Affiliation: National Cancer Institute
- Conditional control of gene expression in the mouseM Lewandoski
Section of Genetics of Vertebrate Development, Laboratory of Cancer and Developmental Biology, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
Nat Rev Genet 2:743-55. 2001..Here, I review these systems and discuss certain studies that exemplify the advantages and limitations of each system...
- Analysis of mouse development with conditional mutagenesisM Lewandoski
Laboratory of Cancer and Developmental Biology, NCI Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
Handb Exp Pharmacol . 2007..In this review, I discuss the application of these technologies to mouse development, focusing on recent innovations and experimental designs that specifically aid the study of the mouse embryo...
- An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombinationE N Meyers
Department of Anatomy, University of California, San Francisco 94143 0452, USA
Nat Genet 18:136-41. 1998..Analysis of embryos carrying different combinations of these alleles revealed requirements for Fgf8 gene function during gastrulation, as well as cardiac, craniofacial, forebrain, midbrain and cerebellar development...
- Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud developmentX Sun
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California, USA
Nat Genet 25:83-6. 2000....
- Fgf8 signalling from the AER is essential for normal limb developmentM Lewandoski
Department of Anatomy and Program in Developmental Biology, School of Medicine, San Francisco, California, USA
Nat Genet 26:460-3. 2000..Our data identify Fgf8 as the only known AER-Fgf individually necessary for normal limb development, and provide insight into the function of Fgf signalling from the AER in the normal outgrowth and patterning of the limb...