Research Topics
| Gabriele S LeverichSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The poor prognosis of childhood-onset bipolar disorderGabriele S Leverich
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Pediatr 150:485-90. 2007..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthoodRobert M Post
Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
J Clin Psychiatry 71:864-72. 2010..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...- Course of bipolar illness after history of childhood traumaGabriele S Leverich
Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
Lancet 367:1040-2. 2006 - Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizersGabriele S Leverich
Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
Am J Psychiatry 163:232-9. 2006..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression... - Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and GermanyRobert M Post
Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
Int Clin Psychopharmacol 26:96-106. 2011.... - Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Clin Psychiatry 66:370-4. 2005..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness... - Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatientsRobert M Post
Bipolar Collaborative Network, Bethesda, Maryland, USA
J Clin Psychiatry 73:924-30. 2012..The long-term impact of prior antidepressant exposure on the subsequent course of bipolar illness remains controversial... - Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar NetworkGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Clin Psychiatry 64:506-15. 2003..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder... - A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar NetworkRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:396-406. 2003..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations... - An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)Robert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:310-9. 2003..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed... - Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart methodRobert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
J Clin Psychiatry 64:680-90; quiz 738-9. 2003..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated... - Early physical and sexual abuse associated with an adverse course of bipolar illnessGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892-1272, USA
Biol Psychiatry 51:288-97. 2002.... - Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disordersGabriela V Obrocea
National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
Biol Psychiatry 51:253-60. 2002..These preliminary data in a treatment refractory subgroup may help in the further definition of the range of clinical utility of these widely used anticonvulsants... - Earliest symptoms discriminating juvenile-onset bipolar illness from ADHDDavid A Luckenbaugh
Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
Bipolar Disord 11:441-51. 2009.... - Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorderKirk D Denicoff
Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Depress Anxiety 15:1-9. 2002.... - Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar childrenEmily L Fergus
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
J Affect Disord 77:71-8. 2003..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community... - Parental attitudes towards early intervention in children at high risk for affective disordersRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg. 10, Rm. 3S239, 10 Center Drive, MSC-1272, Bethesda, MD 20892-1272, USA
J Affect Disord 70:117-24. 2002.... - A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disordersSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Bipolar Disord 9:426-34. 2007..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD... - A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depressionMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
Am J Psychiatry 164:1242-9. 2007..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue... - Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorderRalph W Kupka
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 9:531-5. 2007..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder... - Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHDRobert M Post
J Clin Psychiatry 65:898-902. 2004 - Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment NetworkTrisha Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
Int Clin Psychopharmacol 22:376-81. 2007..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted... - Incidence of childhood-onset bipolar illness in the USA and EuropeRobert M Post
Department of Psychiatry, George Washington University, Washington, DC, USA
Br J Psychiatry 192:150-1. 2008..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration... - High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposureRalph W Kupka
Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
Biol Psychiatry 51:305-11. 2002..These variables appear to be independent risk factors for the development of hypothyroidism, especially in women with bipolar disorder... - Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholismEric Levander
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
J Affect Disord 101:211-7. 2007..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)... - Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trialSusan L McElroy
Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
J Affect Disord 101:275-81. 2007..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole... - New findings from the Bipolar Collaborative Network: clinical implications for therapeuticsRobert M Post
Penn State College of Medicine, Hershey, PA, USA
Curr Psychiatry Rep 8:489-97. 2006..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss... - Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar NetworkWillem A Nolen
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Am J Psychiatry 161:1447-54. 2004..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder... - Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trialSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:617-24. 2005..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002... - Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatientsRalph W Kupka
Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
Am J Psychiatry 162:1273-80. 2005..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective... - Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
Am J Psychiatry 160:883-9. 2003..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study... - Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 60:1020-2. 2006..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder... - Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
J Clin Psychiatry 67:1551-60. 2006..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder... - Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenonTrisha Suppes
Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
Arch Gen Psychiatry 62:1089-96. 2005..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved... - Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studiesRalph W Kupka
Altrecht Institute for Mental Health Care and University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Psychiatry 64:1483-94. 2003..Several risk factors have been suggested to be associated with rapid cycling. The purpose of this meta-analysis was to compare clinical studies for the evidence of discriminating factors between rapid and non-rapid cycling... - Are bipolar mood symptoms affected by the phase of the menstrual cycle?Geetha Shivakumar
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
J Womens Health (Larchmt) 17:473-8. 2008..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue... - High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorderM Nadine Breunis
Department of Immunology, Erasmus University Rotterdam (MNB, HAD, Rotterdam, The Netherlands
Biol Psychiatry 53:157-65. 2003..CONCLUSION: The T cell system was found to be activated in both symptomatic and euthymic patients with bipolar disorder. The pathophysiological significance of these findings remains to be explored... - Correlates of overweight and obesity in 644 patients with bipolar disorderSusan L McElroy
Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
J Clin Psychiatry 63:207-13. 2002....