J D Lifson

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, MD 21702, USA
    J Med Primatol 31:205-16. 2002
  2. pmc Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Virol 74:2584-93. 2000
  3. pmc Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
  4. ncbi request reprint Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo
    R J Gorelick
    AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland, 21702 1201, USA
    Virology 253:259-70. 1999
  5. ncbi request reprint Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    J Med Primatol 32:201-10. 2003
  6. pmc The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Virol 71:9508-14. 1997
  7. ncbi request reprint Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences
    R J Gorelick
    SAIC Frederick, National Cancer Institute, Frederick, Maryland, 21702 1201
    Virology 256:92-104. 1999
  8. pmc Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1
    M T Esser
    AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
    J Virol 75:1152-64. 2001
  9. pmc Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs
    I Frank
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York, 10021, USA
    J Virol 76:2936-51. 2002
  10. ncbi request reprint Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma
    B Ling
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
    J Med Primatol 31:154-63. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, MD 21702, USA
    J Med Primatol 31:205-16. 2002
    ..Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naïve controls...
  2. pmc Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Virol 74:2584-93. 2000
    ..These findings may be particularly important in relation to prospects for control of primate lentiviruses in the settings of both prophylactic and therapeutic vaccination for prevention of AIDS...
  3. pmc Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
    ..The results help establish the underlying feasibility of efforts to develop vaccines for the prevention of AIDS, although the exact nature of the protective host responses involved remains to be elucidated...
  4. ncbi request reprint Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo
    R J Gorelick
    AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland, 21702 1201, USA
    Virology 253:259-70. 1999
    ..NC mutations can therefore be used to generate replication defective virions for candidate vaccines in the SIV macaque model for primate lentiviral diseases...
  5. ncbi request reprint Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    J Med Primatol 32:201-10. 2003
    ..Comparative analysis of virologic and immunologic parameters in this model system may provide important insights for understanding the basis of effective immunologic control of SIV infection...
  6. pmc The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Virol 71:9508-14. 1997
    ....
  7. ncbi request reprint Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences
    R J Gorelick
    SAIC Frederick, National Cancer Institute, Frederick, Maryland, 21702 1201
    Virology 256:92-104. 1999
    ..The evolutionary pressure to maintain CCHC NC Zn2+ fingers depends mainly on its function in infection processes, in addition to its function in genome packaging...
  8. pmc Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1
    M T Esser
    AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
    J Virol 75:1152-64. 2001
    ..The results suggest that the immunopathogenesis of HIV infection may not depend solely on direct cytopathic effects of HIV replication, but that effects due to noninfectious HIV-1 virions may also contribute importantly...
  9. pmc Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs
    I Frank
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York, 10021, USA
    J Virol 76:2936-51. 2002
    ....
  10. ncbi request reprint Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma
    B Ling
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
    J Med Primatol 31:154-63. 2002
    ..The SIVmac infected Ch Rh subspecies are an acceptable model for HIV/AIDS...
  11. ncbi request reprint Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo
    L Villamide-Herrera
    Center for Biomedical Research, Population Council, New York, New York 10021, USA
    AIDS Res Hum Retroviruses 20:871-84. 2004
    ..This pilot study provides the proof of principle that sc injected ex vivo SIV-recombinant canarypox-infected DCs safely induce low-level SIV-specific immune responses in vivo...
  12. ncbi request reprint CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques
    N Teleshova
    Population Council, 1230 York Avenue, New York, NY 10021, USA
    J Leukoc Biol 79:257-67. 2006
    ..The ability of C274 to stimulate B cells and DCs in healthy and infected monkeys suggests its possible use as a broad-acting adjuvant to be applied in the rhesus macaque model for the development of preventative and therapeutic vaccines...
  13. ncbi request reprint Evaluation of aldrithiol-2-inactivated preparations of HIV type 1 subtypes A, B, and D as reagents to monitor T cell responses
    A Rutebemberwa
    U S Military HIV Research Program Henry Jackson Foundation, 13 Taft Court, Rockville, MD 20850, USA
    AIDS Res Hum Retroviruses 23:532-42. 2007
    ..In conclusion, AT-2-inactivated HIV-1 virions stimulated both CD4 and CD8 HIV-1-specific responses and may provide an additional reagent for screening HIV-1-specific responses in HIV seropositives and vaccinees...
  14. ncbi request reprint Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T lymphocyte depletion in vivo
    S M Crowe
    Department of Medicine, San Francisco General Hospital University of California 94110
    Clin Immunol Immunopathol 65:143-51. 1992
    ..HIV-infected MDM express viral gp120 on their surface and fuse with CD4-bearing cells in a fashion similar to lymphoid cells. Macrophages may contribute to CD4 lymphocyte depletion in vivo by this fusion mechanism...
  15. pmc Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors
    S Crotty
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143-0414, USA
    J Virol 75:7435-52. 2001
    ....
  16. pmc Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo
    S Glushakova
    Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Virol 73:3968-74. 1999
    ..Thus, Nef can facilitate HIV-1 replication in human lymphoid tissue ex vivo by increasing the numbers of productively infected cells and by increasing the responsiveness to IL-2 stimulation...
  17. ncbi request reprint Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent
    J Linnen
    Genelabs Technologies, Redwood City, CA 94063, USA
    Science 271:505-8. 1996
    ..Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States...
  18. ncbi request reprint Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein
    J D Lifson
    Nature 323:725-8. 1986
    ..This process may contribute to the loss of CD4+ T cells seen in AIDS...
  19. pmc Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in m
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 88:8082-6. 1991
    ....
  20. pmc A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cells
    I Frank
    Center for Biomedical Research, Population Council, New York, New York 10065, USA
    J Virol 82:5329-39. 2008
    ....