Daniel Levy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Lifetime risk of developing coronary heart disease
    D M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Massachusetts 01702, USA
    Lancet 353:89-92. 1999
  2. pmc Description of the Framingham Heart Study data for Genetic Analysis Workshop 13
    L Adrienne Cupples
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S2. 2003
  3. pmc Consistency of linkage results across exams and methods in the Framingham Heart Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts, USA
    BMC Genet 4:S30. 2003
  4. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
  5. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
  6. pmc A multi-marker approach to predict incident CKD and microalbuminuria
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    J Am Soc Nephrol 21:2143-9. 2010
  7. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
  8. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
  9. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
  10. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Lifetime risk of developing coronary heart disease
    D M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Massachusetts 01702, USA
    Lancet 353:89-92. 1999
    ..The lifetime risk of developing coronary heart disease has not been estimated in a general population. We investigated the lifetime risks of initial coronary events at different ages...
  2. pmc Description of the Framingham Heart Study data for Genetic Analysis Workshop 13
    L Adrienne Cupples
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S2. 2003
  3. pmc Consistency of linkage results across exams and methods in the Framingham Heart Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts, USA
    BMC Genet 4:S30. 2003
    ..We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data...
  4. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
    ..Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD)...
  5. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  6. pmc A multi-marker approach to predict incident CKD and microalbuminuria
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    J Am Soc Nephrol 21:2143-9. 2010
    ..In conclusion, circulating homocysteine, aldosterone, and BNP provide incremental information regarding risk for incident CKD and MA beyond traditional risk factors...
  7. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  8. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
    ..We tested the hypothesis that the relative burden of CVD attributable to diabetes mellitus (DM) has increased over the past 5 decades...
  9. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  10. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
    ..We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits...
  11. pmc Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:440-3. 2008
    ..Neither cysC nor MA was significantly associated with AAC in age- and gender- or multivariable-adjusted models. In conclusion, CKD, cysC, and MA are not associated with CAC or AAC when accounting for cardiovascular disease risk factors...
  12. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  13. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  14. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  15. pmc Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 28:1165-71. 2008
    ..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study...
  16. ncbi request reprint Mitral annular calcification is a predictor for incident atrial fibrillation
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, MA 01702 5827, USA
    Atherosclerosis 173:291-4. 2004
    ..Mitral annular calcification (MAC) has been associated with adverse cardiovascular disease outcomes and stroke in longitudinal and community-based cohorts. Prospective data are limited on its association with atrial fibrillation (AF)...
  17. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  18. ncbi request reprint Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    J Am Soc Nephrol 17:521-7. 2006
    ..Further research is warranted to understand whether traditional and novel vascular risk factor burden, as well as metabolic derangements found in early kidney disease, can account for the CKD-MAC association...
  19. pmc Gene expression signatures of coronary heart disease
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1418-26. 2013
    ..To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and 188 age- and sex-matched controls who were participants in the Framingham Heart Study...
  20. ncbi request reprint Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    ..Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals...
  21. pmc Cross-sectional relations of lipid concentrations to left ventricular structural attributes
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Am J Cardiol 105:1297-9. 2010
    ..In conclusion, these data do not support an independent association between lipid concentrations and left ventricular structure...
  22. pmc Neck circumference as a novel measure of cardiometabolic risk: the Framingham Heart study
    Sarah Rosner Preis
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 95:3701-10. 2010
    ..Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat...
  23. pmc Long-term trends in the incidence of heart failure after myocardial infarction
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 118:2057-62. 2008
    ....
  24. pmc Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Study, Framingham, Mass, USA
    Circulation 121:200-7. 2010
    ..Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial...
  25. pmc Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 125:2836-43. 2012
    ..Although impaired vascular function is hypothesized to influence the BP response during exercise, limited data exist on the association of vascular function with exercise BP in the community...
  26. pmc Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    Renate B Schnabel
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:1728-33. 2013
    ..Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality...
  27. pmc Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 119:1101-7. 2009
    ..Biomarkers of extracellular matrix remodeling are associated with prevalent hypertension in cross-sectional studies, but their relations to longitudinal changes in blood pressure (BP) and hypertension incidence are unknown...
  28. ncbi request reprint Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    N Engl J Med 351:33-41. 2004
    ..Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension...
  29. ncbi request reprint Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Bethesda, MD, USA
    Hypertension 43:957-62. 2004
    ..Additional investigations are warranted to confirm these findings...
  30. ncbi request reprint Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  31. pmc Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Am Coll Cardiol 60:1249-56. 2012
    ..The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker of cardiac fibrosis, with incident heart failure (HF) in the community...
  32. ncbi request reprint Cross-classification of microalbuminuria and reduced glomerular filtration rate: associations between cardiovascular disease risk factors and clinical outcomes
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arch Intern Med 167:1386-92. 2007
    ..Concordance between reduced eGFR and MA and associated cardiovascular disease (CVD) and all-cause mortality according to these definitions is uncertain...
  33. pmc Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005
    Sarah Rosner Preis
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Circulation 119:1728-35. 2009
    ..Despite population declines in all-cause mortality, women with diabetes mellitus may have experienced an increase in mortality rates compared with men...
  34. pmc Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:1194-8. 2008
    ..35 (p <0.001). In conclusion, high CysC is associated with CVD risk factors even in the absence of CKD. The strong associations between CysC and CVD risk factors may partially explain why CysC is a strong predictor of incident CVD...
  35. pmc Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study)
    Sarah Rosner Preis
    Center for Population Studies, National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 103:1710-5. 2009
    ..Approximately 25% of intermediate-risk individuals have high CAC scores and may be eligible for reclassification into a higher-risk category...
  36. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  37. pmc A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study
    Joanne M Murabito
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S6. 2007
    ..Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified...
  38. pmc Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    Andrew D Johnson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Hypertension 57:903-10. 2011
    ..Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure, including pharmacogenetic interactions...
  39. pmc Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 124:24-30. 2011
    ..We hypothesized that subclinical cardiac and noncardiac organ dysfunction would accelerate the manifestation of HF...
  40. ncbi request reprint Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study
    Ravi Dhingra
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Hypertension 47:861-7. 2006
    ..In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk...
  41. ncbi request reprint The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination
    Greta Lee Splansky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Am J Epidemiol 165:1328-35. 2007
    ....
  42. pmc Predictors of new-onset heart failure: differences in preserved versus reduced ejection fraction
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circ Heart Fail 6:279-86. 2013
    ..The differences in risk factors predisposing to the 2 subtypes of HF are poorly understood. We sought to identify clinical predictors of new-onset HF and to explore differences in HFPEF versus HFREF...
  43. pmc Aortic stiffness, blood pressure progression, and incident hypertension
    Bernhard M Kaess
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    JAMA 308:875-81. 2012
    ..Vascular stiffness and blood pressure pulsatility are related; however, temporal relationships between vascular stiffening and blood pressure elevation have not been fully delineated...
  44. pmc Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 119:1586-91. 2009
    ..Whether the associations of pericardial fat and measures of cardiac structure and function are independent of the systemic effects of obesity and visceral adiposity has not been fully explored...
  45. ncbi request reprint Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Circulation 112:1728-35. 2005
    ....
  46. pmc Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community
    Jennifer E Ho
    National Heart, Lung, and Blood Institute, Framingham Heart Study, MA, USA
    Eur Heart J 33:1734-41. 2012
    ..Of patients presenting with HF, 30-55% have a preserved ejection fraction (HFPEF) rather than a reduced ejection fraction (HFREF). Our objective was to examine discriminating clinical features in new-onset HFPEF vs. HFREF...
  47. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
    ..Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association...
  48. pmc A systems biology framework identifies molecular underpinnings of coronary heart disease
    Tianxiao Huan
    From the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1427-34. 2013
    ..The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD...
  49. ncbi request reprint Lifetime risk for developing congestive heart failure: the Framingham Heart Study
    Donald M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Circulation 106:3068-72. 2002
    ..Congestive heart failure (CHF) is an increasing public health problem...
  50. ncbi request reprint Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study
    Michael H Freitag
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Hypertension 41:978-83. 2003
    ..Additional investigations are warranted to confirm these findings and elucidate the basis for these gender-related differences...
  51. ncbi request reprint Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Hypertens 18:657-65. 2005
    ..We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample...
  52. ncbi request reprint Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:6257-62. 2005
    ..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power...
  53. ncbi request reprint Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta
    Craig R Walsh
    National Heart, Lung and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Am J Cardiol 93:421-5. 2004
    ..EBCT AV calcium was associated with calcium deposits in the coronary arteries and the thoracic aorta, but these associations were confounded by age and risk factors...
  54. pmc Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study
    Sarah Rosner Preis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 120:212-20. 2009
    ..Our objective was to examine CVD risk factor level changes among individuals with and without type 2 diabetes mellitus from 1970 to 2005 in the Framingham Heart Study...
  55. ncbi request reprint Relations of insulin sensitivity to longitudinal blood pressure tracking: variations with baseline age, body mass index, and blood pressure
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 112:1719-27. 2005
    ..The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP)...
  56. pmc Chronic kidney disease as a predictor of cardiovascular disease (from the Framingham Heart Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Bethesda, MD, USA
    Am J Cardiol 102:47-53. 2008
    ..004 for interaction). Stage 3b CKD was associated with CVD, but was not a CVD risk equivalent. In conclusion, CVD risk in the setting of CKD is higher in the setting of low high-density lipoprotein cholesterol...
  57. ncbi request reprint Is baseline autonomic tone associated with new onset atrial fibrillation?: Insights from the framingham heart study
    Jagmeet P Singh
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Ann Noninvasive Electrocardiol 9:215-20. 2004
    ..Little is known about the impact of baseline autonomic tone and the development of new onset AF in a population-based cohort. The purpose of this study was to assess the role of HRV as a predictor of new onset AF...
  58. ncbi request reprint Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 67:70-4. 2005
    ..Microalbuminuria is a powerful risk factor for cardiovascular disease. It is not known whether genetic factors play a role in the expression of microalbuminuria in population-based samples...
  59. pmc Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits
    Chunyu Liu
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Hypertension 60:949-56. 2012
    ..Replication in independent samples, however, is needed to confirm these putative associations...
  60. ncbi request reprint Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring
    Caroline S Fox
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 291:2851-5. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States. Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected individuals is a heritable condition...
  61. ncbi request reprint Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study
    Ravi Dhingra
    National Heart, Lung, and Blood Institute Framingham Heart Study, Bethesda, Maryland, USA
    Am J Hypertens 17:891-6. 2004
    ..We tested the hypothesis that sodium intake is associated with left ventricular (LV) mass and left ventricular hypertrophy (LVH), independent of BP, in the community...
  62. ncbi request reprint Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 110:522-7. 2004
    ..Although declines in coronary heart disease (CHD) mortality have been noted, there is still uncertainty about the magnitude of the decline and whether the trend is similar for sudden cardiac death (SCD)...
  63. pmc Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study
    Tulio Diaz
    Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA
    Echocardiography 26:247-53. 2009
    ..Adjusting for cardiovascular risk factors, DUST was not associated with CVD or mortality risk (P > 0.30 for both). The follow-up component of our study suggests that DUST is not independently associated with adverse prognosis...
  64. pmc Health insurance and cardiovascular disease risk factors
    Erica L Brooks
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Am J Med 123:741-7. 2010
    ..Compared with those with health insurance, the uninsured receive less care for chronic conditions, such as hypertension and diabetes, and experience higher mortality...
  65. ncbi request reprint Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
    JAMA 289:1251-7. 2003
    ..Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF)...
  66. pmc Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
    ....
  67. ncbi request reprint Warfarin and aspirin use and the predictors of major bleeding complications in atrial fibrillation (the Framingham Heart Study)
    Colleen Sam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 94:947-51. 2004
    ..61), but participants using warfarin were younger. A total of 65 participants (17%) had major bleeding complications <or=5 years after initial AF. Age was not a significant predictor of bleeding...
  68. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
    ..The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated...