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Genomes and Genes | W LiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformationW Li
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell Biol 18:5888-98. 1998..Competition with endogenous PKC-delta for NM1 and IGF-IR association by PKC-deltaK376R is probably an important mechanism underlying the PKC-deltaK376R-mediated inhibition of cell transformation by NM1 and IGF-IR...
Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activityW Li
Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:24550-5. 1997..Taken together, our results demonstrate that serine 643 of PKC-delta is a major autophosphorylation site, and phosphorylation of this site plays an important role in controlling its enzymatic activity and biological function...- IFN-gamma increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic ratsC E Egwuagu
Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892 1858, USA
J Immunol 162:510-7. 1999.... - Cortical brain regions engaged by masked emotional faces in adolescents and adults: an fMRI studyD S Pine
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
Emotion 1:137-47. 2001..Adolescents and adults differed in the degree to which posterior hemisphere brain areas were engaged by viewing masked facial displays of emotion... - The expression of GABA(A) receptor alpha2 subunit is upregulated by testosterone in rat cerebral cortexL Zhang
Behavioral Endocrinology Branch, NIMH, NIH, Bethesda, MD 20892, USA
Neurosci Lett 265:25-8. 1999..As the effects of T are developmental-stage-specific, they may have an organizational impact on brain development... - Expression of the Krüppel-type zinc finger protein rKr2 in the developing nervous systemG Lovas
Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4160, USA
Glia 34:110-20. 2001..The stage-specific expression pattern and the subcellular localization of rKr2 recommend a role for this Krüppel-type gene in the progression of neural stem cells and in the early development of the oligodendrocyte lineage... - Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis ratsC E Egwuagu
Laboratory of Immunology, National Eye Institute, Bethesda, Maryland 20892, USA
Clin Immunol 91:196-205. 1999..Our data underscore the danger in extrapolation of cytokine effects in the mouse to humans without corroborating evidence in other species... - Stem cell properties of human dental pulp stem cellsS Gronthos
Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, NIDCR, NIH, Bethesda, MD 20892, USA
J Dent Res 81:531-5. 2002..Taken together, these results demonstrate that DPSCs possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation... - Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of actionN Kedei
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Biochem Pharmacol 85:313-24. 2013.... - A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formationW Li
of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD, USA
Oncogene 26:7204-12. 2007.... - Interferon-gamma induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factorsC E Egwuagu
Laboratories of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
Oncogene 25:3670-9. 2006.... - Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lensW Li
National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
Dev Biol 210:44-55. 1999.... - Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)J M Peters
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 20:5119-28. 2000..These results are the first to provide in vivo evidence of significant roles for PPARbeta in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation... - Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lensW Li
Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 274:9686-91. 1999.... - Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factorsW Li
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Invest Ophthalmol Vis Sci 40:976-82. 1999..The present study was undertaken to investigate the molecular mechanisms of IFN-gamma action... - Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferationB Ouyang
Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267, USA
Cell Growth Differ 9:877-85. 1998..The molecular cloning of hBub1 cDNA will facilitate the study of its role in spindle checkpoint control as well as its potential role in certain genetic disorders... - The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsW Li
Department of Pharmacology, New York University Medical Center, New York 10016
Mol Cell Biol 12:5824-33. 1992..Nck probably functions as an adaptor protein which links surface receptors with tyrosine kinase activity to downstream signalling pathways involved in the control of cell proliferation... - BUBR1 phosphorylation is regulated during mitotic checkpoint activationW Li
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267, USA
Cell Growth Differ 10:769-75. 1999..Considering its strong homology to BUB1 protein kinase, BUBR1 may also play an important role in mitotic checkpoint control by phosphorylation of a critical cellular component(s) of the mitotic checkpoint pathway... - Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent mannerN Jain
Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Dr, Singapore 117609
J Biol Chem 274:24392-400. 1999..These results indicate that PKC delta is likely to be the kinase that phosphorylates Stat3 in response to IL-6 stimulation and suggest a possible regulatory role of PKC delta on Stat3 function... - Preconditioning with spreading depression activates specifically protein kinase CdeltaK Kurkinen
AI Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
Neuroreport 12:269-73. 2001..A significant increase at mRNA level, protein amount and autophosphorylation at 12 h confirmed the late activation of PKCdelta, which may be involved in neuronal protection by preconditioning... - The alpha1-6-fucosyltransferase gene and its biological significanceE Miyoshi
Department of Biochemistry, Osaka University Medical School, Room B 1, 2 2 Yamadaoka, Suita, Osaka, Japan
Biochim Biophys Acta 1473:9-20. 1999..In this review, we focus on alpha1-6FucT and summarize its properties, gene expression and biological significance... - Improved transduction of primary murine hepatocytes by recombinant adeno-associated virus 2 vectors in vivoL Zhong
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
Gene Ther 11:1165-9. 2004.... - Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cellsJ Li
Cancer Research Institute, School of Xiangya Medicine, Central South University, Changsha, China
J Protein Chem 20:265-71. 2001..These proteins included Fas, zinc-finger protein (ZNF), RAB, and Ah receptor-interacting protein (AIP). The functional implications of the identified proteins are discussed... - Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22J Qian
Cancer Research Institute, Human Medical University, Changsha, PR China
J Cancer Res Clin Oncol 127:613-8. 2001..To clone the putative tumor suppressor gene(s) in a refined region at 9p21-22 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC)... - An improved rat model of obstructive jaundice and its reversal by internal and external drainageW Li
Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China
J Surg Res 101:4-15. 2001..CONCLUSIONS: We have developed a simple and reproducible rat model that allows for the study of reversal of OJ by ID or ED. We also demonstrated that ID is superior to ED in reversing impaired liver function in OJ... - The gene mutated in cocoa mice, carrying a defect of organelle biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3 geneT Suzuki
Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B161, Denver, Colorado 80262, USA
Genomics 78:30-7. 2001..Analysis of coa-mutant mice and cultured coa-mutant mouse melanocytes indicates that the normal coa gene product is involved in early stages of melanosome biogenesis and maturation... - In vivo studies of the anti-tumor effects of a human prolactin antagonist, hPRL-G129RN Y Chen
Oncology Research Institute, Cancer Center, Greenville Hospital System, Department of Microbiology and Molecular Medicine, Clemson University, Greenville, SC 29605, USA
Int J Oncol 20:813-8. 2002..Based on these results, we believe that hPRL-G129R can be used to improve the outcome of human breast cancer treatment in the near future... - Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferationH Liu
Box 0640, University of California, San Francisco, CA 94143-0640, USA
J Dent Res 83:496-9. 2004..This study shows that Dentonin can promote DPSC proliferation, with a potential role in pulp repair. Further studies are required to determine the usefulness of this material in vivo... - CYP6B cytochrome p450 monooxygenases from Papilio canadensis and Papilio glaucus: potential contributions of sequence divergence to host plant associationsW Li
Department of Entomology, University of Illinois, Urbana, IL 61801-3795, USA
Insect Mol Biol 11:543-51. 2002..Thus, changes in p450 regulation as well as catalytic activity may play a role in the evolution of host plant associations in herbivorous insects... - Characterization and evolution of furanocoumarin-inducible cytochrome P450s in the parsnip webworm, Depressaria pastinacellaW Li
Department of Entomology, University of Illinois, Urbana, IL 61801, USA
Insect Mol Biol 13:603-13. 2004..Characterization of these P450 cDNAs will allow for functional analyses aimed at elucidating the molecular mechanisms underlying the coevolutionary interactions between this herbivore and its principal host plant... 
Neonatal vaccination with Bacillus Calmette-Guérin elicits long-term protection in mouse-allergic responsesH Shen
Department of Respiratory Disease, Second Hospital of Medical School of Zhejiang University, Hangzhou, China
Allergy 63:555-63. 2008..This study was aimed to investigate the impact of neonatal BCG treatment on allergic asthma and possible mechanism(s) underlying the action of BCG in different ages of mice...- Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact modelW Li
Molecular Biology Center, Research Institute of Surgery and Daping Hospital, 10 Changjiang Zhilu, Third Military Medical University, Chongqing 400042, PR China
Neuroscience 151:1198-207. 2008..These results highlight the potential benefit of chronic caffeine intake for preventing TBI and provide a rationale for the epidemiological investigation of the potential association between TBI and human caffeine intake... - Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic miceC Y Li
Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
Leukemia 21:2277-86. 2007..1 and Pax5 in transgenic hematopoietic stem cells. These data suggested that EDAG was a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment... - Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancerX Xu
Laboratory of Molecular Oncology, Beijing Institute for Cancer Research, School of Oncology, Peking University, Hai Dian District, Beijing, China
Oncogene 26:7371-9. 2007..Moreover, p42.3 might be involved in cell proliferation and tumorigenesis; therefore, this gene might have potential applications in the diagnosis or treatment of GC... - Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasionS Sengupta
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Oncogene 26:2894-901. 2007..LPA downregulates TIMP3, which may have targets other than metalloproteinases. Our in vivo metastasis mouse model is useful for studying the efficacy of therapeutic regimes of ovarian cancer... - Amelogenins in human developing and mature dental pulpL Ye
Department of Orofacial Sciences, University of California at San Francisco, Box #0422, San Francisco, CA 94143-0422, USA
J Dent Res 85:814-8. 2006..These studies suggest that odontoblasts actively synthesize and secrete amelogenin protein during human tooth development, and that low-molecular-weight amelogenins can enhance pulp cell proliferation... - Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated proteinW Li
Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, People's Republic of China
Int J Gynecol Cancer 16:1620-30. 2006..Together, these data provide strong evidence for the potential use of siRNA as a novel radiation/chemotherapy-sensitizing agent... - Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cellsJ Pearlberg
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cold Spring Harb Symp Quant Biol 70:449-59. 2005..These results point to the near-term goal of establishing comprehensive, unbiased screens that will allow queries on the roles of all human proteins... - Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient miceG Valverde-Franco
J T N Wong Laboratories for Mineralized Tissue Research, and Centre for Bone and Periodontal Research, McGill University, 740 Avenue Dr Penfield, Montreal H3A 1A4, Quebec, Canada
Hum Mol Genet 15:1783-92. 2006..These results identify Fgfr3 signaling as a potential target for intervention in degenerative disorders of cartilage metabolism... - Levan (beta-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E pQ Xu
Central Research Institute, Mizkan Group Co Ltd, Handa, Japan
Clin Exp Allergy 36:94-101. 2006..However, the formulations previously examined were not chemically pure, and this is a major limitation for elucidation of the molecular mechanisms for their activities... - Characterization of human primary enamel organ epithelial cells in vitroP K DenBesten
University of California at San Francisco, 94143 0640, USA
Arch Oral Biol 50:689-94. 2005..Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ... - The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)B R Jones
Graduate Center for Toxicology, 306 Health Sciences Research Building, University of Kentucky, Lexington, KY 40536 0305, USA
Mol Pharmacol 68:701-10. 2005..Rather, the observed difference in protein synthesis suggests an intrinsic role for the translational regulation of rat Mrp2 protein... - Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cellsF Li
Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
Endothelium 11:199-206. 2004..These results indicate that small-molecular-weight peptides derived from the degradation of porcine SIS are biologically active in the recruitment of murine endothelial cells in vitro and in vivo... - Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinaseX Wang
Division of Molecular Physiology and MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
EMBO J 20:4370-9. 2001..In contrast, regulation of eEF2 by stimuli that activate Erk is insensitive to rapamycin, but blocked by inhibitors of MEK/Erk signalling, consistent with the involvement of p90(RSK1)... - Molecular analysis of multiple CYP6B genes from polyphagous Papilio speciesW Li
Department of Entomology, University of Illinois, Urbana, IL 61801, USA
Insect Biochem Mol Biol 31:999-1011. 2001..glaucus maintains its association with rutaceous hostplants and P. canadensis has differentiated to utilize hostplants in other families more extensively... - Regulation of Smad7 promoter by direct association with Smad3 and Smad4R P Nagarajan
Department of Medical Genetics, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 274:33412-8. 1999..Taken together, these data provided the first evidence that Smad7 transcription is regulated by TGF-beta and activin signaling through direct binding of Smad3 and Smad4 to the Smad7 promoter... - The physical association and phosphorylation of Cdc25C protein phosphatase by PrkB Ouyang
Division of Hematology Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine ML 508, K pavilion, 231 Bethesda Avenue, Cincinnati, Ohio, OH 45267 0508, USA
Oncogene 18:6029-36. 1999..Together, these observations strongly suggest that Prk's role in mitosis is at least partly mediated through direct regulation of Cdc25C... - The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalingE J Lowenstein
Department of Pharmacology, New York University Medical Center, New York 10016
Cell 70:431-42. 1992..These results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling... - UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cellsW Mao
Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
FEBS Lett 443:326-30. 1999..These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain... - Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-CE E Saffman
Departments of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
Mol Cell Biol 18:4855-62. 1998..In addition, oskar translation commences prior to posterior localization of oskar RNA in Bic-C- oocytes, indicating that Bic-C may regulate oskar translation during oogenesis... - Identification of the gene responsible for Best macular dystrophyK Petrukhin
Department of Human Genetics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Nat Genet 19:241-7. 1998..The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts... - Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strainR Pohjanvirta
National Public Health Institute, Department of Environmental Medicine, FIN 70701 Kuopio, Finland
Mol Pharmacol 54:86-93. 1998..These findings suggest that there is a relatively small region in the AhR trans-activation domain that may be capable of providing selectivity to its function... - Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cellsH Y She
Ben May Institute for Cancer Research, University of Chicago, Illinois 60637, USA
Mol Biol Cell 8:1709-21. 1997..This study suggests that Grb2 translocates WASp from the cytoplasm to the plasma membrane and the Grb2-WASp complex may play a role in linking receptor tyrosine kinases to the actin cytoskeleton... - PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphataseS Spencer
Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
J Cell Biol 138:845-60. 1997..pombe results in a dominant-negative inhibition of cytokinesis. PSTPIP is therefore a novel actin-associated protein, potentially involved with cytokinesis, whose tyrosine phosphorylation is regulated by PTP HSCF... - Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injuryR M Friedlander
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
J Exp Med 185:933-40. 1997..Our data suggest that genetic manipulation using ICE family dominant negative inhibitors can ameliorate the extent of ischemia-induced brain injury and preserve neurological function... - Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cellsA Mondino
Department of Microbiology, University of Minnesota, Minneapolis 55455, USA
J Immunol 157:2048-57. 1996..Thus, defective IL-2 gene transcription appears to be due, at least in part, to a selective block in the expression of the AP-1 Fos and Jun family members in anergic T cells... - Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathwayZ Lan
Departments of Internal Medicine and Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Blood 95:633-8. 2000..Results of these combined studies strongly suggested that the oncogenic transforming ability of Tyro3 was mediated at least in part by the PI3 kinase pathway. (Blood. 2000;95:633-638).. - Noggin is a negative regulator of neuronal differentiation in developing neocortexW Li
Department of Physiology and Neurobiology, University of Connecticut, Storrs, Conn, USA
Dev Neurosci 22:68-73. 2000.... - Cloning and expression profile of chicken radixinW Li
Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Biochim Biophys Acta 1491:327-32. 2000..The 3'-UTR of moesin, but not ezrin, was also conserved, suggesting an essential, and possibly specific, regulatory function. A distinct pattern of radixin expression is seen in chicken tissues, suggesting a cell-type-specific function... - 5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cellsW Li
Department of Plastic and Reconstructive Surgery, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-3192, Hamamatsu, Japan
J Photochem Photobiol B 60:79-86. 2001..These findings demonstrate that P-gp does not mediate the ALA-fluorescence kinetics, and multidrug resistant leukemia cells do not have cross-resistance to ALA-PDT... - CD28 signaling augments Elk-1-dependent transcription at the c-fos gene during antigen stimulationW Li
Department of Medicine, Rheumatic and Autoimmune Diseases Section, and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunol 167:827-35. 2001.... - Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stressS Uemura
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, Calif, USA
Circ Res 88:1291-8. 2001..This novel mechanism of redox-sensitive MMP-9 expression by hyperglycemia may provide a rationale for antioxidant therapy to modulate diabetic vascular complications... - Intracellular protein scaffold-mediated display of random peptide libraries for phenotypic screens in mammalian cellsB Peelle
Rigel Inc, 240 E. Grand Ave, South San Francisco, CA 94080, USA
Chem Biol 8:521-34. 2001.... - Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformationP Sachdev
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 276:26461-71. 2001..Conversely, constitutively activated (ca) Rho is more effective than ca Rac or ca Cdc42 in rescuing the focus forming ability of the mutants. By contrast, ca Cdc42 is most effective in rescuing the colony forming ability of both mutants... - Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patientsL Staib
Department of Surgery, University of Ulm, Germany
Int J Cancer 92:79-87. 2001.... - Use of protein kinase C inhibitors results in rapid [Mg(2+)](i) mobilization in primary cultured rat aortic smooth muscle cells: are certain kinase C isoforms natural homeostatic regulators of cystolic free Mg(2+)T Zheng
Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Box 31, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Eur J Pharmacol 413:R1-3. 2001.... - A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophyK Zhang
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Genet 27:89-93. 2001..Our results are therefore the first to implicate the biosynthesis of fatty acids in the pathogenesis of inherited macular degeneration... - p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinaseH Wu
American Health Foundation, Valhalla, New York, NY 10595, USA
Oncogene 19:4557-62. 2000..Furthermore, BUBR1 phosphorylates p55CDC in vitro, and the phosphorylation of p55CDC by BUBR1 appears to be correlated with spindle checkpoint activation. Together, our studies strongly suggest that BUBR1 may target APC via p55CDC... - Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bbM Chen
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
Mol Cell Biol 20:7867-80. 2000..This is the first report of Nckbeta's role in receptor tyrosine kinase signaling to the actin cytoskeleton... - The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and RafW Li
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 USA
Genes Dev 14:895-900. 2000..Sur-8 interacts with Ras and Raf and is able to form a ternary complex with the two proteins. Thus, Sur-8 may function as a scaffold that enhances Ras-MAP kinase signal transduction by facilitating the interaction between Ras and Raf... - Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesisM Mohammadi
Department of Pharmacology, New York University Medical Center, New York 10016
Nature 358:681-4. 1992....