Genomes and Genes
Affiliation: National Institutes of Health
- Caspases in synaptic plasticityZheng Li
Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Mol Brain 5:15. 2012..In this article, we review the studies on the non-apoptotic functions of caspases in neurons, with a focus on their roles in synaptic plasticity, learning and memory and neurodegeneration...
- Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalizationZheng Li
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 141:859-71. 2010..NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD...
- Age-dependent regulation of synaptic connections by dopamine D2 receptorsJie Min Jia
Unit on Synapse Development and Plasticity, National Institute of Mental Health, US National Institutes of Health, Bethesda, Maryland, USA
Nat Neurosci 16:1627-36. 2013....
- Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmissionSong Jiao
Unit on Synapse Development and Plasticity, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 70:758-72. 2011..We further demonstrate that the intensity and duration of caspase-3 activation determine whether it leads to cell death or LTD, thus fine-tuning of caspase-3 activation is critical in distinguishing between these two pathways...
- The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesZheng Li
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 119:873-87. 2004..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
- The Novel Caspase-3 Substrate Gap43 is Involved in AMPA Receptor Endocytosis and Long-Term DepressionMeng Hsuan Han
National Institute of Mental Health, Bethesda, Maryland 20892
Mol Cell Proteomics 12:3719-31. 2013..Our study has identified Gap43 as a key caspase-3 substrate involved in LTD and AMPA receptor endocytosis, uncovered a novel postsynaptic function for Gap43 and provided new insights into how long-term synaptic depression is induced. ..
- Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injuryZhonghua Hu
Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e39357. 2012..These pathways can potentially be targeted for development of novel TBI treatment...
- Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implicationsXiao Sheng Jiang
Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
Hum Mol Genet 19:1347-57. 2010..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention...
- Some assembly required: the development of neuronal synapsesZheng Li
The Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
Nat Rev Mol Cell Biol 4:833-41. 2003
- Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synucleinXian Lin
Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 64:807-27. 2009....