Gabriele S Leverich

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
  2. ncbi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
  3. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
  4. ncbi request reprint Course of bipolar illness after history of childhood trauma
    Gabriele S Leverich
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Lancet 367:1040-2. 2006
  5. doi request reprint Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Int Clin Psychopharmacol 26:96-106. 2011
  6. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
  7. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
  8. doi request reprint Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
  9. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
  10. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003

Collaborators

Detail Information

Publications39

  1. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  2. ncbi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
    ..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...
  3. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  4. ncbi request reprint Course of bipolar illness after history of childhood trauma
    Gabriele S Leverich
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Lancet 367:1040-2. 2006
  5. doi request reprint Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Int Clin Psychopharmacol 26:96-106. 2011
    ....
  6. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  7. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  8. doi request reprint Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
    ..The long-term impact of prior antidepressant exposure on the subsequent course of bipolar illness remains controversial...
  9. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  10. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  11. doi request reprint Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, 5415 West Cedar Lane Suite 201B, Bethesda, MD 20814, USA
    J Affect Disord 147:288-94. 2013
    ....
  12. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  13. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  14. ncbi request reprint Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients...
  15. doi request reprint Earliest symptoms discriminating juvenile-onset bipolar illness from ADHD
    David A Luckenbaugh
    Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Bipolar Disord 11:441-51. 2009
    ....
  16. ncbi request reprint Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorder
    Kirk D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 15:1-9. 2002
    ....
  17. ncbi request reprint Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children
    Emily L Fergus
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    J Affect Disord 77:71-8. 2003
    ..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community...
  18. ncbi request reprint Parental attitudes towards early intervention in children at high risk for affective disorders
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Affect Disord 70:117-24. 2002
    ....
  19. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  20. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  21. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  22. ncbi request reprint Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  23. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  24. doi request reprint Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  25. ncbi request reprint High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
    Ralph W Kupka
    Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
    Biol Psychiatry 51:305-11. 2002
    ..We assessed the prevalence of thyroperoxidase antibodies (TPO-Abs) and thyroid failure in outpatients with bipolar disorder compared with two control groups...
  26. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  27. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  28. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  29. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  30. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  31. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  32. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  33. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  34. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  35. ncbi request reprint New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  36. ncbi request reprint Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studies
    Ralph W Kupka
    Altrecht Institute for Mental Health Care and University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 64:1483-94. 2003
    ..Several risk factors have been suggested to be associated with rapid cycling. The purpose of this meta-analysis was to compare clinical studies for the evidence of discriminating factors between rapid and non-rapid cycling...
  37. ncbi request reprint High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder
    M Nadine Breunis
    Department of Immunology, Erasmus University Rotterdam MNB, HAD, Rotterdam, The Netherlands
    Biol Psychiatry 53:157-65. 2003
    ..In the present study, we investigated other signs of immune activation in bipolar patients, in particular an activation of the T cell system...
  38. ncbi request reprint Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  39. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...