Richard J Levine

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 194:1034-41. 2006
  2. ncbi request reprint Circulating angiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Clin Obstet Gynecol 48:372-86. 2005
  3. ncbi request reprint Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 190:707-13. 2004
  4. ncbi request reprint Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
  5. ncbi request reprint Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
  6. pmc Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study
    Richard J Levine
    Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Epidemiology, Statistics, and Prevention Research, Bethesda, MD 20892, USA
    BMJ 339:b4336. 2009
  7. pmc Circulating soluble endoglin and placental abruption
    Caroline Signore
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Prenat Diagn 28:852-8. 2008
  8. ncbi request reprint Urinary placental growth factor and risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    JAMA 293:77-85. 2005
  9. ncbi request reprint Circulating angiogenic factors and placental abruption
    Caroline Signore
    Epidemiology Branch and the Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Obstet Gynecol 108:338-44. 2006
  10. pmc Circulating angiogenic factors in gestational proteinuria without hypertension
    Alexander M Holston
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Am J Obstet Gynecol 200:392.e1-10. 2009

Detail Information

Publications32

  1. ncbi request reprint Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 194:1034-41. 2006
    ..The purpose of this study was to determine whether serum fms-like tyrosine kinase 1 (sFlt1) concentration during preeclampsia were associated with mid trimester blood pressure, other maternal characteristics, or pregnancy outcomes...
  2. ncbi request reprint Circulating angiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Clin Obstet Gynecol 48:372-86. 2005
  3. ncbi request reprint Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 190:707-13. 2004
    ..The purpose was to determine whether preeclampsia (PE) is caused by microfragments of syncytial trophoblast shed into the maternal circulation that stimulate an exaggerated inflammatory response...
  4. ncbi request reprint Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  5. ncbi request reprint Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  6. pmc Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study
    Richard J Levine
    Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Epidemiology, Statistics, and Prevention Research, Bethesda, MD 20892, USA
    BMJ 339:b4336. 2009
    ..To determine if pre-eclampsia is associated with reduced thyroid function during and after pregnancy...
  7. pmc Circulating soluble endoglin and placental abruption
    Caroline Signore
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Prenat Diagn 28:852-8. 2008
    ..Our objective was to investigate whether serum concentrations of a novel anti-angiogenic factor, soluble endoglin (sEng), could predict placental abruption...
  8. ncbi request reprint Urinary placental growth factor and risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    JAMA 293:77-85. 2005
    ..In the absence of glomerular disease leading to proteinuria, sFlt1 is too large a molecule to be filtered into the urine, while PlGF is readily filtered...
  9. ncbi request reprint Circulating angiogenic factors and placental abruption
    Caroline Signore
    Epidemiology Branch and the Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Obstet Gynecol 108:338-44. 2006
    ..Our objective was to determine whether circulating angiogenic factors are altered in another placental vascular disease, abruptio placentae...
  10. pmc Circulating angiogenic factors in gestational proteinuria without hypertension
    Alexander M Holston
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Am J Obstet Gynecol 200:392.e1-10. 2009
    ..Our goal was to determine whether obstetric outcomes and serum angiogenic factors are altered in women with gestational proteinuria without hypertension...
  11. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ....
  12. ncbi request reprint Pregnancy outcomes in smokers who develop pre-eclampsia
    Lauren A Beste
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Paediatr Perinat Epidemiol 19:12-8. 2005
    ..In conclusion, among women who developed pre-eclampsia, smoking during pregnancy was not associated with disease severity. We found no evidence that pre-eclampsia and smoking act synergistically to restrict fetal growth...
  13. ncbi request reprint Glucose tolerance and risk of gestational diabetes mellitus in nulliparous women who smoke during pregnancy
    Lucinda J England
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 160:1205-13. 2004
    ..9, 95% confidence interval: 1.0, 3.6). These findings support an association between smoking and gestational diabetes mellitus...
  14. ncbi request reprint Smoking before pregnancy and risk of gestational hypertension and preeclampsia
    Lucinda J England
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Am J Obstet Gynecol 186:1035-40. 2002
    ..Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia...
  15. ncbi request reprint Adverse pregnancy outcomes in snuff users
    Lucinda J England
    Division of Epidemiology, Statistics, and Prevention Research, Department of Health and Human Services, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 189:939-43. 2003
    ..The purpose of the study was to evaluate the effects of smokeless tobacco use during pregnancy...
  16. doi request reprint Maternal serum theobromine and the development of preeclampsia
    Mark A Klebanoff
    Epidemiology Branch, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Epidemiology 20:727-32. 2009
    ....
  17. ncbi request reprint Maternal serum caffeine metabolites and small-for-gestational age birth
    Mark A Klebanoff
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    Am J Epidemiol 155:32-7. 2002
    ..07. The authors conclude that maternal third-trimester serum paraxanthine concentration, which reflects caffeine consumption, was associated with a higher risk of reduced fetal growth, particularly among women who smoked...
  18. pmc Folate and vitamin B12 in idiopathic male infertility
    Laurel E Murphy
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Asian J Androl 13:856-61. 2011
    ..Although additional data are needed to confirm these initial findings, our results suggest that PEMT and TCblR, genes involved in choline and B12 metabolism, merit further investigation in idiopathic male infertility...
  19. ncbi request reprint Reliability of maternal recall and reporting of child births and deaths in rural Egypt
    Malla R Rao
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Paediatr Perinat Epidemiol 17:125-31. 2003
    ....
  20. ncbi request reprint Circulating angiogenic proteins in trisomy 13
    Yuval Bdolah
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 194:239-45. 2006
    ..This may then contribute to the increased risk of preeclampsia that has been observed in these patients. Our objective was to characterize the maternal circulating angiogenic proteins in trisomy 13 pregnancies...
  21. ncbi request reprint Abortion, changed paternity, and risk of preeclampsia in nulliparous women
    Audrey F Saftlas
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Am J Epidemiol 157:1108-14. 2003
    ..An immune-based etiologic mechanism is proposed, whereby prolonged exposure to fetal antigens from a previous pregnancy protects against preeclampsia in a subsequent pregnancy with the same father...
  22. ncbi request reprint Neonatal outcomes in pregnancies with preeclampsia or gestational hypertension and in normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation
    Mounira Habli
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 197:406.e1-7. 2007
    ..The purpose of this study was to compare neonatal outcomes of pregnancies with preeclampsia or gestational hypertension with those of normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation separately...
  23. ncbi request reprint Misclassification of maternal smoking status and its effects on an epidemiologic study of pregnancy outcomes
    Lucinda J England
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 9:1005-13. 2007
    ..The potential for this type of bias should be considered when conducting and interpreting epidemiologic studies of smoking and pregnancy outcomes...
  24. ncbi request reprint Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia
    Sarosh Rana
    Maternal Fetal Medicine Division, Women and Infants Hospital, Brown University, Providence, RI, USA
    Hypertension 50:137-42. 2007
    ..In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia...
  25. ncbi request reprint Angiogenic factors and preeclampsia
    May Lee Tjoa
    Department of Medicine, Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Front Biosci 12:2395-402. 2007
    ..This review will focus on the role of angiogenic factors in normal and abnormal placental development and indicate how measurement of circulating angiogenic factors may help identify women at risk of preeclampsia...
  26. ncbi request reprint First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  27. ncbi request reprint Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Hypertension 43:988-92. 2004
    ..1, 95% CI 1.7 to 134.9; high PlGF and low SHBG, OR 4.1, 95% CI 0.45 to 38.2; low PlGF and high SHBG, OR 8.7, 95% CI 1.2 to 60.3. Altered angiogenesis and insulin resistance are additive insults that lead to preeclampsia...
  28. ncbi request reprint Twenty-four-hour urine insulin as a measure of hyperinsulinaemia/insulin resistance before onset of pre-eclampsia and gestational hypertension
    Stephen P Emery
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    BJOG 112:1479-85. 2005
    ..To evaluate levels of 24-hour urine insulin excretion before the onset of pre-eclampsia and gestational hypertension...
  29. ncbi request reprint Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study
    Yasir Ruhayel
    CRC, Department of Clinical Sciences, Lund University, Malmo University Hospital, Malmo, Sweden
    Clin Endocrinol (Oxf) 67:85-92. 2007
    ....
  30. ncbi request reprint Increased risk of preeclampsia among nulliparous pregnant women with idiopathic hematuria
    Catherine O Stehman-Breen
    Division of Nephrology, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Obstet Gynecol 187:703-8. 2002
    ..Our purpose was to determine the risk of preeclampsia and gestational hypertension among nulliparous pregnant women with idiopathic hematuria...
  31. ncbi request reprint The interval between pregnancies and preeclampsia
    Audrey F Saftlas
    N Engl J Med 346:1831-2; author reply 1831-2. 2002
  32. ncbi request reprint Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia
    Richard J Levine
    Am J Obstet Gynecol 186:1107; author reply 1108. 2002