seropositives and vaccinees...
- Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T lymphocyte depletion in vivoS M Crowe
Department of Medicine, San Francisco General Hospital University of California 94110
Clin Immunol Immunopathol 65:143-51. 1992..HIV-infected MDM express viral gp120 on their surface and fuse with CD4-bearing cells in a fashion similar to lymphoid cells. Macrophages may contribute to CD4 lymphocyte depletion in vivo by this fusion mechanism...
- Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectorsS Crotty
Department of Microbiology and Immunology, University of California, San Francisco, California 94143-0414, USA
J Virol 75:7435-52. 2001....
- Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivoS Glushakova
Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
J Virol 73:3968-74. 1999..Thus, Nef can facilitate HIV-1 replication in human lymphoid tissue ex vivo by increasing the numbers of productively infected cells and by increasing the responsiveness to IL-2 stimulation...
- Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agentJ Linnen
Genelabs Technologies, Redwood City, CA 94063, USA
Science 271:505-8. 1996..Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States...
- Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoproteinJ D Lifson
Nature 323:725-8. 1986..This process may contribute to the loss of CD4+ T cells seen in AIDS...
- Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in mE A Berger
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 88:8082-6. 1991....
- A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cellsI Frank
Center for Biomedical Research, Population Council, New York, New York 10065, USA
J Virol 82:5329-39. 2008....