Zheng Li

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Caspases in synaptic plasticity
    Zheng Li
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Brain 5:15. 2012
  2. pmc Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
    Zheng Li
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:859-71. 2010
  3. pmc Age-dependent regulation of synaptic connections by dopamine D2 receptors
    Jie Min Jia
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 16:1627-36. 2013
  4. pmc Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
    Song Jiao
    Unit on Synapse Development and Plasticity, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:758-72. 2011
  5. ncbi request reprint The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
  6. pmc The Novel Caspase-3 Substrate Gap43 is Involved in AMPA Receptor Endocytosis and Long-Term Depression
    Meng Hsuan Han
    National Institute of Mental Health, Bethesda, Maryland 20892
    Mol Cell Proteomics 12:3719-31. 2013
  7. pmc Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury
    Zhonghua Hu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e39357. 2012
  8. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
  9. ncbi request reprint Some assembly required: the development of neuronal synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Nat Rev Mol Cell Biol 4:833-41. 2003
  10. pmc Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:807-27. 2009

Collaborators

  • Morgan H Sheng
  • Yong Chen
  • Forbes D Porter
  • Xiao Sheng Jiang
  • Yasunori Hayashi
  • Huaibin Cai
  • Gay Rudow
  • Jie Min Jia
  • Zhonghua Hu
  • Song Jiao
  • Meng Hsuan Han
  • Xian Lin
  • Jun Zhao
  • Cai Yun Chen
  • Daniel Lindberg
  • Sanford P Markey
  • Marjan Gucek
  • MARIA F BRAGA
  • Jun Zhu
  • Camila Almeida-Suhett
  • Lee Eiden
  • Danni Yu
  • Kang Tu
  • Ann M Marini
  • Juan C Troncoso
  • Loukia Parisiadou
  • Chengsong Xie
  • Wan Jou Yang
  • Zhihua Liu
  • Lixin Sun
  • Jung Hwa Tao-Cheng
  • Lizhen Wang
  • Jinhui Ding
  • Paul E Gallant
  • Hoon Shim
  • Zsu Zsu Chen
  • Cai Xia Long
  • Xing Long Gu

Detail Information

Publications10

  1. pmc Caspases in synaptic plasticity
    Zheng Li
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Brain 5:15. 2012
    ..In this article, we review the studies on the non-apoptotic functions of caspases in neurons, with a focus on their roles in synaptic plasticity, learning and memory and neurodegeneration...
  2. pmc Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
    Zheng Li
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:859-71. 2010
    ..NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD...
  3. pmc Age-dependent regulation of synaptic connections by dopamine D2 receptors
    Jie Min Jia
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 16:1627-36. 2013
    ....
  4. pmc Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
    Song Jiao
    Unit on Synapse Development and Plasticity, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:758-72. 2011
    ..We further demonstrate that the intensity and duration of caspase-3 activation determine whether it leads to cell death or LTD, thus fine-tuning of caspase-3 activation is critical in distinguishing between these two pathways...
  5. ncbi request reprint The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
    ..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
  6. pmc The Novel Caspase-3 Substrate Gap43 is Involved in AMPA Receptor Endocytosis and Long-Term Depression
    Meng Hsuan Han
    National Institute of Mental Health, Bethesda, Maryland 20892
    Mol Cell Proteomics 12:3719-31. 2013
    ..Our study has identified Gap43 as a key caspase-3 substrate involved in LTD and AMPA receptor endocytosis, uncovered a novel postsynaptic function for Gap43 and provided new insights into how long-term synaptic depression is induced. ..
  7. pmc Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury
    Zhonghua Hu
    Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e39357. 2012
    ..These pathways can potentially be targeted for development of novel TBI treatment...
  8. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention...
  9. ncbi request reprint Some assembly required: the development of neuronal synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Nat Rev Mol Cell Biol 4:833-41. 2003
  10. pmc Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:807-27. 2009
    ....