Qian Li

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Pharmacol Exp Ther 291:999-1007. 1999
  2. ncbi request reprint Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Neurosci 20:7888-95. 2000
  3. ncbi request reprint Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1264, USA
    J Neurochem 84:1256-65. 2003
  4. ncbi request reprint Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior
    Andrew Holmes
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Building 10, Room 3C217, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 178:276-85. 2005
  5. ncbi request reprint Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB)
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Pharmacol Exp Ther 308:481-6. 2004
  6. ncbi request reprint Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress
    Olga A Tjurmina
    Laboratory of Clinical Science, NIMH, NIH, Bldg 10, Rm 3D41, 10 Center Dr, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:99-104. 2004
  7. ncbi request reprint Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1031-44. 2003
  8. ncbi request reprint Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0431, USA
    J Neurosci 24:10868-77. 2004
  9. ncbi request reprint Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0431, USA
    Neuropsychopharmacology 32:1813-21. 2007
  10. doi request reprint Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice
    Jian Ping Zhou
    Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
    Brain Res 1191:12-9. 2008

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Pharmacol Exp Ther 291:999-1007. 1999
    ....
  2. ncbi request reprint Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Neurosci 20:7888-95. 2000
    ..Finally, alterations in G-protein coupling to 5-HT(1A) receptors are unlikely to be involved in the desensitization of 5-HT(1A) receptors in 5-HTT -/- mice...
  3. ncbi request reprint Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1264, USA
    J Neurochem 84:1256-65. 2003
    ..These changes may not be mediated by alterations in their gene expression or in the level of Gq/11 proteins. The alterations in these receptors may be related to the altered behaviors of 5-HTT knockout mice...
  4. ncbi request reprint Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior
    Andrew Holmes
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Building 10, Room 3C217, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 178:276-85. 2005
    ....
  5. ncbi request reprint Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB)
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Pharmacol Exp Ther 308:481-6. 2004
    ..In addition, fenfluramine showed a low capability to compete with [(3)H]AFM. The present results suggest that both AFM and DASB are highly selective SERT ligands potentially suitable for use in human PET studies of SERT...
  6. ncbi request reprint Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress
    Olga A Tjurmina
    Laboratory of Clinical Science, NIMH, NIH, Bldg 10, Rm 3D41, 10 Center Dr, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:99-104. 2004
    ..Our results indicate that SERT function not only restrains stress-induced EPI release but also is required for the increase in adrenal catecholamine synthesis and AT(2) receptor expression...
  7. ncbi request reprint Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1031-44. 2003
    ..These behavioral findings in the first galanin receptor null mutant mouse are consistent with the hypothesis that galanin exerts anxiolytic actions via the GAL-R1 receptor under conditions of relatively high stress...
  8. ncbi request reprint Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0431, USA
    J Neurosci 24:10868-77. 2004
    ..Thus, the present results demonstrate that medial hypothalamic 5-HT1A receptors regulate stress responses and locomotor activity but may not regulate exploratory anxiety-like behaviors...
  9. ncbi request reprint Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0431, USA
    Neuropsychopharmacology 32:1813-21. 2007
    ..Our results suggest that an upregulation of the CCK response system and 5-HT(1A)R in the hypothalamus of Tg/Tg mice may mediate the alterations in the observed behaviors of these mice...
  10. doi request reprint Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice
    Jian Ping Zhou
    Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
    Brain Res 1191:12-9. 2008
    ..The peripherally administered PTD-rhBDNF exhibited neuroprotective effects in brain and raise the possibility of delivery of the exogenous rhBDNF in treatment of the brain diseases...
  11. ncbi request reprint Determination of the three-dimensional structure of Gynoside A in solution using NMR and molecular modeling
    Qian Li
    Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, PR China
    Molecules 12:907-16. 2007
    ..Except for some quantitative details the overall structure of Gynoside A in pyridine-d5 shared many common features with that in DMSO-d6. The structure in pyridine-d5 had lower energies than that in DMSO-d6 solution...
  12. doi request reprint Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells
    Lina Wu
    Center for Human Disease Genomics, Health Science Center, Peking University, 38 Xue Yuan Road, Beijing, 100083, P R China
    Mol Cancer Ther 7:222-32. 2008
    ..In addition, Ad5-hHSG increased the sensitivity of these cell lines to two chemotherapeutic agents, VP16 and CHX, and radiation. These results suggest that Ad5-hHSG may serve as an effective therapeutic drug against tumors...
  13. doi request reprint Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41)
    Rui Chen
    Department of General Medicine, Kanazawa Medical University, 1 1 Daigaku, Uchinada machi, Kahoku gun, Ishikawa, 920 0293, Japan
    Neurochem Res 33:1759-67. 2008
    ..TJ-41 increased the daily running activity of the model, which was independent of brain recovery...
  14. ncbi request reprint Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques
    Qian Li
    Department of Chemistry, New York University, School of Medicine, New York, NY 11219, USA
    Chembiochem 8:1679-87. 2007
    ..A representative compound, STB-8, was used in ex vivo and in vivo imaging experiments on an AD transgenic mouse model and demonstrated excellent blood-brain barrier (BBB) permeability and specific staining of the AD beta-amyloid plaques...
  15. ncbi request reprint [Genetic status of a AB chimeric blood group family]
    Bao cheng Yang
    Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518035, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:417-20. 2007
    ..In conclusion, analysis of chimeric blood group by using genotyping techniques clearly demonstrating genetic status of this rare chimeric blood group promotes further elucidation of the existing state of specific genetic status...
  16. pmc Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice
    Jian Hua Mao
    Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 11:161-73. 2007
    ..These data have implications for the design of approaches to targeted cancer therapy involving the crosstalk between Aurora-A kinase and p53 pathways...
  17. ncbi request reprint [The effect of matrix metalloproteinase-9 in granulocyte colony stimulation factor-induced stem cell mobilization]
    Feng Yan Jin
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, China Academy Medical Sciences and Peking Union Medical College, Tianjin 300020, China
    Zhonghua Yi Xue Za Zhi 86:2966-70. 2006
    ..To investigate the effects of matrix metalloproteinase-9 (MMP-9) on granulocyte colony stimulation factor (G-CSF)-induced hematopoietic stem/progenitor cell (HSPC) mobilization in healthy donors of hematopoietic stem cells...
  18. ncbi request reprint The roles of MMP-2/TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats
    Qian Li
    Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, China
    Acta Cardiol 62:485-91. 2007
    ....
  19. ncbi request reprint [Effect of baicalin on HSP70 expression of hippocampal neurons in focal brain ischemia-reperfusion injury rats]
    Ping Liu
    Institute of Pharmacology, School of Medicine, Shandong University, Jinan 250012, China
    Yao Xue Xue Bao 41:619-24. 2006
    ..To investigate the effect of baicalin on the hippocampal neuronal apoptosis and the expression of HSP70 in rats with focal brain ischemia-reperfusion injury...
  20. ncbi request reprint Cloning and characterization of a plastidic glycerol 3-phosphate dehydrogenase cDNA from Dunaliella salina
    Qinghua He
    Key Laboratory of Bio resources and Eco environment, Sichuan University, Ministry of Education, Chengdu, Sichuan Province, PR China
    J Plant Physiol 164:214-20. 2007
    ..salina can catalyze the step from dihydroxyacetone phosphate to glycerol directly. This is unique and a possible explanation for the fast glycerol synthesis found in D. salina...
  21. pmc Role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infection
    Qian Li
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Infect Immun 71:4873-82. 2003
    ..Signals delivered by pattern recognition receptors other than TLR4 are sufficient for the increased expression of the TNF-alpha transcript and at least some genes associated with macrophage tolerance...
  22. ncbi request reprint Specific oligobodies against human brain acetylcholinesterase
    Xing Mei Zhang
    Beijing Institute of Pharmacology and Toxicology, Beijin 100850, China
    Brain Res 989:147-51. 2003
    ....
  23. ncbi request reprint Cytotoxic activity of the recombinant anti-mesothelin immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas
    Qian Li
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Anticancer Res 24:1327-35. 2004
    ....
  24. ncbi request reprint Dysregulation of HSG triggers vascular proliferative disorders
    Kuang Hueih Chen
    The Institute of Cardiovascular Science and The Institute of Molecular Medicine, Peking University, Beijing 100083, China
    Nat Cell Biol 6:872-83. 2004
    ..Thus, rHSG functions as a cell proliferation suppressor, whereas dysregulation of rHSG results in proliferative disorders...
  25. ncbi request reprint Alternative therapy of Alzheimer's disease via supplementation with choline acetyltransferase
    Ai Ling Fu
    Department of Biochemistry and Pharmacology, Institute of Pharmacology and Toxicology, Tai Ping Road, 27, 100850 Beijing, China
    Neurosci Lett 368:258-62. 2004
    ..Our results imply a novel and potentially effective way for Alzheimer's disease therapy...
  26. ncbi request reprint Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice
    Jiang Hua Mao
    Cancer Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Oncogene 24:7924-34. 2005
    ..The nature of these early events may determine the overall genomic signature observed in the resulting tumor...
  27. ncbi request reprint Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes
    Annaiah Cariappa
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Immunity 23:397-407. 2005
    ..The bone marrow represents a unique type of secondary lymphoid organ in which mature B cells are strategically positioned in the path of circulating microbes...
  28. ncbi request reprint Noninvasive genotyping of 9 Y-chromosome specific STR loci using circulatory fetal DNA in maternal plasma by multiplex PCR
    Zhihui Deng
    Shenzhen Blood Center, Shenzhen, Guang Dong, 518035, PR of China
    Prenat Diagn 26:362-8. 2006
    ....
  29. ncbi request reprint A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase
    Shao Ping Wu
    Department of Biochemistry and Pharmacology, Beijing Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Tai Ping Road, 27, Beijing 100850, China
    Biochem Biophys Res Commun 346:1-6. 2006
    ..The results imply that iv delivery of PTD-TH is therapeutically effective on the 6-OHDA-induced PD in rats, the PTD-mediated human TH treatment opening a promising therapeutic direction in treatment of PD...
  30. doi request reprint Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention
    Ghenet K Hagos
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Pharmacol 74:1381-91. 2008
    ..The results provide a direction for lead compound refinement. The evidence for a contribution from the NO mimetic activity of nitrates in vitro was equivocal, and combinations of nitrates with acetylsalicylic acid were inactive...