Zheng Li

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury
    Zhonghua Hu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e39357. 2012
  2. pmc Caspases in synaptic plasticity
    Zheng Li
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Brain 5:15. 2012
  3. pmc Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
    Zheng Li
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:859-71. 2010
  4. ncbi request reprint The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
  5. pmc Age-dependent regulation of synaptic connections by dopamine D2 receptors
    Jie Min Jia
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 16:1627-36. 2013
  6. pmc Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
    Song Jiao
    Unit on Synapse Development and Plasticity, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:758-72. 2011
  7. doi request reprint miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression
    Zhonghua Hu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Commun 5:3263. 2014
  8. pmc The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression
    Meng Hsuan Han
    National Institute of Mental Health, Bethesda, Maryland 20892
    Mol Cell Proteomics 12:3719-31. 2013
  9. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
  10. ncbi request reprint NMDA Receptor-Dependent LTD Is Required for Consolidation But Not Acquisition of Fear Memory
    Xing Liu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, and The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, People s Republic of China
    J Neurosci 34:8741-8. 2014

Collaborators

Detail Information

Publications13

  1. pmc Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury
    Zhonghua Hu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e39357. 2012
    ..These pathways can potentially be targeted for development of novel TBI treatment...
  2. pmc Caspases in synaptic plasticity
    Zheng Li
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Brain 5:15. 2012
    ..In this article, we review the studies on the non-apoptotic functions of caspases in neurons, with a focus on their roles in synaptic plasticity, learning and memory and neurodegeneration...
  3. pmc Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
    Zheng Li
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:859-71. 2010
    ..NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD...
  4. ncbi request reprint The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
    ..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
  5. pmc Age-dependent regulation of synaptic connections by dopamine D2 receptors
    Jie Min Jia
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 16:1627-36. 2013
    ....
  6. pmc Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
    Song Jiao
    Unit on Synapse Development and Plasticity, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:758-72. 2011
    ..We further demonstrate that the intensity and duration of caspase-3 activation determine whether it leads to cell death or LTD, thus fine-tuning of caspase-3 activation is critical in distinguishing between these two pathways...
  7. doi request reprint miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression
    Zhonghua Hu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Commun 5:3263. 2014
    ..These findings reveal a miRNA-mediated mechanism and a role for AMPA receptor exocytosis in long-lasting spine plasticity, and identify a number of candidate miRNAs involved in LTD. ..
  8. pmc The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression
    Meng Hsuan Han
    National Institute of Mental Health, Bethesda, Maryland 20892
    Mol Cell Proteomics 12:3719-31. 2013
    ..Our study has identified Gap43 as a key caspase-3 substrate involved in LTD and AMPA receptor endocytosis, uncovered a novel postsynaptic function for Gap43 and provided new insights into how long-term synaptic depression is induced. ..
  9. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention...
  10. ncbi request reprint NMDA Receptor-Dependent LTD Is Required for Consolidation But Not Acquisition of Fear Memory
    Xing Liu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, and The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, People s Republic of China
    J Neurosci 34:8741-8. 2014
    ..These findings indicate that NMDAR-LTD is required for consolidation, but not the acquisition of fear memory. Our study also shows that Bax plays an important role in depressive behavior. ..
  11. doi request reprint Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact
    Camila P Almeida-Suhett
    1 Program in Neuroscience, F Edward H├ębert School of Medicine Uniformed Services University of the Health Sciences, Bethesda, Maryland
    J Neurotrauma 31:683-90. 2014
    ..These transcriptional responses to mTBI may underlie long-term changes in excitatory and inhibitory neuronal imbalance in hippocampus, leading to long-term behavioral consequences of mTBI...
  12. ncbi request reprint Some assembly required: the development of neuronal synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Nat Rev Mol Cell Biol 4:833-41. 2003
  13. pmc Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:807-27. 2009
    ....