Lei Li

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A subcortical maternal complex essential for preimplantation mouse embryogenesis
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 15:416-25. 2008
  2. ncbi request reprint Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos
    Mami Ohsugi
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:259-69. 2008
  3. pmc Maternal control of early mouse development
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:859-70. 2010
  4. pmc A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 37:865-78. 2010
  5. pmc BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 103:4068-73. 2006
  6. ncbi request reprint Verification and tissue-specific expression of nifU-like gene from the amphioxus Branchiostoma belcheri
    Lei Li
    Department of Marine Biology, Ocean University of China, Qingdao, People s Republic of China
    DNA Seq 18:363-70. 2007
  7. ncbi request reprint Development of a high throughput transformation system for insertional mutagenesis in Magnaporthe oryzae
    Melania F Betts
    Department of Plant Sciences, Division of Plant Pathology and Microbiology, University of Arizona, Tucson, AZ 85721 0036, USA
    Fungal Genet Biol 44:1035-49. 2007
  8. ncbi request reprint hMRE11 plays an important role in U937 cellular response to DNA double-strand breaks following etoposide
    Ling Bo Liu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:10-5. 2007
  9. ncbi request reprint Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    Chenggang Wu
    Department of Biochemistry and the Siebens Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Proteomics 7:1775-85. 2007
  10. ncbi request reprint Mirl is highly upregulated and localized to nuclei during infectious hyphal growth in the rice blast fungus
    Lei Li
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907, USA
    Mol Plant Microbe Interact 20:448-58. 2007

Collaborators

  • Jurrien Dean
  • Da Jin Li
  • Boris Baibakov
  • Ping Zheng
  • Maureen E Hoatlin
  • W Wang
  • Kevin R Brown
  • Wai-Sum O
  • Yun Zhang
  • Ting Xie
  • Mark R Cookson
  • Vern Schramm
  • Xiao Fan Zhao
  • Tony Pawson
  • Margaret Spitz
  • Qingjie Wang
  • Ling Bo Liu
  • Chunxin Fan
  • Jinhu Yin
  • Qi Wan
  • Zhijiang Yan
  • Xiaofei Yu
  • Yuk Yin Li
  • Tomonori Kaneko
  • Martin Lee Miller
  • Mami Ohsugi
  • Xiao Lei Shi
  • Shawn S C Li
  • Shicui Zhang
  • Min Chen
  • Peng George Wang
  • Qingsheng Qi
  • Melania F Betts
  • Chenggang Wu
  • Jemy A Gutierrez
  • Jing Luan
  • Leonard Wu
  • Xin Wang
  • Jae Il Park
  • Shao Ping Ji
  • Wei Ming Li
  • Ping Zou
  • Tong Qiao
  • Chang Xu
  • Jin Rong Xu
  • Mingxia Liao
  • Wen Jiang
  • Xia Zhang
  • Shengwei Zou
  • Lin Pei
  • Fang Liu
  • Shuna Sun
  • Wen li Xie
  • Xia Wu
  • Changxia Sun
  • Kenneth S Bruno
  • Ke Ning
  • Jinghe Yang
  • Jing lan Wang
  • Frank P Marx
  • M Page Haynes
  • Xiaohua Ni
  • Erich M Sturgis
  • Karen M Vasquez
  • Ti Lin
  • Johan P de Winter
  • Parameswary A Muniandy
  • Xi Shen
  • Christopher L Woodcock
  • Andrzej Stasiak
  • Ranjan Sen
  • Stacie Stone
  • Fekret Osman
  • Chantal D├ęcaillet
  • Mathieu Delannoy
  • Alicja Z Stasiak
  • Beatrice Schuster
  • Jurgen Steltenpool
  • Matthew C Whitby
  • Danielle Daee
  • Kyungjae Myung
  • Anneke B Oostra
  • Michael M Seidman
  • Angelos Constantinou
  • Hans Joenje
  • Chen Ling
  • Detlev Schindler
  • Hansen Du
  • Zhang Hua Zhu
  • Marina Olhovsky

Detail Information

Publications49

  1. pmc A subcortical maternal complex essential for preimplantation mouse embryogenesis
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 15:416-25. 2008
    ..However, these embryos do not progress beyond cleavage stage development and female mice are sterile. The proteins are conserved in humans, and similar maternal effect mutations may result in recurrent embryonic loss...
  2. ncbi request reprint Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos
    Mami Ohsugi
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:259-69. 2008
    ..If so, the plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development...
  3. pmc Maternal control of early mouse development
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:859-70. 2010
    ..Nevertheless, significant gaps remain in our mechanistic understanding of the networks that regulate early mammalian embryogenesis, which provide an impetus and opportunities for future investigations...
  4. pmc A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 37:865-78. 2010
    ..Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human...
  5. pmc BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
    Leonard Wu
    Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 103:4068-73. 2006
    ..Implications of the conserved ability of type IA topoisomerases to catalyze dissolution and how the evolution of factors such as BLAP75/RMI1 might confer specificity on the execution of this process are discussed...
  6. ncbi request reprint Verification and tissue-specific expression of nifU-like gene from the amphioxus Branchiostoma belcheri
    Lei Li
    Department of Marine Biology, Ocean University of China, Qingdao, People s Republic of China
    DNA Seq 18:363-70. 2007
    ..Taken together, it is highly likely that NifU-like protein plays some tissue-dependent and critical role in amphioxus...
  7. ncbi request reprint Development of a high throughput transformation system for insertional mutagenesis in Magnaporthe oryzae
    Melania F Betts
    Department of Plant Sciences, Division of Plant Pathology and Microbiology, University of Arizona, Tucson, AZ 85721 0036, USA
    Fungal Genet Biol 44:1035-49. 2007
    ..3% of conidia being transformed. The phenotypic data is accessible via a public database called MGOS and all strains are publicly available. This represents the most comprehensive insertional mutagenesis analysis of a fungal pathogen...
  8. ncbi request reprint hMRE11 plays an important role in U937 cellular response to DNA double-strand breaks following etoposide
    Ling Bo Liu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:10-5. 2007
    ..95 +/- 2.91% (P < 0.05). It is concluded that the nuclear focus formation of hMRE11 protein may be a response to DNA damage induced by topoisomerase II inhibitor VP-16 in human promonocytic cell line U937...
  9. ncbi request reprint Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    Chenggang Wu
    Department of Biochemistry and the Siebens Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Proteomics 7:1775-85. 2007
    ....
  10. ncbi request reprint Mirl is highly upregulated and localized to nuclei during infectious hyphal growth in the rice blast fungus
    Lei Li
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907, USA
    Mol Plant Microbe Interact 20:448-58. 2007
    ..These data suggest that the expression but not the nuclear localization of MIR1 is specific to infectious hyphae and that reporter genes based on MIR1 may be suitable for monitoring infectious growth in M. grisea...
  11. ncbi request reprint Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals
    Jae Il Park
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Cell 11:683-95. 2006
    ....
  12. ncbi request reprint Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
    Xin Wang
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell 23:331-41. 2006
    ..These findings reveal a phosphorylation-dependent function of Rad17 in an ATR-Rad17-Claspin-Chk1-signaling cascade that responds to specific replication stress...
  13. ncbi request reprint [Blocking the escape of leukemic cells from killing of T cell by combining anti-Fas ribozyme and CD80-IgG fusion protein]
    Ling Bo Liu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Yi Xue Za Zhi 85:3469-74. 2005
    ....
  14. ncbi request reprint Construction of a novel system for cell surface display of heterologous proteins on Pichia pastoris
    Qingjie Wang
    State Key Laboratory of Microbial Technology, Life Science School, Shandong University, Jinan, 250100, P R China
    Biotechnol Lett 29:1561-6. 2007
    ..pastoris surface was confirmed by confocal laser scanning microscopy. Fluorescence microscopy and western blot analysis confirmed that EGFP can be successfully cleaved from the cell surface by treating with enterokinase...
  15. ncbi request reprint Characterization, evolution and tissue-specific expression of AmphiCalbin, a novel gene encoding EF-hand calcium-binding protein in amphioxus Branchiostoma belcheri
    Jing Luan
    Department of Marine Biology, Ocean University of China, Qingdao 266003, China
    Acta Biochim Biophys Sin (Shanghai) 39:891-900. 2007
    ..It is proposed that AmphiCalbin might play a role in the digestive system and gonads. These observations lay the foundation for further understanding of the function of the unnamed EFCaBPs...
  16. doi request reprint Linear motif atlas for phosphorylation-dependent signaling
    Martin Lee Miller
    Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark
    Sci Signal 1:ra2. 2008
    ..The atlas is available as a community resource (http://netphorest.info)...
  17. doi request reprint Fibrinogen-related protein from amphioxus Branchiostoma belcheri is a multivalent pattern recognition receptor with a bacteriolytic activity
    Chunxin Fan
    Department of Marine Biology, Ocean University of China, Qingdao 266003, China
    Mol Immunol 45:3338-46. 2008
    ..It also bolsters the notion that the hepatic caecum of amphioxus is equivalent to the vertebrate liver, acting as a major tissue in acute phase response...
  18. ncbi request reprint The SH3 domain--a family of versatile peptide- and protein-recognition module
    Tomonori Kaneko
    Department of Biochemistry and the Siebens Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Front Biosci 13:4938-52. 2008
    ....
  19. doi request reprint Optimization of an effective directed differentiation medium for differentiating mouse bone marrow mesenchymal stem cells into hepatocytes in vitro
    Xiao Lei Shi
    Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, No 321 Zhongshan Road, Nanjing 210008, PR China
    Cell Biol Int 32:959-65. 2008
    ..Uniform design was adequate for choosing the MEDDM of mMSCs. MEDDM containing 35 ng/ml FGF and 30 ng/ml OSM was effective in differentiating mMSCs into hepatocytes...
  20. pmc Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis
    Xiaofei Yu
    Department of Genetics, Development and Cell Biology, Plant Science Institute, Iowa State University, Ames, IA 50011, USA
    Proc Natl Acad Sci U S A 105:7618-23. 2008
    ..Thus, our study establishes an important mechanism by which Jmj domain proteins modulate specific gene expression by interacting with pathway-specific transcription factors such as BES1...
  21. doi request reprint Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary
    Yuk Yin Li
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 79:200-8. 2008
    ..The presence of ADM and the gene expression of ADM and its receptor components in the female reproductive system suggest a paracrine effect of ADM on ovarian steroidogenesis...
  22. doi request reprint Construction of a novel Pichia pastoris cell-surface display system based on the cell wall protein Pir1
    Qingjie Wang
    Life Science School, Shandong University, Jinan, 250100, People s Republic of China
    Curr Microbiol 56:352-7. 2008
    ..The repetitive sequences of Pir1 are required for cell wall retention, and the C-terminal sequence contributes to the irregular distribution of fusion proteins in P. pastoris...
  23. doi request reprint Effects of dexamethasone and dibutyryl cAMP on stanniocalcin-1 mRNA expression in rat primary Sertoli and Leydig cells
    Lei Li
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Mol Cell Endocrinol 283:96-103. 2008
    ..Taken together, this study provides the first evidence of the regulation of STC1 expression in the male reproductive system...
  24. ncbi request reprint Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases
    Jemy A Gutierrez
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    ACS Chem Biol 2:725-34. 2007
    ..Comparing K d ratios for mimics of early and late transition states removes limitations inherent to the enzyme and provides a better predictive tool in discriminating between possible transition-state structures...
  25. ncbi request reprint Experimental study of recombinant eukaryotic expression vector of human eNOS in ECV304
    Tong Qiao
    Department of Vascular Surgery, Affiliated Drum Tower Hospital of Medical school, Nanjing University, China
    Swiss Med Wkly 136:19-25. 2006
    ..We designed the eukaryotic expression vector pcDNA3.1-eNOS to study the regulated expression of eNOS (in the presence of various chemical agents) and to evaluate the exogenous NO effect on EC proliferation in vitro...
  26. ncbi request reprint Prokaryotic expression and polyclonal antibody preparation of novel ZLG10 protein involved in infection of RSV on SPC-A1 cells
    Lei Li
    Institute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, PR China
    Protein Expr Purif 41:170-6. 2005
    ..Together, our data demonstrate that ZLG10, a novel protein expressed and purified in this report, might be a potential effective therapeutic candidate for treating RSV infections...
  27. ncbi request reprint Advances in the study of luminescence probes for proteins
    Changxia Sun
    Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, Jinan 250100, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 803:173-90. 2004
    ..Preliminary results indicate that they possess great potential for ultrasensitive protein detection. This review summarizes recent developments of the above-mentioned probes for proteins and 195 references are cited...
  28. ncbi request reprint Determination of dysprosium by resonance light scattering technique in the presence of BPMPHD
    Shuna Sun
    Key Lab for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, Jinan 250100, China
    Spectrochim Acta A Mol Biomol Spectrosc 60:261-4. 2004
    ..0 x 10(-10)-1.0 x 10(-5) mol l(-1). The detection limit (S/N=2) is 5.6 x 10(-12) mol l(-1). Synthetic samples are determined satisfactorily. A new sensitive method for detection of dysprosium has been proposed...
  29. ncbi request reprint Gene fusion of molecular adjuvant C3d to hCGbeta enhances the anti-hCGbeta antibody response in DNA immunization
    Da Jin Li
    Institute of Obstetrics and Gynecology, Fudan University, 200011 Shanghai, People s Republic of China
    J Reprod Immunol 60:129-41. 2003
    ..To express the hCGbeta-C3d3 fusion protein in a CHO cell continual expression system to investigate further the adjuvant effects of C3d on contraceptive vaccination...
  30. ncbi request reprint The COP9 signalosome: an alternative lid for the 26S proteasome?
    Lei Li
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Trends Cell Biol 13:507-9. 2003
    ..g. deubiquitination). Here, we discuss how these findings support a central role for CSN in ubiquitination of substrate proteins and their proteolysis..
  31. ncbi request reprint Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses
    Wei Wang
    Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, MD 20850, USA
    Biochem Biophys Res Commun 305:981-8. 2003
    ..Synleurin gene (slrn) maps to human chromosome at 5q12. The name synleurin reflects its synergistic effect on cytokine stimulation and its prominent leucine-rich repeats...
  32. ncbi request reprint [Analysis of protein phosphorylation by combination of IMAC, phosphatase with biological mass spectrometry]
    Jing lan Wang
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:459-66. 2003
    ..Finally, the phosphorylation sites were determined by tandem mass spectrometry analysis and database searching...
  33. ncbi request reprint Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
    Frank P Marx
    Department of Neurology, Laboratory of Neurodegeneration, University of Tubingen, Tubingen, Germany
    Hum Mol Genet 12:1223-31. 2003
    ....
  34. ncbi request reprint Isolation and characterization of a novel human NM23-H1B gene, a different transcript of NM23-H1
    Xiaohua Ni
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P R China
    J Hum Genet 48:96-100. 2003
    ..A high transcription level was also found in grade IV prostatic adenocarcinoma PC3...
  35. ncbi request reprint Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
    M Page Haynes
    Section of Cardiovascular Medicine, Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 278:2118-23. 2003
    ..This complex formation results in the successive activation of PI3-kinase, Akt, and eNOS with consequent enhanced NO release, implicating c-Src as a critical upstream regulator of the estrogen-stimulated PI3-kinase/Akt/eNOS pathway...
  36. ncbi request reprint XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030 4009, USA
    Oral Oncol 38:475-7. 2002
    ..The objective was to assess whether two polymorphisms in the nucleotide excision repair gene XPD (ERCC2) are markers of SCCHN risk...
  37. ncbi request reprint Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN
    Ke Ning
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Canada M5T 2S8
    J Neurosci 24:4052-60. 2004
    ....
  38. ncbi request reprint Two PAK kinase genes, CHM1 and MST20, have distinct functions in Magnaporthe grisea
    Lei Li
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907, USA
    Mol Plant Microbe Interact 17:547-56. 2004
    ..However, CHM1 appears to be essential for appressorial penetration and CHM1 and MST20 may have redundant functions in M. grisea...
  39. ncbi request reprint Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
    Shao Ping Ji
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, 103 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E4
    Nat Med 12:324-9. 2006
    ..These results suggest a potential strategy for treating drug addiction with the Tat-3L4F peptide...
  40. pmc Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems
    Lei Li
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
    Mol Biol Cell 17:1126-40. 2006
    ..Our results suggest that cleavage body components are highly dynamic in nature...
  41. ncbi request reprint Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity
    Shengwei Zou
    Department of Neuroscience, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 25:4385-95. 2005
    ..These data may provide a new avenue to identify specific targets for therapeutics to modulate glutamate receptor-governed diseases, such as stroke...
  42. ncbi request reprint Transfection of promyelocytic leukemia in retrovirus vector inhibits growth of human bladder cancer cells
    Lei Li
    Institute of Urology, First Hospital of Xi an Jiaotong University, China
    Acta Pharmacol Sin 26:610-5. 2005
    ..To construct a recombinant retrovirus vector carrying human promyelocytic leukemia (PML) cDNA and identify its expression and biology role in bladder cancer UM-UC-2 cells for future gene therapy...
  43. pmc Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae
    Lei Li
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Genetics 170:569-80. 2005
    ..We propose that pol3-L612M cells need the Rad27 flap endonuclease and MMR complexes composed of Msh2/Msh6, Mlh1/Pms1, and Exo1 for correct processing of Okazaki fragments...
  44. pmc BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
    Jinhu Yin
    Laboratory of Genetics, National Institute on Aging, National Institute of Health, Baltimore, MD 21224, USA
    EMBO J 24:1465-76. 2005
    ..Thus, BLAP75 is an essential component of the BLM-associated cellular machinery that maintains genome integrity...
  45. ncbi request reprint Generation of a dataset for studying ligand effect on homodimer interface
    Lei Li
    MAE, NTU, Singapore
    Front Biosci 10:1977-84. 2005
    ..We also found that ligands occupying = 7% interface area have negligible effect on dimer interaction...
  46. ncbi request reprint High level expression, purification, and characterization of the shrimp antimicrobial peptide, Ch-penaeidin, in Pichia pastoris
    Lei Li
    School of Life Sciences, Shandong University, Jinan 250100, China
    Protein Expr Purif 39:144-51. 2005
    ..Together, these observations indicate that rCHP is an effective antimicrobial peptide that can be successfully produced at high levels in the yeast, and therefore may be a potential antimicrobial candidate for practical use...
  47. pmc Cellular localization and role of kinase activity of PMK1 in Magnaporthe grisea
    Kenneth S Bruno
    Department of Botany and Plant Pathology, Lilly Hall, Purdue University, West Lafayette, IN 47907, USA
    Eukaryot Cell 3:1525-32. 2004
    ..Overexpression of these PMK1 mutant alleles may interfere with the function of native PMK1 during appressorium formation...
  48. ncbi request reprint [Mutations in beta myosin heavy chain gene: two mutations in Chinese with familial hypertrophic cardiomyopathy and the correlation between the genotype and phenotype]
    Wen li Xie
    Department of Cardiology, Second Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 84:1610-3. 2004
    ..To study the disease-causing gene mutation in Chinese with hypertrophic cardiomyopathy (HCM), and to analyze the correlation between the genotype and phenotype...
  49. pmc Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions
    Karen M Vasquez
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Science Park Research Division, Park Road 1 C, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 99:5848-53. 2002
    ..Addition of XPA decreases the nonspecific DNA aggregate formation. These results support the hypothesis that the NER machinery is targeted to helical distortions and demonstrate that RPA can recognize damaged DNA even without XPA...