Stewart J Levine

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc From bedside to bench to clinic trials: identifying new treatments for severe asthma
    Amarjit Mishra
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Dis Model Mech 6:877-88. 2013
  2. pmc Apolipoprotein mimetic peptides: a new approach for the treatment of asthma
    Xianglan Yao
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute Bethesda, MD, USA
    Front Pharmacol 3:37. 2012
  3. pmc Paradoxical effects of rapamycin on experimental house dust mite-induced asthma
    Karin Fredriksson
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e33984. 2012
  4. pmc Achieving symptom control in patients with moderate asthma
    Nargues A Weir
    The Advanced Lung Disease and Transplant Clinic, Inova Fairfax Hospital, Falls Church, VA
    Clin Med Insights Circ Respir Pulm Med 6:1-11. 2012
  5. pmc Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes
    Stewart J Levine
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Building 10, Room 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Ann Intern Med 152:232-7. 2010
  6. pmc Molecular mechanisms of soluble cytokine receptor generation
    Stewart J Levine
    Pulmonary and Vascular Medicine Branch, NHLBI, NIH, Bethesda, MD 20892 1590, USA
    J Biol Chem 283:14177-81. 2008
  7. ncbi request reprint Proteomics of lung cell biology and pulmonary disease
    Stewart J Levine
    National Institutes of Health, Pulmonary Critical Care Medicine Branch, NHLBI, Building 10, Room 6D03, MSC 1590, Bethesda, MD 0892 1590, USA
    Expert Rev Respir Med 1:255-69. 2007
  8. ncbi request reprint Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells
    Stewart J Levine
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 289:L233-43. 2005
  9. ncbi request reprint Mechanisms of soluble cytokine receptor generation
    Stewart J Levine
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:5343-8. 2004
  10. pmc Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice
    Xianglan Yao
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 302:L206-15. 2012

Collaborators

  • Xianglan Yao
  • Aminul Islam
  • Jing Zhang
  • Nalini Raghavachari
  • Marcelo J A Amar
  • Toyoko Hiroi
  • Børge G Nordestgaard
  • Michael P Vitek
  • Xiaoyan Shen
  • Gyorgy Csako
  • Arnold S Kristof
  • Man Yu
  • Thomas L Leto
  • Morten Dahl
  • Farshid N Rouhani
  • Karin Fredriksson
  • Xinle Cui
  • Zu Xi Yu
  • Amarjit Mishra
  • Xuan Qu
  • Karen J Keeran
  • Cuilian Dai
  • Maryann Kaler
  • Feras I Hawari
  • Barbara Adamik
  • Pradeep K Dagur
  • Jonathan K Lam
  • J Philip McCoy
  • Katharine S Meyer
  • Boris L Vaisman
  • Gayle J Zywicke
  • Nargues A Weir
  • Alan T Remaley
  • Hai yan Qi
  • Joel Moss
  • Mathew P Daniels
  • Feras Hawari
  • Christopher Looze
  • Souheil El-Chemaly
  • Caitriona A Buckley
  • Yanqin Yang
  • Elizabeth M Mushaben
  • Gayle Z Nugent
  • Rosemarie A Cuento
  • Jill A Fielhaber
  • Mona Ghias
  • John A Stonik
  • Maureen L Sampson
  • Cathy L Knapper
  • Stephen J Demosky
  • Yueqin Liu
  • Sara Alsaaty
  • Li Yuan Chen
  • James H Shelhamer
  • Rong Fong Shen
  • Wells W Wu
  • Matthew Ingham
  • Lester Leung
  • David Yui
  • Catherine A Meitin
  • Mario Stylianou
  • Dianne Miskinis-Hilligoss
  • Caitriona Buckley
  • Christian A Combs
  • Weidong Geng
  • Sura Alsaaty
  • Marion Lawrence
  • Dianne Miskinis

Detail Information

Publications32

  1. pmc From bedside to bench to clinic trials: identifying new treatments for severe asthma
    Amarjit Mishra
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Dis Model Mech 6:877-88. 2013
    ....
  2. pmc Apolipoprotein mimetic peptides: a new approach for the treatment of asthma
    Xianglan Yao
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute Bethesda, MD, USA
    Front Pharmacol 3:37. 2012
    ..Thus, site-directed delivery of inhaled apolipoprotein E or apolipoprotein A-I mimetic peptides may represent novel treatment approaches that can be developed for asthma, including severe disease...
  3. pmc Paradoxical effects of rapamycin on experimental house dust mite-induced asthma
    Karin Fredriksson
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e33984. 2012
    ..Thus, consistent with the context-dependent effects of rapamycin on inflammation, the timing of mTOR inhibition may be an important determinant of efficacy and toxicity in HDM-induced asthma...
  4. pmc Achieving symptom control in patients with moderate asthma
    Nargues A Weir
    The Advanced Lung Disease and Transplant Clinic, Inova Fairfax Hospital, Falls Church, VA
    Clin Med Insights Circ Respir Pulm Med 6:1-11. 2012
    ..Lastly, the development of new asthma treatments, perhaps based upon personalized medicine, may revolutionize the future treatment of moderate asthma...
  5. pmc Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes
    Stewart J Levine
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Building 10, Room 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Ann Intern Med 152:232-7. 2010
    ..Therefore, future clinical trials need to clearly establish the efficacy and safety of biological modifiers of Th2 immune pathways before these approaches can enter routine clinical practice for the treatment of severe asthma...
  6. pmc Molecular mechanisms of soluble cytokine receptor generation
    Stewart J Levine
    Pulmonary and Vascular Medicine Branch, NHLBI, NIH, Bethesda, MD 20892 1590, USA
    J Biol Chem 283:14177-81. 2008
    ....
  7. ncbi request reprint Proteomics of lung cell biology and pulmonary disease
    Stewart J Levine
    National Institutes of Health, Pulmonary Critical Care Medicine Branch, NHLBI, Building 10, Room 6D03, MSC 1590, Bethesda, MD 0892 1590, USA
    Expert Rev Respir Med 1:255-69. 2007
    ....
  8. ncbi request reprint Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells
    Stewart J Levine
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 289:L233-43. 2005
    ....
  9. ncbi request reprint Mechanisms of soluble cytokine receptor generation
    Stewart J Levine
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:5343-8. 2004
    ....
  10. pmc Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice
    Xianglan Yao
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 302:L206-15. 2012
    ..These results raise the possibility that the polymorphic apoE alleles may modify disease severity in human asthma...
  11. ncbi request reprint Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex
    Aminul Islam
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 281:6860-73. 2006
    ....
  12. ncbi request reprint An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding
    Xinle Cui
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 278:28677-85. 2003
    ..We propose that ARTS-1 is a multifunctional aminopeptidase that may modulate inflammatory events by promoting IL-6Ralpha and TNFR1 shedding...
  13. pmc Apolipoprotein A-I attenuates ovalbumin-induced neutrophilic airway inflammation via a granulocyte colony-stimulating factor-dependent mechanism
    Cuilian Dai
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Am J Respir Cell Mol Biol 47:186-95. 2012
    ..Furthermore, these findings suggest that apoA-I may play an important role in modulating the severity of neutrophilic airway inflammation in asthma...
  14. pmc Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway
    Xianglan Yao
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Am J Respir Crit Care Med 182:1228-38. 2010
    ..Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma...
  15. pmc 5A, an apolipoprotein A-I mimetic peptide, attenuates the induction of house dust mite-induced asthma
    Xianglan Yao
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:576-83. 2011
    ..These data support the conclusion that strategies using apoA-I mimetic peptides, such as 5A, might be developed further as a possible new treatment approach for asthma...
  16. ncbi request reprint Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding
    Xinle Cui
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    J Immunol 171:6814-9. 2003
    ....
  17. pmc An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release
    Barbara Adamik
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Biochem Biophys Res Commun 371:505-9. 2008
    ..This identifies RBMX as an ARTS-1-associated protein that regulates both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains...
  18. pmc The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses
    Karin Fredriksson
    Laboratory of Asthma and Lung Inflammation, Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:4497-509. 2014
    ..Collectively, these results identify a novel role for the VLDLR as a negative regulator of DC-mediated adaptive immune responses in HDM-induced allergic airway inflammation. ..
  19. ncbi request reprint Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch
    Caitriona A Buckley
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Inst, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1132-8. 2005
    ....
  20. pmc cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2
    Aminul Islam
    Pulmonary and Vascular Medicine Branch and Translational Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    J Biol Chem 283:25364-71. 2008
    ....
  21. pmc Circulating TNFR1 exosome-like vesicles partition with the LDL fraction of human plasma
    Jing Zhang
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 366:579-84. 2008
    ..Thus, a distinct population of TNFR1 exosome-like vesicles circulate in human plasma and may modulate TNF-mediated inflammation...
  22. pmc Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors
    Feras I Hawari
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:1297-302. 2004
    ....
  23. ncbi request reprint Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation
    Farshid N Rouhani
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Respir Med 99:1175-82. 2005
    ..To assess whether tumor necrosis factor (TNF) antagonism can attenuate eosinophilic airway inflammation in patients with mild-to-moderate allergic asthma...
  24. pmc New kids on the block: the emerging role of apolipoproteins in the pathogenesis and treatment of asthma
    Xianglan Yao
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Chest 140:1048-54. 2011
    ....
  25. ncbi request reprint The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles
    Aminul Islam
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 282:9591-9. 2007
    ..We conclude that the association between BIG2 and TNFR1 selectively regulates the extracellular release of TNFR1 exosome-like vesicles from human vascular endothelial cells via an ARF1- and ARF3-dependent mechanism...
  26. pmc Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways
    Man Yu
    Pulmonary and Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:1180-8. 2011
    ..Thus, the ability of dsRNA to induce the cleavage and shedding of the 34-kDa sTNFR1 from human bronchial epithelial cells represents a novel mechanism by which innate immune responses to viral infections are modulated...
  27. pmc Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein
    Christopher Looze
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building, Room 6D03, MSC 1590, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 378:433-8. 2009
    ..Given the important role of exosomes as intercellular messengers, the discovery of PPARgamma as a component of human plasma exosomes identifies a potential new pathway for the paracrine transfer of nuclear receptors...
  28. pmc A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages
    Hai yan Qi
    Critical Care Medicine Department, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:5286-92. 2011
    ..These data suggest that lipid mediators play a role in the regulation of autophagy, demonstrating a connection between the two seemingly separate innate immune responses, induction of autophagy and lipid mediator generation...
  29. pmc Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding
    Xinle Cui
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Clin Invest 110:515-26. 2002
    ..We propose that formation of a TNFR1-ARTS-1 molecular complex represents a novel mechanism by which TNFR1 shedding is regulated...
  30. pmc Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses
    Man Yu
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, United States
    Cytokine Growth Factor Rev 22:63-72. 2011
    ..This review focuses on signaling pathways mediated by TLR3, RLRs and the NLRP3 inflammasome, as well as the potential use of agonists and antagonists that target these pathways to treat disease...
  31. pmc Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis
    Boris L Vaisman
    Cardiovascular Pulmonary Branch, National Heart, Lung, and Blood Institute, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 53:158-67. 2012
    ..In summary, expression of hABCA1 in EC appears to play a role in decreasing diet-induced atherosclerosis in mice and is associated with increased plasma HDL-C levels and beneficial gene expression changes in EC...
  32. pmc Lymphatics in lung disease
    Souheil El-Chemaly
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Ann N Y Acad Sci 1131:195-202. 2008
    ..Understanding the role of lymphatics in human lung disease appears likely to contribute to the understanding of the pathogenesis of disease and the development of novel therapeutic targets...