Affiliation: National Institutes of Health
- Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physiciansC J O'Donnell
Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
Circulation 95:1132-7. 1997..The objective of this study was to examine whether definite hypertension and borderline isolated systolic hypertension predict subsequent cardiovascular disease and mortality...
- Evidence for heritability of abdominal aortic calcific deposits in the Framingham Heart StudyChristopher J O'Donnell
National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
Circulation 106:337-41. 2002..Little is known about the heritability of aortic calcification...
- Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart StudyC J O'Donnell
National Heart, Lung, and Blood Institute s Framingham Heart Study, Mass 01701, USA
Circulation 97:1766-72. 1998..We investigated these relations in a large population-based sample of men and women by using association and linkage analyses...
- Epidemiologic appraisal of hypertension as a coronary risk factor in the elderlyChristopher J O'Donnell
National Heart, Lung, and Blood Institute s Framingham Heart Study, MA 01701, USA
Am J Geriatr Cardiol 11:86-92. 2002..The goal of therapy should be to improve the multivariate risk profile as well as the level of the blood pressure...
- Genetic and environmental contributions to platelet aggregation: the Framingham heart studyC J O'Donnell
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
Circulation 103:3051-6. 2001..However, the contribution of genetic versus environmental influences on interindividual variation in platelet aggregability is poorly characterized...
- Weighing the evidence for infection as a risk factor for coronary heart diseaseC J O'Donnell
Framingham Heart Study, 5 Thurber Street, Framingham, MA 01702, USA
Curr Cardiol Rep 2:280-7. 2000..The results of ongoing larger observational studies and antibiotic treatment trials may yield important information regarding the presence and magnitude of risk, if any, beyond that conferred by established coronary risk factors...
- Platelet glycoprotein IIIa Pl(a) polymorphism, fibrinogen, and platelet aggregability: The Framingham Heart StudyD Feng
Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA
Circulation 104:140-4. 2001..This interaction may be responsible for the conflicting findings regarding Pl(A) genotype and platelet aggregability. Further study of this gene-environment interaction may provide insight into cardiovascular disease risk...
- Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring populationF K Welty
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
Circulation 95:825-30. 1997..The aim of this study was to utilize subjects with hypobetalipoproteinemia to examine the relation between thrombotic potential and low levels of LDL cholesterol...
- Hemostatic state and atrial fibrillation (the Framingham Offspring Study)D Feng
Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Cardiol 87:168-71. 2001....
- Prediction of coronary heart disease using risk factor categoriesP W Wilson
Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
Circulation 97:1837-47. 1998....
- Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort studyR S Vasan
From the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
Lancet 358:1682-6. 2001..We aimed to establish the best frequency of BP screening by assessing the rates and determinants of progression to hypertension...
- Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart StudyC Lahoz
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Atherosclerosis 154:529-37. 2001..51 (P=0.0262). Conclusions: The presence of the apo E2 or apo E4 alleles in men is associated with significantly greater CVD risk. This genotypic information may help to identify individuals at increased risk for CVD events...
- Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohortK J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circulation 104:1367-73. 2001..Moderate alcohol consumers have lower rates of cardiovascular disease than abstainers. One proposed mechanism is a beneficial effect on hemostatic parameters, but previous studies have provided conflicting results...
- Echocardiographic features of the right heart in sleep-disordered breathing: the Framingham Heart StudyU C Guidry
National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Massachusetts, USA
Am J Respir Crit Care Med 164:933-8. 2001..Whether the RV hypertrophy observed in persons with SDB is associated with increased morbidity and mortality remains unknown...
- Heritability of longitudinal change in lung function. The Framingham studyD J Gottlieb
Research Service, VA Boston Healthcare System, and Department of Medicine and Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Am J Respir Crit Care Med 164:1655-9. 2001....
- Impact of atrial fibrillation on the risk of death: the Framingham Heart StudyE J Benjamin
National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Mass, USA
Circulation 98:946-52. 1998..Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors...
- Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart StudyS Demissie
Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA
Aging Cell 5:325-30. 2006....
- Alcohol consumption and risk of intermittent claudication in the Framingham Heart StudyL Djousse
Department of Medicine, Section of Preventive Medicine and Epidemiology Boston University School of Medicine, Boston, Massachusetts, USA
Circulation 102:3092-7. 2000..The purpose of this study was to assess the relation of alcohol consumption and type of beverage to the development of IC among participants in the Framingham Heart Study...
- Why is left ventricular hypertrophy so predictive of morbidity and mortality?E J Benjamin
National Heart, Lung, and Blood Institute s Framingham Heart Study, MA 01702, USA
Am J Med Sci 317:168-75. 1999....
- Impact of high-normal blood pressure on the risk of cardiovascular diseaseR S Vasan
Framingham Heart Study, Mass 01702, USA
N Engl J Med 345:1291-7. 2001..Information is limited regarding the absolute and relative risk of cardiovascular disease in persons with high-normal blood pressure (systolic pressure of 130 to 139 mm Hg, diastolic pressure of 85 to 89 mm Hg, or both)...
- Lifetime risk of developing coronary heart diseaseD M Lloyd-Jones
National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Massachusetts 01702, USA
Lancet 353:89-92. 1999..The lifetime risk of developing coronary heart disease has not been estimated in a general population. We investigated the lifetime risks of initial coronary events at different ages...
- Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamicsK K Ho
Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass 02215 5491, USA
Circulation 96:842-8. 1997..Despite much recent interest in quantification of heart rate variability (HRV), the prognostic value of conventional measures of HRV and of newer indices based on nonlinear dynamics is not universally accepted...
- Genome scan for quantity of hand osteoarthritis: the Framingham StudyS Demissie
Boston University School of Public Health, Boston, Massachusetts
Arthritis Rheum 46:946-52. 2002..To search for markers linked to quantity of radiographic hand osteoarthritis (OA) in the Framingham Heart Study...
- Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sampleC S Fox
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
Kidney Int 69:2064-9. 2006..Our cross-sectional observations raise the possibility that dietary salt intake may be associated with early renovascular damage...
- Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burdenS K Chan
Department of Medicine (Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Cardiovasc Magn Reson 3:331-8. 2001..62-0.85). These data demonstrate that MRI is a reproducible technique for assessing aortic anatomy and total aortic atherosclerosis, but increased slice density should be considered if serial evaluation of slice-specific data is desired...
- Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarctionC P Cannon
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 283:2941-7. 2000..Rapid time to treatment with thrombolytic therapy is associated with lower mortality in patients with acute myocardial infarction (MI). However, data on time to primary angioplasty and its relationship to mortality are inconclusive...
- Genetic factors contribute to the variance in frequency domain measures of heart rate variabilityJ P Singh
National Heart, Lung and Blood Institute, Framingham Heart Study, Boston, MA, USA
Auton Neurosci 90:122-6. 2001..Recognition of the genetic determinants of HRV may provide additional insight into the pathophysiology of the autonomic nervous system and offer clues toward its modulation...
- The validity of different definitions of radiographic worsening for longitudinal studies of knee osteoarthritisM P Lavalley
Boston University Arthritis Center, A203, 715 Albany Street, Boston, MA 02118, USA
J Clin Epidemiol 54:30-9. 2001..Definitions incorporating both osteophytes and joint space narrowing offer the most precise estimation of the association of risk factors with disease worsening...
- Associated symptoms in the ten days before diagnosis of Kawasaki diseaseAnnette L Baker
Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr 154:592-595.e2. 2009..To describe common associated symptoms within the 10 days before diagnosis in subjects enrolled in the Pediatric Heart Network's trial of steroid therapy in Kawasaki disease (KD)...
- A trial of darbepoetin alfa in type 2 diabetes and chronic kidney diseaseMarc A Pfeffer
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 361:2019-32. 2009..Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately tested...