Daniel Levy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Hypertension from Framingham to ALLHAT: translating clinical trials into practice
    Daniel Levy
    Framingham Heart Study, Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Cleve Clin J Med 74:672-8. 2007
  2. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  3. pmc Consent for genetic research in the Framingham Heart Study
    Daniel Levy
    Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MA 01702, USA
    Am J Med Genet A 152:1250-6. 2010
  4. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
  5. pmc Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
  6. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
  7. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
  8. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
  9. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
  10. pmc Altered blood pressure progression in the community and its relation to clinical events
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702 5803, USA
    Arch Intern Med 168:1450-7. 2008

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Hypertension from Framingham to ALLHAT: translating clinical trials into practice
    Daniel Levy
    Framingham Heart Study, Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Cleve Clin J Med 74:672-8. 2007
    ..Rather, our priority should be to treat more patients and to treat them more aggressively...
  2. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  3. pmc Consent for genetic research in the Framingham Heart Study
    Daniel Levy
    Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MA 01702, USA
    Am J Med Genet A 152:1250-6. 2010
    ..Published 2010 Wiley-Liss, Inc...
  4. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  5. pmc Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
    ....
  6. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
    ..Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association...
  7. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
    ..Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD)...
  8. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  9. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
    ..Knowledge about the pathophysiological processes that determine arterial stiffness may help guide therapeutic approaches...
  10. pmc Altered blood pressure progression in the community and its relation to clinical events
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702 5803, USA
    Arch Intern Med 168:1450-7. 2008
    ..Long-term blood pressure (BP) progression and its importance as a predictor of clinical outcome have not been well characterized across different periods...
  11. pmc Relations of biomarkers representing distinct biological pathways to left ventricular geometry
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 118:2252-8, 5p following 2258. 2008
    ..Several biological pathways are activated concomitantly during left ventricular (LV) remodeling. However, the relative contribution of circulating biomarkers representing these distinct pathways to LV geometry is unclear...
  12. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  13. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  14. pmc Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 58:134-7. 2009
    ..Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence of offspring obesity...
  15. pmc Galectin 3 and incident atrial fibrillation in the community
    Jennifer E Ho
    Boston University and the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA Section of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, MA Electronic address
    Am Heart J 167:729-734.e1. 2014
    ..The same mechanisms that lead to cardiac fibrosis in heart failure may influence development of atrial fibrosis and atrial fibrillation (AF). We examined the association of Gal-3 and incident AF in the community...
  16. ncbi request reprint Mitral annular calcification is a predictor for incident atrial fibrillation
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, MA 01702 5827, USA
    Atherosclerosis 173:291-4. 2004
    ..Mitral annular calcification (MAC) has been associated with adverse cardiovascular disease outcomes and stroke in longitudinal and community-based cohorts. Prospective data are limited on its association with atrial fibrillation (AF)...
  17. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  18. pmc A multi-marker approach to predict incident CKD and microalbuminuria
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    J Am Soc Nephrol 21:2143-9. 2010
    ..In conclusion, circulating homocysteine, aldosterone, and BNP provide incremental information regarding risk for incident CKD and MA beyond traditional risk factors...
  19. pmc Multimarker approach for the prediction of heart failure incidence in the community
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 122:1700-6. 2010
    ..There are no data, however, on the incremental utility of a parsimonious set of biomarkers (reflecting pathways implicated in HF) for predicting HF risk in the community...
  20. pmc Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:440-3. 2008
    ..Neither cysC nor MA was significantly associated with AAC in age- and gender- or multivariable-adjusted models. In conclusion, CKD, cysC, and MA are not associated with CAC or AAC when accounting for cardiovascular disease risk factors...
  21. ncbi request reprint Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    ..Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
  22. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  23. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  24. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
    ..We tested the hypothesis that the relative burden of CVD attributable to diabetes mellitus (DM) has increased over the past 5 decades...
  25. ncbi request reprint Lifetime risk for developing congestive heart failure: the Framingham Heart Study
    Donald M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Circulation 106:3068-72. 2002
    ..Congestive heart failure (CHF) is an increasing public health problem...
  26. ncbi request reprint Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
    Am J Cardiol 96:227-32. 2005
    ..The interaction does not appear to be mediated through effects on high-density lipoprotein cholesterol...
  27. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  28. ncbi request reprint A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 148:102-10. 2008
    ..Risk stratification may facilitate cost-effective approaches to management...
  29. ncbi request reprint Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  30. ncbi request reprint Natural history of asymptomatic left ventricular systolic dysfunction in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 108:977-82. 2003
    ..We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community...
  31. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
    ..Risk factors that predict HF in individuals with AF in the community are not well established...
  32. ncbi request reprint Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta
    Craig R Walsh
    National Heart, Lung and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Am J Cardiol 93:421-5. 2004
    ..EBCT AV calcium was associated with calcium deposits in the coronary arteries and the thoracic aorta, but these associations were confounded by age and risk factors...
  33. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  34. pmc Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    Renate B Schnabel
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:1728-33. 2013
    ..Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality...
  35. pmc Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Eur J Cardiovasc Prev Rehabil 18:664-73. 2011
    ..Recent experimental studies have highlighted the potential role of the natriuretic peptides and aldosterone in mediating salt sensitivity...
  36. pmc Circulating angiogenic cell populations, vascular function, and arterial stiffness
    Susan Cheng
    Framingham Heart Study, Framingham, MA 02118, United States
    Atherosclerosis 220:145-50. 2012
    ..We examined the extent to which lower quantities of these circulating angiogenic cell phenotypes may be related to impaired vascular function and greater arterial stiffness...
  37. pmc Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 106:668-72. 2010
    ..In conclusion, subjects with prolonged QRS durations, even without bundle branch block, are at increased risk for future pacemaker implantation. Such individuals may warrant monitoring for progressive conduction disease...
  38. pmc Relation of multiple inflammatory biomarkers to incident atrial fibrillation
    Renate B Schnabel
    National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
    Am J Cardiol 104:92-6. 2009
    ..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events...
  39. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  40. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  41. ncbi request reprint Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  42. pmc Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 28:1165-71. 2008
    ..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study...
  43. ncbi request reprint Low-grade albuminuria and the risks of hypertension and blood pressure progression
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 111:1370-6. 2005
    ....
  44. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
    ..We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits...
  45. pmc Insulin resistance and atrial fibrillation (from the Framingham Heart Study)
    Joao D Fontes
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 109:87-90. 2012
    ..18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF...
  46. pmc Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 120:1195-202. 2009
    ..Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass...
  47. pmc Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Study, Framingham, Mass, USA
    Circulation 121:200-7. 2010
    ..Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial...
  48. ncbi request reprint Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study
    Daniel Levy
    NHLBI Framingham Heart Study, Framingham, Mass, USA
    Circulation 115:3079-85. 2007
    ..Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community...
  49. ncbi request reprint Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  50. ncbi request reprint Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study
    Ravi Dhingra
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Hypertension 47:861-7. 2006
    ..In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk...
  51. pmc Gene expression signatures of coronary heart disease
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1418-26. 2013
    ..To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and 188 age- and sex-matched controls who were participants in the Framingham Heart Study...
  52. ncbi request reprint Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Bethesda, MD, USA
    Hypertension 43:957-62. 2004
    ..Additional investigations are warranted to confirm these findings...
  53. ncbi request reprint Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    ..Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals...
  54. ncbi request reprint Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study
    Johan Sundstrom
    The Framingham Heart Study, Framingham, MA, USA
    Eur Heart J 25:523-30. 2004
    ..Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling...
  55. pmc Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 125:2836-43. 2012
    ..Although impaired vascular function is hypothesized to influence the BP response during exercise, limited data exist on the association of vascular function with exercise BP in the community...
  56. pmc Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 119:1101-7. 2009
    ..Biomarkers of extracellular matrix remodeling are associated with prevalent hypertension in cross-sectional studies, but their relations to longitudinal changes in blood pressure (BP) and hypertension incidence are unknown...
  57. pmc Neck circumference as a novel measure of cardiometabolic risk: the Framingham Heart study
    Sarah Rosner Preis
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 95:3701-10. 2010
    ..Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat...
  58. ncbi request reprint Multiple biomarkers and the risk of incident hypertension
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Hypertension 49:432-8. 2007
    ..These data support the premise that abnormalities in multiple biological pathways antedate the onset of overt hypertension...
  59. ncbi request reprint Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    Christopher Newton-Cheh
    Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Hypertension 49:846-56. 2007
    ..16; 95% CI: 1.00 to 1.33). ARR is a heritable trait influenced by clinical and genetic factors. There is a continuous gradient of increasing risk of BP progression across ARR levels in nonhypertensive individuals...
  60. ncbi request reprint Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample
    Anjali A Patwardhan
    Boston University School of Medicine, Boston, MA, USA
    Sleep 29:1301-6. 2006
    ..We examined the association of OSAH with natriuretic peptides in a community-based sample...
  61. pmc Cross-sectional relations of lipid concentrations to left ventricular structural attributes
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Am J Cardiol 105:1297-9. 2010
    ..In conclusion, these data do not support an independent association between lipid concentrations and left ventricular structure...
  62. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  63. ncbi request reprint Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    J Am Soc Nephrol 17:521-7. 2006
    ..Further research is warranted to understand whether traditional and novel vascular risk factor burden, as well as metabolic derangements found in early kidney disease, can account for the CKD-MAC association...
  64. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
    ..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
  65. ncbi request reprint Heritability and genetic linkage of plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, MA 01702 5827, USA
    Circulation 108:13-6. 2003
    ..It is unknown to what extent genetic factors contribute to variation in plasma natriuretic peptide levels...
  66. pmc Long-term trends in the incidence of heart failure after myocardial infarction
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 118:2057-62. 2008
    ....
  67. pmc Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:1194-8. 2008
    ..35 (p <0.001). In conclusion, high CysC is associated with CVD risk factors even in the absence of CKD. The strong associations between CysC and CVD risk factors may partially explain why CysC is a strong predictor of incident CVD...
  68. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...
  69. pmc Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 124:24-30. 2011
    ..We hypothesized that subclinical cardiac and noncardiac organ dysfunction would accelerate the manifestation of HF...
  70. ncbi request reprint Relative importance of borderline and elevated levels of coronary heart disease risk factors
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 142:393-402. 2005
    ..Clinical trials indicate that a sizable proportion of adults have multiple borderline coronary risk factors and may benefit from treatment...
  71. pmc P wave duration and risk of longitudinal atrial fibrillation in persons ≥ 60 years old (from the Framingham Heart Study)
    Jared W Magnani
    Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 107:917-921.e1. 2011
    ..In conclusion, maximum P wave duration at the upper fifth percentile was associated with long-term AF risk in an elderly community-based cohort. P wave duration is an electrocardiographic endophenotype for AF...
  72. pmc Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute
    Douglas S Lee
    Director, Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 119:3070-7. 2009
    ..The contributions of risk factors and disease pathogenesis to heart failure with preserved ejection fraction (HFPEF) versus heart failure with reduced ejection fraction (HFREF) have not been fully explored...
  73. pmc Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Hypertens 29:62-9. 2011
    ....
  74. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  75. pmc A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study
    Joanne M Murabito
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S6. 2007
    ..Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified...
  76. ncbi request reprint Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    N Engl J Med 351:33-41. 2004
    ..Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension...
  77. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  78. pmc Aortic root diameter and longitudinal blood pressure tracking
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    Hypertension 52:473-7. 2008
    ..Our prospective study does not support the notion that a smaller AoR predisposes to hypertension...
  79. ncbi request reprint Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  80. ncbi request reprint Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Arterioscler Thromb Vasc Biol 22:1662-7. 2002
    ..The objective of this study was to examine the relationship between C-reactive protein (CRP) and carotid atherosclerosis...
  81. ncbi request reprint Long-term trends in the incidence of and survival with heart failure
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    N Engl J Med 347:1397-402. 2002
    ..Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized...
  82. ncbi request reprint Impact of obesity on plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 109:594-600. 2004
    ..The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impaired natriuretic peptide response...
  83. ncbi request reprint Obesity and the risk of new-onset atrial fibrillation
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2471-7. 2004
    ..Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF...
  84. pmc Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med Genet 9:67. 2008
    ..We assessed the role of genetic variation in three subunits of the neuromuscular nicotinic acetylcholine receptor positioned on chromosome 2q, a region showing replicated evidence of linkage to blood pressure...
  85. ncbi request reprint Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence
    Johan Sundstrom
    The Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 45:28-33. 2005
    ..02) and diastolic pressure 4 years later (P=0.04). In summary, serum UA level was an independent predictor of hypertension incidence and longitudinal BP progression at short-term follow-up in our community-based sample...
  86. ncbi request reprint Monocyte cytokine production, systemic inflammation and cardiovascular disease in very elderly men and women: the Framingham Heart Study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702 5827, USA
    Eur J Cardiovasc Prev Rehabil 11:214-5. 2004
    ..Further studies are warranted to examine the prognostic implications of CRP and related cytokines for CVD in the elderly...
  87. ncbi request reprint Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Ann Intern Med 138:10-6. 2003
    ..Although hypertension is a principal precursor of congestive heart failure (CHF), the separate relations of systolic, diastolic, and pulse pressure with risk for heart failure have not been fully elucidated...
  88. ncbi request reprint Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study
    Michael H Freitag
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Hypertension 41:978-83. 2003
    ..Additional investigations are warranted to confirm these findings and elucidate the basis for these gender-related differences...
  89. ncbi request reprint Genome scan linkage results for heart rate variability (the Framingham Heart Study)
    Jagmeet P Singh
    National Heart, Lung and Blood Institute s NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Am J Cardiol 90:1290-3. 2002
    ..Recognition of the genetic determinants of HRV may provide additional insights into the pathophysiology of the autonomic nervous system and offer clues to its modulation...
  90. ncbi request reprint Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study
    Craig R Walsh
    Framingham Heart Study, Framingham, Mass 01702, USA
    Am Heart J 144:733-9. 2002
    ..We sought to determine the association of aortic atherosclerosis, detected by calcific deposits in the abdominal aorta seen on lateral lumbar radiographs, with risk for congestive heart failure (CHF)...
  91. ncbi request reprint The epidemiology of "asymptomatic" left ventricular systolic dysfunction: implications for screening
    Thomas J Wang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702 5827, USA
    Ann Intern Med 138:907-16. 2003
    ..Given the increasing prevalence of heart failure, additional studies are needed to develop effective strategies to detect and optimally manage individuals with asymptomatic left ventricular dysfunction in the community...
  92. ncbi request reprint A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Thromb Res 110:57-64. 2003
    ..It remains unknown what role, if any, is played by other genetic variants in the inter-individual variability in levels of fibrinogen in the general population...
  93. ncbi request reprint Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Circulation 115:1345-53. 2007
    ..Although it has been shown that obese individuals have reduced natriuretic peptide levels, conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors...
  94. ncbi request reprint Characteristics of Framingham offspring participants with long-lived parents
    Dellara F Terry
    Boston University School of Medicine, Geriatrics Section, Boston Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Arch Intern Med 167:438-44. 2007
    ..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...
  95. ncbi request reprint Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 49:1285-90. 2007
    ..The present study was suggestive of modest relations between common genetic variants at the NOS3 locus and arterial stiffness...
  96. ncbi request reprint Maternal influence on blood pressure suggests involvement of mitochondrial DNA in the pathogenesis of hypertension: the Framingham Heart Study
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    J Hypertens 25:2067-73. 2007
    ..To investigate the contribution of the mitochondrial genome to hypertension and quantitative blood pressure (BP) phenotypes in the Framingham Heart Study cohort, a randomly ascertained, community-based sample...
  97. ncbi request reprint Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life
    Douglas S Lee
    Institute for Clinical Evaluative Sciences and University Health Network, University of Toronto, Toronto, Canada
    Hypertension 50:869-76. 2007
    ..Higher blood pressure and BMI in midlife are harbingers of increased risk of heart failure in later life. Early risk factor modification may decrease heart failure burden...
  98. ncbi request reprint Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 51 Sawyer Rd, Suite 100, Waltham, MA 02453, USA
    Circulation 115:2628-36. 2007
    ..Increased aortic stiffness is associated with numerous common diseases of aging, including heart disease, stroke, and renal disease. However, the prevalence and correlates of abnormally high aortic stiffness are incompletely understood...
  99. pmc On the replication of genetic associations: timing can be everything!
    Jessica Lasky-Su
    SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Hum Genet 82:849-58. 2008
    ..If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed...
  100. ncbi request reprint Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...
  101. ncbi request reprint Novel approach to examining first cardiovascular events after hypertension onset
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1120, Chicago, IL 60611, USA
    Hypertension 45:39-45. 2005
    ..These results represent a novel approach to understanding the complications of hypertension and may help target therapies for patients with new-onset hypertension to optimize prevention strategies...