Xiaoling Li

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc SIRT1 performs a balancing act on the tight-rope toward longevity
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Aging (Albany NY) 1:669-73. 2009
  2. pmc SIRT1 and energy metabolism
    Xiaoling Li
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Acta Biochim Biophys Sin (Shanghai) 45:51-60. 2013
  3. pmc Mammalian sirtuins and energy metabolism
    Xiaoling Li
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Int J Biol Sci 7:575-87. 2011
  4. pmc Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    FASEB J 26:656-67. 2012
  5. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
  6. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
  7. pmc The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
    Xiumei Guo
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, ResearchTriangle Park, NC 27709, USA
    Sci Rep 2:640. 2012
  8. pmc Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Mol Cell Biol 32:1226-36. 2012
  9. pmc DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    Xiumei Guo
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:13223-32. 2010
  10. ncbi request reprint Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis
    Nevzat Kazgan
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Gastroenterology 146:1006-16. 2014

Collaborators

Detail Information

Publications11

  1. pmc SIRT1 performs a balancing act on the tight-rope toward longevity
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Aging (Albany NY) 1:669-73. 2009
    ..These findings point toward the involvement of other players in SIRT1-regulated hepatic metabolism. Here we discuss our findings, and comment on some of the controversy surrounding this protein in the current literature...
  2. pmc SIRT1 and energy metabolism
    Xiaoling Li
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Acta Biochim Biophys Sin (Shanghai) 45:51-60. 2013
    ..This review focuses on the role of SIRT1 in regulating energy metabolism at different metabolic tissues...
  3. pmc Mammalian sirtuins and energy metabolism
    Xiaoling Li
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Int J Biol Sci 7:575-87. 2011
    ..This review focuses on the involvement of two nuclear sirtuins, SIRT1 and SIRT6, and three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5, in regulation of diverse metabolic processes...
  4. pmc Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    FASEB J 26:656-67. 2012
    ..Taken together, our findings indicate that SIRT1 plays a vital role in the regulation of systemic energy and steroid hormone homeostasis...
  5. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
    ....
  6. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
    ..Taken together, our data indicate that SIRT1 plays a vital role in the regulation of hepatic lipid homeostasis and that pharmacological activation of SIRT1 may be important for the prevention of obesity-associated metabolic diseases...
  7. pmc The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
    Xiumei Guo
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, ResearchTriangle Park, NC 27709, USA
    Sci Rep 2:640. 2012
    ..Our findings reveal a novel mechanism for environmental regulation of SIRT1 activity, which may have important implications in understanding the molecular mechanism of stress response, cell survival, and aging...
  8. pmc Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Mol Cell Biol 32:1226-36. 2012
    ..Taken together, our findings indicate that SIRT1 plays a vital role in the regulation of hepatic bile acid homeostasis through the HNF1α/FXR signaling pathway...
  9. pmc DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    Xiumei Guo
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:13223-32. 2010
    ..These findings may have important implications in understanding the molecular mechanisms of tumorigenesis, Down syndrome, and aging...
  10. ncbi request reprint Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis
    Nevzat Kazgan
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Gastroenterology 146:1006-16. 2014
    ..However, little is known about its role in the small intestine, which absorbs and senses nutrients. We investigated the functions of intestinal SIRT1 in systemic bile acid and cholesterol metabolism in mice...
  11. pmc Sirtuin 1 in lipid metabolism and obesity
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC 27709, USA
    Ann Med 43:198-211. 2011
    ..It includes brief overviews of sirtuin signaling, with emphasis on SIRT1's role in the liver, macrophage, brain, and adipose tissue as it relates to obesity...