W Li

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation
    W Li
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 18:5888-98. 1998
  2. ncbi Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity
    W Li
    Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:24550-5. 1997
  3. ncbi IFN-gamma increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats
    C E Egwuagu
    Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1858, USA
    J Immunol 162:510-7. 1999
  4. ncbi Cortical brain regions engaged by masked emotional faces in adolescents and adults: an fMRI study
    D S Pine
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Emotion 1:137-47. 2001
  5. ncbi The expression of GABA(A) receptor alpha2 subunit is upregulated by testosterone in rat cerebral cortex
    L Zhang
    Behavioral Endocrinology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Neurosci Lett 265:25-8. 1999
  6. ncbi Expression of the Krüppel-type zinc finger protein rKr2 in the developing nervous system
    G Lovas
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4160, USA
    Glia 34:110-20. 2001
  7. ncbi Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats
    C E Egwuagu
    Laboratory of Immunology, National Eye Institute, Bethesda, Maryland 20892, USA
    Clin Immunol 91:196-205. 1999
  8. ncbi Stem cell properties of human dental pulp stem cells
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, NIDCR, NIH, Bethesda, MD 20892, USA
    J Dent Res 81:531-5. 2002
  9. pmc Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action
    N Kedei
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem Pharmacol 85:313-24. 2013
  10. ncbi A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation
    W Li
    of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD, USA
    Oncogene 26:7204-12. 2007

Detail Information

Publications71

  1. pmc Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation
    W Li
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 18:5888-98. 1998
    ..Competition with endogenous PKC-delta for NM1 and IGF-IR association by PKC-deltaK376R is probably an important mechanism underlying the PKC-deltaK376R-mediated inhibition of cell transformation by NM1 and IGF-IR...
  2. ncbi Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity
    W Li
    Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:24550-5. 1997
    ..Taken together, our results demonstrate that serine 643 of PKC-delta is a major autophosphorylation site, and phosphorylation of this site plays an important role in controlling its enzymatic activity and biological function...
  3. ncbi IFN-gamma increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats
    C E Egwuagu
    Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1858, USA
    J Immunol 162:510-7. 1999
    ....
  4. ncbi Cortical brain regions engaged by masked emotional faces in adolescents and adults: an fMRI study
    D S Pine
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Emotion 1:137-47. 2001
    ..Adolescents and adults differed in the degree to which posterior hemisphere brain areas were engaged by viewing masked facial displays of emotion...
  5. ncbi The expression of GABA(A) receptor alpha2 subunit is upregulated by testosterone in rat cerebral cortex
    L Zhang
    Behavioral Endocrinology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Neurosci Lett 265:25-8. 1999
    ..As the effects of T are developmental-stage-specific, they may have an organizational impact on brain development...
  6. ncbi Expression of the Krüppel-type zinc finger protein rKr2 in the developing nervous system
    G Lovas
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4160, USA
    Glia 34:110-20. 2001
    ..The stage-specific expression pattern and the subcellular localization of rKr2 recommend a role for this Krüppel-type gene in the progression of neural stem cells and in the early development of the oligodendrocyte lineage...
  7. ncbi Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats
    C E Egwuagu
    Laboratory of Immunology, National Eye Institute, Bethesda, Maryland 20892, USA
    Clin Immunol 91:196-205. 1999
    ..Our data underscore the danger in extrapolation of cytokine effects in the mouse to humans without corroborating evidence in other species...
  8. ncbi Stem cell properties of human dental pulp stem cells
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, NIDCR, NIH, Bethesda, MD 20892, USA
    J Dent Res 81:531-5. 2002
    ..Taken together, these results demonstrate that DPSCs possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation...
  9. pmc Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action
    N Kedei
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem Pharmacol 85:313-24. 2013
    ....
  10. ncbi A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation
    W Li
    of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD, USA
    Oncogene 26:7204-12. 2007
    ....
  11. ncbi Interferon-gamma induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factors
    C E Egwuagu
    Laboratories of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Oncogene 25:3670-9. 2006
    ....
  12. ncbi Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens
    W Li
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 210:44-55. 1999
    ....
  13. pmc Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
    J M Peters
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:5119-28. 2000
    ..These results are the first to provide in vivo evidence of significant roles for PPARbeta in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation...
  14. ncbi Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens
    W Li
    Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:9686-91. 1999
    ....
  15. ncbi Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors
    W Li
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 40:976-82. 1999
    ..The present study was undertaken to investigate the molecular mechanisms of IFN-gamma action...
  16. ncbi Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation
    B Ouyang
    Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267, USA
    Cell Growth Differ 9:877-85. 1998
    ..The molecular cloning of hBub1 cDNA will facilitate the study of its role in spindle checkpoint control as well as its potential role in certain genetic disorders...
  17. pmc The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
    W Li
    Department of Pharmacology, New York University Medical Center, New York 10016
    Mol Cell Biol 12:5824-33. 1992
    ..Nck probably functions as an adaptor protein which links surface receptors with tyrosine kinase activity to downstream signalling pathways involved in the control of cell proliferation...
  18. ncbi BUBR1 phosphorylation is regulated during mitotic checkpoint activation
    W Li
    Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267, USA
    Cell Growth Differ 10:769-75. 1999
    ..Considering its strong homology to BUB1 protein kinase, BUBR1 may also play an important role in mitotic checkpoint control by phosphorylation of a critical cellular component(s) of the mitotic checkpoint pathway...
  19. ncbi Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner
    N Jain
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Dr, Singapore 117609
    J Biol Chem 274:24392-400. 1999
    ..These results indicate that PKC delta is likely to be the kinase that phosphorylates Stat3 in response to IL-6 stimulation and suggest a possible regulatory role of PKC delta on Stat3 function...
  20. ncbi Preconditioning with spreading depression activates specifically protein kinase Cdelta
    K Kurkinen
    AI Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    Neuroreport 12:269-73. 2001
    ..A significant increase at mRNA level, protein amount and autophosphorylation at 12 h confirmed the late activation of PKCdelta, which may be involved in neuronal protection by preconditioning...
  21. ncbi The alpha1-6-fucosyltransferase gene and its biological significance
    E Miyoshi
    Department of Biochemistry, Osaka University Medical School, Room B 1, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochim Biophys Acta 1473:9-20. 1999
    ..In this review, we focus on alpha1-6FucT and summarize its properties, gene expression and biological significance...
  22. ncbi Improved transduction of primary murine hepatocytes by recombinant adeno-associated virus 2 vectors in vivo
    L Zhong
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Gene Ther 11:1165-9. 2004
    ....
  23. ncbi Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells
    J Li
    Cancer Research Institute, School of Xiangya Medicine, Central South University, Changsha, China
    J Protein Chem 20:265-71. 2001
    ..These proteins included Fas, zinc-finger protein (ZNF), RAB, and Ah receptor-interacting protein (AIP). The functional implications of the identified proteins are discussed...
  24. ncbi Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22
    J Qian
    Cancer Research Institute, Human Medical University, Changsha, PR China
    J Cancer Res Clin Oncol 127:613-8. 2001
    ..To clone the putative tumor suppressor gene(s) in a refined region at 9p21-22 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC)...
  25. ncbi An improved rat model of obstructive jaundice and its reversal by internal and external drainage
    W Li
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Surg Res 101:4-15. 2001
    ..CONCLUSIONS: We have developed a simple and reproducible rat model that allows for the study of reversal of OJ by ID or ED. We also demonstrated that ID is superior to ED in reversing impaired liver function in OJ...
  26. ncbi The gene mutated in cocoa mice, carrying a defect of organelle biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3 gene
    T Suzuki
    Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B161, Denver, Colorado 80262, USA
    Genomics 78:30-7. 2001
    ..Analysis of coa-mutant mice and cultured coa-mutant mouse melanocytes indicates that the normal coa gene product is involved in early stages of melanosome biogenesis and maturation...
  27. ncbi In vivo studies of the anti-tumor effects of a human prolactin antagonist, hPRL-G129R
    N Y Chen
    Oncology Research Institute, Cancer Center, Greenville Hospital System, Department of Microbiology and Molecular Medicine, Clemson University, Greenville, SC 29605, USA
    Int J Oncol 20:813-8. 2002
    ..Based on these results, we believe that hPRL-G129R can be used to improve the outcome of human breast cancer treatment in the near future...
  28. ncbi Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation
    H Liu
    Box 0640, University of California, San Francisco, CA 94143 0640, USA
    J Dent Res 83:496-9. 2004
    ..This study shows that Dentonin can promote DPSC proliferation, with a potential role in pulp repair. Further studies are required to determine the usefulness of this material in vivo...
  29. ncbi CYP6B cytochrome p450 monooxygenases from Papilio canadensis and Papilio glaucus: potential contributions of sequence divergence to host plant associations
    W Li
    Department of Entomology, University of Illinois, Urbana, IL 61801 3795, USA
    Insect Mol Biol 11:543-51. 2002
    ..Thus, changes in p450 regulation as well as catalytic activity may play a role in the evolution of host plant associations in herbivorous insects...
  30. ncbi Characterization and evolution of furanocoumarin-inducible cytochrome P450s in the parsnip webworm, Depressaria pastinacella
    W Li
    Department of Entomology, University of Illinois, Urbana, IL 61801, USA
    Insect Mol Biol 13:603-13. 2004
    ..Characterization of these P450 cDNAs will allow for functional analyses aimed at elucidating the molecular mechanisms underlying the coevolutionary interactions between this herbivore and its principal host plant...
  31. doi Neonatal vaccination with Bacillus Calmette-Guérin elicits long-term protection in mouse-allergic responses
    H Shen
    Department of Respiratory Disease, Second Hospital of Medical School of Zhejiang University, Hangzhou, China
    Allergy 63:555-63. 2008
    ..This study was aimed to investigate the impact of neonatal BCG treatment on allergic asthma and possible mechanism(s) underlying the action of BCG in different ages of mice...
  32. doi Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model
    W Li
    Molecular Biology Center, Research Institute of Surgery and Daping Hospital, 10 Changjiang Zhilu, Third Military Medical University, Chongqing 400042, PR China
    Neuroscience 151:1198-207. 2008
    ..These results highlight the potential benefit of chronic caffeine intake for preventing TBI and provide a rationale for the epidemiological investigation of the potential association between TBI and human caffeine intake...
  33. ncbi Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice
    C Y Li
    Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
    Leukemia 21:2277-86. 2007
    ..1 and Pax5 in transgenic hematopoietic stem cells. These data suggested that EDAG was a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment...
  34. ncbi Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer
    X Xu
    Laboratory of Molecular Oncology, Beijing Institute for Cancer Research, School of Oncology, Peking University, Hai Dian District, Beijing, China
    Oncogene 26:7371-9. 2007
    ..Moreover, p42.3 might be involved in cell proliferation and tumorigenesis; therefore, this gene might have potential applications in the diagnosis or treatment of GC...
  35. ncbi Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion
    S Sengupta
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Oncogene 26:2894-901. 2007
    ..LPA downregulates TIMP3, which may have targets other than metalloproteinases. Our in vivo metastasis mouse model is useful for studying the efficacy of therapeutic regimes of ovarian cancer...
  36. pmc Amelogenins in human developing and mature dental pulp
    L Ye
    Department of Orofacial Sciences, University of California at San Francisco, Box 0422, San Francisco, CA 94143 0422, USA
    J Dent Res 85:814-8. 2006
    ..These studies suggest that odontoblasts actively synthesize and secrete amelogenin protein during human tooth development, and that low-molecular-weight amelogenins can enhance pulp cell proliferation...
  37. ncbi Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein
    W Li
    Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, People s Republic of China
    Int J Gynecol Cancer 16:1620-30. 2006
    ..Together, these data provide strong evidence for the potential use of siRNA as a novel radiation/chemotherapy-sensitizing agent...
  38. ncbi Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells
    J Pearlberg
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Symp Quant Biol 70:449-59. 2005
    ..These results point to the near-term goal of establishing comprehensive, unbiased screens that will allow queries on the roles of all human proteins...
  39. ncbi Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice
    G Valverde-Franco
    J T N Wong Laboratories for Mineralized Tissue Research, and Centre for Bone and Periodontal Research, McGill University, 740 Avenue Dr Penfield, Montreal H3A 1A4, Quebec, Canada
    Hum Mol Genet 15:1783-92. 2006
    ..These results identify Fgfr3 signaling as a potential target for intervention in degenerative disorders of cartilage metabolism...
  40. ncbi Levan (beta-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E p
    Q Xu
    Central Research Institute, Mizkan Group Co Ltd, Handa, Japan
    Clin Exp Allergy 36:94-101. 2006
    ..However, the formulations previously examined were not chemically pure, and this is a major limitation for elucidation of the molecular mechanisms for their activities...
  41. ncbi Characterization of human primary enamel organ epithelial cells in vitro
    P K DenBesten
    University of California at San Francisco, 94143 0640, USA
    Arch Oral Biol 50:689-94. 2005
    ..Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ...
  42. ncbi The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)
    B R Jones
    Graduate Center for Toxicology, 306 Health Sciences Research Building, University of Kentucky, Lexington, KY 40536 0305, USA
    Mol Pharmacol 68:701-10. 2005
    ..Rather, the observed difference in protein synthesis suggests an intrinsic role for the translational regulation of rat Mrp2 protein...
  43. ncbi Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells
    F Li
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Endothelium 11:199-206. 2004
    ..These results indicate that small-molecular-weight peptides derived from the degradation of porcine SIS are biologically active in the recruitment of murine endothelial cells in vitro and in vivo...
  44. pmc Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    X Wang
    Division of Molecular Physiology and MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 20:4370-9. 2001
    ..In contrast, regulation of eEF2 by stimuli that activate Erk is insensitive to rapamycin, but blocked by inhibitors of MEK/Erk signalling, consistent with the involvement of p90(RSK1)...
  45. ncbi Molecular analysis of multiple CYP6B genes from polyphagous Papilio species
    W Li
    Department of Entomology, University of Illinois, Urbana, IL 61801, USA
    Insect Biochem Mol Biol 31:999-1011. 2001
    ..glaucus maintains its association with rutaceous hostplants and P. canadensis has differentiated to utilize hostplants in other families more extensively...
  46. ncbi Regulation of Smad7 promoter by direct association with Smad3 and Smad4
    R P Nagarajan
    Department of Medical Genetics, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 274:33412-8. 1999
    ..Taken together, these data provided the first evidence that Smad7 transcription is regulated by TGF-beta and activin signaling through direct binding of Smad3 and Smad4 to the Smad7 promoter...
  47. ncbi The physical association and phosphorylation of Cdc25C protein phosphatase by Prk
    B Ouyang
    Division of Hematology Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine ML 508, K pavilion, 231 Bethesda Avenue, Cincinnati, Ohio, OH 45267 0508, USA
    Oncogene 18:6029-36. 1999
    ..Together, these observations strongly suggest that Prk's role in mitosis is at least partly mediated through direct regulation of Cdc25C...
  48. ncbi The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
    E J Lowenstein
    Department of Pharmacology, New York University Medical Center, New York 10016
    Cell 70:431-42. 1992
    ..These results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling...
  49. ncbi UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    W Mao
    Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
    FEBS Lett 443:326-30. 1999
    ..These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain...
  50. pmc Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C
    E E Saffman
    Departments of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
    Mol Cell Biol 18:4855-62. 1998
    ..In addition, oskar translation commences prior to posterior localization of oskar RNA in Bic-C- oocytes, indicating that Bic-C may regulate oskar translation during oogenesis...
  51. ncbi Identification of the gene responsible for Best macular dystrophy
    K Petrukhin
    Department of Human Genetics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Nat Genet 19:241-7. 1998
    ..The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts...
  52. ncbi Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain
    R Pohjanvirta
    National Public Health Institute, Department of Environmental Medicine, FIN 70701 Kuopio, Finland
    Mol Pharmacol 54:86-93. 1998
    ..These findings suggest that there is a relatively small region in the AhR trans-activation domain that may be capable of providing selectivity to its function...
  53. pmc Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells
    H Y She
    Ben May Institute for Cancer Research, University of Chicago, Illinois 60637, USA
    Mol Biol Cell 8:1709-21. 1997
    ..This study suggests that Grb2 translocates WASp from the cytoplasm to the plasma membrane and the Grb2-WASp complex may play a role in linking receptor tyrosine kinases to the actin cytoskeleton...
  54. pmc PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase
    S Spencer
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Cell Biol 138:845-60. 1997
    ..pombe results in a dominant-negative inhibition of cytokinesis. PSTPIP is therefore a novel actin-associated protein, potentially involved with cytokinesis, whose tyrosine phosphorylation is regulated by PTP HSCF...
  55. pmc Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury
    R M Friedlander
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    J Exp Med 185:933-40. 1997
    ..Our data suggest that genetic manipulation using ICE family dominant negative inhibitors can ameliorate the extent of ischemia-induced brain injury and preserve neurological function...
  56. ncbi Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells
    A Mondino
    Department of Microbiology, University of Minnesota, Minneapolis 55455, USA
    J Immunol 157:2048-57. 1996
    ..Thus, defective IL-2 gene transcription appears to be due, at least in part, to a selective block in the expression of the AP-1 Fos and Jun family members in anergic T cells...
  57. ncbi Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway
    Z Lan
    Departments of Internal Medicine and Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Blood 95:633-8. 2000
    ..Results of these combined studies strongly suggested that the oncogenic transforming ability of Tyro3 was mediated at least in part by the PI3 kinase pathway. (Blood. 2000;95:633-638)..
  58. ncbi Noggin is a negative regulator of neuronal differentiation in developing neocortex
    W Li
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Conn, USA
    Dev Neurosci 22:68-73. 2000
    ....
  59. ncbi Cloning and expression profile of chicken radixin
    W Li
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Biochim Biophys Acta 1491:327-32. 2000
    ..The 3'-UTR of moesin, but not ezrin, was also conserved, suggesting an essential, and possibly specific, regulatory function. A distinct pattern of radixin expression is seen in chicken tissues, suggesting a cell-type-specific function...
  60. ncbi 5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells
    W Li
    Department of Plastic and Reconstructive Surgery, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-3192, Hamamatsu, Japan
    J Photochem Photobiol B 60:79-86. 2001
    ..These findings demonstrate that P-gp does not mediate the ALA-fluorescence kinetics, and multidrug resistant leukemia cells do not have cross-resistance to ALA-PDT...
  61. ncbi CD28 signaling augments Elk-1-dependent transcription at the c-fos gene during antigen stimulation
    W Li
    Department of Medicine, Rheumatic and Autoimmune Diseases Section, and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 167:827-35. 2001
    ....
  62. ncbi Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress
    S Uemura
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    Circ Res 88:1291-8. 2001
    ..This novel mechanism of redox-sensitive MMP-9 expression by hyperglycemia may provide a rationale for antioxidant therapy to modulate diabetic vascular complications...
  63. ncbi Intracellular protein scaffold-mediated display of random peptide libraries for phenotypic screens in mammalian cells
    B Peelle
    Rigel Inc, 240 E. Grand Ave, South San Francisco, CA 94080, USA
    Chem Biol 8:521-34. 2001
    ....
  64. ncbi Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation
    P Sachdev
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 276:26461-71. 2001
    ..Conversely, constitutively activated (ca) Rho is more effective than ca Rac or ca Cdc42 in rescuing the focus forming ability of the mutants. By contrast, ca Cdc42 is most effective in rescuing the colony forming ability of both mutants...
  65. ncbi Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients
    L Staib
    Department of Surgery, University of Ulm, Germany
    Int J Cancer 92:79-87. 2001
    ....
  66. ncbi Use of protein kinase C inhibitors results in rapid [Mg(2+)](i) mobilization in primary cultured rat aortic smooth muscle cells: are certain kinase C isoforms natural homeostatic regulators of cystolic free Mg(2+)
    T Zheng
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Box 31, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Eur J Pharmacol 413:R1-3. 2001
    ....
  67. ncbi A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
    K Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Genet 27:89-93. 2001
    ..Our results are therefore the first to implicate the biosynthesis of fatty acids in the pathogenesis of inherited macular degeneration...
  68. ncbi p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase
    H Wu
    American Health Foundation, Valhalla, New York, NY 10595, USA
    Oncogene 19:4557-62. 2000
    ..Furthermore, BUBR1 phosphorylates p55CDC in vitro, and the phosphorylation of p55CDC by BUBR1 appears to be correlated with spindle checkpoint activation. Together, our studies strongly suggest that BUBR1 may target APC via p55CDC...
  69. pmc Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb
    M Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 20:7867-80. 2000
    ..This is the first report of Nckbeta's role in receptor tyrosine kinase signaling to the actin cytoskeleton...
  70. pmc The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
    W Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 USA
    Genes Dev 14:895-900. 2000
    ..Sur-8 interacts with Ras and Raf and is able to form a ternary complex with the two proteins. Thus, Sur-8 may function as a scaffold that enhances Ras-MAP kinase signal transduction by facilitating the interaction between Ras and Raf...
  71. ncbi Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, New York 10016
    Nature 358:681-4. 1992
    ....